Incidental Mutation 'R8813:Tnxb'
ID 672580
Institutional Source Beutler Lab
Gene Symbol Tnxb
Ensembl Gene ENSMUSG00000033327
Gene Name tenascin XB
Synonyms Tnx, TN-MHC
MMRRC Submission 068648-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8813 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 34879431-34938789 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 34938136 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tryptophan to Arginine at position 3073 (W3073R)
Ref Sequence ENSEMBL: ENSMUSP00000127487 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087399] [ENSMUST00000168533]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000087399
AA Change: W3953R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000084661
Gene: ENSMUSG00000033327
AA Change: W3953R

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
low complexity region 33 44 N/A INTRINSIC
low complexity region 69 89 N/A INTRINSIC
low complexity region 92 103 N/A INTRINSIC
EGF 173 201 1.59e1 SMART
EGF 204 232 7.41e0 SMART
EGF 235 263 2.64e1 SMART
EGF 266 294 2.64e1 SMART
EGF 297 325 9.13e0 SMART
EGF 328 356 2.07e1 SMART
EGF_like 359 387 3.16e1 SMART
EGF_like 390 418 4.64e1 SMART
EGF_like 421 449 3.29e1 SMART
EGF_like 452 480 7.09e1 SMART
EGF 483 511 1.15e1 SMART
EGF 514 542 1.91e1 SMART
EGF_like 545 573 4.11e1 SMART
EGF 576 604 7.95e0 SMART
EGF 607 635 1.23e1 SMART
EGF_like 638 666 4.93e1 SMART
EGF_like 674 702 5.24e1 SMART
EGF 705 733 2.29e1 SMART
FN3 736 816 4.12e-3 SMART
FN3 827 904 1.21e-9 SMART
FN3 1047 1126 3.97e-5 SMART
FN3 1142 1223 3.62e-8 SMART
low complexity region 1230 1241 N/A INTRINSIC
FN3 1242 1320 2.31e-6 SMART
FN3 1351 1431 8.77e-7 SMART
FN3 1460 1539 3.01e-5 SMART
FN3 1556 1636 2.76e-4 SMART
FN3 1657 1736 5.78e-7 SMART
FN3 1752 1832 4.7e-7 SMART
FN3 1851 1929 1.95e-4 SMART
FN3 1955 2034 4.56e-5 SMART
FN3 2066 2145 2.23e-8 SMART
FN3 2164 2244 7.75e-8 SMART
FN3 2279 2358 8.5e-5 SMART
FN3 2387 2467 2.94e-8 SMART
FN3 2501 2580 1.7e-4 SMART
low complexity region 2588 2598 N/A INTRINSIC
FN3 2607 2687 6.75e-8 SMART
FN3 2716 2795 7.4e-5 SMART
FN3 2822 2902 1.35e-7 SMART
FN3 2931 3010 5.61e-5 SMART
FN3 3026 3106 6.01e-5 SMART
FN3 3120 3199 6.45e-5 SMART
FN3 3214 3293 9.54e-8 SMART
FN3 3316 3396 2.81e-5 SMART
FN3 3416 3502 1.98e-5 SMART
FN3 3518 3596 5.65e-10 SMART
FN3 3607 3682 7.63e-7 SMART
FN3 3695 3770 6.54e-6 SMART
FBG 3787 3997 8.88e-125 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000168533
AA Change: W3073R

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000127487
Gene: ENSMUSG00000033327
AA Change: W3073R

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
low complexity region 33 44 N/A INTRINSIC
low complexity region 69 89 N/A INTRINSIC
low complexity region 92 103 N/A INTRINSIC
EGF 173 201 1.59e1 SMART
EGF 204 232 7.41e0 SMART
EGF 235 263 2.64e1 SMART
EGF 266 294 2.64e1 SMART
EGF 297 325 9.13e0 SMART
EGF 328 356 2.07e1 SMART
