Mutagenetix > Incidental Mutation

Incidental Mutation 'R8812:Myh1'

672508

Institutional Source

Beutler Lab

Gene Symbol

Myh1

Ensembl Gene

ENSMUSG00000056328

Gene Name

myosin, heavy polypeptide 1, skeletal muscle, adult

Synonyms

A530084A17Rik, Myhsf2, Myhs-f2, Myhs-f, IId/x, IId, myosin heavy chain 2X, MYHC-IIX, MyHC-IId/x

MMRRC Submission

068647-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R8812 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

67200052-67224575 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 67209141 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glycine to Arginine at position 626 (G626R)

Ref Sequence

ENSEMBL: ENSMUSP00000117569 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000018637] [ENSMUST00000075734] [ENSMUST00000124516]

AlphaFold

Q5SX40

Predicted Effect

probably benign
Transcript: ENSMUST00000018637
AA Change: G626R

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000018637
Gene: ENSMUSG00000056328
AA Change: G626R

Domain	Start	End	E-Value	Type
Pfam:Myosin_N	35	76	1.8e-15	PFAM
MYSc	80	786	N/A	SMART
IQ	787	809	1.18e-3	SMART
low complexity region	860	883	N/A	INTRINSIC
low complexity region	931	945	N/A	INTRINSIC
Pfam:Myosin_tail_1	1075	1933	N/A	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000075734
AA Change: G626R

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000075147
Gene: ENSMUSG00000056328
AA Change: G626R

Domain	Start	End	E-Value	Type
Pfam:Myosin_N	35	74	7.2e-14	PFAM
MYSc	80	786	N/A	SMART
IQ	787	809	1.18e-3	SMART
Pfam:Myosin_tail_1	850	1931	1.9e-165	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000124516
AA Change: G626R

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000117569
Gene: ENSMUSG00000056328
AA Change: G626R

