Mutagenetix > Incidental Mutation

Incidental Mutation 'R8814:Vmn2r7'

672592

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r7

Ensembl Gene

ENSMUSG00000116028

Gene Name

Synonyms

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.088) question?

Stock #

R8814 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

64690660-64719602 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 64716563 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 112 (I112T)

Ref Sequence

ENSEMBL: ENSMUSP00000131220 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000161972] [ENSMUST00000168072]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000161972
AA Change: I203T

PolyPhen 2 Score 0.137 (Sensitivity: 0.92; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000124192
Gene: ENSMUSG00000062200
AA Change: I203T

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:ANF_receptor	90	507	3.8e-77	PFAM
Pfam:NCD3G	549	602	3.4e-17	PFAM
Pfam:7tm_3	635	869	1.1e-47	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000168072
AA Change: I112T

PolyPhen 2 Score 0.137 (Sensitivity: 0.92; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000131220
Gene: ENSMUSG00000116028
AA Change: I112T

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	1	416	5.1e-72	PFAM
Pfam:Peripla_BP_6	63	245	6.1e-10	PFAM
Pfam:NCD3G	458	511	1.8e-17	PFAM
Pfam:7tm_3	542	779	4.3e-76	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.2%

Validation Efficiency

100% (51/51)

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4922502D21Rik	T	C	6: 129,325,604		probably benign	Het
Brd7	A	G	8: 88,345,154	V361A	probably benign	Het
C6	A	T	15: 4,792,784	Q595L	probably benign	Het
Cacna2d3	T	A	14: 29,097,815	Y532F	probably damaging	Het
Cep85l	A	T	10: 53,348,969	Y175N	probably benign	Het
Clca3a2	G	T	3: 144,797,764	N808K	probably benign	Het
Cpsf4	T	G	5: 145,178,868	S201R	probably benign	Het
Crispld2	A	G	8: 120,015,345	H144R	possibly damaging	Het
Cyp1b1	T	C	17: 79,713,359	E318G	probably benign	Het
Fam109a	G	T	5: 121,853,045	V157L	probably benign	Het
Fer1l4	A	G	2: 156,052,243	F47L	probably benign	Het
Flnb	A	G	14: 7,927,409	D1873G	probably damaging	Het
Gm47995	A	G	1: 151,198,988	M181V	probably benign	Het
Hace1	A	G	10: 45,652,701	Y346C	probably damaging	Het
Hemgn	G	T	4: 46,400,717	Q48K	possibly damaging	Het
Hhip	T	C	8: 80,051,472	D143G	probably damaging	Het
Ift74	C	T	4: 94,662,636	Q342*	probably null	Het
Kng2	A	T	16: 23,004,011	I197N	probably benign	Het
Lcat	G	A	8: 105,941,970	P167S	probably damaging	Het
Lmntd2	G	A	7: 141,210,084	R672W	probably damaging	Het
Mroh2b	G	T	15: 4,941,625	L1037F	possibly damaging	Het
Msh4	A	G	3: 153,872,320	S640P	probably damaging	Het
Mterf1b	T	C	5: 4,197,456	S366P	probably damaging	Het
Nrxn1	A	T	17: 90,630,101	C643S	probably damaging	Het
Olfr1164	T	A	2: 88,092,971	I322F	probably benign	Het
Olfr1496	T	A	19: 13,781,533	I305N	possibly damaging	Het
Olfr485	T	A	7: 108,159,065	K269N	probably benign	Het
Olfr605	A	G	7: 103,442,913	V70A	probably benign	Het
Olfr709-ps1	T	A	7: 106,926,818	I214F	probably damaging	Het
Pask	C	A	1: 93,320,585	R998L	probably benign	Het
Pcdh8	A	G	14: 79,768,897	L742P	probably benign	Het
Psma3	A	G	12: 70,978,806	E32G	probably benign	Het
Samd11	T	C	4: 156,247,884	E500G	probably benign	Het
Scarb1	A	T	5: 125,294,092	D305E	probably benign	Het
Serpinb6b	A	G	13: 32,978,304	H362R	possibly damaging	Het
Siglec1	G	A	2: 131,072,744	T1484M	probably damaging	Het
Slfn8	A	G	11: 83,016,679	V346A	possibly damaging	Het
Slitrk6	G	C	14: 110,749,938	A779G	probably benign	Het
Soga1	C	T	2: 157,030,531	W965*	probably null	Het
Sub1	A	C	15: 11,984,231	V124G	probably damaging	Het
Tbc1d32	A	G	10: 56,196,592	I277T	possibly damaging	Het
Tln2	C	A	9: 67,221,411	E1465D	possibly damaging	Het
Trappc10	A	G	10: 78,202,919	Y780H	probably damaging	Het
Trim28	T	A	7: 13,028,527	N359K	probably damaging	Het
Tspan15	G	A	10: 62,188,056	T281M	probably benign	Het
Uaca	A	G	9: 60,866,398	N396D	possibly damaging	Het
Vmn1r84	A	G	7: 12,362,458	S103P	probably damaging	Het
Vmn2r22	C	G	6: 123,637,830	R267T	probably damaging	Het
Vmn2r70	T	A	7: 85,565,961	I122F	probably benign	Het
Vmn2r79	C	G	7: 87,002,506	T371S	probably benign	Het
Vps8	T	C	16: 21,576,650	L1230P	probably damaging	Het
Zfp26	A	T	9: 20,438,434	V278D	probably benign	Het