EGF_like 359 387 3.16e1 SMART
EGF_like 390 418 4.64e1 SMART
EGF_like 421 449 3.29e1 SMART
EGF_like 452 480 7.09e1 SMART
EGF 483 511 1.15e1 SMART
EGF 514 542 1.91e1 SMART
EGF_like 545 573 4.11e1 SMART
EGF 576 604 7.95e0 SMART
EGF 607 635 1.23e1 SMART
EGF_like 638 666 4.93e1 SMART
EGF_like 674 702 5.24e1 SMART
EGF 705 733 2.29e1 SMART
FN3 736 816 4.12e-3 SMART
FN3 827 904 1.21e-9 SMART
FN3 924 1003 3.97e-5 SMART
FN3 1019 1100 3.62e-8 SMART
low complexity region 1107 1118 N/A INTRINSIC
FN3 1119 1197 2.31e-6 SMART
FN3 1228 1308 8.77e-7 SMART
FN3 1337 1416 3.01e-5 SMART
FN3 1433 1513 2.76e-4 SMART
FN3 1534 1613 5.78e-7 SMART
FN3 1629 1709 4.7e-7 SMART
FN3 1728 1806 1.95e-4 SMART
FN3 1832 1911 4.56e-5 SMART
FN3 1943 2022 2.23e-8 SMART
FN3 2051 2130 5.61e-5 SMART
FN3 2146 2226 6.01e-5 SMART
FN3 2240 2319 6.45e-5 SMART
FN3 2334 2413 9.54e-8 SMART
FN3 2436 2516 2.81e-5 SMART
FN3 2536 2622 1.98e-5 SMART
FN3 2638 2716 5.65e-10 SMART
FN3 2727 2802 7.63e-7 SMART
FN3 2815 2890 6.54e-6 SMART
FBG 2907 3117 8.88e-125 SMART
Meta Mutation Damage Score 0.8852 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.5%
Validation Efficiency 96% (48/50)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing, and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. It is one of four genes in this cluster which have been duplicated. The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice have stretchy skin, similar to patients with human Ehlers-Danlos syndrome. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AA467197 T C 2: 122,482,622 (GRCm39) L62P probably damaging Het
Amotl2 T G 9: 102,607,291 (GRCm39) S700A probably damaging Het
Ccdc7a A G 8: 129,549,942 (GRCm39) S1259P possibly damaging Het
Cenpj C T 14: 56,790,355 (GRCm39) E565K probably damaging Het
Clmp C T 9: 40,692,549 (GRCm39) R273* probably null Het
Cops7b A T 1: 86,528,846 (GRCm39) Q191L probably benign Het
Cyp2c23 A G 19: 44,002,054 (GRCm39) F312L probably benign Het
Dgkd G A 1: 87,843,266 (GRCm39) C169Y probably damaging Het
Dlec1 A T 9: 118,956,498 (GRCm39) N724I probably benign Het
Dmxl1 T C 18: 50,090,406 (GRCm39) V2831A probably damaging Het
Dnah5 G T 15: 28,229,719 (GRCm39) G118W probably damaging Het
Dnah6 G T 6: 73,104,937 (GRCm39) T1884K probably damaging Het
Dnai4 T C 4: 102,947,697 (GRCm39) E193G possibly damaging Het
Efnb2 T A 8: 8,670,731 (GRCm39) S290C probably damaging Het
Eif1ad6 A G 12: 87,668,593 (GRCm39) D75G probably damaging Het
Eif2ak4 C A 2: 118,278,806 (GRCm39) T990K probably damaging Het
Erich3 A G 3: 154,468,827 (GRCm39) D1093G unknown Het
H2-DMa T C 17: 34,354,734 (GRCm39) probably benign Het
Habp2 G A 19: 56,295,216 (GRCm39) D36N probably benign Het
Kcnk13 G T 12: 100,027,647 (GRCm39) G241W probably damaging Het
Kdm6b GGGTGGTGGTGGTGGTGG GGGTGGTGGTGGTGGTGGTGG 11: 69,297,655 (GRCm39) probably benign Het
Kdm6b TGG TGGGGG 11: 69,297,658 (GRCm39) probably benign Het
