Incidental Mutation 'R8816:Or9s15'
ID 672710
Institutional Source Beutler Lab
Gene Symbol Or9s15
Ensembl Gene ENSMUSG00000062497
Gene Name olfactory receptor family 9 subfamily S member 15
Synonyms Olfr1411, MOR208-3, GA_x6K02T2R7CC-81157497-81156526
MMRRC Submission 068726-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # R8816 (G1)
Quality Score 225.009
Status Not validated
Chromosome 1
Chromosomal Location 92524243-92525214 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 92524768 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Serine at position 176 (C176S)
Ref Sequence ENSEMBL: ENSMUSP00000140373 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073748] [ENSMUST00000190844] [ENSMUST00000216444]
AlphaFold Q8VFC4
Predicted Effect probably damaging
Transcript: ENSMUST00000073748
AA Change: C176S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000073422
Gene: ENSMUSG00000062497
AA Change: C176S

DomainStartEndE-ValueType
low complexity region 16 27 N/A INTRINSIC
Pfam:7tm_4 38 314 7.4e-53 PFAM
Pfam:7tm_1 48 297 1.2e-17 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000190844
AA Change: C176S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000140373
Gene: ENSMUSG00000062497
AA Change: C176S

DomainStartEndE-ValueType
low complexity region 16 27 N/A INTRINSIC
low complexity region 32 44 N/A INTRINSIC
Pfam:7tm_1 48 297 6.7e-25 PFAM
Pfam:7tm_4 146 290 2.9e-45 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216444
AA Change: C176S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca6 T A 11: 110,127,513 (GRCm39) H348L probably benign Het
Alpk1 A T 3: 127,478,024 (GRCm39) Y74* probably null Het
Ass1 T C 2: 31,383,189 (GRCm39) probably benign Het
Atp8b4 C T 2: 126,214,084 (GRCm39) probably benign Het
Atrn C A 2: 130,748,798 (GRCm39) N106K probably damaging Het
Atrn T C 2: 130,846,494 (GRCm39) V1256A probably damaging Het
Bicdl1 T A 5: 115,862,804 (GRCm39) Q150H probably damaging Het
Bltp3b T C 10: 89,626,597 (GRCm39) probably benign Het
Cdhr4 T C 9: 107,872,791 (GRCm39) V280A possibly damaging Het
Cfap54 C T 10: 92,714,454 (GRCm39) V2642I unknown Het
Chd2 T C 7: 73,140,245 (GRCm39) H661R probably damaging Het
Cntnap2 A G 6: 46,833,076 (GRCm39) D763G possibly damaging Het
Csnk1g2 T C 10: 80,474,093 (GRCm39) C160R probably damaging Het
Cyb5r4 T C 9: 86,904,286 (GRCm39) S19P probably benign Het
Cyp4a30b G A 4: 115,309,834 (GRCm39) V12M probably benign Het
Dpp6 C T 5: 27,930,711 (GRCm39) P848S probably benign Het
Dzip1 T C 14: 119,159,785 (GRCm39) Y141C probably benign Het
Eif2b3 C A 4: 116,928,052 (GRCm39) Q424K probably benign Het
Fbxw14 G A 9: 109,105,305 (GRCm39) R287* probably null Het
Fcgbp T G 7: 27,784,412 (GRCm39) S157R probably benign Het
Fmnl2 T G 2: 53,004,214 (GRCm39) V642G unknown Het
Gpr119 C T X: 47,762,276 (GRCm39) R287Q possibly damaging Het
Grm7 C T 6: 111,230,966 (GRCm39) T463I possibly damaging Het
Haus4 G A 14: 54,779,710 (GRCm39) R305C probably benign Het
Htr1f A G 16: 64,746,537 (GRCm39) S252P probably benign Het
Ino80b T C 6: 83,098,861 (GRCm39) Q359R probably damaging Het
Itgad C A 7: 127,797,542 (GRCm39) Y924* probably null Het
Itpr2 A G 6: 146,142,710 (GRCm39) Y1703H probably damaging Het
Kif5c T A 2: 49,584,799 (GRCm39) V174E probably damaging Het
Kifc2 A G 15: 76,548,371 (GRCm39) E405G probably damaging Het
Klk1b3 T C 7: 43,851,668 (GRCm39) V242A possibly damaging Het
