Incidental Mutation 'R8812:Lrp6'
| ID |
672484 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lrp6
|
| Ensembl Gene |
ENSMUSG00000030201 |
| Gene Name |
low density lipoprotein receptor-related protein 6 |
| Synonyms |
ska, Cd, skax26, ska26 |
| MMRRC Submission |
068647-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.964)
|
| Stock # |
R8812 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
134423439-134543876 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 134433141 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Leucine
at position 1397
(M1397L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000032322
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000032322]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000032322
AA Change: M1397L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000032322
Gene: ENSMUSG00000030201
AA Change: M1397L
| Domain | Start | End | E-Value | Type |
|---|
|
LY
|
43 |
85 |
1.55e-2 |
SMART |
|
LY
|
87 |
129 |
1.91e-11 |
SMART |
|
LY
|
130 |
173 |
5.19e-13 |
SMART |
|
LY
|
174 |
216 |
1.39e-13 |
SMART |
|
LY
|
217 |
258 |
2.87e-6 |
SMART |
|
EGF
|
285 |
324 |
2.16e-1 |
SMART |
|
low complexity region
|
330 |
341 |
N/A |
INTRINSIC |
|
LY
|
352 |
394 |
1.29e-8 |
SMART |
|
LY
|
395 |
437 |
5.73e-15 |
SMART |
|
LY
|
438 |
481 |
1.07e-14 |
SMART |
|
LY
|
482 |
524 |
3.07e-15 |
SMART |
|
LY
|
525 |
565 |
4.66e-6 |
SMART |
|
EGF
|
591 |
628 |
1.47e-3 |
SMART |
|
LY
|
654 |
696 |
2.06e-7 |
SMART |
|
LY
|
697 |
739 |
3.73e-14 |
SMART |
|
LY
|
740 |
783 |
3.37e-12 |
SMART |
|
LY
|
784 |
825 |
1.17e-6 |
SMART |
|
LY
|
827 |
865 |
1.91e-2 |
SMART |
|
EGF
|
892 |
930 |
7.35e-4 |
SMART |
|
LY
|
957 |
999 |
1.41e-5 |
SMART |
|
LY
|
1005 |
1048 |
5.32e-1 |
SMART |
|
LY
|
1049 |
1093 |
5e-6 |
SMART |
|
LY
|
1094 |
1136 |
4.25e-9 |
SMART |
|
LY
|
1137 |
1177 |
1.91e-2 |
SMART |
|
EGF
|
1206 |
1250 |
1.23e1 |
SMART |
|
LDLa
|
1248 |
1287 |
2.42e-12 |
SMART |
|
LDLa
|
1288 |
1324 |
4.37e-10 |
SMART |
|
LDLa
|
1325 |
1362 |
1.66e-10 |
SMART |
|
transmembrane domain
|
1371 |
1393 |
N/A |
INTRINSIC |
|
low complexity region
|
1429 |
1438 |
N/A |
INTRINSIC |
|
low complexity region
|
1444 |
1457 |
N/A |
INTRINSIC |
|
low complexity region
|
1508 |
1524 |
N/A |
INTRINSIC |
|
low complexity region
|
1566 |
1573 |
N/A |
INTRINSIC |
|
low complexity region
|
1596 |
1608 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009]
PHENOTYPE: Animals homozygous for this mutation exhibit partial embryonic lethality, growth retardation, crooked tail, abnormal vertebrae, small skull with occasional bent nose, absence of the third molars and small and/or unerupted lower incisors. Heterozygotes exhibit a crooked tail and abnormal vertebrae. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 81 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2210408I21Rik |
C |
A |
13: 77,480,471 (GRCm39) |
P1167Q |
probably damaging |
Het |
| Abtb3 |
A |
G |
10: 85,463,113 (GRCm39) |
Q626R |
probably damaging |
Het |
| Adcy10 |
A |
T |
1: 165,378,867 (GRCm39) |
Q885H |
probably damaging |
Het |
| Alkal2 |
C |
T |
12: 30,940,055 (GRCm39) |
L139F |
probably damaging |
Het |
| Ankrd17 |
A |
T |
5: 90,441,062 (GRCm39) |
M439K |
probably benign |
Het |
| Arl11 |
C |
A |
14: 61,548,422 (GRCm39) |
Y77* |
probably null |
Het |
| Bcas3 |
T |
C |
11: 85,449,973 (GRCm39) |
Y669H |
probably benign |
Het |
| Bpifb3 |
C |
T |
2: 153,764,516 (GRCm39) |
A136V |
probably benign |
Het |
| Ccne2 |
A |
G |
4: 11,202,279 (GRCm39) |
T345A |
probably benign |
Het |
| Ciz1 |
T |
C |
2: 32,254,286 (GRCm39) |
S76P |
probably benign |
Het |
| Clip4 |
A |
T |
17: 72,107,800 (GRCm39) |
