Incidental Mutation 'R8825:Vmn2r77'
ID |
673384 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r77
|
Ensembl Gene |
ENSMUSG00000090949 |
Gene Name |
vomeronasal 2, receptor 77 |
Synonyms |
EG546983 |
MMRRC Submission |
068728-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.079)
|
Stock # |
R8825 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
7 |
Chromosomal Location |
86444349-86461240 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to T
at 86452855 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Tyrosine to Phenylalanine
at position 524
(Y524F)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000129540
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164996]
|
AlphaFold |
L7N2B7 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000164996
AA Change: Y524F
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000129540 Gene: ENSMUSG00000090949 AA Change: Y524F
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
78 |
467 |
1.4e-30 |
PFAM |
Pfam:NCD3G
|
510 |
562 |
1e-20 |
PFAM |
Pfam:7tm_3
|
594 |
830 |
2.6e-52 |
PFAM |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.9%
|
Validation Efficiency |
100% (61/61) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 62 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Arfgap2 |
T |
A |
2: 91,103,906 (GRCm39) |
L334Q |
probably damaging |
Het |
Arhgef18 |
T |
A |
8: 3,436,951 (GRCm39) |
L247Q |
probably damaging |
Het |
Birc6 |
T |
A |
17: 74,920,500 (GRCm39) |
C2100S |
probably damaging |
Het |
Bpi |
A |
G |
2: 158,109,670 (GRCm39) |
D206G |
probably benign |
Het |
C6 |
T |
C |
15: 4,761,170 (GRCm39) |
I10T |
possibly damaging |
Het |
Cactin |
A |
G |
10: 81,161,492 (GRCm39) |
T675A |
probably damaging |
Het |
Cd200 |
G |
A |
16: 45,215,157 (GRCm39) |
R165C |
probably benign |
Het |
Cdkal1 |
C |
T |
13: 29,538,777 (GRCm39) |
V461I |
probably benign |
Het |
Ces2g |
C |
T |
8: 105,693,954 (GRCm39) |
S430F |
probably benign |
Het |
Clcn3 |
A |
T |
8: 61,382,522 (GRCm39) |
H382Q |
probably damaging |
Het |
Crem |
A |
T |
18: 3,268,061 (GRCm39) |
V89E |
probably damaging |
Het |
Crtc2 |
T |
A |
3: 90,166,463 (GRCm39) |
M146K |
probably benign |
Het |
Depdc1b |
T |
G |
13: 108,521,316 (GRCm39) |
D374E |
possibly damaging |
Het |
Dgkg |
T |
A |
16: 22,381,519 (GRCm39) |
H477L |
probably benign |
Het |
Dnhd1 |
T |
A |
7: 105,343,174 (GRCm39) |
V1506D |
possibly damaging |
Het |
Erfl |
A |
G |
7: 24,628,682 (GRCm39) |
V60A |
possibly damaging |
Het |
Exosc10 |
G |
A |
4: 148,653,159 (GRCm39) |
|
probably null |
Het |
Fem1al |
T |
C |
11: 29,773,696 (GRCm39) |
E587G |
probably benign |
Het |
Flnb |
G |
T |
14: 7,887,566 (GRCm38) |
G459C |
probably damaging |
Het |
Golgb1 |
A |
G |
16: 36,739,809 (GRCm39) |
D2757G |
probably benign |
Het |
Gsta4 |
T |
G |
9: 78,116,121 (GRCm39) |
|
probably benign |
Het |
Herc2 |
