Incidental Mutation 'R8725:Or13a26'
ID 673189
Institutional Source Beutler Lab
Gene Symbol Or13a26
Ensembl Gene ENSMUSG00000057997
Gene Name olfactory receptor family 13 subfamily A member 26
Synonyms GA_x6K02T2PBJ9-42850324-42851256, MOR253-3, Olfr541
MMRRC Submission 068574-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.072) question?
Stock # R8725 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 140284166-140285104 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 140284607 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Leucine at position 148 (V148L)
Ref Sequence ENSEMBL: ENSMUSP00000148238 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080681] [ENSMUST00000209857] [ENSMUST00000210357]
AlphaFold Q8VGM0
Predicted Effect probably benign
Transcript: ENSMUST00000080681
AA Change: V148L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000079508
Gene: ENSMUSG00000057997
AA Change: V148L

DomainStartEndE-ValueType
Pfam:7tm_4 33 309 2.2e-49 PFAM
Pfam:7TM_GPCR_Srsx 37 180 5e-8 PFAM
Pfam:7tm_1 43 292 1.2e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000209857
Predicted Effect probably benign
Transcript: ENSMUST00000210357
AA Change: V148L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.5%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acod1 T A 14: 103,287,075 (GRCm39) W69R probably damaging Het
Adamtsl4 C T 3: 95,584,426 (GRCm39) R990Q possibly damaging Het
Ahdc1 T A 4: 132,792,743 (GRCm39) V1328E possibly damaging Het
Bpifb2 A G 2: 153,731,356 (GRCm39) H244R possibly damaging Het
Camk1 C A 6: 113,315,109 (GRCm39) V199L probably damaging Het
Ccdc18 A T 5: 108,328,283 (GRCm39) K661I possibly damaging Het
Cdh16 C T 8: 105,344,874 (GRCm39) V444I probably benign Het
Cep295 A T 9: 15,243,715 (GRCm39) Y1580* probably null Het
Cntnap5c A T 17: 58,362,663 (GRCm39) N339Y probably damaging Het
Col6a3 C G 1: 90,695,328 (GRCm39) probably benign Het
Deup1 T A 9: 15,503,721 (GRCm39) D280V probably damaging Het
Dlat G T 9: 50,560,967 (GRCm39) A360E probably damaging Het
Evpl T A 11: 116,113,019 (GRCm39) D1557V probably benign Het
Ext1 A G 15: 53,208,065 (GRCm39) V232A possibly damaging Het
Gdpd5 T C 7: 99,105,726 (GRCm39) I514T possibly damaging Het
Gm14443 A T 2: 175,010,693 (GRCm39) C584* probably null Het
Gm2696 T A 10: 77,672,034 (GRCm39) C78S unknown Het
Gm4131 T C 14: 62,701,300 (GRCm39) D276G possibly damaging Het
Gm5114 C T 7: 39,060,657 (GRCm39) G64D probably benign Het
Gsx2 G T 5: 75,236,755 (GRCm39) A112S probably benign Het
Hebp1 G T 6: 135,114,919 (GRCm39) R181S probably damaging Het
Hectd4 G A 5: 121,488,557 (GRCm39) G3616D probably damaging Het
Hemgn T G 4: 46,394,638 (GRCm39) T491P probably benign Het
Idh2 TCCCAGGGCC TCC 7: 79,748,079 (GRCm39) probably null Het
Itsn1 T C 16: 91,636,721 (GRCm39) S723P unknown Het
Kat6a G A 8: 23,398,293 (GRCm39) G287D probably damaging Het
Ktn1 T G 14: 47,907,757 (GRCm39) probably benign Het
Lrrc56 C A 7: 140,778,246 (GRCm39) D79E possibly damaging Het
Lrrn1 C T 6: 107,544,303 (GRCm39) Q34* probably null Het
Mlxipl A G 5: 135,157,483 (GRCm39) M340V probably benign Het
Mroh6 T C 15: 75,756,563 (GRCm39) T604A possibly damaging Het
Or1n1 T A 2: 36,749,610 (GRCm39) Y250F probably damaging Het
Or4c122 A T 2: 89,079,658 (GRCm39) S115T probably benign Het
Palb2 A C 7: 121,710,884 (GRCm39) V1022G unknown Het
Pank1 T G 19: 34,855,989 (GRCm39) H163P possibly damaging Het