K94* |
probably null |
Het |
| Cthrc1 |
G |
A |
15: 38,947,866 (GRCm39) |
R195H |
probably damaging |
Het |
| Ddx31 |
T |
C |
2: 28,730,816 (GRCm39) |
|
probably benign |
Het |
| Elf2 |
T |
A |
3: 51,174,188 (GRCm39) |
D113V |
possibly damaging |
Het |
| Esrrb |
A |
G |
12: 86,535,324 (GRCm39) |
N155S |
probably benign |
Het |
| Flnb |
A |
G |
14: 7,887,624 (GRCm38) |
D478G |
probably benign |
Het |
| Galm |
T |
A |
17: 80,435,215 (GRCm39) |
L24H |
probably damaging |
Het |
| Gask1b |
T |
C |
3: 79,816,078 (GRCm39) |
S363P |
possibly damaging |
Het |
| Gon4l |
G |
A |
3: 88,802,314 (GRCm39) |
G975D |
possibly damaging |
Het |
| Hspbp1 |
T |
G |
7: 4,667,783 (GRCm39) |
M237L |
probably benign |
Het |
| Ighv1-62-1 |
A |
T |
12: 115,350,367 (GRCm39) |
M100K |
probably damaging |
Het |
| Ipo8 |
A |
T |
6: 148,676,575 (GRCm39) |
D971E |
possibly damaging |
Het |
| Itgax |
C |
T |
7: 127,732,979 (GRCm39) |
A286V |
probably damaging |
Het |
| Jpt2 |
T |
C |
17: 25,179,578 (GRCm39) |
Q3R |
probably benign |
Het |
| Katnip |
A |
C |
7: 125,396,867 (GRCm39) |
R309S |
probably benign |
Het |
| Klrg2 |
A |
C |
6: 38,613,838 (GRCm39) |
L55R |
probably damaging |
Het |
| Lrrc31 |
T |
A |
3: 30,733,328 (GRCm39) |
Q462L |
probably benign |
Het |
| Lyg2 |
T |
A |
1: 37,949,054 (GRCm39) |
I103F |
probably damaging |
Het |
| Map10 |
T |
C |
8: 126,396,664 (GRCm39) |
V19A |
probably damaging |
Het |
| Map1b |
T |
A |
13: 99,569,323 (GRCm39) |
M1133L |
unknown |
Het |
| Mrgpra4 |
A |
G |
7: 47,631,481 (GRCm39) |
V40A |
probably benign |
Het |
| Myh1 |
G |
A |
11: 67,099,967 (GRCm39) |
G626R |
probably benign |
Het |
| Myo9a |
T |
C |
9: 59,687,030 (GRCm39) |
V45A |
probably benign |
Het |
| Ncdn |
A |
G |
4: 126,638,905 (GRCm39) |
F638S |
possibly damaging |
Het |
| Ncs1 |
T |
A |
2: 31,174,213 (GRCm39) |
M121K |
probably damaging |
Het |
| Nf1 |
T |
C |
11: 79,437,180 (GRCm39) |
V16A |
probably damaging |
Het |
| Nktr |
T |
A |
9: 121,579,317 (GRCm39) |
D1128E |
unknown |
Het |
| Nup205 |
T |
G |
6: 35,191,269 (GRCm39) |
L1000R |
probably damaging |
Het |
| Obscn |
T |
C |
11: 58,925,921 (GRCm39) |
E5604G |
probably damaging |
Het |
| Or1p4-ps1 |
T |
A |
11: 74,208,534 (GRCm39) |
S228T |
unknown |
Het |
| Or2p2 |
T |
C |
13: 21,257,220 (GRCm39) |
N84D |
probably damaging |
Het |
| Or4a68 |
A |
G |
2: 89,270,209 (GRCm39) |
V138A |
probably benign |
Het |
| Or4c35 |
G |
T |
2: 89,808,715 (GRCm39) |
A198S |
possibly damaging |
Het |
| Or51ah3 |
G |
T |
7: 103,209,816 (GRCm39) |
C44F |
probably benign |
Het |
| Or5b96 |
A |
T |
19: 12,867,560 (GRCm39) |
V127E |
probably damaging |
Het |
| Or7g12 |
A |
G |
9: 18,899,812 (GRCm39) |
H176R |
possibly damaging |
Het |
| Ovch2 |
T |
A |
7: 107,392,462 (GRCm39) |
I294F |
probably damaging |
Het |
| Ovch2 |
A |
T |
7: 107,393,251 (GRCm39) |
C207* |
probably null |
Het |
| P3h2 |
T |
A |
16: 25,801,467 (GRCm39) |
Y397F |
possibly damaging |
Het |
| Pappa |
A |
T |
4: 65,123,166 (GRCm39) |
I834F |
possibly damaging |
Het |
| Pcdha11 |
T |
C |
18: 37,140,716 (GRCm39) |
S782P |
probably benign |
Het |
| Pex1 |
T |
C |
5: 3,681,614 (GRCm39) |
V980A |
probably benign |
Het |
| Pik3c2a |
G |
T |
7: 115,951,112 (GRCm39) |
L1258I |
probably damaging |
Het |
| Pmp22 |
T |
A |
11: 63,049,239 (GRCm39) |
*161R |
probably null |
Het |
| Ppp1r26 |
T |
A |
2: 28,341,192 (GRCm39) |
M274K |
probably benign |
Het |
| Ppp6r2 |
T |
C |
15: 89,167,275 (GRCm39) |
V830A |
probably benign |
Het |
| Pramel34 |
T |
C |
5: 93,785,660 (GRCm39) |
T207A |
possibly damaging |
Het |
| Prss1 |
T |
A |
6: 41,439,520 (GRCm39) |
N84K |
probably benign |
Het |
| Rab3il1 |
G |
A |