Klk1b5 G T 7: 43,496,549 (GRCm39) M160I probably benign Het
Lonp2 A G 8: 87,358,073 (GRCm39) Y98C probably damaging Het
Marcksl1 C T 4: 129,408,999 (GRCm39) P193S probably benign Het
Nup133 AAGAGA AAGA 8: 124,638,627 (GRCm39) 900 probably null Het
Nxf7 G A X: 134,484,515 (GRCm39) R513C possibly damaging Het
Or13a19 C A 7: 139,902,793 (GRCm39) Y60* probably null Het
Or4a73 A T 2: 89,420,730 (GRCm39) M243K probably benign Het
Or52e5 T A 7: 104,719,518 (GRCm39) Y281* probably null Het
Or7g32 T G 9: 19,389,477 (GRCm39) D23A possibly damaging Het
Or7g34 A T 9: 19,477,895 (GRCm39) Y262N probably damaging Het
Otof T A 5: 30,540,242 (GRCm39) M965L probably benign Het
Parp12 A G 6: 39,073,508 (GRCm39) F439S probably damaging Het
Pde1a G A 2: 79,959,261 (GRCm39) probably benign Het
Pramel22 T A 4: 143,380,913 (GRCm39) N370I probably damaging Het
Prrc2c T C 1: 162,532,812 (GRCm39) N1268D unknown Het
Pter T C 2: 12,985,114 (GRCm39) V148A probably benign Het
Rb1 A G 14: 73,500,027 (GRCm39) M540T probably damaging Het
Rnasel T A 1: 153,629,641 (GRCm39) N52K probably damaging Het
Rragd A T 4: 33,012,953 (GRCm39) I317F possibly damaging Het
Sla G T 15: 66,664,127 (GRCm39) S81R probably benign Het
T A G 17: 8,653,532 (GRCm39) E57G probably benign Het
Tanc1 T A 2: 59,630,265 (GRCm39) F748L probably damaging Het
Trim33 A G 3: 103,254,052 (GRCm39) T967A probably benign Het
Tro G A X: 149,438,555 (GRCm39) S34L unknown Het
Trpm1 T A 7: 63,851,756 (GRCm39) M158K possibly damaging Het
Vmn1r205 A G 13: 22,776,424 (GRCm39) L226P probably benign Het
Vmn1r56 C T 7: 5,198,733 (GRCm39) V295M probably damaging Het
Vps13c A G 9: 67,778,566 (GRCm39) D208G probably damaging Het
Zfp11 T C 5: 129,735,278 (GRCm39) D61G probably benign Het
Zscan4e C A 7: 11,041,540 (GRCm39) E139* probably null Het
Other mutations in Tnxb
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00094:Tnxb APN 17 34,904,603 (GRCm39) missense probably damaging 1.00
IGL00424:Tnxb APN 17 34,933,666 (GRCm39) missense probably damaging 1.00
IGL00486:Tnxb APN 17 34,911,356 (GRCm39) missense probably damaging 1.00
IGL00952:Tnxb APN 17 34,932,102 (GRCm39) missense probably damaging 1.00
IGL00974:Tnxb APN 17 34,937,707 (GRCm39) critical splice donor site probably null
IGL01017:Tnxb APN 17 34,912,782 (GRCm39) missense probably damaging 0.98
IGL01082:Tnxb APN 17 34,933,584 (GRCm39) missense probably damaging 0.97
IGL01397:Tnxb APN 17 34,933,647 (GRCm39) missense probably damaging 0.99
IGL01473:Tnxb APN 17 34,904,675 (GRCm39) missense probably damaging 0.99
IGL01642:Tnxb APN 17 34,937,488 (GRCm39) missense probably damaging 1.00
IGL01774:Tnxb APN 17 34,907,813 (GRCm39) missense probably damaging 1.00
IGL01971:Tnxb APN 17 34,891,271 (GRCm39) missense probably damaging 1.00
IGL02016:Tnxb APN 17 34,891,249 (GRCm39) missense probably damaging 0.98
IGL02160:Tnxb APN 17 34,933,719 (GRCm39) missense probably benign 0.01
