Incidental Mutation 'R8820:Zfp27'
ID 672983
Institutional Source Beutler Lab
Gene Symbol Zfp27
Ensembl Gene ENSMUSG00000062040
Gene Name zinc finger protein 27
Synonyms Zfp-27, mkr-4
MMRRC Submission 068653-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.611) question?
Stock # R8820 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 29592758-29605997 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 29594013 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 651 (K651E)
Ref Sequence ENSEMBL: ENSMUSP00000054012 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053521] [ENSMUST00000159920] [ENSMUST00000161904] [ENSMUST00000162592] [ENSMUST00000172448]
AlphaFold P10077
Predicted Effect probably benign
Transcript: ENSMUST00000053521
AA Change: K651E

PolyPhen 2 Score 0.146 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000054012
Gene: ENSMUSG00000062040
AA Change: K651E

DomainStartEndE-ValueType
KRAB 1 59 2.94e-12 SMART
internal_repeat_2 108 195 4.1e-6 PROSPERO
ZnF_C2H2 205 227 3.11e-2 SMART
ZnF_C2H2 233 255 8.47e-4 SMART
ZnF_C2H2 261 283 2.09e-3 SMART
ZnF_C2H2 289 311 2.91e-2 SMART
ZnF_C2H2 317 339 4.17e-3 SMART
ZnF_C2H2 345 367 4.79e-3 SMART
ZnF_C2H2 401 423 7.15e-2 SMART
ZnF_C2H2 429 451 3.69e-4 SMART
ZnF_C2H2 457 479 1.08e-1 SMART
ZnF_C2H2 485 507 2.57e-3 SMART
ZnF_C2H2 513 535 1.5e-4 SMART
ZnF_C2H2 541 563 1.38e-3 SMART
ZnF_C2H2 569 591 1.03e-2 SMART
ZnF_C2H2 597 619 3.34e-2 SMART
ZnF_C2H2 625 647 8.34e-3 SMART
ZnF_C2H2 653 675 2.36e-2 SMART
ZnF_C2H2 681 703 6.88e-4 SMART
ZnF_C2H2 709 731 2.27e-4 SMART
ZnF_C2H2 737 759 6.88e-4 SMART
ZnF_C2H2 765 787 1.72e-4 SMART
ZnF_C2H2 793 815 3.83e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000159920
AA Change: K651E

PolyPhen 2 Score 0.146 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000125232
Gene: ENSMUSG00000062040
AA Change: K651E

DomainStartEndE-ValueType
KRAB 1 59 2.94e-12 SMART
internal_repeat_2 108 195 4.1e-6 PROSPERO
ZnF_C2H2 205 227 3.11e-2 SMART
ZnF_C2H2 233 255 8.47e-4 SMART
ZnF_C2H2 261 283 2.09e-3 SMART
ZnF_C2H2 289 311 2.91e-2 SMART
ZnF_C2H2 317 339 4.17e-3 SMART
ZnF_C2H2 345 367 4.79e-3 SMART
ZnF_C2H2 401 423 7.15e-2 SMART
ZnF_C2H2 429 451 3.69e-4 SMART
ZnF_C2H2 457 479 1.08e-1 SMART
ZnF_C2H2 485 507 2.57e-3 SMART
ZnF_C2H2 513 535 1.5e-4 SMART
ZnF_C2H2 541 563 1.38e-3 SMART
ZnF_C2H2 569 591 1.03e-2 SMART
ZnF_C2H2 597 619 3.34e-2 SMART
ZnF_C2H2 625 647 8.34e-3 SMART
ZnF_C2H2 653 675 2.36e-2 SMART
ZnF_C2H2 681 703 6.88e-4 SMART
ZnF_C2H2 709 731 2.27e-4 SMART
ZnF_C2H2 737 759 6.88e-4 SMART
ZnF_C2H2 765 787 1.72e-4 SMART
ZnF_C2H2 793 815 3.83e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000161904
AA Change: K651E

PolyPhen 2 Score 0.146 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000124684
Gene: ENSMUSG00000062040
AA Change: K651E