T |
A |
7: 55,700,626 (GRCm39) |
M1K |
probably null |
Het |
Hip1 |
C |
T |
5: 135,450,976 (GRCm39) |
V879M |
probably damaging |
Het |
Htt |
T |
C |
5: 34,983,304 (GRCm39) |
Y968H |
probably benign |
Het |
Ints11 |
T |
A |
4: 155,969,587 (GRCm39) |
Y154* |
probably null |
Het |
Itih5 |
A |
G |
2: 10,195,231 (GRCm39) |
S208G |
probably benign |
Het |
Lamb2 |
C |
T |
9: 108,362,460 (GRCm39) |
T701I |
probably benign |
Het |
Lgals3 |
T |
A |
14: 47,617,557 (GRCm39) |
Y22* |
probably null |
Het |
Macc1 |
T |
A |
12: 119,409,587 (GRCm39) |
D118E |
probably benign |
Het |
Mad2l2 |
T |
C |
4: 148,225,277 (GRCm39) |
L9P |
probably damaging |
Het |
Mark2 |
T |
C |
19: 7,318,571 (GRCm39) |
T6A |
probably benign |
Het |
Mcat |
T |
C |
15: 83,436,812 (GRCm39) |
N143S |
probably benign |
Het |
Med10 |
T |
G |
13: 69,962,046 (GRCm39) |
C144G |
unknown |
Het |
Miga1 |
A |
T |
3: 151,982,460 (GRCm39) |
F539I |
probably damaging |
Het |
Mon2 |
A |
T |
10: 122,849,776 (GRCm39) |
S1174T |
probably benign |
Het |
Mycbp2 |
C |
A |
14: 103,466,871 (GRCm39) |
W1330C |
probably damaging |
Het |
Myo5b |
T |
C |
18: 74,892,169 (GRCm39) |
S1612P |
possibly damaging |
Het |
Nipal4 |
T |
C |
11: 46,052,873 (GRCm39) |
I31V |
probably benign |
Het |
Obox3 |
A |
T |
7: 15,361,226 (GRCm39) |
V13E |
possibly damaging |
Het |
Or2ag19 |
A |
T |
7: 106,444,636 (GRCm39) |
I273F |
probably damaging |
Het |
Or8g4 |
T |
C |
9: 39,661,994 (GRCm39) |
F104S |
probably damaging |
Het |
Ppic |
A |
G |
18: 53,542,222 (GRCm39) |
V162A |
probably damaging |
Het |
Prkg2 |
T |
C |
5: 99,090,043 (GRCm39) |
K699R |
probably benign |
Het |
Prl2c2 |
T |
A |
13: 13,179,656 (GRCm39) |
L6F |
possibly damaging |
Het |
Rnf148 |
G |
C |
6: 23,654,378 (GRCm39) |
S206C |
probably benign |
Het |
Sec16a |
A |
G |
2: 26,313,586 (GRCm39) |
S474P |
|
Het |
Sema5a |
T |
G |
15: 32,689,498 (GRCm39) |
H1054Q |
probably benign |
Het |
Slc6a18 |
C |
A |
13: 73,813,751 (GRCm39) |
V521F |
probably null |
Het |
Stat2 |
T |
A |
10: 128,127,233 (GRCm39) |
D921E |
possibly damaging |
Het |
Tcf24 |
G |
T |
1: 10,031,224 (GRCm39) |
N42K |
unknown |
Het |
Tgfb2 |
T |
A |
1: 186,361,136 (GRCm39) |
N372Y |
probably damaging |
Het |
Tktl2 |
A |
C |
8: 66,966,319 (GRCm39) |
M626L |
possibly damaging |
Het |
Tmem94 |
A |
G |
11: 115,688,201 (GRCm39) |
D1220G |
probably benign |
Het |
Trcg1 |
A |
G |
9: 57,148,754 (GRCm39) |
T109A |
probably benign |
Het |
Trim30a |
T |
A |
7: 104,060,529 (GRCm39) |
K416* |
probably null |
Het |
Trpm5 |
T |
C |
7: 142,636,753 (GRCm39) |
K395E |
possibly damaging |
Het |
Ufm1 |
T |
A |
3: 53,771,093 (GRCm39) |
|
probably null |
Het |
Unc13b |
T |
A |
4: 43,237,683 (GRCm39) |
|
probably benign |
Het |
Vmn2r16 |
T |
C |
5: 109,487,019 (GRCm39) |
V80A |
probably benign |
Het |
Zfp1007 |
T |
G |
5: 109,826,746 (GRCm39) |
T5P |
probably damaging |