IGL02473:Tnxb APN 17 34,936,736 (GRCm39) missense probably damaging 1.00
IGL02666:Tnxb APN 17 34,903,913 (GRCm39) missense probably benign 0.20
IGL02831:Tnxb APN 17 34,922,545 (GRCm39) missense possibly damaging 0.93
IGL02838:Tnxb APN 17 34,908,606 (GRCm39) missense possibly damaging 0.74
IGL02965:Tnxb APN 17 34,928,628 (GRCm39) missense possibly damaging 0.93
IGL03155:Tnxb APN 17 34,932,569 (GRCm39) missense probably damaging 1.00
IGL03194:Tnxb APN 17 34,914,921 (GRCm39) nonsense probably null
IGL03215:Tnxb APN 17 34,911,499 (GRCm39) missense possibly damaging 0.66
IGL03256:Tnxb APN 17 34,907,694 (GRCm39) missense probably damaging 1.00
BB008:Tnxb UTSW 17 34,907,672 (GRCm39) missense probably damaging 1.00
BB018:Tnxb UTSW 17 34,907,672 (GRCm39) missense probably damaging 1.00
E0370:Tnxb UTSW 17 34,897,917 (GRCm39) missense probably damaging 1.00
R0006:Tnxb UTSW 17 34,901,266 (GRCm39) missense probably benign 0.07
R0049:Tnxb UTSW 17 34,928,542 (GRCm39) missense possibly damaging 0.93
R0050:Tnxb UTSW 17 34,892,299 (GRCm39) missense probably damaging 1.00
R0233:Tnxb UTSW 17 34,918,007 (GRCm39) missense probably benign 0.32
R0233:Tnxb UTSW 17 34,918,007 (GRCm39) missense probably benign 0.32
R0311:Tnxb UTSW 17 34,935,958 (GRCm39) missense probably damaging 0.97
R0326:Tnxb UTSW 17 34,917,153 (GRCm39) missense probably benign 0.32
R0387:Tnxb UTSW 17 34,902,548 (GRCm39) missense probably benign 0.30
R0396:Tnxb UTSW 17 34,890,707 (GRCm39) missense probably damaging 1.00
R0511:Tnxb UTSW 17 34,937,219 (GRCm39) missense probably damaging 0.96
R0540:Tnxb UTSW 17 34,890,892 (GRCm39) missense probably damaging 1.00
R0563:Tnxb UTSW 17 34,935,921 (GRCm39) missense probably benign 0.05
R0575:Tnxb UTSW 17 34,936,180 (GRCm39) missense possibly damaging 0.91
R0586:Tnxb UTSW 17 34,891,118 (GRCm39) missense probably damaging 1.00
R0607:Tnxb UTSW 17 34,890,892 (GRCm39) missense probably damaging 1.00
R0622:Tnxb UTSW 17 34,937,703 (GRCm39) missense probably damaging 1.00
R0624:Tnxb UTSW 17 34,902,522 (GRCm39) missense probably damaging 1.00
R0709:Tnxb UTSW 17 34,908,328 (GRCm39) missense probably damaging 1.00
R0898:Tnxb UTSW 17 34,889,719 (GRCm39) missense probably damaging 1.00
R0970:Tnxb UTSW 17 34,917,917 (GRCm39) missense possibly damaging 0.85
R0972:Tnxb UTSW 17 34,904,117 (GRCm39) missense probably damaging 1.00
R1118:Tnxb UTSW 17 34,904,017 (GRCm39) missense probably damaging 1.00
R1119:Tnxb UTSW 17 34,904,017 (GRCm39) missense probably damaging 1.00
R1226:Tnxb UTSW 17 34,907,903 (GRCm39) missense probably damaging 1.00
R1296:Tnxb UTSW 17 34,890,551 (GRCm39) missense probably damaging 1.00
R1297:Tnxb UTSW 17 34,929,140 (GRCm39) missense probably damaging 0.96
R1349:Tnxb UTSW 17 34,929,267 (GRCm39) missense possibly damaging 0.67
R1356:Tnxb UTSW 17 34,914,446 (GRCm39) missense possibly damaging 0.53
R1372:Tnxb UTSW 17 34,929,267 (GRCm39) missense possibly damaging 0.67