DomainStartEndE-ValueType
KRAB 1 59 2.94e-12 SMART
internal_repeat_2 108 195 4.1e-6 PROSPERO
ZnF_C2H2 205 227 3.11e-2 SMART
ZnF_C2H2 233 255 8.47e-4 SMART
ZnF_C2H2 261 283 2.09e-3 SMART
ZnF_C2H2 289 311 2.91e-2 SMART
ZnF_C2H2 317 339 4.17e-3 SMART
ZnF_C2H2 345 367 4.79e-3 SMART
ZnF_C2H2 401 423 7.15e-2 SMART
ZnF_C2H2 429 451 3.69e-4 SMART
ZnF_C2H2 457 479 1.08e-1 SMART
ZnF_C2H2 485 507 2.57e-3 SMART
ZnF_C2H2 513 535 1.5e-4 SMART
ZnF_C2H2 541 563 1.38e-3 SMART
ZnF_C2H2 569 591 1.03e-2 SMART
ZnF_C2H2 597 619 3.34e-2 SMART
ZnF_C2H2 625 647 8.34e-3 SMART
ZnF_C2H2 653 675 2.36e-2 SMART
ZnF_C2H2 681 703 6.88e-4 SMART
ZnF_C2H2 709 731 2.27e-4 SMART
ZnF_C2H2 737 759 6.88e-4 SMART
ZnF_C2H2 765 787 1.72e-4 SMART
ZnF_C2H2 793 815 3.83e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000162592
AA Change: K651E

PolyPhen 2 Score 0.146 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000123953
Gene: ENSMUSG00000062040
AA Change: K651E

DomainStartEndE-ValueType
KRAB 1 59 2.94e-12 SMART
internal_repeat_2 108 195 4.1e-6 PROSPERO
ZnF_C2H2 205 227 3.11e-2 SMART
ZnF_C2H2 233 255 8.47e-4 SMART
ZnF_C2H2 261 283 2.09e-3 SMART
ZnF_C2H2 289 311 2.91e-2 SMART
ZnF_C2H2 317 339 4.17e-3 SMART
ZnF_C2H2 345 367 4.79e-3 SMART
ZnF_C2H2 401 423 7.15e-2 SMART
ZnF_C2H2 429 451 3.69e-4 SMART
ZnF_C2H2 457 479 1.08e-1 SMART
ZnF_C2H2 485 507 2.57e-3 SMART
ZnF_C2H2 513 535 1.5e-4 SMART
ZnF_C2H2 541 563 1.38e-3 SMART
ZnF_C2H2 569 591 1.03e-2 SMART
ZnF_C2H2 597 619 3.34e-2 SMART
ZnF_C2H2 625 647 8.34e-3 SMART
ZnF_C2H2 653 675 2.36e-2 SMART
ZnF_C2H2 681 703 6.88e-4 SMART
ZnF_C2H2 709 731 2.27e-4 SMART
ZnF_C2H2 737 759 6.88e-4 SMART
ZnF_C2H2 765 787 1.72e-4 SMART
ZnF_C2H2 793 815 3.83e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000172448
AA Change: K651E

PolyPhen 2 Score 0.146 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000127677
Gene: ENSMUSG00000062040
AA Change: K651E

