Incidental Mutation 'R8815:Tanc1'
| ID |
672644 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tanc1
|
| Ensembl Gene |
ENSMUSG00000035168 |
| Gene Name |
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 |
| Synonyms |
1200003E16Rik |
| MMRRC Submission |
068650-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R8815 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
59442386-59676493 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 59621185 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 335
(T335A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000123345
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000037526]
[ENSMUST00000112568]
[ENSMUST00000139863]
|
| AlphaFold |
Q0VGY8 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000037526
AA Change: T335A
PolyPhen 2
Score 0.843 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000036003
Gene: ENSMUSG00000035168
AA Change: T335A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
22 |
N/A |
INTRINSIC |
|
low complexity region
|
60 |
78 |
N/A |
INTRINSIC |
|
low complexity region
|
171 |
191 |
N/A |
INTRINSIC |
|
low complexity region
|
229 |
240 |
N/A |
INTRINSIC |
|
low complexity region
|
439 |
451 |
N/A |
INTRINSIC |
|
low complexity region
|
455 |
475 |
N/A |
INTRINSIC |
|
ANK
|
893 |
925 |
1.06e3 |
SMART |
|
ANK
|
929 |
960 |
2.43e3 |
SMART |
|
ANK
|
964 |
993 |
1.12e-3 |
SMART |
|
Blast:ANK
|
997 |
1028 |
7e-12 |
BLAST |
|
ANK
|
1037 |
1066 |
1.78e3 |
SMART |
|
ANK
|
1075 |
1104 |
2.34e-1 |
SMART |
|
ANK
|
1108 |
1137 |
3.71e-4 |
SMART |
|
ANK
|
1141 |
1170 |
1.51e-4 |
SMART |
|
ANK
|
1174 |
1203 |
4.89e-4 |
SMART |
|
ANK
|
1207 |
1236 |
3.01e-4 |
SMART |
|
ANK
|
1240 |
1269 |
1.99e2 |
SMART |
|
TPR
|
1286 |
1319 |
7.49e1 |
SMART |
|
TPR
|
1333 |
1366 |
2.35e-1 |
SMART |
|
TPR
|
1367 |
1400 |
6.29e-2 |
SMART |
|
low complexity region
|
1416 |
1432 |
N/A |
INTRINSIC |
|
low complexity region
|
1454 |
1483 |
N/A |
INTRINSIC |
|
low complexity region
|
1656 |
1686 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000056900
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000112568
AA Change: T335A
PolyPhen 2
Score 0.790 (Sensitivity: 0.85; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000108187
Gene: ENSMUSG00000035168
AA Change: T335A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
22 |
N/A |
INTRINSIC |
|
low complexity region
|
60 |
78 |
N/A |
INTRINSIC |
|
low complexity region
|
171 |
191 |
N/A |
INTRINSIC |
|
low complexity region
|
229 |
240 |
N/A |
INTRINSIC |
|
low complexity region
|
432 |
444 |
N/A |
INTRINSIC |
|
low complexity region
|
448 |
468 |
N/A |
INTRINSIC |
|
ANK
|
886 |
918 |
1.06e3 |
SMART |
|
ANK
|
922 |
953 |
2.43e3 |
SMART |
|
ANK
|
957 |
986 |
1.12e-3 |
SMART |
|
Blast:ANK
|
990 |
1021 |
7e-12 |
BLAST |
|
ANK
|
1030 |
1059 |
1.78e3 |
SMART |
|
ANK
|
1068 |
1097 |
2.34e-1 |
SMART |
|
ANK
|
1101 |
1130 |
3.71e-4 |
SMART |
|
ANK
|
1134 |
1163 |
1.51e-4 |
SMART |
|
ANK
|
1167 |
1196 |
4.89e-4 |
SMART |
|
ANK
|
1200 |
1229 |
3.01e-4 |
SMART |
|
ANK
|
1233 |
1262 |
1.99e2 |
SMART |
|
TPR
|
1279 |
1312 |
7.49e1 |
SMART |
|
TPR
|
1326 |
1359 |
2.35e-1 |
SMART |
|
TPR
