Incidental Mutation 'R8818:Eid3'
ID 672875
Institutional Source Beutler Lab
Gene Symbol Eid3
Ensembl Gene ENSMUSG00000109864
Gene Name EP300 interacting inhibitor of differentiation 3
Synonyms 1700027M21Rik
MMRRC Submission 068651-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.114) question?
Stock # R8818 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 82702460-82703764 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 82703441 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Aspartic acid at position 301 (N301D)
Ref Sequence ENSEMBL: ENSMUSP00000147261 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020484] [ENSMUST00000211623] [ENSMUST00000218694] [ENSMUST00000219368] [ENSMUST00000219442] [ENSMUST00000219962]
AlphaFold Q3V124
Predicted Effect probably benign
Transcript: ENSMUST00000020484
SMART Domains Protein: ENSMUSP00000020484
Gene: ENSMUSG00000020250

DomainStartEndE-ValueType
Pfam:Pyr_redox_2 13 350 9.7e-69 PFAM
Pfam:FAD_binding_2 14 69 2.6e-8 PFAM
Pfam:Pyr_redox 192 273 1.3e-18 PFAM
Pfam:Pyr_redox_dim 370 483 8.4e-31 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000211623
AA Change: N301D

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably benign
Transcript: ENSMUST00000218694
Predicted Effect probably benign
Transcript: ENSMUST00000219368
Predicted Effect probably benign
Transcript: ENSMUST00000219442
Predicted Effect probably benign
Transcript: ENSMUST00000219962
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 98% (55/56)
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca14 G T 7: 119,815,524 (GRCm39) M257I probably benign Het
Adam23 T C 1: 63,584,627 (GRCm39) V345A probably damaging Het
Anxa6 T G 11: 54,902,578 (GRCm39) N52T possibly damaging Het
Arhgef15 G A 11: 68,841,938 (GRCm39) H496Y probably damaging Het
Atp2a3 A G 11: 72,872,765 (GRCm39) E771G probably damaging Het
B3gnt5 A G 16: 19,588,347 (GRCm39) T189A possibly damaging Het
Becn1 A T 11: 101,186,230 (GRCm39) S125T probably damaging Het
Bltp1 T G 3: 37,050,697 (GRCm39) M3011R possibly damaging Het
Ccdc180 A G 4: 45,900,484 (GRCm39) M283V probably benign Het
Cdh17 T C 4: 11,771,323 (GRCm39) F35S probably damaging Het
Clcn1 T A 6: 42,282,477 (GRCm39) I515N probably damaging Het
Cyp4f17 A G 17: 32,743,068 (GRCm39) Y247C probably damaging Het
Dcp1a T A 14: 30,240,899 (GRCm39) H236Q possibly damaging Het
Dnah11 T A 12: 117,874,764 (GRCm39) N4034Y probably damaging Het
Dsg1a A G 18: 20,473,599 (GRCm39) I891V possibly damaging Het
Fbrs C A 7: 127,078,694 (GRCm39) D108E unknown Het
Fbxw14 A C 9: 109,116,071 (GRCm39) probably benign Het
Fzd8 A G 18: 9,214,474 (GRCm39) T519A probably benign Het
Gldc C G 19: 30,078,212 (GRCm39) M928I probably benign Het
Gpr3 C A 4: 132,938,538 (GRCm39) V45L possibly damaging Het
Gramd1b A T 9: 40,215,780 (GRCm39) I690K probably benign Het
Grhl2 T A 15: 37,270,912 (GRCm39) D33E probably damaging Het
