Mutagenetix > Incidental Mutation

Incidental Mutation 'R8824:Ubxn10'

673316

Institutional Source

Beutler Lab

Gene Symbol

Ubxn10

Ensembl Gene

ENSMUSG00000043621

Gene Name

UBX domain protein 10

Synonyms

5730509E04Rik, Ubxd3

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.068) question?

Stock #

R8824 (G1)

Quality Score

146.008

Status

Validated

Chromosome

Chromosomal Location

138709837-138737167 bp(-) (GRCm38)

Type of Mutation

critical splice donor site (2 bp from exon)

DNA Base Change (assembly)

A to G at 138735867 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000101436 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000030530] [ENSMUST00000105808] [ENSMUST00000105810] [ENSMUST00000105810] [ENSMUST00000124660]

AlphaFold

Q8BG34

Predicted Effect

probably benign
Transcript: ENSMUST00000030530

SMART Domains

Protein: ENSMUSP00000030530
Gene: ENSMUSG00000028750

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
PA2c	21	143	1.83e-50	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000105808

SMART Domains

Protein: ENSMUSP00000101434
Gene: ENSMUSG00000028750

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
PA2c	21	143	1.83e-50	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000105810

SMART Domains

Protein: ENSMUSP00000101436
Gene: ENSMUSG00000043621

Domain	Start	End	E-Value	Type
low complexity region	60	77	N/A	INTRINSIC
UBX	188	270	5.36e-4	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000105810

SMART Domains

Protein: ENSMUSP00000101436
Gene: ENSMUSG00000043621

Domain	Start	End	E-Value	Type
low complexity region	60	77	N/A	INTRINSIC
UBX	188	270	5.36e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000124660

SMART Domains

Protein: ENSMUSP00000124341
Gene: ENSMUSG00000028750

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
PA2c	21	128	1.4e-37	SMART

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.5%
20x: 98.5%

Validation Efficiency

100% (63/63)