Domain	Start	End	E-Value	Type
Pfam:Myosin_N	35	76	1.8e-15	PFAM
MYSc	80	786	N/A	SMART
IQ	787	809	1.18e-3	SMART
low complexity region	860	883	N/A	INTRINSIC
low complexity region	931	945	N/A	INTRINSIC
Pfam:Myosin_tail_1	1075	1933	N/A	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.2%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. Myosin heavy chains are encoded by a multigene family. In mammals at least 10 different myosin heavy chain (MYH) isoforms have been described from striated, smooth, and nonmuscle cells. These isoforms show expression that is spatially and temporally regulated during development. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a targeted null mutation exhibit reduced growth, muscular weakness, kyphosis, and abnormal kinetics of muscle contraction and relaxation. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 81 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2210408I21Rik	C	A	13: 77,332,352 (GRCm38)	P1167Q	probably damaging	Het
Adcy10	A	T	1: 165,551,298 (GRCm38)	Q885H	probably damaging	Het
Alkal2	C	T	12: 30,890,056 (GRCm38)	L139F	probably damaging	Het
Ankrd17	A	T	5: 90,293,203 (GRCm38)	M439K	probably benign	Het
Arl11	C	A	14: 61,310,973 (GRCm38)	Y77*	probably null	Het
Bcas3	T	C	11: 85,559,147 (GRCm38)	Y669H	probably benign	Het
Bpifb3	C	T	2: 153,922,596 (GRCm38)	A136V	probably benign	Het
Btbd11	A	G	10: 85,627,249 (GRCm38)	Q626R	probably damaging	Het
C87414	T	C	5: 93,637,801 (GRCm38)	T207A	possibly damaging	Het
Ccne2	A	G	4: 11,202,279 (GRCm38)	T345A	probably benign	Het
Ciz1	T	C	2: 32,364,274 (GRCm38)	S76P	probably benign	Het
Clip4	A	T	17: 71,800,805 (GRCm38)	K94*	probably null	Het
Cthrc1	G	A	15: 39,084,471 (GRCm38)	R195H	probably damaging	Het
D430042O09Rik	A	C	7: 125,797,695 (GRCm38)	R309S	probably benign	Het
Ddx31	T	C	2: 28,840,804 (GRCm38)		probably benign	Het
Elf2	T	A	3: 51,266,767 (GRCm38)	D113V	possibly damaging	Het
Esrrb	A	G	12: 86,488,550 (GRCm38)	N155S	probably benign	Het
Fam198b	T	C	3: 79,908,771 (GRCm38)	S363P	possibly damaging	Het
Flnb	A	G	14: 7,887,624 (GRCm38)	D478G	probably benign	Het
Galm	T	A	17: 80,127,786 (GRCm38)	L24H	probably damaging	Het
Gm14124	T	A	2: 150,267,704 (GRCm38)	C105S	possibly damaging	Het
Gon4l	G	A	3: 88,895,007 (GRCm38)	G975D	possibly damaging	Het
Hspbp1	T	G	7: 4,664,784 (GRCm38)	M237L	probably benign	Het
Ighv1-62-1	A	T	12: 115,386,747 (GRCm38)	M100K	probably damaging	Het
Ipo8	A	T	6: 148,775,077 (GRCm38)	D971E	possibly damaging	Het
Itgax	C	T	7: 128,133,807 (GRCm38)	A286V	probably damaging	Het
Jpt2	T	C	17: 24,960,604 (GRCm38)	Q3R	probably benign	Het
Klrg2	A	C	6: 38,636,903 (GRCm38)	L55R	probably damaging	Het
Lrp6	T	A	6: 134,456,178 (GRCm38)	M1397L	probably benign	Het
Lrrc31	T	A	3: 30,679,179 (GRCm38)	Q462L	probably benign	Het
Lyg2	T	A	1: 37,909,973 (GRCm38)	I103F	probably damaging	Het
Map10	T	C	8: 125,669,925 (GRCm38)	V19A	probably damaging	Het
Map1b	T	A	13: 99,432,815 (GRCm38)	M1133L	unknown	Het
