Incidental Mutation 'R8822:Gpr26'
ID 673119
Institutional Source Beutler Lab
Gene Symbol Gpr26
Ensembl Gene ENSMUSG00000040125
Gene Name G protein-coupled receptor 26
Synonyms 9630036A11Rik
MMRRC Submission 068655-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # R8822 (G1)
Quality Score 185.009
Status Validated
Chromosome 7
Chromosomal Location 131567891-131587362 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 131568997 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 114 (Y114C)
Ref Sequence ENSEMBL: ENSMUSP00000041664 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000045840] [ENSMUST00000124096]
AlphaFold Q8BZA7
Predicted Effect probably damaging
Transcript: ENSMUST00000045840
AA Change: Y114C

PolyPhen 2 Score 0.982 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000041664
Gene: ENSMUSG00000040125
AA Change: Y114C

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 15 309 1.9e-7 PFAM
Pfam:7tm_1 22 294 1.4e-33 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000124096
SMART Domains Protein: ENSMUSP00000130971
Gene: ENSMUSG00000030849

DomainStartEndE-ValueType
Pfam:Pkinase 1 118 4.8e-19 PFAM
Pfam:Pkinase_Tyr 1 118 1.7e-50 PFAM
low complexity region 146 160 N/A INTRINSIC
Meta Mutation Damage Score 0.8465 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 100% (65/65)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a G protein-couple receptor protein. G-protein-coupled receptors are a large family of membrane proteins that are involved in cellular responses to environmental stimuli, neurotransmitters, and hormones. The encoded protein may play a role in neurodegenerative diseases. Epigenetic silencing of this gene has been observed in gliomas. [provided by RefSeq, Sep 2016]
PHENOTYPE: Mice homozygous for one null allele exhibit increased anxiety- and depression-related behaviors and alcohol preference. Female mice homozygous for another allele display increased susceptibility to diet-induced obesity with increased food intake. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adrb1 T C 19: 56,711,849 (GRCm39) V349A probably damaging Het
Atp2a2 A G 5: 122,629,772 (GRCm39) V99A possibly damaging Het
Bank1 T A 3: 135,809,640 (GRCm39) D418V possibly damaging Het
Cacna1d A G 14: 29,900,692 (GRCm39) V331A probably benign Het
Cd28 A T 1: 60,808,820 (GRCm39) N178I possibly damaging Het
Cdcp3 A T 7: 130,843,706 (GRCm39) probably null Het
Ceacam12 T C 7: 17,803,378 (GRCm39) probably benign Het
Cfap54 G A 10: 92,875,003 (GRCm39) A494V probably benign Het
Chpt1 A G 10: 88,324,268 (GRCm39) V180A probably damaging Het
Cplane1 T C 15: 8,201,262 (GRCm39) I13T probably damaging Het
Cplx3 A G 9: 57,514,471 (GRCm39) V493A probably benign Het
Cyp4a31 G A 4: 115,422,225 (GRCm39) E70K probably benign Het
Fam151a A T 4: 106,602,842 (GRCm39) M254L probably benign Het
Fyco1 A T 9: 123,648,184 (GRCm39) I1250N probably damaging Het
Gm6685 T G 11: 28,289,768 (GRCm39) Q16P probably benign Het
Helb A T 10: 119,941,389 (GRCm39) V433D probably benign Het
Hps3 A G 3: 20,057,391 (GRCm39) W930R probably benign Het
Igdcc4 C T 9: 65,031,298 (GRCm39) T412I possibly damaging Het
Klhl35 T C 7: 99,122,055 (GRCm39) V485A probably benign Het
Lmo7 A G 14: 102,121,610 (GRCm39) D225G probably damaging Het
Myo15a C T 11: 60,367,740 (GRCm39) R167C probably damaging Het
Obp2a A T 2: 25,590,188 (GRCm39) D29V probably damaging Het
Or10d3 C A 9: 39,461,812 (GRCm39) M118I probably benign Het
Or13a22 A G 7: 140,072,926 (GRCm39) Y125C possibly damaging Het
Or52b2 A G 7: 104,986,809 (GRCm39) V38A probably benign Het
Or5d47 A G 2: 87,804,785 (GRCm39) S75P possibly damaging Het
Or8g4 A G 9: 39,661,700 (GRCm39) Y6C probably benign Het
Pde6b A G 5: 108,551,328 (GRCm39) E204G probably benign Het
Pkd1 T C 17: 24,784,615 (GRCm39) V387A probably benign Het
Pkd1l1 A T 11: 8,806,312 (GRCm39) I2054K Het
Pkp1 T A 1: 135,807,661 (GRCm39) M536L probably benign Het
Platr25 T C 13: 62,848,658 (GRCm39) E68G probably benign Het