Other mutations in Vmn2r7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00961:Vmn2r7	APN	3	64715813	missense	possibly damaging	0.60
IGL01762:Vmn2r7	APN	3	64691435	missense	probably benign	0.39
IGL01903:Vmn2r7	APN	3	64719443	missense	probably benign	0.00
IGL02263:Vmn2r7	APN	3	64691447	missense	probably damaging	1.00
IGL02458:Vmn2r7	APN	3	64693025	missense	probably damaging	0.97
IGL02593:Vmn2r7	APN	3	64693022	missense	probably damaging	1.00
IGL02797:Vmn2r7	APN	3	64691245	missense	possibly damaging	0.80
IGL03047:Vmn2r7	UTSW	3	64707218	missense	possibly damaging	0.81
PIT4504001:Vmn2r7	UTSW	3	64715976	missense	probably benign	0.01
R0193:Vmn2r7	UTSW	3	64691039	missense	probably damaging	1.00
R0329:Vmn2r7	UTSW	3	64691018	missense	probably damaging	1.00
R0609:Vmn2r7	UTSW	3	64716479	missense	probably benign	0.44
R0735:Vmn2r7	UTSW	3	64716367	missense	probably benign	0.02
R0941:Vmn2r7	UTSW	3	64716579	missense	probably benign
R1065:Vmn2r7	UTSW	3	64707138	missense	possibly damaging	0.82
R1378:Vmn2r7	UTSW	3	64691604	missense	possibly damaging	0.59
R1445:Vmn2r7	UTSW	3	64724802	missense	probably benign	0.01
R1506:Vmn2r7	UTSW	3	64707079	missense	probably benign
R1509:Vmn2r7	UTSW	3	64716460	nonsense	probably null
R1519:Vmn2r7	UTSW	3	64716455	missense	possibly damaging	0.95
R1706:Vmn2r7	UTSW	3	64691459	missense	possibly damaging	0.79
R2113:Vmn2r7	UTSW	3	64691604	missense	possibly damaging	0.59
R3725:Vmn2r7	UTSW	3	64724991	missense	possibly damaging	0.65
R3874:Vmn2r7	UTSW	3	64719611	missense	possibly damaging	0.69
R3902:Vmn2r7	UTSW	3	64719516	missense	possibly damaging	0.46
R4084:Vmn2r7	UTSW	3	64692993	missense	probably benign	0.08
R4117:Vmn2r7	UTSW	3	64715717	intron	probably benign
R4333:Vmn2r7	UTSW	3	64690778	missense	probably damaging	1.00
R4551:Vmn2r7	UTSW	3	64690689	missense	possibly damaging	0.86
R4643:Vmn2r7	UTSW	3	64716404	missense	probably damaging	1.00
R4654:Vmn2r7	UTSW	3	64719443	missense	probably benign	0.00
R5091:Vmn2r7	UTSW	3	64690784	missense	possibly damaging	0.63
R5109:Vmn2r7	UTSW	3	64690667	missense	probably null	0.84
R5372:Vmn2r7	UTSW	3	64716324	missense	probably damaging	1.00
R5415:Vmn2r7	UTSW	3	64716237	missense	probably benign	0.07
R5740:Vmn2r7	UTSW	3	64707233	missense	probably benign
R5977:Vmn2r7	UTSW	3	64716043	nonsense	probably null
R6019:Vmn2r7	UTSW	3	64716222	missense	probably damaging	1.00
R6058:Vmn2r7	UTSW	3	64725015	missense	probably benign	0.00
R6139:Vmn2r7	UTSW	3	64715918	missense	probably damaging	1.00
R6696:Vmn2r7	UTSW	3	64707074	missense	probably benign	0.01
R6887:Vmn2r7	UTSW	3	64690827	missense	probably damaging	1.00
R6918:Vmn2r7	UTSW	3	64691339	missense	probably benign	0.03
R6949:Vmn2r7	UTSW	3	64691121	missense	probably damaging	0.99
R6980:Vmn2r7	UTSW	3	64716566	missense	possibly damaging	0.67
R7196:Vmn2r7	UTSW	3	64715777	missense	probably benign	0.00
R7286:Vmn2r7	UTSW	3	64690880	missense	probably benign	0.00
R7455:Vmn2r7	UTSW	3	64716593	missense	probably benign
R7557:Vmn2r7	UTSW	3	64724973	missense	probably benign
R7864:Vmn2r7	UTSW	3	64691526	missense	probably benign	0.10
R8046:Vmn2r7	UTSW	3	64707058	missense	probably damaging	1.00
R8068:Vmn2r7	UTSW	3	64716086	missense	probably benign	0.01
R8252:Vmn2r7	UTSW	3	64693106	missense	probably benign	0.00
R9497:Vmn2r7	UTSW	3	64707053	missense	probably benign	0.04
R9722:Vmn2r7	UTSW	3	64690986	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TGGCAGTGGAACTCTTTACTGC -3'
(R):5'- TCTACAGTAGGATGTGAGGGC -3'

Sequencing Primer
(F):5'- GTGGAACTCTTTACTGCATCAACAGC -3'
(R):5'- TGTGAGGGCAAAGGGATCCC -3'

Posted On

2021-04-30