Mrgpra4	A	G	7: 47,981,733 (GRCm38)	V40A	probably benign	Het
Myo9a	T	C	9: 59,779,747 (GRCm38)	V45A	probably benign	Het
Ncdn	A	G	4: 126,745,112 (GRCm38)	F638S	possibly damaging	Het
Ncs1	T	A	2: 31,284,201 (GRCm38)	M121K	probably damaging	Het
Nf1	T	C	11: 79,546,354 (GRCm38)	V16A	probably damaging	Het
Nktr	T	A	9: 121,750,251 (GRCm38)	D1128E	unknown	Het
Nup205	T	G	6: 35,214,334 (GRCm38)	L1000R	probably damaging	Het
Obscn	T	C	11: 59,035,095 (GRCm38)	E5604G	probably damaging	Het
Olfr1240	A	G	2: 89,439,865 (GRCm38)	V138A	probably benign	Het
Olfr1260	G	T	2: 89,978,371 (GRCm38)	A198S	possibly damaging	Het
Olfr1370	T	C	13: 21,073,050 (GRCm38)	N84D	probably damaging	Het
Olfr1446	A	T	19: 12,890,196 (GRCm38)	V127E	probably damaging	Het
Olfr409-ps1	T	A	11: 74,317,708 (GRCm38)	S228T	unknown	Het
Olfr615	G	T	7: 103,560,609 (GRCm38)	C44F	probably benign	Het
Olfr834	A	G	9: 18,988,516 (GRCm38)	H176R	possibly damaging	Het
Ovch2	A	T	7: 107,794,044 (GRCm38)	C207*	probably null	Het
Ovch2	T	A	7: 107,793,255 (GRCm38)	I294F	probably damaging	Het
P3h2	T	A	16: 25,982,717 (GRCm38)	Y397F	possibly damaging	Het
Pappa	A	T	4: 65,204,929 (GRCm38)	I834F	possibly damaging	Het
Pcdha11	T	C	18: 37,007,663 (GRCm38)	S782P	probably benign	Het
Pex1	T	C	5: 3,631,614 (GRCm38)	V980A	probably benign	Het
Pik3c2a	G	T	7: 116,351,877 (GRCm38)	L1258I	probably damaging	Het
Pmp22	T	A	11: 63,158,413 (GRCm38)	*161R	probably null	Het
Ppp1r26	T	A	2: 28,451,180 (GRCm38)	M274K	probably benign	Het
Ppp6r2	T	C	15: 89,283,072 (GRCm38)	V830A	probably benign	Het
Prss1	T	A	6: 41,462,586 (GRCm38)	N84K	probably benign	Het
Rab3il1	G	A	19: 10,026,777 (GRCm38)	A18T	probably damaging	Het
Sbf2	A	T	7: 110,329,862 (GRCm38)	S1471T	probably damaging	Het
Setdb1	T	A	3: 95,356,060 (GRCm38)	D45V	probably damaging	Het
Sik3	G	T	9: 46,178,513 (GRCm38)	V275L	probably benign	Het
Skint6	C	A	4: 112,988,952 (GRCm38)	M659I	probably benign	Het
Slc24a1	T	A	9: 64,928,703 (GRCm38)	D714V	unknown	Het
Slc26a5	T	A	5: 21,813,882 (GRCm38)	D653V	probably damaging	Het
Snrnp27	A	T	6: 86,676,214 (GRCm38)	C141S	probably benign	Het
Stradb	A	G	1: 58,994,319 (GRCm38)	I380M	probably benign	Het
Sult1e1	T	C	5: 87,587,642 (GRCm38)	Y59C	probably benign	Het
Tas2r122	C	T	6: 132,711,739 (GRCm38)	A64T	probably benign	Het
Tep1	C	T	14: 50,837,132 (GRCm38)	C1812Y	probably damaging	Het
Tln2	C	A	9: 67,221,411 (GRCm38)	E1465D	possibly damaging	Het
Trio	A	T	15: 27,905,225 (GRCm38)	C152S	unknown	Het
Tro	G	A	X: 150,655,559 (GRCm38)	S34L	unknown	Het
Vmn1r15	A	G	6: 57,258,138 (GRCm38)		probably benign	Het
Vmn1r19	A	G	6: 57,404,451 (GRCm38)		probably benign	Het
Vmn1r75	A	G	7: 11,880,703 (GRCm38)	T121A	possibly damaging	Het
Vmn2r32	A	G	7: 7,474,670 (GRCm38)	F241L	probably damaging	Het
Vmn2r66	A	G	7: 85,005,685 (GRCm38)	L472P	probably damaging	Het
Ylpm1	G	T	12: 84,996,792 (GRCm38)	W101C	unknown	Het
Zdbf2	C	A	1: 63,308,113 (GRCm38)	H1884N	probably benign	Het