R1521:Tnxb UTSW 17 34,930,477 (GRCm39) missense probably damaging 1.00
R1522:Tnxb UTSW 17 34,937,612 (GRCm39) missense probably damaging 1.00
R1532:Tnxb UTSW 17 34,929,804 (GRCm39) missense probably damaging 1.00
R1735:Tnxb UTSW 17 34,936,944 (GRCm39) missense probably damaging 1.00
R1778:Tnxb UTSW 17 34,902,548 (GRCm39) missense probably benign 0.30
R1802:Tnxb UTSW 17 34,922,863 (GRCm39) missense probably damaging 0.98
R1824:Tnxb UTSW 17 34,911,307 (GRCm39) nonsense probably null
R1838:Tnxb UTSW 17 34,897,884 (GRCm39) missense probably damaging 0.96
R1863:Tnxb UTSW 17 34,889,848 (GRCm39) missense probably damaging 1.00
R1865:Tnxb UTSW 17 34,922,431 (GRCm39) nonsense probably null
R1867:Tnxb UTSW 17 34,890,821 (GRCm39) missense probably damaging 1.00
R1883:Tnxb UTSW 17 34,908,539 (GRCm39) missense probably benign 0.01
R1884:Tnxb UTSW 17 34,908,539 (GRCm39) missense probably benign 0.01
R1889:Tnxb UTSW 17 34,914,799 (GRCm39) missense probably damaging 0.97
R1969:Tnxb UTSW 17 34,898,055 (GRCm39) missense probably benign 0.20
R1989:Tnxb UTSW 17 34,912,859 (GRCm39) missense probably damaging 1.00
R1989:Tnxb UTSW 17 34,902,351 (GRCm39) missense probably benign 0.08
R1991:Tnxb UTSW 17 34,901,225 (GRCm39) missense probably damaging 1.00
R1991:Tnxb UTSW 17 34,890,878 (GRCm39) missense probably damaging 1.00
R1992:Tnxb UTSW 17 34,890,878 (GRCm39) missense probably damaging 1.00
R2001:Tnxb UTSW 17 34,911,553 (GRCm39) missense possibly damaging 0.82
R2018:Tnxb UTSW 17 34,890,724 (GRCm39) missense probably benign 0.04
R2030:Tnxb UTSW 17 34,937,443 (GRCm39) missense probably damaging 1.00
R2037:Tnxb UTSW 17 34,918,179 (GRCm39) missense probably damaging 1.00
R2103:Tnxb UTSW 17 34,901,225 (GRCm39) missense probably damaging 1.00
R2116:Tnxb UTSW 17 34,891,201 (GRCm39) missense probably damaging 1.00
R2206:Tnxb UTSW 17 34,928,391 (GRCm39) missense possibly damaging 0.86
R2207:Tnxb UTSW 17 34,928,391 (GRCm39) missense possibly damaging 0.86
R2215:Tnxb UTSW 17 34,923,114 (GRCm39) missense possibly damaging 0.93
R2413:Tnxb UTSW 17 34,937,252 (GRCm39) missense probably damaging 0.99
R2680:Tnxb UTSW 17 34,922,594 (GRCm39) missense possibly damaging 0.51
R2910:Tnxb UTSW 17 34,891,424 (GRCm39) missense probably damaging 1.00
R2984:Tnxb UTSW 17 34,897,636 (GRCm39) nonsense probably null
R3120:Tnxb UTSW 17 34,911,329 (GRCm39) missense possibly damaging 0.86
R3429:Tnxb UTSW 17 34,922,561 (GRCm39) missense probably damaging 0.98
R3429:Tnxb UTSW 17 34,891,605 (GRCm39) nonsense probably null
R3552:Tnxb UTSW 17 34,937,695 (GRCm39) missense probably damaging 1.00
R3698:Tnxb UTSW 17 34,909,407 (GRCm39) critical splice donor site probably null
R3720:Tnxb UTSW 17 34,931,938 (GRCm39) missense possibly damaging 0.95
R3841:Tnxb UTSW 17 34,917,897 (GRCm39) missense possibly damaging 0.72
R3848:Tnxb UTSW 17 34,909,369 (GRCm39) missense possibly damaging 0.82
