Incidental Mutation 'R8557:Mier1'
ID 673232
Institutional Source Beutler Lab
Gene Symbol Mier1
Ensembl Gene ENSMUSG00000028522
Gene Name MEIR1 treanscription regulator
Synonyms 4933425I22Rik, 5830411K19Rik
MMRRC Submission 068520-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8557 (G1)
Quality Score 223.009
Status Validated
Chromosome 4
Chromosomal Location 102971587-103022951 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 102996543 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000102471 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030247] [ENSMUST00000097945] [ENSMUST00000106855] [ENSMUST00000106857] [ENSMUST00000106858]
AlphaFold Q5UAK0
Predicted Effect probably null
Transcript: ENSMUST00000030247
SMART Domains Protein: ENSMUSP00000030247
Gene: ENSMUSG00000028522

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
low complexity region 57 65 N/A INTRINSIC
low complexity region 100 121 N/A INTRINSIC
low complexity region 176 193 N/A INTRINSIC
ELM2 198 251 1.14e-11 SMART
SANT 300 349 7.01e-9 SMART
low complexity region 382 409 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000097945
SMART Domains Protein: ENSMUSP00000095558
Gene: ENSMUSG00000028522

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
low complexity region 85 93 N/A INTRINSIC
low complexity region 128 149 N/A INTRINSIC
low complexity region 204 221 N/A INTRINSIC
ELM2 226 279 1.14e-11 SMART
SANT 328 377 7.01e-9 SMART
low complexity region 410 437 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000106855
SMART Domains Protein: ENSMUSP00000102468
Gene: ENSMUSG00000028522

DomainStartEndE-ValueType
ELM2 1 53 2.51e-8 SMART
SANT 102 151 7.01e-9 SMART
low complexity region 184 211 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000106857
SMART Domains Protein: ENSMUSP00000102470
Gene: ENSMUSG00000028522

DomainStartEndE-ValueType
low complexity region 2 17 N/A INTRINSIC
low complexity region 40 48 N/A INTRINSIC
low complexity region 83 104 N/A INTRINSIC
low complexity region 159 176 N/A INTRINSIC
ELM2 181 234 1.14e-11 SMART
SANT 283 332 7.01e-9 SMART
low complexity region 365 392 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000106858
SMART Domains Protein: ENSMUSP00000102471
Gene: ENSMUSG00000028522

