Incidental Mutation 'R8819:Tnfsf10'
ID 672912
Institutional Source Beutler Lab
Gene Symbol Tnfsf10
Ensembl Gene ENSMUSG00000039304
Gene Name tumor necrosis factor (ligand) superfamily, member 10
Synonyms APO-2L, A330042I21Rik, Trail
MMRRC Submission 068652-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8819 (G1)
Quality Score 225.009
Status Validated
Chromosome 3
Chromosomal Location 27371226-27393814 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 27389451 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 171 (V171M)
Ref Sequence ENSEMBL: ENSMUSP00000040271 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000046383] [ENSMUST00000174840]
AlphaFold P50592
Predicted Effect probably benign
Transcript: ENSMUST00000046383
AA Change: V171M

PolyPhen 2 Score 0.070 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000040271
Gene: ENSMUSG00000039304
AA Change: V171M

DomainStartEndE-ValueType
transmembrane domain 20 42 N/A INTRINSIC
TNF 146 290 5.35e-37 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000174840
AA Change: V171M

PolyPhen 2 Score 0.683 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000133917
Gene: ENSMUSG00000039304
AA Change: V171M

DomainStartEndE-ValueType
transmembrane domain 15 37 N/A INTRINSIC
Pfam:TNF 156 226 7.1e-17 PFAM
Meta Mutation Damage Score 0.0846 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 100% (52/52)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
PHENOTYPE: Homozygotes for a null allele show thymus hyperplasia, abnormal negative T cell selection, increased susceptibility to autoimmune diseases and to tumor initiation and metastasis, and resistance to induced hepatitis. Homozygotes for another null allele are unable to control A20 lymphoma progression. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca17 A G 17: 24,547,576 (GRCm39) L266P probably damaging Het
Als2cl T C 9: 110,714,855 (GRCm39) F125L probably benign Het
Arhgap33 T C 7: 30,228,165 (GRCm39) I406V probably benign Het
Bag5 T C 12: 111,677,709 (GRCm39) N38S probably benign Het
Clk2 T A 3: 89,082,730 (GRCm39) M392K probably damaging Het
Cngb1 C T 8: 95,980,037 (GRCm39) probably null Het
Cps1 T A 1: 67,267,439 (GRCm39) N1402K possibly damaging Het
Cracd CTGAGGCAGCGCGAGGCCGAGAGGCAGGAGGAGGAAG C 5: 77,004,793 (GRCm39) probably benign Het
Cyp2u1 T C 3: 131,092,016 (GRCm39) H168R probably damaging Het
Dapl1 T C 2: 59,335,056 (GRCm39) L70P probably damaging Het
Ddr2 T A 1: 169,805,483 (GRCm39) K836* probably null Het
Dnmbp C T 19: 43,889,854 (GRCm39) V638M probably benign Het
Dsel A G 1: 111,787,994 (GRCm39) L847P probably benign Het
Eef1b2 T C 1: 63,217,268 (GRCm39) probably benign Het
Eif1ad8 C T 12: 87,563,910 (GRCm39) R82* probably null Het
Fbll1 T C 11: 35,688,802 (GRCm39) K154E probably benign Het
Fbxw17 A T 13: 50,587,351 (GRCm39) K437M possibly damaging Het
Fktn T C 4: 53,735,001 (GRCm39) V174A possibly damaging Het
Frem1 C A 4: 82,821,754 (GRCm39) S2118I probably damaging Het
Gabrb3 T C 7: 57,442,329 (GRCm39) S212P probably damaging Het
Gimap9 A G 6: 48,654,821 (GRCm39) D136G probably benign Het
Hps1 T C 19: 42,759,648 (GRCm39) I55V probably benign Het
Huwe1 A G X: 150,669,993 (GRCm39) K1482R probably benign Het
Ift46 C T 9: 44,701,819 (GRCm39) T283I probably damaging Het