Het |
Zfp64 |
T |
C |
2: 168,793,552 (GRCm39) |
S65G |
probably benign |
Het |
Zng1 |
A |
G |
19: 24,926,601 (GRCm39) |
V150A |
probably benign |
Het |
|
Other mutations in Vmn2r77 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00954:Vmn2r77
|
APN |
7 |
86,449,975 (GRCm39) |
missense |
probably benign |
0.06 |
IGL01105:Vmn2r77
|
APN |
7 |
86,460,872 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL01367:Vmn2r77
|
APN |
7 |
86,461,124 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL01634:Vmn2r77
|
APN |
7 |
86,460,857 (GRCm39) |
missense |
probably benign |
|
IGL01805:Vmn2r77
|
APN |
7 |
86,460,395 (GRCm39) |
missense |
probably benign |
0.18 |
IGL01868:Vmn2r77
|
APN |
7 |
86,452,224 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01980:Vmn2r77
|
APN |
7 |
86,450,678 (GRCm39) |
missense |
probably benign |
0.14 |
IGL02055:Vmn2r77
|
APN |
7 |
86,450,763 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02066:Vmn2r77
|
APN |
7 |
86,452,836 (GRCm39) |
nonsense |
probably null |
|
IGL02185:Vmn2r77
|
APN |
7 |
86,444,360 (GRCm39) |
missense |
unknown |
|
IGL02200:Vmn2r77
|
APN |
7 |
86,451,187 (GRCm39) |
missense |
probably benign |
0.04 |
IGL02336:Vmn2r77
|
APN |
7 |
86,451,224 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02445:Vmn2r77
|
APN |
7 |
86,452,848 (GRCm39) |
nonsense |
probably null |
|
IGL02557:Vmn2r77
|
APN |
7 |
86,444,342 (GRCm39) |
unclassified |
probably benign |
|
IGL02659:Vmn2r77
|
APN |
7 |
86,449,979 (GRCm39) |
missense |
probably benign |
0.32 |
IGL02978:Vmn2r77
|
APN |
7 |
86,460,555 (GRCm39) |
missense |
probably benign |
|
IGL03180:Vmn2r77
|
APN |
7 |
86,450,843 (GRCm39) |
missense |
possibly damaging |
0.85 |
IGL03255:Vmn2r77
|
APN |
7 |
86,461,131 (GRCm39) |
missense |
probably benign |
0.04 |
IGL03273:Vmn2r77
|
APN |
7 |
86,460,494 (GRCm39) |
missense |
probably damaging |
0.99 |
R0046:Vmn2r77
|
UTSW |
7 |
86,451,146 (GRCm39) |
missense |
possibly damaging |
0.73 |
R0047:Vmn2r77
|
UTSW |
7 |
86,460,858 (GRCm39) |
missense |
probably benign |
0.01 |
R0066:Vmn2r77
|
UTSW |
7 |
86,449,964 (GRCm39) |
missense |
probably benign |
0.17 |
R0066:Vmn2r77
|
UTSW |
7 |
86,449,964 (GRCm39) |
missense |
probably benign |
0.17 |
R0389:Vmn2r77
|
UTSW |
7 |
86,450,702 (GRCm39) |
missense |
probably benign |
0.29 |
R0635:Vmn2r77
|
UTSW |
7 |
86,460,383 (GRCm39) |
missense |
probably benign |
|
R0689:Vmn2r77
|
UTSW |
7 |
86,460,872 (GRCm39) |
missense |
probably damaging |
0.99 |
R0827:Vmn2r77
|
UTSW |
7 |
86,451,224 (GRCm39) |
missense |
probably damaging |
1.00 |
R1167:Vmn2r77
|
UTSW |
7 |
86,450,954 (GRCm39) |
missense |
probably benign |
0.02 |
R1228:Vmn2r77
|
UTSW |
7 |
86,450,242 (GRCm39) |
critical splice donor site |
probably null |
|
R1353:Vmn2r77
|
UTSW |
7 |
86,451,394 (GRCm39) |
missense |
probably benign |
0.29 |
R1392:Vmn2r77
|
UTSW |
7 |
