Incidental Mutation 'R8811:Or6f1'
ID 672406
Institutional Source Beutler Lab
Gene Symbol Or6f1
Ensembl Gene ENSMUSG00000054498
Gene Name olfactory receptor family 6 subfamily F member 1
Synonyms Olfr308, GA_x6K02T2NHDJ-9786435-9787361, MOR104-1
MMRRC Submission 068646-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.121) question?
Stock # R8811 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 85970232-85971158 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 85970989 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Methionine at position 57 (T57M)
Ref Sequence ENSEMBL: ENSMUSP00000150391 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044256] [ENSMUST00000214977]
AlphaFold Q8VFP2
Predicted Effect probably damaging
Transcript: ENSMUST00000044256
AA Change: T57M

PolyPhen 2 Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000049454
Gene: ENSMUSG00000054498
AA Change: T57M

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.3e-53 PFAM
Pfam:7tm_1 41 290 2.2e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214977
AA Change: T57M

PolyPhen 2 Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (54/54)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca17 T G 17: 24,536,212 (GRCm39) K485T probably benign Het
Abcc12 G T 8: 87,280,023 (GRCm39) L337M probably damaging Het
Adcy4 T C 14: 56,010,221 (GRCm39) D687G probably benign Het
Aldoc T A 11: 78,215,610 (GRCm39) I98N probably damaging Het
Aoah T A 13: 21,184,121 (GRCm39) V395D probably damaging Het
Arap1 C T 7: 101,036,403 (GRCm39) R397W probably damaging Het
Arl16 A T 11: 120,357,526 (GRCm39) M63K probably damaging Het
Atf7 T C 15: 102,502,144 (GRCm39) D4G probably damaging Het
Atp6v0d2 A T 4: 19,922,397 (GRCm39) V34D probably benign Het
Calhm4 T A 10: 33,917,661 (GRCm39) K263N probably benign Het
Camk1g C G 1: 193,044,408 (GRCm39) G2A probably damaging Het
Cenpe A G 3: 134,929,001 (GRCm39) T302A probably damaging Het
Cps1 T C 1: 67,253,246 (GRCm39) V1246A probably benign Het
Csmd3 T C 15: 47,560,139 (GRCm39) D1397G Het
Ddx39b T A 17: 35,463,435 (GRCm39) S115T probably benign Het
Dnaja3 C A 16: 4,514,383 (GRCm39) T305K probably benign Het
Dusp7 C G 9: 106,248,241 (GRCm39) H290D probably benign Het
Emilin2 T A 17: 71,582,282 (GRCm39) D148V possibly damaging Het
Erbin C T 13: 104,022,824 (GRCm39) R5Q probably damaging Het
Fam3b T C 16: 97,313,715 (GRCm39) probably benign Het
Foxn3 T C 12: 99,162,951 (GRCm39) S317G probably benign Het
Gipc1 T A 8: 84,388,919 (GRCm39) M177K possibly damaging Het
Grpel2 A C 18: 61,851,823 (GRCm39) probably benign Het
Htr1a G C 13: 105,581,101 (GRCm39) A114P probably damaging Het
Iqch A T 9: 63,452,195 (GRCm39) M210K possibly damaging Het
Kdelr3 T C 15: 79,410,052 (GRCm39) I179T possibly damaging Het
Lat2 C T 5: 134,635,553 (GRCm39) probably benign Het
Mcrip1 A G 11: 120,435,605 (GRCm39) V10A probably damaging Het