|
1360 |
1393 |
6.29e-2 |
SMART |
|
low complexity region
|
1409 |
1425 |
N/A |
INTRINSIC |
|
low complexity region
|
1447 |
1476 |
N/A |
INTRINSIC |
|
low complexity region
|
1649 |
1679 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000139863
AA Change: T335A
PolyPhen 2
Score 0.843 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000123345
Gene: ENSMUSG00000035168
AA Change: T335A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
22 |
N/A |
INTRINSIC |
|
low complexity region
|
60 |
78 |
N/A |
INTRINSIC |
|
low complexity region
|
171 |
191 |
N/A |
INTRINSIC |
|
low complexity region
|
229 |
240 |
N/A |
INTRINSIC |
|
low complexity region
|
439 |
451 |
N/A |
INTRINSIC |
|
low complexity region
|
455 |
475 |
N/A |
INTRINSIC |
|
ANK
|
893 |
925 |
1.06e3 |
SMART |
|
ANK
|
929 |
960 |
2.43e3 |
SMART |
|
ANK
|
964 |
993 |
1.12e-3 |
SMART |
|
Blast:ANK
|
997 |
1028 |
7e-12 |
BLAST |
|
ANK
|
1037 |
1066 |
1.78e3 |
SMART |
|
ANK
|
1075 |
1104 |
2.34e-1 |
SMART |
|
ANK
|
1108 |
1137 |
3.71e-4 |
SMART |
|
ANK
|
1141 |
1170 |
1.51e-4 |
SMART |
|
ANK
|
1174 |
1203 |
4.89e-4 |
SMART |
|
ANK
|
1207 |
1236 |
3.01e-4 |
SMART |
|
ANK
|
1240 |
1269 |
1.99e2 |
SMART |
|
TPR
|
1286 |
1319 |
7.49e1 |
SMART |
|
TPR
|
1333 |
1366 |
2.35e-1 |
SMART |
|
TPR
|
1367 |
1400 |
6.29e-2 |
SMART |
|
low complexity region
|
1416 |
1432 |
N/A |
INTRINSIC |
|
low complexity region
|
1454 |
1483 |
N/A |
INTRINSIC |
|
low complexity region
|
1656 |
1686 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
99% (70/71) |
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a gene trap vector exhibit decreased spine density in the CA3 region and impaired spatial memory. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 74 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700066M21Rik |
A |
T |
1: 57,421,943 (GRCm39) |
Q106H |
probably damaging |
Het |
| Acad9 |
T |
C |
3: 36,139,590 (GRCm39) |
C397R |
probably damaging |
Het |
| Ankfn1 |
T |
G |
11: 89,282,602 (GRCm39) |
R348S |
probably damaging |
Het |
| Ankrd61 |
A |
G |
5: 143,831,336 (GRCm39) |
C28R |
probably benign |
Het |
| Ano5 |
C |
T |
7: 51,194,548 (GRCm39) |
R94* |
probably null |
Het |
| Apela |
A |
T |
8: 65,489,590 (GRCm39) |
F10I |
unknown |
Het |
| Arhgap31 |
T |
C |
16: 38,429,790 (GRCm39) |
S362G |
probably benign |
Het |
| Arhgef18 |
C |
A |
8: 3,430,410 (GRCm39) |
H94Q |
probably benign |
Het |
| Astn2 |
A |
T |
4: 65,830,834 (GRCm39) |
L585Q |
possibly damaging |
Het |
| Atf3 |
G |
T |
1: 190,909,564 (GRCm39) |
A35D |
probably benign |
Het |
| Atp10b |
A |
T |
11: 43,093,978 (GRCm39) |
R507S |
possibly damaging |
Het |
| Brip1 |
A |
C |
11: 86,080,598 (GRCm39) |
V156G |
probably benign |
Het |
| Ccdc27 |
T |
A |
4: 154,111,205 (GRCm39) |
M636L |
probably benign |
Het |
| Ceacam5 |
T |
A |
7: 17,493,285 (GRCm39) |
N769K |
possibly damaging |
Het |
| Cklf |
C |
T |
8: 104,977,560 (GRCm39) |
|
probably benign |
Het |
| Cpeb4 |
G |
A |
11: 31,870,546 (GRCm39) |
V474M |
probably damaging |
Het |
| Dip2c |
T |
A |
13: 9,673,834 (GRCm39) |
C1091* |
probably null |
Het |
| Eef1akmt4 |
T |
A |
16: 20,437,288 (GRCm39) |
I210N |
possibly damaging |