19: 10,004,141 (GRCm39) |
A18T |
probably damaging |
Het |
| Sbf2 |
A |
T |
7: 109,929,069 (GRCm39) |
S1471T |
probably damaging |
Het |
| Setdb1 |
T |
A |
3: 95,263,371 (GRCm39) |
D45V |
probably damaging |
Het |
| Sik3 |
G |
T |
9: 46,089,811 (GRCm39) |
V275L |
probably benign |
Het |
| Skint6 |
C |
A |
4: 112,846,149 (GRCm39) |
M659I |
probably benign |
Het |
| Slc24a1 |
T |
A |
9: 64,835,985 (GRCm39) |
D714V |
unknown |
Het |
| Slc26a5 |
T |
A |
5: 22,018,880 (GRCm39) |
D653V |
probably damaging |
Het |
| Snrnp27 |
A |
T |
6: 86,653,196 (GRCm39) |
C141S |
probably benign |
Het |
| Stradb |
A |
G |
1: 59,033,478 (GRCm39) |
I380M |
probably benign |
Het |
| Sult1e1 |
T |
C |
5: 87,735,501 (GRCm39) |
Y59C |
probably benign |
Het |
| Tas2r122 |
C |
T |
6: 132,688,702 (GRCm39) |
A64T |
probably benign |
Het |
| Tep1 |
C |
T |
14: 51,074,589 (GRCm39) |
C1812Y |
probably damaging |
Het |
| Tln2 |
C |
A |
9: 67,128,693 (GRCm39) |
E1465D |
possibly damaging |
Het |
| Trio |
A |
T |
15: 27,905,311 (GRCm39) |
C152S |
unknown |
Het |
| Tro |
G |
A |
X: 149,438,555 (GRCm39) |
S34L |
unknown |
Het |
| Vmn1r15 |
A |
G |
6: 57,235,123 (GRCm39) |
|
probably benign |
Het |
| Vmn1r19 |
A |
G |
6: 57,381,436 (GRCm39) |
|
probably benign |
Het |
| Vmn1r75 |
A |
G |
7: 11,614,630 (GRCm39) |
T121A |
possibly damaging |
Het |
| Vmn2r32 |
A |
G |
7: 7,477,669 (GRCm39) |
F241L |
probably damaging |
Het |
| Vmn2r66 |
A |
G |
7: 84,654,893 (GRCm39) |
L472P |
probably damaging |
Het |
| Ylpm1 |
G |
T |
12: 85,043,566 (GRCm39) |
W101C |
unknown |
Het |
| Zdbf2 |
C |
A |
1: 63,347,272 (GRCm39) |
H1884N |
probably benign |
Het |
| Zfp1005 |
T |
A |
2: 150,109,624 (GRCm39) |
C105S |
possibly damaging |
Het |
|
| Other mutations in Lrp6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00340:Lrp6
|
APN |
6 |
134,433,053 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL00765:Lrp6
|
APN |
6 |
134,518,817 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL00898:Lrp6
|
APN |
6 |
134,456,702 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00916:Lrp6
|
APN |
6 |
134,461,252 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00961:Lrp6
|
APN |
6 |
134,484,609 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01620:Lrp6
|
APN |
6 |
134,488,225 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01765:Lrp6
|
APN |
6 |
134,433,108 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02066:Lrp6
|
APN |
6 |
134,427,900 (GRCm39) |
nonsense |
probably null |
|
|
IGL02067:Lrp6
|
APN |
6 |
134,457,359 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02169:Lrp6
|
APN |
6 |
134,490,290 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02281:Lrp6
|
APN |
6 |
134,434,697 (GRCm39) |
missense |
probably benign |
0.40 |
|
IGL02484:Lrp6
|
APN |
6 |
134,518,886 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL02724:Lrp6
|
APN |
6 |
134,461,228 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02876:Lrp6
|
APN |
6 |
134,433,077 (GRCm39) |
missense |
probably benign |
0.43 |
|
IGL03011:Lrp6
|
APN |
6 |
134,497,380 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL03352:Lrp6
|
APN |
6 |
134,456,726 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Aileron
|
UTSW |
6 |
134,439,579 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Cielo
|
UTSW |
6 |
134,484,624 (GRCm39) |
nonsense |
probably null |
|
|
Coiled
|
UTSW |
6 |
134,484,521 (GRCm39) |
nonsense |
probably null |
|
|
flap
|
UTSW |
6 |
134,463,549 (GRCm39) |
missense |
probably damaging |
0.99 |
|
soar
|
UTSW |
6 |
134,488,169 (GRCm39) |
missense |
probably damaging |
0.97 |
|
Swoop
|
UTSW |
6 |
134,463,504 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