Mib1 C T 18: 10,755,643 (GRCm39) L350F probably benign Het
Nhlrc2 T A 19: 56,583,344 (GRCm39) V605E probably benign Het
Nup133 AAGAGA AAGA 8: 124,638,627 (GRCm39) 900 probably null Het
Nutm2 A T 13: 50,623,989 (GRCm39) I229F probably benign Het
Phkb T C 8: 86,745,156 (GRCm39) V611A possibly damaging Het
Polg2 A T 11: 106,670,208 (GRCm39) Y21N probably benign Het
Prss28 T A 17: 25,528,627 (GRCm39) I23N probably benign Het
Ptprz1 G A 6: 23,030,661 (GRCm39) V1856I probably benign Het
Slc22a22 A T 15: 57,108,237 (GRCm39) I526N probably damaging Het
Slc24a4 T C 12: 102,180,133 (GRCm39) F68S probably damaging Het
Slc37a3 A G 6: 39,322,274 (GRCm39) S377P probably damaging Het
Smoc2 T C 17: 14,545,896 (GRCm39) S62P probably damaging Het
Sox4 A G 13: 29,136,911 (GRCm39) S32P probably damaging Het
Stxbp2 A T 8: 3,689,541 (GRCm39) Q426L Het
Synrg T G 11: 83,910,410 (GRCm39) S937A probably benign Het
Tbr1 C A 2: 61,642,196 (GRCm39) T487K possibly damaging Het
Tll2 T C 19: 41,195,012 (GRCm39) T25A probably benign Het
Trim31 T C 17: 37,210,875 (GRCm39) F169S probably benign Het
Tro G A X: 149,438,555 (GRCm39) S34L unknown Het
Tspear T C 10: 77,665,463 (GRCm39) F83S probably benign Het
Ubr5 C A 15: 38,041,123 (GRCm39) A254S Het
Ubtfl1 A G 9: 18,321,459 (GRCm39) E329G probably benign Het
Vmn2r45 A G 7: 8,474,881 (GRCm39) W716R probably damaging Het
Vmn2r67 T C 7: 84,799,895 (GRCm39) M448V probably damaging Het
Wwc2 T G 8: 48,336,579 (GRCm39) I228L possibly damaging Het
Zbtb20 T C 16: 43,430,857 (GRCm39) V383A probably benign Het
Other mutations in Or6f1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01113:Or6f1 APN 7 85,970,361 (GRCm39) missense probably benign
IGL03141:Or6f1 APN 7 85,970,909 (GRCm39) missense probably damaging 0.97
PIT4519001:Or6f1 UTSW 7 85,970,941 (GRCm39) missense probably damaging 1.00
R0206:Or6f1 UTSW 7 85,970,854 (GRCm39) missense probably benign 0.22
R0206:Or6f1 UTSW 7 85,970,854 (GRCm39) missense probably benign 0.22
R0401:Or6f1 UTSW 7 85,970,500 (GRCm39) missense probably benign 0.02
R2132:Or6f1 UTSW 7 85,970,687 (GRCm39) missense possibly damaging 0.94
R3983:Or6f1 UTSW 7 85,970,942 (GRCm39) missense probably damaging 1.00
R4596:Or6f1 UTSW 7 85,970,631 (GRCm39) missense probably damaging 1.00
R5532:Or6f1 UTSW 7 85,970,879 (GRCm39) missense possibly damaging 0.90
R7326:Or6f1 UTSW 7 85,970,782 (GRCm39) missense probably damaging 0.99
R7480:Or6f1 UTSW 7 85,970,888 (GRCm39) missense probably benign 0.18
R8746:Or6f1 UTSW 7 85,970,437 (GRCm39) missense probably damaging 1.00
R8971:Or6f1 UTSW 7 85,970,369 (GRCm39) missense possibly damaging 0.71
R9497:Or6f1 UTSW 7 85,970,989 (GRCm39) missense probably damaging 0.98
R9666:Or6f1 UTSW 7 85,970,444 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TAGCGGTCATAAGCCATGGC -3'
(R):5'- CTTCTGGACTTTAAGTTTCAGTGAG -3'

Sequencing Primer
(F):5'- CTGCCAAGAGGAAGTATTCTGTGC -3'
(R):5'- GTTTGAAAATCAGCACCATGATCAC -3'
Posted On 2021-04-30