Het |
| Fbxo38 |
A |
T |
18: 62,666,587 (GRCm39) |
H195Q |
probably damaging |
Het |
| Fbxw14 |
G |
A |
9: 109,105,305 (GRCm39) |
R287* |
probably null |
Het |
| Fes |
A |
G |
7: 80,033,619 (GRCm39) |
S211P |
possibly damaging |
Het |
| Fry |
G |
T |
5: 150,317,603 (GRCm39) |
R861L |
possibly damaging |
Het |
| Galnt12 |
A |
G |
4: 47,113,908 (GRCm39) |
|
probably benign |
Het |
| Gm14226 |
G |
A |
2: 154,866,538 (GRCm39) |
W165* |
probably null |
Het |
| Gm40460 |
GCAGCAGCTGGACTGGCAGCAGCAGGGCTTACAGCAGCTGGACTGGCAGCAGCAGGGCTTACAGCAGCTGGACTGGCAGCAGCAGGGCTTACAGCAGCTGGACTGGCAGCAG |
GCAGCAGCTGGACTGGCAGCAGCAGGGCTTACAGCAGCTGGACTGGCAGCAGCAGGGCTTACAGCAGCTGGACTGGCAGCAG |
7: 141,794,171 (GRCm39) |
|
probably benign |
Het |
| Gm40460 |
CACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG |
CACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG |
7: 141,794,554 (GRCm39) |
|
probably benign |
Het |
| Gprc6a |
A |
G |
10: 51,497,079 (GRCm39) |
V488A |
probably benign |
Het |
| Haus8 |
A |
T |
8: 71,705,910 (GRCm39) |
|
probably benign |
Het |
| Helb |
A |
T |
10: 119,948,692 (GRCm39) |
C26S |
possibly damaging |
Het |
| Icam1 |
A |
T |
9: 20,937,862 (GRCm39) |
I300F |
probably benign |
Het |
| Ip6k1 |
A |
G |
9: 107,918,211 (GRCm39) |
N181S |
probably benign |
Het |
| Itga2b |
C |
A |
11: 102,351,687 (GRCm39) |
R546L |
possibly damaging |
Het |
| Kif27 |
A |
T |
13: 58,476,818 (GRCm39) |
Y611N |
probably damaging |
Het |
| Lpcat2 |
A |
G |
8: 93,640,979 (GRCm39) |
I475V |
possibly damaging |
Het |
| Lrit2 |
A |
G |
14: 36,794,487 (GRCm39) |
K517R |
probably benign |
Het |
| Lrp1b |
A |
T |
2: 40,555,171 (GRCm39) |
I4085N |
|
Het |
| Lrrc32 |
T |
A |
7: 98,148,242 (GRCm39) |
S341T |
probably damaging |
Het |
| Lrrn2 |
T |
A |
1: 132,866,831 (GRCm39) |
I632K |
possibly damaging |
Het |
| Mettl22 |
A |
G |
16: 8,300,178 (GRCm39) |
Q194R |
probably benign |
Het |
| Mfhas1 |
T |
A |
8: 36,057,394 (GRCm39) |
V623E |
probably damaging |
Het |
| Mitd1 |
T |
C |
1: 37,929,315 (GRCm39) |
D26G |
probably damaging |
Het |
| Myo1a |
C |
T |
10: 127,546,043 (GRCm39) |
T222M |
probably benign |
Het |
| Naf1 |
A |
G |
8: 67,317,333 (GRCm39) |
K275R |
possibly damaging |
Het |
| Nf1 |
T |
C |
11: 79,332,491 (GRCm39) |
L765P |
probably damaging |
Het |
| Or12k7 |
G |
T |
2: 36,958,429 (GRCm39) |
M37I |
probably benign |
Het |
| Or52a5 |
A |
G |
7: 103,427,063 (GRCm39) |
L163P |
possibly damaging |
Het |
| Or5ac16 |
T |
A |
16: 59,022,264 (GRCm39) |
H175L |
possibly damaging |
Het |
| Or9r3 |
T |
A |
10: 129,947,808 (GRCm39) |
I284F |
probably damaging |
Het |
| Pappa |
A |
G |
4: 65,099,347 (GRCm39) |
H622R |
probably benign |
Het |
| Pcdhb4 |
A |
T |
18: 37,442,055 (GRCm39) |
Y455F |
probably damaging |
Het |
| Pepd |
A |
G |
7: 34,671,116 (GRCm39) |
Y220C |
probably damaging |
Het |
| Pias3 |
T |
C |
3: 96,607,381 (GRCm39) |
I172T |
probably damaging |
Het |
| Polq |
T |
A |
16: 36,853,893 (GRCm39) |
H415Q |
probably damaging |
Het |
| Pp2d1 |
A |
T |
17: 53,814,897 (GRCm39) |
M609K |
probably benign |
Het |
| Ppm1m |
G |
A |
9: 106,076,237 (GRCm39) |
|
probably benign |
Het |
| Prss22 |
T |
A |
17: 24,215,662 (GRCm39) |