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
low complexity region 57 65 N/A INTRINSIC
low complexity region 100 121 N/A INTRINSIC
low complexity region 176 193 N/A INTRINSIC
ELM2 198 251 1.14e-11 SMART
SANT 300 349 7.01e-9 SMART
low complexity region 382 409 N/A INTRINSIC
Meta Mutation Damage Score 0.9756 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 100% (60/60)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that was first identified in Xenopus laevis by its role in a mesoderm induction early response (MIER). The encoded protein functions as a transcriptional regulator. Alternatively spliced transcript variants encode multiple isoforms, some of which lack a C-terminal nuclear localization signal. [provided by RefSeq, May 2013]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610040J01Rik T C 5: 64,055,954 (GRCm39) V230A probably benign Het
Ablim2 A T 5: 35,985,483 (GRCm39) H260L probably damaging Het
Acp4 C T 7: 43,905,272 (GRCm39) probably null Het
Acvr2b G T 9: 119,261,654 (GRCm39) V416L probably damaging Het
Adipoq A T 16: 22,965,430 (GRCm39) probably benign Het
Amhr2 A G 15: 102,362,847 (GRCm39) Q538R probably benign Het
Apoh C T 11: 108,300,062 (GRCm39) T237I probably damaging Het
Aspm C T 1: 139,384,494 (GRCm39) T97I probably benign Het
Atg16l2 A T 7: 100,939,863 (GRCm39) H499Q probably benign Het
Bicdl2 G A 17: 23,886,536 (GRCm39) R375H probably benign Het
C3 T C 17: 57,531,383 (GRCm39) T304A probably benign Het
Cast A T 13: 74,852,301 (GRCm39) D647E probably damaging Het
Chrm2 T C 6: 36,501,010 (GRCm39) V289A probably benign Het
Clock T C 5: 76,377,217 (GRCm39) D694G probably damaging Het
Cyp4a31 C T 4: 115,427,438 (GRCm39) R215C possibly damaging Het
Dctn2 T C 10: 127,114,062 (GRCm39) L334P probably damaging Het
Dnah11 A G 12: 117,842,247 (GRCm39) I4444T probably benign Het
Egf C A 3: 129,548,600 (GRCm39) R5L unknown Het
Ercc1 A G 7: 19,082,480 (GRCm39) N11S probably benign Het
Eri3 T C 4: 117,472,520 (GRCm39) S113P possibly damaging Het
Fasn A G 11: 120,706,610 (GRCm39) V958A probably benign Het
Fgf10 A G 13: 118,918,132 (GRCm39) K140R probably benign Het
Gfra2 G A 14: 71,214,737 (GRCm39) M163I probably benign Het
Gm14403 T C 2: 177,201,354 (GRCm39) I191T probably damaging Het
Hdlbp T A 1: 93,341,219 (GRCm39) E977D probably damaging Het
Hectd4 A G 5: 121,448,714 (GRCm39) N354S possibly damaging Het
Hpgds A T 6: 65,096,999 (GRCm39) I170N probably benign Het
Limk2 A G 11: 3,296,379 (GRCm39) V356A possibly damaging Het
Map4 A G 9: 109,893,370 (GRCm39) probably null Het
Mettl13 C T 1: 162,371,921 (GRCm39) G316D possibly damaging Het
Mia2 T A 12: 59,148,274 (GRCm39) L45I probably damaging Het
Mob3a G T 10: 80,527,008 (GRCm39) R106S probably benign Het
Mug2 T A 6: 122,040,660 (GRCm39) F737I probably damaging Het
Myo7a C T 7: 97,703,081 (GRCm39) A2053T probably benign Het
Myrip A G 9: 120,246,252 (GRCm39) S127G probably benign Het
Naaladl2 T A 3: 24,262,528 (GRCm39) K395I probably benign Het
Nedd4l A T 18: 65,336,986 (GRCm39) M678L probably benign Het
Nefh A T 11: 4,891,233 (GRCm39) I462N probably damaging Het
Nfe2 A G 15: 103,157,025 (GRCm39) M322T probably benign Het
Ogfr GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG 2: 180,237,059 (GRCm39) probably benign Het
Or2z2 T A 11: 58,346,562 (GRCm39) D71V probably damaging Het
Or56b1 T A 7: 104,285,103 (GRCm39) V74E possibly damaging Het
Pkdcc A G 17: 83,528,495 (GRCm39) N288S probably benign Het
Sacs G A 14: 61,444,725 (GRCm39) C2257Y probably damaging Het
Sec23a G T 12: 59,052,056 (GRCm39) Q90K probably damaging Het
Shisal2a T A 4: 108,225,085 (GRCm39) N159I probably benign Het
Slc30a6 A G 17: 74,712,685 (GRCm39) T61A possibly damaging Het
Slc39a11 C A 11: 113,141,385 (GRCm39) A234S probably damaging Het
Smg6 C A 11: 75,047,064 (GRCm39) N1252K probably damaging Het
Spata2 A T 2: 167,326,227 (GRCm39) D197E probably damaging Het
Spen C T 4: 141,197,681 (GRCm39) A3396T probably benign Het
Spocd1 T C 4: 129,842,761 (GRCm39) F59L probably damaging Het
Tectb T A 19: 55,181,105 (GRCm39) probably benign Het
Tnnc1 G A 14: 30,932,562 (GRCm39) V82I probably damaging Het
Traf7 A T 17: 24,729,015 (GRCm39) V513D probably damaging Het
Tut4 T A 4: 108,399,908 (GRCm39) probably null Het
Vmn2r111 A T 17: 22,790,910 (GRCm39) Y129* probably null Het
Vrtn T A 12: 84,696,690 (GRCm39) F480Y probably benign Het
Vwa8 A T 14: 79,246,649 (GRCm39) I664F probably damaging Het
Vwde A T 6: 13,193,136 (GRCm39) V401E probably damaging Het
Zfp655 A T 5: 145,180,835 (GRCm39) N231I probably benign Het
Other mutations in Mier1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01586:Mier1 APN 4 103,012,769 (GRCm39) missense probably damaging 0.99
IGL01599:Mier1 APN 4 103,012,738 (GRCm39) missense possibly damaging 0.58
IGL01996:Mier1 APN 4 102,984,473 (GRCm39) missense possibly damaging 0.93
IGL02228:Mier1 APN 4 102,988,259 (GRCm39) missense possibly damaging 0.85
R0194:Mier1 UTSW 4 102,996,716 (GRCm39) splice site probably null
R0505:Mier1 UTSW 4 103,012,820 (GRCm39) splice site probably benign
R0684:Mier1 UTSW 4 102,996,631 (GRCm39) missense probably damaging 0.99
R0691:Mier1 UTSW 4 102,996,699 (GRCm39) missense probably benign 0.07
R2997:Mier1 UTSW 4 102,988,233 (GRCm39) missense probably damaging 1.00
R4273:Mier1 UTSW 4 103,019,628 (GRCm39) missense possibly damaging 0.93
R4728:Mier1 UTSW 4 102,997,402 (GRCm39) missense probably damaging 1.00
R4769:Mier1 UTSW 4 102,997,417 (GRCm39) missense probably benign 0.01
R4798:Mier1 UTSW 4 102,988,195 (GRCm39) missense probably damaging 1.00
R5075:Mier1 UTSW 4 102,996,670 (GRCm39) missense probably benign 0.02
R5260:Mier1 UTSW 4 103,019,907 (GRCm39) missense probably benign 0.04
R5663:Mier1 UTSW 4 103,007,739 (GRCm39) missense probably damaging 0.96
R5924:Mier1 UTSW 4 103,016,899 (GRCm39) nonsense probably null
R7253:Mier1 UTSW 4 102,996,544 (GRCm39) splice site probably null
R7304:Mier1 UTSW 4 102,996,599 (GRCm39) nonsense probably null
R7641:Mier1 UTSW 4 102,996,637 (GRCm39) missense possibly damaging 0.89
R7998:Mier1 UTSW 4 103,019,812 (GRCm39) missense probably benign 0.09
R8000:Mier1 UTSW 4 102,988,240 (GRCm39) missense probably damaging 1.00
R9353:Mier1 UTSW 4 103,012,800 (GRCm39) missense probably damaging 0.97
R9537:Mier1 UTSW 4 103,019,758 (GRCm39) missense probably benign 0.00
R9759:Mier1 UTSW 4 103,019,725 (GRCm39) missense probably benign 0.13
Predicted Primers PCR Primer
(F):5'- TGTGGTATATGGACTGAATAATGGC -3'
(R):5'- CTGTGGTTTCATTAATCCTACAGGG -3'

Sequencing Primer
(F):5'- GGCAAAAATTGTACGTGATTTCAAAC -3'
(R):5'- CAGGGATCTTGGAAAATAAATGTTCC -3'
Posted On 2021-05-28