Incidental Mutation 'R8825:Vmn2r16'
| ID |
673377 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r16
|
| Ensembl Gene |
ENSMUSG00000092080 |
| Gene Name |
vomeronasal 2, receptor 16 |
| Synonyms |
EG384220 |
| MMRRC Submission |
068728-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.154)
|
| Stock # |
R8825 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
109478247-109512347 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 109487019 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 80
(V80A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000127838
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000165180]
|
| AlphaFold |
A0A3B2WCY4 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000165180
AA Change: V80A
PolyPhen 2
Score 0.415 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000127838
Gene: ENSMUSG00000092080
AA Change: V80A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
76 |
425 |
2.3e-28 |
PFAM |
|
Pfam:NCD3G
|
509 |
563 |
8.2e-19 |
PFAM |
|
Pfam:7tm_3
|
596 |
831 |
3.5e-56 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.9%
|
| Validation Efficiency |
100% (61/61) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 62 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Arfgap2 |
T |
A |
2: 91,103,906 (GRCm39) |
L334Q |
probably damaging |
Het |
| Arhgef18 |
T |
A |
8: 3,436,951 (GRCm39) |
L247Q |
probably damaging |
Het |
| Birc6 |
T |
A |
17: 74,920,500 (GRCm39) |
C2100S |
probably damaging |
Het |
| Bpi |
A |
G |
2: 158,109,670 (GRCm39) |
D206G |
probably benign |
Het |
| C6 |
T |
C |
15: 4,761,170 (GRCm39) |
I10T |
possibly damaging |
Het |
| Cactin |
A |
G |
10: 81,161,492 (GRCm39) |
T675A |
probably damaging |
Het |
| Cd200 |
G |
A |
16: 45,215,157 (GRCm39) |
R165C |
probably benign |
Het |
| Cdkal1 |
C |
T |
13: 29,538,777 (GRCm39) |
V461I |
probably benign |
Het |
| Ces2g |
C |
T |
8: 105,693,954 (GRCm39) |
S430F |
probably benign |
Het |
| Clcn3 |
A |
T |
8: 61,382,522 (GRCm39) |
H382Q |
probably damaging |
Het |
| Crem |
A |
T |
18: 3,268,061 (GRCm39) |
V89E |
probably damaging |
Het |
| Crtc2 |
T |
A |
3: 90,166,463 (GRCm39) |
M146K |
probably benign |
Het |
| Depdc1b |
T |
G |
13: 108,521,316 (GRCm39) |
D374E |
possibly damaging |
Het |
| Dgkg |
T |
A |
16: 22,381,519 (GRCm39) |
H477L |
probably benign |
Het |
| Dnhd1 |
T |
A |
7: 105,343,174 (GRCm39) |
V1506D |
possibly damaging |
Het |
| Erfl |
A |
G |
7: 24,628,682 (GRCm39) |
V60A |
possibly damaging |
Het |
| Exosc10 |
G |
A |
4: 148,653,159 (GRCm39) |
|
probably null |
Het |
| Fem1al |
T |
C |
11: 29,773,696 (GRCm39) |
E587G |
probably benign |
Het |
| Flnb |
G |
T |
14: 7,887,566 (GRCm38) |
G459C |
probably damaging |
Het |
| Golgb1 |
A |
G |
16: 36,739,809 (GRCm39) |
D2757G |
probably benign |
Het |
| Gsta4 |
T |
G |
9: 78,116,121 (GRCm39) |
|
probably benign |
Het |
| Herc2 |
T |
A |
7: 55,700,626 (GRCm39) |
M1K |
probably null |
Het |
| Hip1 |
C |
T |
5: 135,450,976 (GRCm39) |
V879M |
probably damaging |
Het |
| Htt |
T |
C |
5: 34,983,304 (GRCm39) |
Y968H |
probably benign |
Het |
| Ints11 |
T |
A |
4: 155,969,587 (GRCm39) |
Y154* |
probably null |
Het |
| Itih5 |
A |
G |
2: 10,195,231 (GRCm39) |
S208G |
probably benign |
Het |
| Lamb2 |
C |
T |
9: 108,362,460 (GRCm39) |
T701I |
probably benign |
Het |
| Lgals3 |
T |
A |
14: 47,617,557 (GRCm39) |
Y22* |
probably null |
Het |
| Macc1 |
T |
A |
12: 119,409,587 (GRCm39) |
D118E |
probably benign |
Het |
| Mad2l2 |
T |
C |
4: 148,225,277 (GRCm39) |
L9P |
probably damaging |
Het |
| Mark2 |
T |
C |
19: 7,318,571 (GRCm39) |
T6A |
probably benign |
Het |
| Mcat |
T |
C |
15: 83,436,812 (GRCm39) |
N143S |
probably benign |
Het |
| Med10 |
T |
G |
13: 69,962,046 (GRCm39) |
C144G |
unknown |
Het |
| Miga1 |
A |
T |
3: 151,982,460 (GRCm39) |
F539I |
probably damaging |
Het |
| Mon2 |
A |
T |
10: 122,849,776 (GRCm39) |
S1174T |
probably benign |
Het |
| Mycbp2 |
C |
A |
14: 103,466,871 (GRCm39) |
W1330C |
probably damaging |
Het |
| Myo5b |
T |
C |
18: 74,892,169 (GRCm39) |
S1612P |
possibly damaging |
Het |
| Nipal4 |
T |
C |
11: 46,052,873 (GRCm39) |
I31V |
probably benign |
Het |
| Obox3 |
A |
T |
7: 15,361,226 (GRCm39) |
V13E |
possibly damaging |
Het |
| Or2ag19 |
A |
T |
7: 106,444,636 (GRCm39) |
I273F |
probably damaging |
Het |
| Or8g4 |
T |
C |
9: 39,661,994 (GRCm39) |
F104S |
probably damaging |
Het |
| Ppic |
A |
G |
18: 53,542,222 (GRCm39) |