Other mutations in Myh1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00427:Myh1	APN	11	67,220,865 (GRCm38)	missense	probably damaging	0.99
IGL00514:Myh1	APN	11	67,219,784 (GRCm38)	missense	probably damaging	1.00
IGL00851:Myh1	APN	11	67,217,910 (GRCm38)	missense	probably damaging	0.96
IGL01061:Myh1	APN	11	67,217,862 (GRCm38)	missense	probably benign	0.05
IGL01113:Myh1	APN	11	67,202,180 (GRCm38)	missense	probably benign	0.00
IGL01125:Myh1	APN	11	67,220,660 (GRCm38)	missense	probably benign
IGL01391:Myh1	APN	11	67,217,863 (GRCm38)	missense	probably benign	0.00
IGL01392:Myh1	APN	11	67,221,301 (GRCm38)	missense	probably benign	0.20
IGL01404:Myh1	APN	11	67,222,151 (GRCm38)	missense	possibly damaging	0.83
IGL01700:Myh1	APN	11	67,211,412 (GRCm38)	missense	probably damaging	1.00
IGL01739:Myh1	APN	11	67,214,528 (GRCm38)	missense	probably damaging	0.99
IGL01759:Myh1	APN	11	67,219,906 (GRCm38)	missense	probably damaging	1.00
IGL01922:Myh1	APN	11	67,210,466 (GRCm38)	critical splice donor site	probably null
IGL01952:Myh1	APN	11	67,220,392 (GRCm38)	splice site	probably null
IGL02007:Myh1	APN	11	67,220,556 (GRCm38)	missense	probably benign	0.03
IGL02028:Myh1	APN	11	67,210,615 (GRCm38)	missense	probably damaging	1.00
IGL02245:Myh1	APN	11	67,211,487 (GRCm38)	missense	possibly damaging	0.58
IGL02628:Myh1	APN	11	67,206,262 (GRCm38)	unclassified	probably benign
IGL02942:Myh1	APN	11	67,202,482 (GRCm38)	missense	probably damaging	1.00
IGL02967:Myh1	APN	11	67,209,070 (GRCm38)	missense	possibly damaging	0.76
IGL03031:Myh1	APN	11	67,206,387 (GRCm38)	missense	possibly damaging	0.47
IGL03187:Myh1	APN	11	67,206,525 (GRCm38)	missense	possibly damaging	0.56
IGL03302:Myh1	APN	11	67,211,502 (GRCm38)	missense	probably benign	0.01
compelling	UTSW	11	67,219,805 (GRCm38)	critical splice donor site	probably null
convincing	UTSW	11	67,202,539 (GRCm38)	missense	probably damaging	1.00
muscle	UTSW	11	67,206,048 (GRCm38)	nonsense	probably null
Persuasive	UTSW	11	67,209,064 (GRCm38)	missense	possibly damaging	0.90
G1patch:Myh1	UTSW	11	67,201,893 (GRCm38)	missense	probably damaging	1.00
R0041:Myh1	UTSW	11	67,209,078 (GRCm38)	missense	possibly damaging	0.88
R0079:Myh1	UTSW	11	67,213,411 (GRCm38)	missense	probably damaging	1.00
R0081:Myh1	UTSW	11	67,215,857 (GRCm38)	missense	probably benign
R0317:Myh1	UTSW	11	67,217,512 (GRCm38)	missense	probably damaging	1.00
R0465:Myh1	UTSW	11	67,210,417 (GRCm38)	missense	possibly damaging	0.50
R0528:Myh1	UTSW	11	67,220,619 (GRCm38)	missense	probably damaging	1.00
R0731:Myh1	UTSW	11	67,202,533 (GRCm38)	missense	probably damaging	0.98
R0964:Myh1	UTSW	11	67,205,925 (GRCm38)	missense	probably benign
R0964:Myh1	UTSW	11	67,221,604 (GRCm38)	missense	probably damaging	1.00
R1427:Myh1	UTSW	11	67,219,747 (GRCm38)	missense	probably damaging	0.99
R1429:Myh1	UTSW	11	67,217,910 (GRCm38)	missense	possibly damaging	0.78
R1481:Myh1	UTSW	11	67,205,499 (GRCm38)	unclassified	probably benign
R1562:Myh1	UTSW	11	67,211,370 (GRCm38)	missense	probably benign	0.04
R1727:Myh1	UTSW	11	67,210,466 (GRCm38)	critical splice donor site	probably benign
R1796:Myh1	UTSW	11	67,224,357 (GRCm38)	missense	probably benign	0.00
R1808:Myh1	UTSW	11	67,211,474 (GRCm38)	nonsense	probably null
R1836:Myh1	UTSW	11	67,204,822 (GRCm38)	missense	probably damaging	0.98