DomainStartEndE-ValueType
KRAB 1 59 2.94e-12 SMART
internal_repeat_2 108 195 4.1e-6 PROSPERO
ZnF_C2H2 205 227 3.11e-2 SMART
ZnF_C2H2 233 255 8.47e-4 SMART
ZnF_C2H2 261 283 2.09e-3 SMART
ZnF_C2H2 289 311 2.91e-2 SMART
ZnF_C2H2 317 339 4.17e-3 SMART
ZnF_C2H2 345 367 4.79e-3 SMART
ZnF_C2H2 401 423 7.15e-2 SMART
ZnF_C2H2 429 451 3.69e-4 SMART
ZnF_C2H2 457 479 1.08e-1 SMART
ZnF_C2H2 485 507 2.57e-3 SMART
ZnF_C2H2 513 535 1.5e-4 SMART
ZnF_C2H2 541 563 1.38e-3 SMART
ZnF_C2H2 569 591 1.03e-2 SMART
ZnF_C2H2 597 619 3.34e-2 SMART
ZnF_C2H2 625 647 8.34e-3 SMART
ZnF_C2H2 653 675 2.36e-2 SMART
ZnF_C2H2 681 703 6.88e-4 SMART
ZnF_C2H2 709 731 2.27e-4 SMART
ZnF_C2H2 737 759 6.88e-4 SMART
ZnF_C2H2 765 787 1.72e-4 SMART
ZnF_C2H2 793 815 3.83e-2 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency 100% (58/58)
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca17 A G 17: 24,547,576 (GRCm39) L266P probably damaging Het
Abcb1a A T 5: 8,773,204 (GRCm39) T811S possibly damaging Het
Als2cl T C 9: 110,714,855 (GRCm39) F125L probably benign Het
Arhgap33 T C 7: 30,228,165 (GRCm39) I406V probably benign Het
Cdyl T C 13: 36,042,174 (GRCm39) I404T probably damaging Het
Cemip2 G A 19: 21,784,818 (GRCm39) V434M probably damaging Het
Clasrp C T 7: 19,320,362 (GRCm39) R432H unknown Het
Clk2 T A 3: 89,082,730 (GRCm39) M392K probably damaging Het
Cps1 T A 1: 67,267,439 (GRCm39) N1402K possibly damaging Het
Cyp2u1 T C 3: 131,092,016 (GRCm39) H168R probably damaging Het
Dapl1 T C 2: 59,335,056 (GRCm39) L70P probably damaging Het
Ddr2 T A 1: 169,805,483 (GRCm39) K836* probably null Het
Dsel A G 1: 111,787,994 (GRCm39) L847P probably benign Het
Fbxw17 A T 13: 50,587,351 (GRCm39) K437M possibly damaging Het
Fktn T C 4: 53,735,001 (GRCm39) V174A possibly damaging Het
Frem1 C A 4: 82,821,754 (GRCm39) S2118I probably damaging Het
Fzd8 G A 18: 9,213,247 (GRCm39) V110M unknown Het
Gabrb3 T C 7: 57,442,329 (GRCm39) S212P probably damaging Het
Gimap9 A G 6: 48,654,821 (GRCm39) D136G probably benign Het
Gldc C G 19: 30,078,212 (GRCm39) M928I probably benign Het
Hmmr G A 11: 40,612,499 (GRCm39) S206F probably damaging Het
Ift46 C T 9: 44,701,819 (GRCm39) T283I probably damaging Het
Il36b C T 2: 24,049,892 (GRCm39) Q168* probably null Het
Ldb2 G A 5: 44,956,757 (GRCm39) Q27* probably null Het
Lmcd1 T A 6: 112,306,770 (GRCm39) I314N probably damaging Het
Lypd9 T G 11: 58,337,129 (GRCm39) S115R probably damaging Het
Mctp2 C A 7: 71,879,081 (GRCm39) V259L probably benign Het
Midn T G 10: 79,990,234 (GRCm39) S302A probably damaging Het
Ncor2 A G 5: 125,106,291 (GRCm39) V797A Het
Npm2 A G 14: 70,885,768 (GRCm39) S146P probably damaging Het
Npr1 G A 3: 90,372,201 (GRCm39) R204C probably damaging Het
Or1j10 T C 2: 36,267,006 (GRCm39) S73P probably damaging Het
Or1n1b C A 2: 36,780,622 (GRCm39) M79I probably benign Het
Or52n3 T A 7: 104,530,862 (GRCm39) V316D possibly damaging Het
Or6e1 C T 14: 54,520,070 (GRCm39) G94D probably benign Het
Orc2 T C 1: 58,515,639 (GRCm39) N290D probably benign Het
Paip2b A C 6: 83,791,738 (GRCm39) M48R probably damaging Het
Pcdhb15 T A 18: 37,606,971 (GRCm39) S68T probably benign Het
Pcnx1 T A 12: 82,020,022 (GRCm39) H715Q Het
Pcsk2 T A 2: 143,642,990 (GRCm39) H422Q probably damaging Het
Pdzph1 G C 17: 59,187,715 (GRCm39) Y1168* probably null Het
Peli2 G A 14: 48,490,130 (GRCm39) E201K possibly damaging Het
Prelp T C 1: 133,842,878 (GRCm39) N89S probably damaging Het
Proz T A 8: 13,113,253 (GRCm39) F25I probably damaging Het
Rapgef3 T C 15: 97,646,538 (GRCm39) N799S probably benign Het
Relch T A 1: 105,654,179 (GRCm39) F873L possibly damaging Het
Ryr3 G A 2: 112,466,137 (GRCm39) R4795W probably damaging Het