Upswing
|
UTSW |
6 |
134,441,414 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Wingman
|
UTSW |
6 |
134,434,705 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB004:Lrp6
|
UTSW |
6 |
134,497,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB014:Lrp6
|
UTSW |
6 |
134,497,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4494001:Lrp6
|
UTSW |
6 |
134,456,741 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0008:Lrp6
|
UTSW |
6 |
134,462,716 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0008:Lrp6
|
UTSW |
6 |
134,462,716 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0201:Lrp6
|
UTSW |
6 |
134,427,860 (GRCm39) |
nonsense |
probably null |
|
|
R0295:Lrp6
|
UTSW |
6 |
134,434,656 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0370:Lrp6
|
UTSW |
6 |
134,456,729 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0382:Lrp6
|
UTSW |
6 |
134,444,631 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0413:Lrp6
|
UTSW |
6 |
134,484,587 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0468:Lrp6
|
UTSW |
6 |
134,462,624 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0492:Lrp6
|
UTSW |
6 |
134,457,481 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R0584:Lrp6
|
UTSW |
6 |
134,433,039 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0631:Lrp6
|
UTSW |
6 |
134,456,738 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0738:Lrp6
|
UTSW |
6 |
134,519,008 (GRCm39) |
missense |
probably benign |
0.13 |
|
R0907:Lrp6
|
UTSW |
6 |
134,484,488 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1273:Lrp6
|
UTSW |
6 |
134,444,470 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1548:Lrp6
|
UTSW |
6 |
134,436,392 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R1639:Lrp6
|
UTSW |
6 |
134,430,529 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1650:Lrp6
|
UTSW |
6 |
134,445,732 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1696:Lrp6
|
UTSW |
6 |
134,445,686 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1751:Lrp6
|
UTSW |
6 |
134,441,531 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1780:Lrp6
|
UTSW |
6 |
134,441,414 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2013:Lrp6
|
UTSW |
6 |
134,457,337 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2015:Lrp6
|
UTSW |
6 |
134,457,337 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2165:Lrp6
|
UTSW |
6 |
134,436,246 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2294:Lrp6
|
UTSW |
6 |
134,434,705 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2336:Lrp6
|
UTSW |
6 |
134,484,546 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2964:Lrp6
|
UTSW |
6 |
134,444,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3716:Lrp6
|
UTSW |
6 |
134,484,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4017:Lrp6
|
UTSW |
6 |
134,497,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4370:Lrp6
|
UTSW |
6 |
134,483,321 (GRCm39) |
nonsense |
probably null |
|
|
R4521:Lrp6
|
UTSW |
6 |
134,462,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4573:Lrp6
|
UTSW |
6 |
134,447,693 (GRCm39) |
nonsense |
probably null |
|
|
R4645:Lrp6
|
UTSW |
6 |
134,461,213 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4661:Lrp6
|
UTSW |
6 |
134,488,230 (GRCm39) |
missense |
probably benign |
|
|
R4688:Lrp6
|
UTSW |
6 |
134,456,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4784:Lrp6
|
UTSW |
6 |
134,456,502 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5236:Lrp6
|
UTSW |
6 |
134,488,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5506:Lrp6
|
UTSW |
6 |
134,436,259 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5508:Lrp6