R3886:Tnxb UTSW 17 34,937,885 (GRCm39) missense probably damaging 1.00
R4074:Tnxb UTSW 17 34,890,845 (GRCm39) missense probably benign 0.22
R4159:Tnxb UTSW 17 34,930,491 (GRCm39) missense probably damaging 0.99
R4160:Tnxb UTSW 17 34,930,491 (GRCm39) missense probably damaging 0.99
R4161:Tnxb UTSW 17 34,930,491 (GRCm39) missense probably damaging 0.99
R4181:Tnxb UTSW 17 34,928,428 (GRCm39) missense possibly damaging 0.93
R4210:Tnxb UTSW 17 34,929,951 (GRCm39) missense possibly damaging 0.84
R4275:Tnxb UTSW 17 34,917,205 (GRCm39) missense probably damaging 0.98
R4329:Tnxb UTSW 17 34,912,838 (GRCm39) missense probably damaging 1.00
R4394:Tnxb UTSW 17 34,897,636 (GRCm39) nonsense probably null
R4395:Tnxb UTSW 17 34,897,636 (GRCm39) nonsense probably null
R4397:Tnxb UTSW 17 34,897,636 (GRCm39) nonsense probably null
R4540:Tnxb UTSW 17 34,922,309 (GRCm39) missense possibly damaging 0.86
R4673:Tnxb UTSW 17 34,891,514 (GRCm39) missense probably damaging 0.99
R4719:Tnxb UTSW 17 34,908,394 (GRCm39) missense probably damaging 1.00
R4725:Tnxb UTSW 17 34,918,041 (GRCm39) missense probably damaging 0.99
R4753:Tnxb UTSW 17 34,914,909 (GRCm39) missense possibly damaging 0.71
R4777:Tnxb UTSW 17 34,890,917 (GRCm39) missense probably damaging 1.00
R4837:Tnxb UTSW 17 34,936,981 (GRCm39) missense probably damaging 0.98
R4898:Tnxb UTSW 17 34,914,566 (GRCm39) missense possibly damaging 0.95
R4938:Tnxb UTSW 17 34,932,606 (GRCm39) missense probably damaging 1.00
R5044:Tnxb UTSW 17 34,936,457 (GRCm39) missense probably damaging 1.00
R5100:Tnxb UTSW 17 34,929,902 (GRCm39) missense probably damaging 0.99
R5223:Tnxb UTSW 17 34,923,052 (GRCm39) missense possibly damaging 0.51
R5269:Tnxb UTSW 17 34,922,582 (GRCm39) missense possibly damaging 0.95
R5333:Tnxb UTSW 17 34,909,205 (GRCm39) missense probably damaging 1.00
R5454:Tnxb UTSW 17 34,928,599 (GRCm39) missense possibly damaging 0.71
R5470:Tnxb UTSW 17 34,935,947 (GRCm39) missense probably null 1.00
R5475:Tnxb UTSW 17 34,908,567 (GRCm39) missense probably damaging 1.00
R5574:Tnxb UTSW 17 34,929,998 (GRCm39) missense probably benign
R5596:Tnxb UTSW 17 34,907,778 (GRCm39) missense probably damaging 1.00
R5599:Tnxb UTSW 17 34,909,179 (GRCm39) missense probably benign 0.22
R5599:Tnxb UTSW 17 34,909,176 (GRCm39) missense probably damaging 1.00
R5615:Tnxb UTSW 17 34,902,392 (GRCm39) missense probably damaging 1.00
R5620:Tnxb UTSW 17 34,936,504 (GRCm39) nonsense probably null
R5625:Tnxb UTSW 17 34,904,185 (GRCm39) missense probably benign 0.30
R5734:Tnxb UTSW 17 34,917,884 (GRCm39) missense possibly damaging 0.53
R5896:Tnxb UTSW 17 34,891,126 (GRCm39) missense probably damaging 1.00
R5961:Tnxb UTSW 17 34,937,609 (GRCm39) missense probably damaging 1.00
R5974:Tnxb UTSW 17 34,904,681 (GRCm39) missense probably damaging 1.00
R6091:Tnxb UTSW 17 34,929,338 (GRCm39) missense probably damaging 0.98
R6134:Tnxb UTSW 17 34,890,986 (GRCm39) missense probably damaging 0.96