V162A |
probably damaging |
Het |
| Prkg2 |
T |
C |
5: 99,090,043 (GRCm39) |
K699R |
probably benign |
Het |
| Prl2c2 |
T |
A |
13: 13,179,656 (GRCm39) |
L6F |
possibly damaging |
Het |
| Rnf148 |
G |
C |
6: 23,654,378 (GRCm39) |
S206C |
probably benign |
Het |
| Sec16a |
A |
G |
2: 26,313,586 (GRCm39) |
S474P |
|
Het |
| Sema5a |
T |
G |
15: 32,689,498 (GRCm39) |
H1054Q |
probably benign |
Het |
| Slc6a18 |
C |
A |
13: 73,813,751 (GRCm39) |
V521F |
probably null |
Het |
| Stat2 |
T |
A |
10: 128,127,233 (GRCm39) |
D921E |
possibly damaging |
Het |
| Tcf24 |
G |
T |
1: 10,031,224 (GRCm39) |
N42K |
unknown |
Het |
| Tgfb2 |
T |
A |
1: 186,361,136 (GRCm39) |
N372Y |
probably damaging |
Het |
| Tktl2 |
A |
C |
8: 66,966,319 (GRCm39) |
M626L |
possibly damaging |
Het |
| Tmem94 |
A |
G |
11: 115,688,201 (GRCm39) |
D1220G |
probably benign |
Het |
| Trcg1 |
A |
G |
9: 57,148,754 (GRCm39) |
T109A |
probably benign |
Het |
| Trim30a |
T |
A |
7: 104,060,529 (GRCm39) |
K416* |
probably null |
Het |
| Trpm5 |
T |
C |
7: 142,636,753 (GRCm39) |
K395E |
possibly damaging |
Het |
| Ufm1 |
T |
A |
3: 53,771,093 (GRCm39) |
|
probably null |
Het |
| Unc13b |
T |
A |
4: 43,237,683 (GRCm39) |
|
probably benign |
Het |
| Vmn2r77 |
A |
T |
7: 86,452,855 (GRCm39) |
Y524F |
probably benign |
Het |
| Zfp1007 |
T |
G |
5: 109,826,746 (GRCm39) |
T5P |
probably damaging |
Het |
| Zfp64 |
T |
C |
2: 168,793,552 (GRCm39) |
S65G |
probably benign |
Het |
| Zng1 |
A |
G |
19: 24,926,601 (GRCm39) |
V150A |
probably benign |
Het |
|
| Other mutations in Vmn2r16 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01116:Vmn2r16
|
APN |
5 |
109,488,294 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01374:Vmn2r16
|
APN |
5 |
109,478,283 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01391:Vmn2r16
|
APN |
5 |
109,511,627 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL01419:Vmn2r16
|
APN |
5 |
109,510,267 (GRCm39) |
splice site |
probably benign |
|
|
IGL01634:Vmn2r16
|
APN |
5 |
109,488,177 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01845:Vmn2r16
|
APN |
5 |
109,511,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01875:Vmn2r16
|
APN |
5 |
109,478,277 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01910:Vmn2r16
|
APN |
5 |
109,487,951 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02217:Vmn2r16
|
APN |
5 |
109,487,676 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02327:Vmn2r16
|
APN |
5 |
109,487,987 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02491:Vmn2r16
|
APN |
5 |
109,487,703 (GRCm39) |
nonsense |
probably null |
|
|
IGL02531:Vmn2r16
|
APN |
5 |
109,488,134 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02680:Vmn2r16
|
APN |
5 |
109,487,948 (GRCm39) |
missense |
probably benign |
0.44 |
|
IGL02884:Vmn2r16
|
APN |
5 |
109,508,757 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03084:Vmn2r16
|
APN |
5 |
109,478,292 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03096:Vmn2r16
|
APN |
5 |
109,487,751 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03355:Vmn2r16
|
APN |
5 |
109,511,580 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R0280:Vmn2r16
|
UTSW |
5 |
109,488,005 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0594:Vmn2r16
|
UTSW |
5 |
109,511,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1016:Vmn2r16
|
UTSW |
5 |
109,487,754 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1109:Vmn2r16
|
UTSW |
5 |
109,487,652 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1248:Vmn2r16
|
UTSW |
5 |
109,508,643 (GRCm39) |
missense |
probably benign |
0.10 |
|
R1626:Vmn2r16
|
UTSW |
5 |
109,511,443 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1909:Vmn2r16
|
UTSW |
5 |
109,511,853 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1929:Vmn2r16
|
UTSW |
5 |
109,487,124 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1982:Vmn2r16
|
UTSW |
5 |
109,511,890 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3038:Vmn2r16
|
UTSW |
5 |
109,487,199 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3437:Vmn2r16
|
UTSW |
5 |
109,478,362 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3734:Vmn2r16
|
UTSW |
5 |
109,478,280 (GRCm39) |
missense |
probably benign |
0.11 |
|
R3820:Vmn2r16
|
UTSW |
5 |
109,510,143 (GRCm39) |
missense |
probably benign |
0.36 |
|
R3873:Vmn2r16
|
UTSW |
5 |
109,488,177 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4165:Vmn2r16