Kndc1 T C 7: 139,517,909 (GRCm39) F1615S probably damaging Het
Lmtk2 T A 5: 144,112,793 (GRCm39) L1171* probably null Het
Myh10 A G 11: 68,693,778 (GRCm39) E1530G probably damaging Het
Nav3 T A 10: 109,699,721 (GRCm39) S258C possibly damaging Het
Nudcd3 C T 11: 6,100,587 (GRCm39) G186S probably damaging Het
Otog C T 7: 45,950,905 (GRCm39) S374F possibly damaging Het
P2ry2 T A 7: 100,647,763 (GRCm39) I181F possibly damaging Het
Pde11a T C 2: 76,121,577 (GRCm39) I335V probably benign Het
Phyhip A C 14: 70,704,375 (GRCm39) D198A probably damaging Het
Pik3r5 A T 11: 68,385,060 (GRCm39) Y655F probably damaging Het
Rab6a T C 7: 100,279,145 (GRCm39) I95T possibly damaging Het
Sgsm1 T C 5: 113,435,097 (GRCm39) E99G probably damaging Het
Skint10 A T 4: 112,603,892 (GRCm39) F98L probably benign Het
Slc35c2 A G 2: 165,119,378 (GRCm39) S321P probably benign Het
Smyd1 T A 6: 71,192,868 (GRCm39) E447V probably damaging Het
Smyd4 T C 11: 75,281,232 (GRCm39) V235A probably benign Het
Sod2 A G 17: 13,227,253 (GRCm39) Y69C probably benign Het
Spns1 G A 7: 125,971,593 (GRCm39) S319F possibly damaging Het
Tfap2b A G 1: 19,284,337 (GRCm39) S82G probably benign Het
Tln2 C A 9: 67,128,693 (GRCm39) E1465D possibly damaging Het
Tln2 A G 9: 67,128,799 (GRCm39) I1430T probably damaging Het
Trio G T 15: 27,741,357 (GRCm39) N2680K probably damaging Het
Trmt10c A T 16: 55,854,522 (GRCm39) V371D probably damaging Het
Trpm3 T C 19: 22,965,580 (GRCm39) S1692P probably damaging Het
Usb1 G T 8: 96,071,984 (GRCm39) C228F probably benign Het
Veph1 G T 3: 66,065,646 (GRCm39) H474N probably benign Het
Wls A G 3: 159,639,928 (GRCm39) T520A possibly damaging Het
Ywhae T C 11: 75,623,878 (GRCm39) Y9H probably damaging Het
Zranb3 C T 1: 127,964,347 (GRCm39) V127M possibly damaging Het
Other mutations in Or9s15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01382:Or9s15 APN 1 92,524,922 (GRCm39) missense possibly damaging 0.46
IGL02011:Or9s15 APN 1 92,524,621 (GRCm39) missense probably damaging 1.00
PIT4810001:Or9s15 UTSW 1 92,524,876 (GRCm39) missense probably benign 0.04
R2036:Or9s15 UTSW 1 92,524,328 (GRCm39) missense probably benign 0.19
R2044:Or9s15 UTSW 1 92,524,691 (GRCm39) missense probably benign 0.00
R4133:Or9s15 UTSW 1 92,524,465 (GRCm39) missense probably benign 0.09
R4406:Or9s15 UTSW 1 92,525,036 (GRCm39) missense possibly damaging 0.90
R4568:Or9s15 UTSW 1 92,525,113 (GRCm39) missense probably benign 0.09
R4701:Or9s15 UTSW 1 92,525,160 (GRCm39) missense probably benign 0.00
R4801:Or9s15 UTSW 1 92,524,720 (GRCm39) missense probably benign 0.01
R4802:Or9s15 UTSW 1 92,524,720 (GRCm39) missense probably benign 0.01
R6564:Or9s15 UTSW 1 92,524,285 (GRCm39) missense probably benign
R7082:Or9s15 UTSW 1 92,524,140 (GRCm39) start gained probably benign
R7349:Or9s15 UTSW 1 92,524,904 (GRCm39) missense possibly damaging 0.95
R7589:Or9s15 UTSW 1 92,524,781 (GRCm39) missense probably benign 0.00
R9051:Or9s15 UTSW 1 92,524,978 (GRCm39) missense probably damaging 1.00
R9267:Or9s15 UTSW 1 92,524,996 (GRCm39) missense probably benign
R9267:Or9s15 UTSW 1 92,524,994 (GRCm39) missense probably damaging 1.00
Z1177:Or9s15 UTSW 1 92,524,988 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- TGGCTACCACTGAGGCTTTC -3'
(R):5'- AGGTGGAGAAGACCTTGTGC -3'

Sequencing Primer
(F):5'- CCTCTTAGCTGTGATGGCCTATGAC -3'
(R):5'- TGCATCCTGAGAATGGTCAC -3'
Posted On 2021-04-30