R6325:Tnxb UTSW 17 34,911,398 (GRCm39) missense probably damaging 1.00
R6358:Tnxb UTSW 17 34,897,968 (GRCm39) missense probably damaging 0.98
R6362:Tnxb UTSW 17 34,913,362 (GRCm39) missense probably damaging 1.00
R6432:Tnxb UTSW 17 34,936,891 (GRCm39) missense probably damaging 1.00
R6461:Tnxb UTSW 17 34,890,872 (GRCm39) missense probably damaging 1.00
R6467:Tnxb UTSW 17 34,912,898 (GRCm39) missense probably damaging 1.00
R6476:Tnxb UTSW 17 34,909,166 (GRCm39) missense probably damaging 0.98
R6477:Tnxb UTSW 17 34,938,513 (GRCm39) missense probably damaging 1.00
R6631:Tnxb UTSW 17 34,937,222 (GRCm39) missense probably damaging 1.00
R6774:Tnxb UTSW 17 34,928,606 (GRCm39) nonsense probably null
R6787:Tnxb UTSW 17 34,929,710 (GRCm39) missense probably benign 0.02
R6805:Tnxb UTSW 17 34,917,127 (GRCm39) missense possibly damaging 0.93
R6860:Tnxb UTSW 17 34,932,131 (GRCm39) missense probably damaging 0.99
R6883:Tnxb UTSW 17 34,937,493 (GRCm39) missense probably damaging 1.00
R7049:Tnxb UTSW 17 34,936,242 (GRCm39) critical splice donor site probably null
R7107:Tnxb UTSW 17 34,890,314 (GRCm39) missense unknown
R7172:Tnxb UTSW 17 34,914,994 (GRCm39) missense probably damaging 1.00
R7206:Tnxb UTSW 17 34,923,075 (GRCm39) missense possibly damaging 0.71
R7219:Tnxb UTSW 17 34,898,039 (GRCm39) missense probably benign 0.08
R7237:Tnxb UTSW 17 34,901,170 (GRCm39) missense possibly damaging 0.82
R7257:Tnxb UTSW 17 34,935,475 (GRCm39) missense probably benign 0.44
R7269:Tnxb UTSW 17 34,914,428 (GRCm39) missense probably damaging 1.00
R7302:Tnxb UTSW 17 34,897,875 (GRCm39) missense probably benign 0.41
R7372:Tnxb UTSW 17 34,936,228 (GRCm39) missense possibly damaging 0.72
R7384:Tnxb UTSW 17 34,937,492 (GRCm39) missense probably damaging 1.00
R7447:Tnxb UTSW 17 34,937,444 (GRCm39) missense probably damaging 1.00
R7449:Tnxb UTSW 17 34,922,335 (GRCm39) missense possibly damaging 0.93
R7480:Tnxb UTSW 17 34,934,747 (GRCm39) missense probably damaging 0.96
R7506:Tnxb UTSW 17 34,934,665 (GRCm39) missense possibly damaging 0.89
R7586:Tnxb UTSW 17 34,935,382 (GRCm39) missense probably damaging 0.98
R7688:Tnxb UTSW 17 34,890,880 (GRCm39) missense probably benign 0.23
R7690:Tnxb UTSW 17 34,908,494 (GRCm39) missense probably benign 0.03
R7690:Tnxb UTSW 17 34,908,501 (GRCm39) missense probably damaging 1.00
R7732:Tnxb UTSW 17 34,913,254 (GRCm39) missense probably damaging 1.00
R7735:Tnxb UTSW 17 34,890,398 (GRCm39) missense unknown
R7760:Tnxb UTSW 17 34,931,911 (GRCm39) missense probably damaging 0.96
R7874:Tnxb UTSW 17 34,930,417 (GRCm39) missense probably damaging 1.00
R7909:Tnxb UTSW 17 34,911,428 (GRCm39) missense probably benign 0.02
R7922:Tnxb UTSW 17 34,933,577 (GRCm39) missense probably damaging 1.00
R7931:Tnxb UTSW 17 34,907,672 (GRCm39) missense probably damaging 1.00
R7949:Tnxb UTSW 17 34,936,103 (GRCm39) missense probably damaging 1.00