Pcdha12 A G 18: 37,154,736 (GRCm39) Q485R probably benign Het
Pcdhb15 T A 18: 37,608,734 (GRCm39) S655R probably damaging Het
Pcdhgb1 T A 18: 37,814,467 (GRCm39) C319* probably null Het
Pipox A T 11: 77,774,804 (GRCm39) L93* probably null Het
Pkd1l1 A C 11: 8,911,482 (GRCm39) V265G Het
Pld3 G A 7: 27,239,079 (GRCm39) Q149* probably null Het
Pramel34 A T 5: 93,784,316 (GRCm39) Y383N probably damaging Het
Prpf3 T A 3: 95,748,021 (GRCm39) T415S possibly damaging Het
Rasgef1b G A 5: 99,447,895 (GRCm39) T105I unknown Het
Rere G T 4: 150,701,792 (GRCm39) E24* probably null Het
Rftn1 G T 17: 50,354,408 (GRCm39) A318D probably damaging Het
Ric3 A T 7: 108,637,924 (GRCm39) D277E probably benign Het
Rnf44 A T 13: 54,831,826 (GRCm39) M82K probably damaging Het
Rsph14 T C 10: 74,795,516 (GRCm39) N223S probably benign Het
Rusc2 A G 4: 43,415,396 (GRCm39) E234G probably damaging Het
Scfd2 T C 5: 74,642,900 (GRCm39) N349S probably benign Het
Sema3d G A 5: 12,555,822 (GRCm39) C183Y probably damaging Het
Setd2 T C 9: 110,402,912 (GRCm39) I74T Het
Slc39a12 T C 2: 14,454,670 (GRCm39) S563P probably damaging Het
Slc9a8 A T 2: 167,315,454 (GRCm39) D526V probably damaging Het
Smpdl3b G T 4: 132,461,060 (GRCm39) T339N probably damaging Het
Speer1e A T 5: 11,236,408 (GRCm39) Q147L probably benign Het
Spi1 G A 2: 90,945,516 (GRCm39) G199D probably damaging Het
Stx2 T C 5: 129,070,564 (GRCm39) T118A probably damaging Het
Synj2 C A 17: 6,088,015 (GRCm39) S1355R possibly damaging Het
Taf15 A G 11: 83,389,964 (GRCm39) T245A probably benign Het
Tnrc6b C T 15: 80,760,653 (GRCm39) A120V probably damaging Het
Usp19 G T 9: 108,370,934 (GRCm39) G198W probably damaging Het
Wdtc1 G T 4: 133,041,114 (GRCm39) H46N probably damaging Het
Zbtb1 C A 12: 76,432,646 (GRCm39) R211S probably damaging Het
Zc3h8 A G 2: 128,775,207 (GRCm39) V151A probably benign Het
Zfp219 T C 14: 52,244,899 (GRCm39) T499A possibly damaging Het
Zfp689 A G 7: 127,047,940 (GRCm39) F31L probably damaging Het
Zfp879 C T 11: 50,729,321 (GRCm39) D26N probably damaging Het
Other mutations in Or13a26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01011:Or13a26 APN 7 140,284,350 (GRCm39) missense probably damaging 1.00
IGL01872:Or13a26 APN 7 140,284,176 (GRCm39) missense possibly damaging 0.59
IGL02814:Or13a26 APN 7 140,285,046 (GRCm39) missense probably damaging 1.00
R0690:Or13a26 UTSW 7 140,284,700 (GRCm39) missense possibly damaging 0.88
R1019:Or13a26 UTSW 7 140,284,407 (GRCm39) missense probably damaging 1.00
R1665:Or13a26 UTSW 7 140,284,707 (GRCm39) missense probably damaging 1.00
R1696:Or13a26 UTSW 7 140,284,409 (GRCm39) nonsense probably null
R4065:Or13a26 UTSW 7 140,284,182 (GRCm39) missense probably benign
R4517:Or13a26 UTSW 7 140,285,004 (GRCm39) missense probably damaging 1.00
R5549:Or13a26 UTSW 7 140,284,712 (GRCm39) splice site probably null
R6327:Or13a26 UTSW 7 140,284,616 (GRCm39) missense probably damaging 1.00
R7288:Or13a26 UTSW 7 140,284,942 (GRCm39) nonsense probably null
R7307:Or13a26 UTSW 7 140,285,060 (GRCm39) missense probably benign 0.39
R7454:Or13a26 UTSW 7 140,284,547 (GRCm39) missense probably damaging 1.00
R9404:Or13a26 UTSW 7 140,284,722 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGGGAAAACACCATCTCCTTC -3'
(R):5'- TGTAGCCATAGGACAACAGTG -3'

Sequencing Primer
(F):5'- TTCAAAGGATGCATGGCCC -3'
(R):5'- TAGCACGAAGTTGATGCCTC -3'
Posted On 2021-04-30