T87S |
probably benign |
Het |
| Ptprf |
C |
A |
4: 118,095,125 (GRCm39) |
V254L |
possibly damaging |
Het |
| Ripply3 |
A |
G |
16: 94,136,723 (GRCm39) |
E128G |
possibly damaging |
Het |
| Rrm2 |
A |
C |
12: 24,760,470 (GRCm39) |
I185L |
possibly damaging |
Het |
| Sbsn |
T |
A |
7: 30,454,227 (GRCm39) |
|
probably benign |
Het |
| Sdc3 |
T |
A |
4: 130,546,336 (GRCm39) |
S232T |
probably benign |
Het |
| Slx4 |
G |
C |
16: 3,803,458 (GRCm39) |
P1119A |
probably benign |
Het |
| Smc5 |
C |
T |
19: 23,221,422 (GRCm39) |
R369Q |
probably damaging |
Het |
| Speer4a3 |
A |
G |
5: 26,158,191 (GRCm39) |
S54P |
probably damaging |
Het |
| Spns1 |
G |
A |
7: 125,971,593 (GRCm39) |
S319F |
possibly damaging |
Het |
| Sptbn4 |
G |
A |
7: 27,106,657 (GRCm39) |
Q924* |
probably null |
Het |
| Srcap |
G |
C |
7: 127,158,037 (GRCm39) |
D2638H |
unknown |
Het |
| Srsf12 |
T |
C |
4: 33,226,045 (GRCm39) |
S103P |
possibly damaging |
Het |
| Them4 |
C |
T |
3: 94,231,610 (GRCm39) |
T149I |
probably damaging |
Het |
| Trpc7 |
T |
C |
13: 56,970,312 (GRCm39) |
Y424C |
possibly damaging |
Het |
| Ttn |
C |
T |
2: 76,628,364 (GRCm39) |
D14599N |
probably damaging |
Het |
| Ttn |
A |
T |
2: 76,698,244 (GRCm39) |
L186H |
|
Het |
| Usp17lc |
T |
C |
7: 103,067,524 (GRCm39) |
F273S |
probably benign |
Het |
| Vwa5b2 |
T |
C |
16: 20,419,516 (GRCm39) |
S620P |
probably damaging |
Het |
|
| Other mutations in Tanc1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00340:Tanc1
|
APN |
2 |
59,621,185 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL00484:Tanc1
|
APN |
2 |
59,623,520 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00688:Tanc1
|
APN |
2 |
59,645,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00765:Tanc1
|
APN |
2 |
59,636,645 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL01576:Tanc1
|
APN |
2 |
59,628,079 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01590:Tanc1
|
APN |
2 |
59,615,817 (GRCm39) |
missense |
probably benign |
|
|
IGL02016:Tanc1
|
APN |
2 |
59,673,934 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02373:Tanc1
|
APN |
2 |
59,626,372 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02539:Tanc1
|
APN |
2 |
59,663,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02540:Tanc1
|
APN |
2 |
59,663,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02541:Tanc1
|
APN |
2 |
59,663,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02543:Tanc1
|
APN |
2 |
59,663,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02559:Tanc1
|
APN |
2 |
59,554,998 (GRCm39) |
splice site |
probably benign |
|
|
IGL02626:Tanc1
|
APN |
2 |
59,630,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02669:Tanc1
|
APN |
2 |
59,630,330 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02902:Tanc1
|
APN |
2 |
59,623,431 (GRCm39) |
splice site |
probably benign |
|
|
Oreja
|
UTSW |
2 |
59,622,148 (GRCm39) |
synonymous |
silent |
|
|
R0178:Tanc1
|
UTSW |
2 |
59,665,791 (GRCm39) |
nonsense |
probably null |
|
|
R0347:Tanc1
|
UTSW |
2 |
59,673,335 (GRCm39) |
missense |
probably benign |
|
|
R0570:Tanc1
|
UTSW |
2 |
59,626,382 (GRCm39) |
splice site |
probably benign |
|
|