|
UTSW |
6 |
134,441,479 (GRCm39) |
missense |
probably benign |
0.31 |
|
R6001:Lrp6
|
UTSW |
6 |
134,441,481 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6319:Lrp6
|
UTSW |
6 |
134,518,798 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6537:Lrp6
|
UTSW |
6 |
134,457,458 (GRCm39) |
missense |
probably benign |
|
|
R6552:Lrp6
|
UTSW |
6 |
134,431,692 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6559:Lrp6
|
UTSW |
6 |
134,490,217 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6575:Lrp6
|
UTSW |
6 |
134,518,934 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R6585:Lrp6
|
UTSW |
6 |
134,484,521 (GRCm39) |
nonsense |
probably null |
|
|
R6700:Lrp6
|
UTSW |
6 |
134,456,523 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6724:Lrp6
|
UTSW |
6 |
134,463,504 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7159:Lrp6
|
UTSW |
6 |
134,484,514 (GRCm39) |
missense |
probably benign |
|
|
R7266:Lrp6
|
UTSW |
6 |
134,484,364 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7339:Lrp6
|
UTSW |
6 |
134,427,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7341:Lrp6
|
UTSW |
6 |
134,427,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7342:Lrp6
|
UTSW |
6 |
134,427,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7348:Lrp6
|
UTSW |
6 |
134,427,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7359:Lrp6
|
UTSW |
6 |
134,427,923 (GRCm39) |
nonsense |
probably null |
|
|
R7366:Lrp6
|
UTSW |
6 |
134,427,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7368:Lrp6
|
UTSW |
6 |
134,427,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7501:Lrp6
|
UTSW |
6 |
134,463,471 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7548:Lrp6
|
UTSW |
6 |
134,484,471 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7652:Lrp6
|
UTSW |
6 |
134,488,208 (GRCm39) |
nonsense |
probably null |
|
|
R7771:Lrp6
|
UTSW |
6 |
134,439,579 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7927:Lrp6
|
UTSW |
6 |
134,497,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8717:Lrp6
|
UTSW |
6 |
134,434,711 (GRCm39) |
missense |
probably benign |
0.41 |
|
R8726:Lrp6
|
UTSW |
6 |
134,484,624 (GRCm39) |
nonsense |
probably null |
|
|
R8792:Lrp6
|
UTSW |
6 |
134,463,549 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8855:Lrp6
|
UTSW |
6 |
134,445,785 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8866:Lrp6
|
UTSW |
6 |
134,445,785 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8994:Lrp6
|
UTSW |
6 |
134,518,656 (GRCm39) |
missense |
probably benign |
|
|
R9021:Lrp6
|
UTSW |
6 |
134,518,930 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9089:Lrp6
|
UTSW |
6 |
134,488,169 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9154:Lrp6
|
UTSW |
6 |
134,518,855 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9263:Lrp6
|
UTSW |
6 |
134,457,467 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9287:Lrp6
|
UTSW |
6 |
134,483,259 (GRCm39) |
missense |
probably benign |
0.21 |
|
R9545:Lrp6
|
UTSW |
6 |
134,483,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9574:Lrp6
|
UTSW |
6 |
134,447,662 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9640:Lrp6
|
UTSW |
6 |
134,441,414 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Lrp6
|
UTSW |
6 |
134,433,120 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
Z1177:Lrp6
|
UTSW |
6 |
134,439,504 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTAGAACTTAAAACTGGACAAGAGC -3'
(R):5'- GTCTGTCCCTTCTAGCCAAAAG -3'
Sequencing Primer
(F):5'- GAGCAGATTCTCATAAATCGCTTGCC -3'
(R):5'- ACAATGATACTTCCTGGTCTGTTG -3'
|
| Posted On |
2021-04-30 |
Incidental Mutation