Allele List at MGI

Other mutations in this stock

Total: 65 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Accsl	A	T	2: 93,862,850	V260D	probably damaging	Het
Adora2a	G	A	10: 75,326,179	A51T	probably damaging	Het
Afg1l	G	A	10: 42,438,387	P128S	possibly damaging	Het
Ago4	C	A	4: 126,507,184	V623L	probably benign	Het
Akap11	A	T	14: 78,516,347	N112K		Het
C1ra	A	T	6: 124,517,695	I306F	probably damaging	Het
Ccdc73	A	G	2: 104,991,877	N724D	possibly damaging	Het
Cd248	A	G	19: 5,069,617	I498V	probably benign	Het
Clrn1	A	T	3: 58,884,893	S50T	probably benign	Het
Col7a1	A	G	9: 108,967,025	K1553R	unknown	Het
Cxcr6	A	C	9: 123,810,941	T343P	probably benign	Het
Cyp11b2	T	A	15: 74,856,065	Q56L	probably damaging	Het
Dip2a	A	G	10: 76,278,486		probably null	Het
Dnmbp	A	G	19: 43,849,837	V742A	probably benign	Het
Dusp16	A	T	6: 134,739,769	S192T	probably benign	Het
Ehbp1	A	T	11: 22,232,053	D87E	probably damaging	Het
Fgl1	A	G	8: 41,199,711	V150A	probably benign	Het
Flt3	T	C	5: 147,334,863	D873G	probably damaging	Het
Gart	T	C	16: 91,630,703	D469G	possibly damaging	Het
Gm28168	T	G	1: 117,947,895	S85A	probably benign	Het
Golgb1	A	G	16: 36,915,689	D1807G	probably benign	Het
Grm8	A	G	6: 27,761,352	L291S	probably damaging	Het
Gucy2d	C	T	7: 98,443,469	P18S	possibly damaging	Het
Ifna15	C	T	4: 88,557,761	C162Y	probably damaging	Het
Iqub	C	A	6: 24,479,308	E412*	probably null	Het
Krt4	T	A	15: 101,920,642	D312V		Het
Krtap26-1	A	T	16: 88,647,415	I106N	probably damaging	Het
Krtap26-1	T	C	16: 88,647,436	Y99C	probably damaging	Het
Lipn	T	C	19: 34,084,716	I357T	probably benign	Het
Lrrc14b	A	G	13: 74,363,949	L4P	probably damaging	Het
Mrgpra9	A	T	7: 47,235,293	C209S	probably benign	Het
Myh7b	A	G	2: 155,630,381	N1291D	probably benign	Het
Myo5a	A	G	9: 75,167,046	T746A	probably damaging	Het
Myom2	A	C	8: 15,114,169	E1021D	possibly damaging	Het
Ncoa2	C	T	1: 13,177,185	R338H	probably benign	Het
Ncor2	A	G	5: 125,118,757	F91L		Het
Neb	C	G	2: 52,216,911	A4407P	probably damaging	Het
Olfr1135	T	C	2: 87,671,960	M136V	possibly damaging	Het
Olfr1272	A	G	2: 90,296,012	I283T	probably damaging	Het
Olfr347	A	T	2: 36,735,191	Y290F	probably damaging	Het
Olfr502	T	G	7: 108,523,143	Y269S	probably benign	Het
Olfr74	A	G	2: 87,974,003	F221L	probably benign	Het
Olfr819	C	T	10: 129,965,792	V297M	probably damaging	Het
Peg10	T	TCCC	6: 4,756,451		probably benign	Het
Piwil4	C	A	9: 14,727,475	K298N	probably benign	Het
Prkcz	G	A	4: 155,344,828		probably benign	Het
Prkg2	G	A	5: 98,942,208	P691L	possibly damaging	Het
Ptprc	T	A	1: 138,113,708	K89*	probably null	Het
Rapgef3	C	T	15: 97,766,908	A25T	probably benign	Het
Rreb1	C	T	13: 37,930,516	T617I	probably damaging	Het
Rsph1	A	C	17: 31,273,376	V72G	possibly damaging	Het
Shc2	A	G	10: 79,637,702	V50A	probably benign	Het
Slc38a9	G	A	13: 112,701,487	R262H	probably benign	Het
Slco6c1	T	A	1: 97,128,159	N6Y	possibly damaging	Het
Smarca5	A	G	8: 80,705,332	F886L	probably benign	Het
Tas1r2	A	G	4: 139,653,763		probably benign	Het
Tnrc6c	T	A	11: 117,739,854		probably benign	Het
Trim30b	T	A	7: 104,357,906		probably benign	Het
Trim55	T	C	3: 19,672,962	S398P	probably benign	Het
Ttc39c	T	A	18: 12,686,946		probably benign	Het
Usf3	A	G	16: 44,215,613	N152S	probably benign	Het
Vps13b	T	A	15: 35,533,299	V839E	probably damaging	Het
Zeb1	T	A	18: 5,748,680		probably benign	Het
Zfp780b	T	C	7: 27,963,468	Y554C	probably benign	Het
Zhx2	C	T	15: 57,821,280	T15I	probably damaging	Het

Other mutations in Ubxn10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02149:Ubxn10	APN	4	138721273	missense	probably benign	0.00
IGL03216:Ubxn10	APN	4	138720739	missense	probably damaging	1.00
PIT1430001:Ubxn10	UTSW	4	138720888	missense	probably benign	0.01
R0885:Ubxn10	UTSW	4	138720570	missense	probably damaging	1.00
R2031:Ubxn10	UTSW	4	138721263	missense	possibly damaging	0.92
R4117:Ubxn10	UTSW	4	138720965	missense	probably benign	0.01
R4461:Ubxn10	UTSW	4	138720876	missense	probably benign	0.31
R4737:Ubxn10	UTSW	4	138735948	intron	probably benign
R4804:Ubxn10	UTSW	4	138721204	missense	possibly damaging	0.71
R5739:Ubxn10	UTSW	4	138720823	missense	probably benign	0.01
R6524:Ubxn10	UTSW	4	138720883	nonsense	probably null
R7252:Ubxn10	UTSW	4	138720876	missense	probably benign
R9189:Ubxn10	UTSW	4	138720822	missense	possibly damaging	0.81

Predicted Primers

PCR Primer
(F):5'- CTAAGAGTTGCTCAGCCTCC -3'
(R):5'- CATTCAAGATGGGTTGGCAGC -3'

Sequencing Primer
(F):5'- GAAAGCAGCAGATCCTGGCC -3'
(R):5'- GGTTGGCAGCCATATTCCTTAAGC -3'

Posted On

2021-07-15