|
UTSW |
5 |
109,478,427 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4373:Vmn2r16
|
UTSW |
5 |
109,511,667 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4575:Vmn2r16
|
UTSW |
5 |
109,511,665 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R4576:Vmn2r16
|
UTSW |
5 |
109,511,665 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R4578:Vmn2r16
|
UTSW |
5 |
109,511,665 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R4637:Vmn2r16
|
UTSW |
5 |
109,478,280 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4696:Vmn2r16
|
UTSW |
5 |
109,487,168 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5026:Vmn2r16
|
UTSW |
5 |
109,508,722 (GRCm39) |
nonsense |
probably null |
|
|
R5180:Vmn2r16
|
UTSW |
5 |
109,478,391 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5433:Vmn2r16
|
UTSW |
5 |
109,511,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5955:Vmn2r16
|
UTSW |
5 |
109,511,613 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R5958:Vmn2r16
|
UTSW |
5 |
109,510,153 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R6353:Vmn2r16
|
UTSW |
5 |
109,488,119 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6389:Vmn2r16
|
UTSW |
5 |
109,478,344 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6819:Vmn2r16
|
UTSW |
5 |
109,488,412 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6994:Vmn2r16
|
UTSW |
5 |
109,487,969 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7061:Vmn2r16
|
UTSW |
5 |
109,511,620 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7063:Vmn2r16
|
UTSW |
5 |
109,511,650 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7220:Vmn2r16
|
UTSW |
5 |
109,508,772 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7268:Vmn2r16
|
UTSW |
5 |
109,488,331 (GRCm39) |
nonsense |
probably null |
|
|
R7420:Vmn2r16
|
UTSW |
5 |
109,511,736 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7591:Vmn2r16
|
UTSW |
5 |
109,510,223 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7644:Vmn2r16
|
UTSW |
5 |
109,487,837 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7939:Vmn2r16
|
UTSW |
5 |
109,487,705 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R7977:Vmn2r16
|
UTSW |
5 |
109,488,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7987:Vmn2r16
|
UTSW |
5 |
109,488,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8023:Vmn2r16
|
UTSW |
5 |
109,488,272 (GRCm39) |
nonsense |
probably null |
|
|
R8427:Vmn2r16
|
UTSW |
5 |
109,488,138 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8436:Vmn2r16
|
UTSW |
5 |
109,511,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8475:Vmn2r16
|
UTSW |
5 |
109,487,073 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8554:Vmn2r16
|
UTSW |
5 |
109,511,997 (GRCm39) |
missense |
probably benign |
0.13 |
|
R8771:Vmn2r16
|
UTSW |
5 |
109,488,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8774:Vmn2r16
|
UTSW |
5 |
109,488,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8774-TAIL:Vmn2r16
|
UTSW |
5 |
109,488,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8775:Vmn2r16
|
UTSW |
5 |
109,488,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8775-TAIL:Vmn2r16
|
UTSW |
5 |
109,488,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8777:Vmn2r16
|
UTSW |
5 |
109,488,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8777-TAIL:Vmn2r16
|
UTSW |
5 |
109,488,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8865:Vmn2r16
|
UTSW |
5 |
109,487,910 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8900:Vmn2r16
|
UTSW |
5 |
109,511,619 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9365:Vmn2r16
|
UTSW |
5 |
109,488,064 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9683:Vmn2r16
|
UTSW |
5 |
109,511,677 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0027:Vmn2r16
|
UTSW |
5 |
109,487,175 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Vmn2r16
|
UTSW |
5 |
109,511,779 (GRCm39) |
frame shift |
probably null |
|
|
Z1088:Vmn2r16
|
UTSW |
5 |
109,488,381 (GRCm39) |
missense |
probably benign |
0.03 |
|
Z1177:Vmn2r16
|
UTSW |
5 |
109,487,864 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAAGATGTCCAATTTCCCAAGC -3'
(R):5'- CTTTGGTCTCCTAGAATTAATTGCC -3'
Sequencing Primer
(F):5'- CCCAAGCTTATTTCAGGAAAGGTAGC -3'
(R):5'- AATTGCCAGTTTTAAGGATGTTGTC -3'
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| Posted On |
2021-07-15 |
Incidental Mutation