Mutagenetix > Incidental Mutation

Incidental Mutation 'K3955:Fcrl6'

67218

Institutional Source

Beutler Lab

Gene Symbol

Fcrl6

Ensembl Gene

ENSMUSG00000070504

Gene Name

Fc receptor-like 6

Synonyms

FcRH6, moFcRH6, mIFGP6, ENSMUSG00000070504

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

K3955 (G3) of strain 706

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

172424209-172430118 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 172425251 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 260 (V260A)

Ref Sequence

ENSEMBL: ENSMUSP00000091861 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094303]

AlphaFold

A1YIY0

Predicted Effect

probably benign
Transcript: ENSMUST00000094303
AA Change: V260A

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)

SMART Domains

Protein: ENSMUSP00000091861
Gene: ENSMUSG00000070504
AA Change: V260A

Domain	Start	End	E-Value	Type
signal peptide	1	16	N/A	INTRINSIC
Pfam:Ig_3	19	91	1.2e-4	PFAM
Pfam:Ig_2	20	106	8e-9	PFAM
Pfam:Ig_3	113	187	1.9e-9	PFAM
transmembrane domain	215	237	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000193431

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000193566

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.5%
3x: 98.9%
10x: 97.4%
20x: 94.9%

Validation Efficiency

100% (42/42)

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Agap1	G	A	1: 89,815,326 (GRCm39)	R738H	probably damaging	Het
Arhgap28	T	C	17: 68,311,001 (GRCm39)	E2G	probably damaging	Het
Atad2b	C	A	12: 5,004,536 (GRCm39)		probably benign	Het
Atmin	T	A	8: 117,683,775 (GRCm39)	C478*	probably null	Het
Calr	T	C	8: 85,572,902 (GRCm39)	Y57C	probably damaging	Het
Cdh13	G	A	8: 119,401,843 (GRCm39)	V82M	probably damaging	Het
Ces3a	A	T	8: 105,777,259 (GRCm39)		probably benign	Het
Dmbt1	T	C	7: 130,721,293 (GRCm39)	Y1854H	probably damaging	Het
Dnah1	T	A	14: 30,988,416 (GRCm39)	M3429L	probably benign	Het
Dscam	A	G	16: 96,474,887 (GRCm39)	F1225S	probably benign	Het
E030025P04Rik	G	A	11: 109,034,778 (GRCm39)	P37S	unknown	Het
Eral1	A	T	11: 77,966,847 (GRCm39)	D189E	probably damaging	Het
Fbxw14	G	T	9: 109,105,313 (GRCm39)	P284Q	possibly damaging	Het
Fezf2	A	T	14: 12,345,097 (GRCm38)	F30Y	probably damaging	Het
Gjb4	A	T	4: 127,245,293 (GRCm39)	V216D	probably benign	Het
Gm9758	G	A	5: 14,963,522 (GRCm39)		probably benign	Het
Gm9758	C	G	5: 14,963,553 (GRCm39)	V92L	probably benign	Het
Gmps	A	C	3: 63,908,954 (GRCm39)	R485S	probably damaging	Het
Gtdc1	C	T	2: 44,642,233 (GRCm39)		probably null	Het
H2-Ob	C	T	17: 34,460,158 (GRCm39)	R19C	probably damaging	Het
Lars2	T	C	9: 123,206,842 (GRCm39)	V103A	probably damaging	Het
Mtrex	A	C	13: 113,047,513 (GRCm39)	Y277*	probably null	Het
Ndnf	G	A	6: 65,678,413 (GRCm39)		probably benign	Het
Nectin1	A	G	9: 43,703,375 (GRCm39)	Y211C	probably damaging	Het
Notch4	C	T	17: 34,787,436 (GRCm39)	T332I	probably damaging	Het
Or13c25	A	G	4: 52,911,081 (GRCm39)	F238L	probably damaging	Het
Or8g28	A	C	9: 39,169,926 (GRCm39)	L14W	probably damaging	Het
Or8g53	A	G	9: 39,683,469 (GRCm39)	I209T	probably benign	Het
Paf1	T	C	7: 28,096,350 (GRCm39)		probably null	Het
Pcdhb1	G	T	18: 37,399,026 (GRCm39)	G326C	probably damaging	Het
Plcl1	A	G	1: 55,737,098 (GRCm39)	Y813C	possibly damaging	Het
Pramel25	T	C	4: 143,521,710 (GRCm39)	I442T	possibly damaging	Het
Prkcq	T	C	2: 11,251,604 (GRCm39)		probably benign	Het
Proser3	G	T	7: 30,242,924 (GRCm39)	P218T	probably damaging	Het
Rccd1	G	A	7: 79,970,419 (GRCm39)	S66F	probably benign	Het
Recql	G	T	6: 142,323,932 (GRCm39)	S54*	probably null	Het
Samd15	G	T	12: 87,247,534 (GRCm39)	G73V	probably benign	Het
Siglec1	T	C	2: 130,923,359 (GRCm39)	N462S	probably benign	Het
Syne2	G	T	12: 75,977,439 (GRCm39)	A1296S	probably damaging	Het
Tlk1	T	C	2: 70,552,045 (GRCm39)	E542G	possibly damaging	Het
Tnks1bp1	C	T	2: 84,892,755 (GRCm39)	T232I	probably benign	Het
Tnrc6c	T	A	11: 117,651,564 (GRCm39)	Y1696N	probably damaging	Het
Uggt1	A	G	1: 36,201,434 (GRCm39)	I1102T	probably benign	Het
Vmn1r84	C	T	7: 12,095,884 (GRCm39)	V270M	probably damaging	Het
Wasf1	C	T	10: 40,812,191 (GRCm39)	P327S	unknown	Het