Plxna4 T C 6: 32,127,431 (GRCm39) D1892G possibly damaging Het
Pramel30 A G 4: 144,057,092 (GRCm39) K92E probably benign Het
Prr12 A G 7: 44,699,763 (GRCm39) L76P unknown Het
Ptprz1 T A 6: 23,002,588 (GRCm39) N1559K probably damaging Het
Rbl2 A T 8: 91,833,346 (GRCm39) N750I possibly damaging Het
Rhpn2 A T 7: 35,090,228 (GRCm39) M617L probably benign Het
Rprd2 A G 3: 95,691,613 (GRCm39) S221P probably damaging Het
S100a4 T C 3: 90,512,358 (GRCm39) S14P probably benign Het
Samd11 A T 4: 156,336,764 (GRCm39) L25Q probably damaging Het
Sash1 G A 10: 8,761,615 (GRCm39) probably benign Het
Scn9a A G 2: 66,370,979 (GRCm39) S534P probably damaging Het
Sec31b C A 19: 44,507,702 (GRCm39) V781F probably benign Het
Setd1a C T 7: 127,385,332 (GRCm39) L680F possibly damaging Het
Slc10a2 T G 8: 5,139,149 (GRCm39) Q265P probably damaging Het
Slc27a1 T A 8: 72,033,308 (GRCm39) D283E probably damaging Het
Slc38a4 G A 15: 96,906,952 (GRCm39) T262M probably benign Het
Slc52a3 T G 2: 151,846,513 (GRCm39) V158G probably benign Het
Snx16 T C 3: 10,484,125 (GRCm39) V64A probably benign Het
Stox1 A T 10: 62,499,900 (GRCm39) W887R probably damaging Het
Tcap G A 11: 98,275,264 (GRCm39) V133M probably benign Het
Ticam1 A G 17: 56,578,444 (GRCm39) L217P probably damaging Het
Tnfrsf12a T C 17: 23,895,188 (GRCm39) S87G probably benign Het
Tyr G A 7: 87,142,330 (GRCm39) R77C probably damaging Het
Uba6 A G 5: 86,294,932 (GRCm39) probably benign Het
Usp24 G A 4: 106,269,410 (GRCm39) V2107M probably benign Het
Wdr64 T C 1: 175,544,920 (GRCm39) S118P probably damaging Het
Zbtb21 G A 16: 97,752,516 (GRCm39) T589I probably damaging Het
Zfp263 G T 16: 3,562,004 (GRCm39) probably benign Het
Zfp318 A G 17: 46,723,831 (GRCm39) T1945A probably benign Het
Zfp644 G T 5: 106,783,087 (GRCm39) R1065S possibly damaging Het
Zfp668 A T 7: 127,466,315 (GRCm39) S290T probably damaging Het
Zfp808 T A 13: 62,320,869 (GRCm39) D699E probably damaging Het
Other mutations in Gpr26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01065:Gpr26 APN 7 131,569,230 (GRCm39) missense probably damaging 1.00
IGL01345:Gpr26 APN 7 131,569,161 (GRCm39) missense possibly damaging 0.90
IGL01658:Gpr26 APN 7 131,585,834 (GRCm39) missense probably benign
IGL02724:Gpr26 APN 7 131,576,121 (GRCm39) critical splice donor site probably null
R0408:Gpr26 UTSW 7 131,576,001 (GRCm39) splice site probably null
R0408:Gpr26 UTSW 7 131,569,249 (GRCm39) missense possibly damaging 0.81
R0547:Gpr26 UTSW 7 131,586,026 (GRCm39) missense probably benign 0.01
R2508:Gpr26 UTSW 7 131,568,823 (GRCm39) missense probably damaging 0.98
R4088:Gpr26 UTSW 7 131,568,805 (GRCm39) missense probably benign 0.00
R4630:Gpr26 UTSW 7 131,568,709 (GRCm39) missense probably damaging 1.00
R4680:Gpr26 UTSW 7 131,576,082 (GRCm39) missense probably benign 0.34
R4756:Gpr26 UTSW 7 131,569,230 (GRCm39) missense probably damaging 1.00
R5229:Gpr26 UTSW 7 131,585,976 (GRCm39) missense probably damaging 1.00
R5610:Gpr26 UTSW 7 131,568,694 (GRCm39) missense possibly damaging 0.94
R6605:Gpr26 UTSW 7 131,585,893 (GRCm39) missense possibly damaging 0.91
R6653:Gpr26 UTSW 7 131,585,830 (GRCm39) missense probably benign 0.00
R7213:Gpr26 UTSW 7 131,569,219 (GRCm39) missense probably damaging 1.00
R7351:Gpr26 UTSW 7 131,576,094 (GRCm39) missense probably damaging 1.00
R7768:Gpr26 UTSW 7 131,576,077 (GRCm39) missense probably damaging 0.99
R7887:Gpr26 UTSW 7 131,568,702 (GRCm39) missense probably benign
R9382:Gpr26 UTSW 7 131,568,963 (GRCm39) missense probably damaging 1.00
R9508:Gpr26 UTSW 7 131,585,830 (GRCm39) missense probably benign 0.00
Z1088:Gpr26 UTSW 7 131,585,823 (GRCm39) frame shift probably null
Z1176:Gpr26 UTSW 7 131,568,954 (GRCm39) missense probably damaging 1.00
Z1176:Gpr26 UTSW 7 131,568,777 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTCAACATGCCACTAACACTGG -3'
(R):5'- CCTTGAGGTACGTGAAGCAGAG -3'

Sequencing Primer
(F):5'- ACTAACACTGGCCGGCGTC -3'
(R):5'- GCGCTGGTGAAGACAGC -3'
Posted On 2021-04-30