R0660:Tanc1
|
UTSW |
2 |
59,674,228 (GRCm39) |
nonsense |
probably null |
|
|
R0664:Tanc1
|
UTSW |
2 |
59,674,228 (GRCm39) |
nonsense |
probably null |
|
|
R0898:Tanc1
|
UTSW |
2 |
59,621,132 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1333:Tanc1
|
UTSW |
2 |
59,673,835 (GRCm39) |
missense |
probably benign |
|
|
R1575:Tanc1
|
UTSW |
2 |
59,621,995 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1608:Tanc1
|
UTSW |
2 |
59,628,038 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R1616:Tanc1
|
UTSW |
2 |
59,615,731 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1703:Tanc1
|
UTSW |
2 |
59,673,365 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1727:Tanc1
|
UTSW |
2 |
59,621,153 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1809:Tanc1
|
UTSW |
2 |
59,630,441 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1812:Tanc1
|
UTSW |
2 |
59,622,023 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1925:Tanc1
|
UTSW |
2 |
59,555,095 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R1951:Tanc1
|
UTSW |
2 |
59,622,156 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R2174:Tanc1
|
UTSW |
2 |
59,674,177 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R2228:Tanc1
|
UTSW |
2 |
59,555,068 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2267:Tanc1
|
UTSW |
2 |
59,667,563 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4191:Tanc1
|
UTSW |
2 |
59,669,357 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4476:Tanc1
|
UTSW |
2 |
59,672,340 (GRCm39) |
splice site |
probably null |
|
|
R4632:Tanc1
|
UTSW |
2 |
59,626,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4825:Tanc1
|
UTSW |
2 |
59,529,766 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4982:Tanc1
|
UTSW |
2 |
59,630,287 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5338:Tanc1
|
UTSW |
2 |
59,626,178 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5657:Tanc1
|
UTSW |
2 |
59,665,051 (GRCm39) |
splice site |
probably null |
|
|
R5672:Tanc1
|
UTSW |
2 |
59,602,697 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5703:Tanc1
|
UTSW |
2 |
59,626,341 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5707:Tanc1
|
UTSW |
2 |
59,588,874 (GRCm39) |
missense |
probably benign |
|
|
R5778:Tanc1
|
UTSW |
2 |
59,529,691 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5795:Tanc1
|
UTSW |
2 |
59,637,926 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R5831:Tanc1
|
UTSW |
2 |
59,615,685 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5849:Tanc1
|
UTSW |
2 |
59,630,248 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5912:Tanc1
|
UTSW |
2 |
59,622,030 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5944:Tanc1
|
UTSW |
2 |
59,667,564 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6057:Tanc1
|
UTSW |
2 |
59,647,837 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6142:Tanc1
|
UTSW |
2 |
59,663,566 (GRCm39) |
nonsense |
probably null |
|
|
R6179:Tanc1
|
UTSW |
2 |
59,673,320 (GRCm39) |
missense |
probably benign |
0.42 |
|
R6185:Tanc1
|
UTSW |
2 |
59,621,929 (GRCm39) |
splice site |
probably null |
|
|
R6192:Tanc1
|
UTSW |
2 |
59,669,305 (GRCm39) |
splice site |