Other mutations in Fcrl6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00903:Fcrl6	APN	1	172,426,674 (GRCm39)	missense	probably benign	0.08
IGL01074:Fcrl6	APN	1	172,426,680 (GRCm39)	missense	possibly damaging	0.89
IGL02146:Fcrl6	APN	1	172,426,264 (GRCm39)	missense	probably benign	0.01
IGL02277:Fcrl6	APN	1	172,426,686 (GRCm39)	missense	probably damaging	1.00
IGL03162:Fcrl6	APN	1	172,425,820 (GRCm39)	missense	probably damaging	1.00
IGL03303:Fcrl6	APN	1	172,425,255 (GRCm39)	missense	probably damaging	0.99
R0051:Fcrl6	UTSW	1	172,426,320 (GRCm39)	missense	probably benign	0.24
R0051:Fcrl6	UTSW	1	172,426,320 (GRCm39)	missense	probably benign	0.24
R1336:Fcrl6	UTSW	1	172,426,791 (GRCm39)	nonsense	probably null
R2125:Fcrl6	UTSW	1	172,426,815 (GRCm39)	missense	probably benign	0.41
R2126:Fcrl6	UTSW	1	172,426,815 (GRCm39)	missense	probably benign	0.41
R5376:Fcrl6	UTSW	1	172,426,847 (GRCm39)	missense	probably damaging	1.00
R5395:Fcrl6	UTSW	1	172,426,287 (GRCm39)	missense	possibly damaging	0.55
R6314:Fcrl6	UTSW	1	172,426,186 (GRCm39)	splice site	probably null
R7525:Fcrl6	UTSW	1	172,425,239 (GRCm39)	missense	probably benign	0.25
R7690:Fcrl6	UTSW	1	172,426,223 (GRCm39)	missense	probably damaging	0.97
R8033:Fcrl6	UTSW	1	172,426,748 (GRCm39)	missense	probably benign	0.03
R8894:Fcrl6	UTSW	1	172,426,856 (GRCm39)	missense	probably benign	0.05
U24488:Fcrl6	UTSW	1	172,426,437 (GRCm39)	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- GCTCAGAAGAGAACCCACAGTTCAG -3'
(R):5'- GAATGTCTCTCCTTCCACAGCCAG -3'

Sequencing Primer
(F):5'- GGCAAATGGGCTTTCTCAC -3'
(R):5'- TTCCACAGCCAGACCTGAG -3'

Posted On

2013-09-03