R7953:Tnxb UTSW 17 34,929,077 (GRCm39) missense probably benign 0.03
R7953:Tnxb UTSW 17 34,928,509 (GRCm39) missense possibly damaging 0.86
R7977:Tnxb UTSW 17 34,929,194 (GRCm39) missense possibly damaging 0.92
R7985:Tnxb UTSW 17 34,935,984 (GRCm39) critical splice donor site probably null
R7987:Tnxb UTSW 17 34,929,194 (GRCm39) missense possibly damaging 0.92
R8040:Tnxb UTSW 17 34,935,532 (GRCm39) missense probably damaging 1.00
R8053:Tnxb UTSW 17 34,923,153 (GRCm39) missense probably damaging 0.98
R8074:Tnxb UTSW 17 34,922,955 (GRCm39) missense probably benign 0.32
R8089:Tnxb UTSW 17 34,891,763 (GRCm39) missense unknown
R8169:Tnxb UTSW 17 34,918,181 (GRCm39) missense possibly damaging 0.96
R8348:Tnxb UTSW 17 34,929,102 (GRCm39) missense possibly damaging 0.92
R8352:Tnxb UTSW 17 34,908,381 (GRCm39) missense probably damaging 1.00
R8362:Tnxb UTSW 17 34,931,946 (GRCm39) missense probably damaging 0.99
R8452:Tnxb UTSW 17 34,908,381 (GRCm39) missense probably damaging 1.00
R8527:Tnxb UTSW 17 34,907,634 (GRCm39) missense probably damaging 1.00
R8754:Tnxb UTSW 17 34,934,882 (GRCm39) missense probably damaging 1.00
R8936:Tnxb UTSW 17 34,904,646 (GRCm39) missense probably damaging 1.00
R8986:Tnxb UTSW 17 34,897,646 (GRCm39) missense possibly damaging 0.66
R9001:Tnxb UTSW 17 34,922,410 (GRCm39) missense probably benign 0.32
R9215:Tnxb UTSW 17 34,891,564 (GRCm39) missense unknown
R9226:Tnxb UTSW 17 34,904,766 (GRCm39) missense probably damaging 1.00
R9276:Tnxb UTSW 17 34,929,134 (GRCm39) missense possibly damaging 0.60
R9279:Tnxb UTSW 17 34,898,088 (GRCm39) missense possibly damaging 0.46
R9363:Tnxb UTSW 17 34,917,294 (GRCm39) missense possibly damaging 0.93
R9367:Tnxb UTSW 17 34,931,993 (GRCm39) missense probably damaging 1.00
R9494:Tnxb UTSW 17 34,904,796 (GRCm39) missense probably damaging 1.00
R9606:Tnxb UTSW 17 34,914,578 (GRCm39) missense possibly damaging 0.82
R9650:Tnxb UTSW 17 34,930,629 (GRCm39) missense probably damaging 0.99
R9677:Tnxb UTSW 17 34,917,878 (GRCm39) missense possibly damaging 0.93
R9690:Tnxb UTSW 17 34,936,171 (GRCm39) missense probably damaging 1.00
R9761:Tnxb UTSW 17 34,903,987 (GRCm39) missense probably benign 0.32
X0004:Tnxb UTSW 17 34,922,389 (GRCm39) missense possibly damaging 0.71
X0010:Tnxb UTSW 17 34,890,908 (GRCm39) missense probably damaging 1.00
X0019:Tnxb UTSW 17 34,913,163 (GRCm39) missense possibly damaging 0.51
X0063:Tnxb UTSW 17 34,922,482 (GRCm39) missense probably damaging 0.98
X0064:Tnxb UTSW 17 34,913,006 (GRCm39) missense probably damaging 1.00
Z1177:Tnxb UTSW 17 34,937,700 (GRCm39) missense probably damaging 0.99
Z1177:Tnxb UTSW 17 34,902,305 (GRCm39) missense probably damaging 1.00
Z1177:Tnxb UTSW 17 34,890,740 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- CTACCATGGGACTGCAGGTAAG -3'
(R):5'- TTCCTCAGCAAGGTTGGCATG -3'

Sequencing Primer
(F):5'- CTGCAGGTAAGTGTGGGCAC -3'
(R):5'- GAGTGTCTCATTTCACAGTTGAGCC -3'
Posted On 2021-04-30