R1848:Myh1	UTSW	11	67,213,630 (GRCm38)	missense	probably benign	0.10
R1851:Myh1	UTSW	11	67,204,398 (GRCm38)	missense	probably damaging	1.00
R1925:Myh1	UTSW	11	67,211,170 (GRCm38)	missense	probably benign	0.01
R1967:Myh1	UTSW	11	67,213,447 (GRCm38)	missense	probably benign	0.08
R1999:Myh1	UTSW	11	67,222,408 (GRCm38)	missense	probably benign	0.04
R2067:Myh1	UTSW	11	67,214,620 (GRCm38)	missense	possibly damaging	0.83
R2111:Myh1	UTSW	11	67,214,620 (GRCm38)	missense	possibly damaging	0.83
R2150:Myh1	UTSW	11	67,222,408 (GRCm38)	missense	probably benign	0.04
R2189:Myh1	UTSW	11	67,221,604 (GRCm38)	missense	probably damaging	1.00
R2352:Myh1	UTSW	11	67,220,537 (GRCm38)	missense	probably benign	0.00
R2436:Myh1	UTSW	11	67,213,271 (GRCm38)	missense	probably benign	0.04
R2483:Myh1	UTSW	11	67,211,226 (GRCm38)	missense	probably benign
R2508:Myh1	UTSW	11	67,213,598 (GRCm38)	missense	possibly damaging	0.61
R2509:Myh1	UTSW	11	67,205,597 (GRCm38)	missense	probably benign	0.01
R2511:Myh1	UTSW	11	67,205,597 (GRCm38)	missense	probably benign	0.01
R2908:Myh1	UTSW	11	67,220,696 (GRCm38)	nonsense	probably null
R2966:Myh1	UTSW	11	67,214,584 (GRCm38)	missense	probably damaging	1.00
R3829:Myh1	UTSW	11	67,205,597 (GRCm38)	missense	probably benign	0.01
R4106:Myh1	UTSW	11	67,211,577 (GRCm38)	missense	probably benign	0.33
R4108:Myh1	UTSW	11	67,211,577 (GRCm38)	missense	probably benign	0.33
R4457:Myh1	UTSW	11	67,220,615 (GRCm38)	missense	probably benign	0.42
R4629:Myh1	UTSW	11	67,209,293 (GRCm38)	missense	probably benign	0.01
R4981:Myh1	UTSW	11	67,224,474 (GRCm38)	utr 3 prime	probably benign
R5032:Myh1	UTSW	11	67,206,048 (GRCm38)	nonsense	probably null
R5239:Myh1	UTSW	11	67,215,225 (GRCm38)	missense	probably benign	0.19
R5241:Myh1	UTSW	11	67,204,449 (GRCm38)	missense	probably benign
R5303:Myh1	UTSW	11	67,202,017 (GRCm38)	missense	probably benign	0.09
R5666:Myh1	UTSW	11	67,221,352 (GRCm38)	missense	probably benign	0.30
R5717:Myh1	UTSW	11	67,208,956 (GRCm38)	missense	probably benign
R5761:Myh1	UTSW	11	67,219,252 (GRCm38)	missense	probably damaging	0.98
R5870:Myh1	UTSW	11	67,201,979 (GRCm38)	missense	possibly damaging	0.70
R6077:Myh1	UTSW	11	67,211,447 (GRCm38)	missense	probably damaging	1.00
R6089:Myh1	UTSW	11	67,220,787 (GRCm38)	splice site	probably null
R6089:Myh1	UTSW	11	67,202,167 (GRCm38)	splice site	probably null
R6197:Myh1	UTSW	11	67,220,967 (GRCm38)	missense	probably benign	0.01
R6460:Myh1	UTSW	11	67,221,376 (GRCm38)	missense	probably benign
R6627:Myh1	UTSW	11	67,215,009 (GRCm38)	missense	probably damaging	1.00
R6634:Myh1	UTSW	11	67,209,064 (GRCm38)	missense	possibly damaging	0.90
R6725:Myh1	UTSW	11	67,201,893 (GRCm38)	missense	probably damaging	1.00
R6784:Myh1	UTSW	11	67,214,570 (GRCm38)	missense	probably damaging	0.99
R6813:Myh1	UTSW	11	67,220,460 (GRCm38)	missense	probably benign	0.34
R6866:Myh1	UTSW	11	67,224,393 (GRCm38)	missense	probably damaging	0.99
R6997:Myh1	UTSW	11	67,220,637 (GRCm38)	missense	possibly damaging	0.94
R7028:Myh1	UTSW	11	67,220,421 (GRCm38)	missense	possibly damaging	0.64
R7133:Myh1	UTSW	11	67,202,586 (GRCm38)	missense	probably benign
R7185:Myh1	UTSW	11	67,207,459 (GRCm38)	missense	probably damaging	1.00
R7194:Myh1	UTSW	11	67,211,357 (GRCm38)	missense	probably benign
R7283:Myh1	UTSW	11	67,201,844 (GRCm38)	critical splice acceptor site	probably null