probably null |
|
|
R6196:Tanc1
|
UTSW |
2 |
59,674,366 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6197:Tanc1
|
UTSW |
2 |
59,674,366 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6230:Tanc1
|
UTSW |
2 |
59,672,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6275:Tanc1
|
UTSW |
2 |
59,673,854 (GRCm39) |
missense |
probably benign |
0.22 |
|
R6415:Tanc1
|
UTSW |
2 |
59,667,458 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6480:Tanc1
|
UTSW |
2 |
59,637,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6578:Tanc1
|
UTSW |
2 |
59,626,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6786:Tanc1
|
UTSW |
2 |
59,622,150 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7006:Tanc1
|
UTSW |
2 |
59,626,188 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7133:Tanc1
|
UTSW |
2 |
59,627,953 (GRCm39) |
missense |
probably benign |
0.16 |
|
R7381:Tanc1
|
UTSW |
2 |
59,615,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7422:Tanc1
|
UTSW |
2 |
59,636,688 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8392:Tanc1
|
UTSW |
2 |
59,636,651 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8692:Tanc1
|
UTSW |
2 |
59,673,989 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8730:Tanc1
|
UTSW |
2 |
59,601,590 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8731:Tanc1
|
UTSW |
2 |
59,673,596 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8813:Tanc1
|
UTSW |
2 |
59,630,265 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8933:Tanc1
|
UTSW |
2 |
59,615,800 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9015:Tanc1
|
UTSW |
2 |
59,622,224 (GRCm39) |
missense |
probably benign |
|
|
R9042:Tanc1
|
UTSW |
2 |
59,673,766 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9154:Tanc1
|
UTSW |
2 |
59,630,132 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9269:Tanc1
|
UTSW |
2 |
59,630,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9283:Tanc1
|
UTSW |
2 |
59,630,174 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9380:Tanc1
|
UTSW |
2 |
59,665,796 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9422:Tanc1
|
UTSW |
2 |
59,637,933 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9428:Tanc1
|
UTSW |
2 |
59,601,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9694:Tanc1
|
UTSW |
2 |
59,626,196 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF028:Tanc1
|
UTSW |
2 |
59,673,613 (GRCm39) |
small deletion |
probably benign |
|
|
RF049:Tanc1
|
UTSW |
2 |
59,673,613 (GRCm39) |
small deletion |
probably benign |
|
|
X0063:Tanc1
|
UTSW |
2 |
59,674,324 (GRCm39) |
nonsense |
probably null |
|
|
X0064:Tanc1
|
UTSW |
2 |
59,674,456 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Tanc1
|
UTSW |
2 |
59,602,873 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
Z1177:Tanc1
|
UTSW |
2 |
59,622,174 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Tanc1
|
UTSW |
2 |
59,621,231 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TCAAGTTAACAGTCCCGCCG -3'
(R):5'- TTTTAGAGAACAGCACAGACACACG -3'
Sequencing Primer
(F):5'- GCTGGCGAAAATAATTATCCCG -3'
(R):5'- ACGTCACATCATGCTTGCGG -3'
|
| Posted On |
2021-04-30 |
Incidental Mutation