Kcnj4 C A 15: 79,369,920 (GRCm39) R20L probably damaging Het
Klhl5 A G 5: 65,305,989 (GRCm39) I319V probably benign Het
Lars2 A T 9: 123,221,892 (GRCm39) E135D possibly damaging Het
Map9 T A 3: 82,291,270 (GRCm39) Y602N possibly damaging Het
Mphosph9 A T 5: 124,463,027 (GRCm39) L6* probably null Het
Naa35 C T 13: 59,748,761 (GRCm39) T131M probably damaging Het
Nucb2 T A 7: 116,121,136 (GRCm39) L22Q possibly damaging Het
Or8g26 A G 9: 39,096,062 (GRCm39) Y193C probably damaging Het
Or8k28 C A 2: 86,286,078 (GRCm39) C179F probably damaging Het
Pcdhb6 C T 18: 37,468,837 (GRCm39) T586I probably benign Het
Ppcs A T 4: 119,279,330 (GRCm39) L74Q probably damaging Het
Ppp6r3 A T 19: 3,517,216 (GRCm39) V677D probably benign Het
Psg27 C T 7: 18,294,337 (GRCm39) G357S probably damaging Het
Ptgdr2 A G 19: 10,918,380 (GRCm39) N299S probably damaging Het
Relb T A 7: 19,353,762 (GRCm39) I39F probably damaging Het
Ripor2 T A 13: 24,901,651 (GRCm39) S907R possibly damaging Het
Rnf170 T G 8: 26,629,043 (GRCm39) D172E probably benign Het
Rnf31 C A 14: 55,832,396 (GRCm39) Q273K probably benign Het
Rrp36 A T 17: 46,983,336 (GRCm39) S93T probably damaging Het
Rsad1 A T 11: 94,439,100 (GRCm39) V120D probably benign Het
Ryr3 C T 2: 112,661,441 (GRCm39) A1870T probably damaging Het
Serpina10 T G 12: 103,595,063 (GRCm39) D52A probably benign Het
Slc47a1 A G 11: 61,261,055 (GRCm39) I115T probably benign Het
Spag17 T A 3: 99,920,543 (GRCm39) M426K probably benign Het
Sppl2b TGTCACAGGT TGT 10: 80,701,903 (GRCm39) probably null Het
Sptbn4 T G 7: 27,063,592 (GRCm39) E2283A possibly damaging Het
Top3a A G 11: 60,633,877 (GRCm39) C740R probably damaging Het
Tpgs2 A T 18: 25,291,365 (GRCm39) V33E probably damaging Het
Treh T C 9: 44,592,823 (GRCm39) I116T probably damaging Het
Trpm3 A T 19: 22,955,952 (GRCm39) N1138I possibly damaging Het
Unc13d AATGCCTCCCATGCC AATGCCTCCCATGCCTCCCATGCC 11: 115,958,998 (GRCm39) probably benign Het
Vamp9 A T 5: 100,089,094 (GRCm39) N120Y probably damaging Het
Zswim9 G T 7: 12,994,456 (GRCm39) Q567K probably benign Het
Other mutations in Eid3
AlleleSourceChrCoordTypePredicted EffectPPH Score
PIT4581001:Eid3 UTSW 10 82,703,589 (GRCm39) missense probably damaging 1.00
R6033:Eid3 UTSW 10 82,703,487 (GRCm39) missense probably damaging 1.00
R6033:Eid3 UTSW 10 82,703,487 (GRCm39) missense probably damaging 1.00
R7450:Eid3 UTSW 10 82,702,737 (GRCm39) missense probably benign 0.17
R8891:Eid3 UTSW 10 82,702,992 (GRCm39) missense probably damaging 1.00
R9039:Eid3 UTSW 10 82,703,565 (GRCm39) missense possibly damaging 0.58
R9171:Eid3 UTSW 10 82,703,316 (GRCm39) missense probably damaging 0.96
R9411:Eid3 UTSW 10 82,703,652 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGTCACAAAAGAGCTTGCAAAATGG -3'
(R):5'- GCCTCTGAAATTTCAAAAGTGGAG -3'

Sequencing Primer
(F):5'- AAGTGGAGATATGCCTACAAAGTTG -3'
(R):5'- GTGGAGACAATATTTTTCCAGTCCTG -3'
Posted On 2021-04-30