R7336:Myh1	UTSW	11	67,220,609 (GRCm38)	missense	probably benign	0.00
R7348:Myh1	UTSW	11	67,202,539 (GRCm38)	missense	probably damaging	1.00
R7369:Myh1	UTSW	11	67,220,698 (GRCm38)	missense	probably damaging	1.00
R7375:Myh1	UTSW	11	67,210,428 (GRCm38)	missense	probably damaging	1.00
R7384:Myh1	UTSW	11	67,224,375 (GRCm38)	missense	possibly damaging	0.46
R7387:Myh1	UTSW	11	67,208,889 (GRCm38)	missense	probably benign	0.14
R7424:Myh1	UTSW	11	67,213,663 (GRCm38)	missense	probably damaging	1.00
R7430:Myh1	UTSW	11	67,205,567 (GRCm38)	nonsense	probably null
R7443:Myh1	UTSW	11	67,220,505 (GRCm38)	missense	probably benign
R7447:Myh1	UTSW	11	67,219,180 (GRCm38)	missense	probably benign	0.01
R7509:Myh1	UTSW	11	67,210,461 (GRCm38)	missense	probably benign	0.40
R7583:Myh1	UTSW	11	67,220,913 (GRCm38)	missense	probably benign	0.00
R7611:Myh1	UTSW	11	67,210,417 (GRCm38)	missense	possibly damaging	0.50
R7617:Myh1	UTSW	11	67,215,875 (GRCm38)	missense	possibly damaging	0.94
R7727:Myh1	UTSW	11	67,215,922 (GRCm38)	missense	probably benign	0.00
R8029:Myh1	UTSW	11	67,211,240 (GRCm38)	critical splice donor site	probably null
R8042:Myh1	UTSW	11	67,206,603 (GRCm38)	missense	probably damaging	1.00
R8060:Myh1	UTSW	11	67,215,251 (GRCm38)	missense	probably benign
R8080:Myh1	UTSW	11	67,211,402 (GRCm38)	missense	probably benign	0.10
R8117:Myh1	UTSW	11	67,222,205 (GRCm38)	missense	probably damaging	1.00
R8171:Myh1	UTSW	11	67,202,572 (GRCm38)	missense	probably damaging	1.00
R8183:Myh1	UTSW	11	67,202,006 (GRCm38)	missense	possibly damaging	0.50
R8397:Myh1	UTSW	11	67,221,639 (GRCm38)	missense	probably damaging	0.97
R8545:Myh1	UTSW	11	67,202,201 (GRCm38)	missense	probably benign	0.00
R8807:Myh1	UTSW	11	67,220,528 (GRCm38)	missense	probably benign	0.02
R8855:Myh1	UTSW	11	67,211,421 (GRCm38)	missense	probably damaging	1.00
R8906:Myh1	UTSW	11	67,205,913 (GRCm38)	missense	probably benign	0.02
R8959:Myh1	UTSW	11	67,211,502 (GRCm38)	missense	probably benign
R8992:Myh1	UTSW	11	67,205,781 (GRCm38)	missense	probably benign
R9140:Myh1	UTSW	11	67,209,263 (GRCm38)	missense	probably benign	0.04
R9293:Myh1	UTSW	11	67,209,103 (GRCm38)	missense	probably benign	0.25
R9366:Myh1	UTSW	11	67,219,288 (GRCm38)	missense	probably damaging	1.00
R9371:Myh1	UTSW	11	67,219,805 (GRCm38)	critical splice donor site	probably null
R9378:Myh1	UTSW	11	67,202,433 (GRCm38)	missense	probably damaging	0.99
R9482:Myh1	UTSW	11	67,217,919 (GRCm38)	missense	probably damaging	1.00
R9507:Myh1	UTSW	11	67,211,223 (GRCm38)	missense	probably benign	0.00
R9558:Myh1	UTSW	11	67,217,792 (GRCm38)	missense	possibly damaging	0.90
R9561:Myh1	UTSW	11	67,217,792 (GRCm38)	missense	possibly damaging	0.90
R9587:Myh1	UTSW	11	67,211,370 (GRCm38)	missense	probably benign	0.03
X0062:Myh1	UTSW	11	67,207,541 (GRCm38)	missense	probably damaging	0.99
Z1177:Myh1	UTSW	11	67,206,318 (GRCm38)	missense	probably damaging	1.00
Z1187:Myh1	UTSW	11	67,204,446 (GRCm38)	missense	probably benign
Z1188:Myh1	UTSW	11	67,204,446 (GRCm38)	missense	probably benign
Z1190:Myh1	UTSW	11	67,204,446 (GRCm38)	missense	probably benign
Z1191:Myh1	UTSW	11	67,204,446 (GRCm38)	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- AGCAGCATCTTGGAAAGTCC -3'
(R):5'- ATGAAGTTGGTACCCTGAAGAG -3'

Sequencing Primer
(F):5'- GGAAAGTCCAACAACTTCCAAAAG -3'
(R):5'- GCTGACACGGTCTGGAAG -3'

Posted On

2021-04-30