Ryr3 A G 2: 112,690,069 (GRCm39) V1180A probably benign Het
Scn11a T C 9: 119,645,586 (GRCm39) I123V probably benign Het
Sema4b G C 7: 79,870,248 (GRCm39) E475D probably damaging Het
Serinc2 C A 4: 130,149,172 (GRCm39) M343I probably damaging Het
Serinc5 G T 13: 92,844,544 (GRCm39) V429F probably benign Het
Smyd2 T A 1: 189,632,018 (GRCm39) K115N probably benign Het
Tenm3 T G 8: 48,763,759 (GRCm39) D765A probably damaging Het
Unc13d AATGCCTCCCATGCC AATGCCTCCCATGCCTCCCATGCC 11: 115,958,998 (GRCm39) probably benign Het
Ythdc2 C T 18: 44,967,531 (GRCm39) R176* probably null Het
Other mutations in Zfp27
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00972:Zfp27 APN 7 29,594,383 (GRCm39) missense probably damaging 0.97
IGL02490:Zfp27 APN 7 29,594,360 (GRCm39) missense possibly damaging 0.73
IGL02899:Zfp27 APN 7 29,595,680 (GRCm39) missense possibly damaging 0.91
R0179:Zfp27 UTSW 7 29,595,850 (GRCm39) missense possibly damaging 0.51
R0234:Zfp27 UTSW 7 29,593,532 (GRCm39) missense possibly damaging 0.73
R0234:Zfp27 UTSW 7 29,593,532 (GRCm39) missense possibly damaging 0.73
R0511:Zfp27 UTSW 7 29,593,947 (GRCm39) missense probably damaging 0.97
R1185:Zfp27 UTSW 7 29,595,254 (GRCm39) missense possibly damaging 0.92
R1185:Zfp27 UTSW 7 29,595,254 (GRCm39) missense possibly damaging 0.92
R1185:Zfp27 UTSW 7 29,595,254 (GRCm39) missense possibly damaging 0.92
R1294:Zfp27 UTSW 7 29,595,737 (GRCm39) missense possibly damaging 0.53
R1581:Zfp27 UTSW 7 29,595,549 (GRCm39) missense possibly damaging 0.53
R1763:Zfp27 UTSW 7 29,594,801 (GRCm39) missense possibly damaging 0.96
R2083:Zfp27 UTSW 7 29,594,208 (GRCm39) missense probably benign 0.06
R2217:Zfp27 UTSW 7 29,595,536 (GRCm39) missense possibly damaging 0.96
R2696:Zfp27 UTSW 7 29,595,792 (GRCm39) missense possibly damaging 0.85
R4084:Zfp27 UTSW 7 29,594,792 (GRCm39) missense possibly damaging 0.91
R4864:Zfp27 UTSW 7 29,594,261 (GRCm39) missense probably damaging 0.99
R6057:Zfp27 UTSW 7 29,594,444 (GRCm39) missense possibly damaging 0.83
R6063:Zfp27 UTSW 7 29,593,727 (GRCm39) missense probably damaging 0.97
R6553:Zfp27 UTSW 7 29,595,818 (GRCm39) missense possibly damaging 0.86
R6585:Zfp27 UTSW 7 29,595,818 (GRCm39) missense possibly damaging 0.86
R6800:Zfp27 UTSW 7 29,593,860 (GRCm39) missense probably benign 0.19
R7051:Zfp27 UTSW 7 29,594,446 (GRCm39) small deletion probably benign
R7052:Zfp27 UTSW 7 29,594,446 (GRCm39) small deletion probably benign
R7066:Zfp27 UTSW 7 29,594,446 (GRCm39) small deletion probably benign
R7106:Zfp27 UTSW 7 29,594,446 (GRCm39) small deletion probably benign
R7432:Zfp27 UTSW 7 29,594,784 (GRCm39) missense probably benign 0.33
R7473:Zfp27 UTSW 7 29,595,324 (GRCm39) missense possibly damaging 0.71
R7670:Zfp27 UTSW 7 29,594,221 (GRCm39) missense possibly damaging 0.94
R7739:Zfp27 UTSW 7 29,593,699 (GRCm39) missense possibly damaging 0.93
R7817:Zfp27 UTSW 7 29,595,815 (GRCm39) missense possibly damaging 0.96
R8750:Zfp27 UTSW 7 29,594,804 (GRCm39) missense possibly damaging 0.53
R8819:Zfp27 UTSW 7 29,594,013 (GRCm39) missense probably benign 0.15
R9189:Zfp27 UTSW 7 29,595,359 (GRCm39) missense possibly damaging 0.76
R9511:Zfp27 UTSW 7 29,593,641 (GRCm39) missense possibly damaging 0.71
R9705:Zfp27 UTSW 7 29,595,342 (GRCm39) missense possibly damaging 0.93
Z1177:Zfp27 UTSW 7 29,595,657 (GRCm39) missense possibly damaging 0.72
Z1177:Zfp27 UTSW 7 29,594,586 (GRCm39) missense probably benign 0.33
Predicted Primers PCR Primer
(F):5'- TGAAGGACTTCCCACACTCTG -3'
(R):5'- TATACACGAGAAGATTCACACCGG -3'

Sequencing Primer
(F):5'- ACTCTGAACACGCGTACGG -3'
(R):5'- TTCACACCGGAGAGAGACAGTAC -3'
Posted On 2021-04-30