Ldb2 G A 5: 44,956,757 (GRCm39) Q27* probably null Het
Lmcd1 T A 6: 112,306,770 (GRCm39) I314N probably damaging Het
Lypd9 T G 11: 58,337,129 (GRCm39) S115R probably damaging Het
Mctp2 C A 7: 71,879,081 (GRCm39) V259L probably benign Het
Midn T G 10: 79,990,234 (GRCm39) S302A probably damaging Het
Ncor2 A G 5: 125,106,291 (GRCm39) V797A Het
Npm2 A G 14: 70,885,768 (GRCm39) S146P probably damaging Het
Npr1 G A 3: 90,372,201 (GRCm39) R204C probably damaging Het
Or2w2 G A 13: 21,757,999 (GRCm39) S209L probably benign Het
Or52n3 T A 7: 104,530,862 (GRCm39) V316D possibly damaging Het
Or6e1 C T 14: 54,520,070 (GRCm39) G94D probably benign Het
Paip2b A C 6: 83,791,738 (GRCm39) M48R probably damaging Het
Pcsk2 T A 2: 143,642,990 (GRCm39) H422Q probably damaging Het
Pdzph1 G C 17: 59,187,715 (GRCm39) Y1168* probably null Het
Peli2 G A 14: 48,490,130 (GRCm39) E201K possibly damaging Het
Prelp T C 1: 133,842,878 (GRCm39) N89S probably damaging Het
Rapgef3 T C 15: 97,646,538 (GRCm39) N799S probably benign Het
Rel C T 11: 23,695,626 (GRCm39) R219H probably damaging Het
Relch T A 1: 105,654,179 (GRCm39) F873L possibly damaging Het
Rimbp3 T C 16: 17,028,771 (GRCm39) S732P probably benign Het
Rock1 A G 18: 10,070,626 (GRCm39) F1196S probably damaging Het
Ryr3 A G 2: 112,690,069 (GRCm39) V1180A probably benign Het
Ryr3 G A 2: 112,466,137 (GRCm39) R4795W probably damaging Het
Scn11a T C 9: 119,645,586 (GRCm39) I123V probably benign Het
Sema4b G C 7: 79,870,248 (GRCm39) E475D probably damaging Het
Serinc2 C A 4: 130,149,172 (GRCm39) M343I probably damaging Het
Serinc5 G T 13: 92,844,544 (GRCm39) V429F probably benign Het
Zfp27 T C 7: 29,594,013 (GRCm39) K651E probably benign Het
Zfp438 A G 18: 5,213,383 (GRCm39) I525T possibly damaging Het
Other mutations in Tnfsf10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02155:Tnfsf10 APN 3 27,389,380 (GRCm39) missense possibly damaging 0.71
IGL03071:Tnfsf10 APN 3 27,389,769 (GRCm39) missense probably damaging 1.00
IGL03157:Tnfsf10 APN 3 27,380,106 (GRCm39) missense possibly damaging 0.77
IGL03226:Tnfsf10 APN 3 27,389,597 (GRCm39) nonsense probably null
R4051:Tnfsf10 UTSW 3 27,389,503 (GRCm39) missense probably damaging 1.00
R4679:Tnfsf10 UTSW 3 27,389,728 (GRCm39) missense probably damaging 0.99
R5799:Tnfsf10 UTSW 3 27,389,742 (GRCm39) missense probably damaging 1.00
R6101:Tnfsf10 UTSW 3 27,389,698 (GRCm39) missense probably damaging 1.00
R6105:Tnfsf10 UTSW 3 27,389,698 (GRCm39) missense probably damaging 1.00
R6882:Tnfsf10 UTSW 3 27,380,182 (GRCm39) missense possibly damaging 0.95
R7362:Tnfsf10 UTSW 3 27,389,497 (GRCm39) missense probably damaging 1.00
R7873:Tnfsf10 UTSW 3 27,389,808 (GRCm39) missense probably benign 0.05
R9034:Tnfsf10 UTSW 3 27,389,379 (GRCm39) missense probably benign 0.00
R9035:Tnfsf10 UTSW 3 27,389,379 (GRCm39) missense probably benign 0.00
R9125:Tnfsf10 UTSW 3 27,380,028 (GRCm39) intron probably benign
R9193:Tnfsf10 UTSW 3 27,371,407 (GRCm39) missense possibly damaging 0.90
R9334:Tnfsf10 UTSW 3 27,389,496 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTTTGGAACCACATTGTGTGC -3'
(R):5'- TTCTGGCGCTCTTCATGAG -3'

Sequencing Primer
(F):5'- CATTGTGTGCAAGCCCAATG -3'
(R):5'- CTTCATGAGCACTATGGGATCCG -3'
Posted On 2021-04-30