86,450,830 (GRCm39) |
missense |
probably benign |
0.00 |
R1392:Vmn2r77
|
UTSW |
7 |
86,450,830 (GRCm39) |
missense |
probably benign |
0.00 |
R1613:Vmn2r77
|
UTSW |
7 |
86,460,356 (GRCm39) |
missense |
probably damaging |
1.00 |
R1654:Vmn2r77
|
UTSW |
7 |
86,461,123 (GRCm39) |
missense |
probably damaging |
1.00 |
R1742:Vmn2r77
|
UTSW |
7 |
86,444,543 (GRCm39) |
missense |
probably benign |
0.35 |
R1827:Vmn2r77
|
UTSW |
7 |
86,450,821 (GRCm39) |
missense |
probably damaging |
0.99 |
R1911:Vmn2r77
|
UTSW |
7 |
86,461,001 (GRCm39) |
missense |
probably damaging |
1.00 |
R1974:Vmn2r77
|
UTSW |
7 |
86,449,964 (GRCm39) |
missense |
probably benign |
0.17 |
R2008:Vmn2r77
|
UTSW |
7 |
86,450,921 (GRCm39) |
missense |
probably benign |
0.31 |
R2093:Vmn2r77
|
UTSW |
7 |
86,450,702 (GRCm39) |
missense |
probably benign |
0.29 |
R2143:Vmn2r77
|
UTSW |
7 |
86,461,152 (GRCm39) |
missense |
probably damaging |
1.00 |
R2269:Vmn2r77
|
UTSW |
7 |
86,460,897 (GRCm39) |
missense |
probably benign |
0.03 |
R2972:Vmn2r77
|
UTSW |
7 |
86,452,893 (GRCm39) |
missense |
probably benign |
0.01 |
R2974:Vmn2r77
|
UTSW |
7 |
86,452,893 (GRCm39) |
missense |
probably benign |
0.01 |
R3037:Vmn2r77
|
UTSW |
7 |
86,450,191 (GRCm39) |
missense |
probably benign |
|
R3694:Vmn2r77
|
UTSW |
7 |
86,450,044 (GRCm39) |
missense |
probably damaging |
1.00 |
R3695:Vmn2r77
|
UTSW |
7 |
86,450,044 (GRCm39) |
missense |
probably damaging |
1.00 |
R3805:Vmn2r77
|
UTSW |
7 |
86,444,368 (GRCm39) |
nonsense |
probably null |
|
R3870:Vmn2r77
|
UTSW |
7 |
86,461,050 (GRCm39) |
missense |
probably damaging |
1.00 |
R4732:Vmn2r77
|
UTSW |
7 |
86,450,195 (GRCm39) |
missense |
probably benign |
0.00 |
R4733:Vmn2r77
|
UTSW |
7 |
86,450,195 (GRCm39) |
missense |
probably benign |
0.00 |
R5009:Vmn2r77
|
UTSW |
7 |
86,451,015 (GRCm39) |
missense |
possibly damaging |
0.82 |
R5201:Vmn2r77
|
UTSW |
7 |
86,460,846 (GRCm39) |
missense |
probably damaging |
0.98 |
R5218:Vmn2r77
|
UTSW |
7 |
86,451,341 (GRCm39) |
missense |
probably damaging |
0.98 |
R5469:Vmn2r77
|
UTSW |
7 |
86,451,271 (GRCm39) |
missense |
probably benign |
0.01 |
R5673:Vmn2r77
|
UTSW |
7 |
86,461,214 (GRCm39) |
missense |
probably benign |
0.05 |
R5771:Vmn2r77
|
UTSW |
7 |
86,461,235 (GRCm39) |
missense |
probably benign |
0.06 |
R5832:Vmn2r77
|
UTSW |
7 |
86,460,670 (GRCm39) |
nonsense |
probably null |
|
R5899:Vmn2r77
|
UTSW |
7 |
86,460,924 (GRCm39) |
missense |
probably damaging |
1.00 |
R6151:Vmn2r77
|
UTSW |
7 |
86,450,878 (GRCm39) |
missense |
probably benign |
0.00 |
R6182:Vmn2r77
|
UTSW |
7 |
86,460,957 (GRCm39) |
missense |
probably damaging |
1.00 |
R6326:Vmn2r77
|
UTSW |
7 |
86,451,031 (GRCm39) |
missense |
probably benign |
|
R6419:Vmn2r77
|
UTSW |
7 |
86,460,767 (GRCm39) |
missense |
probably damaging |
0.99 |
R6549:Vmn2r77
|
UTSW |
7 |
86,450,065 (GRCm39) |
missense |
probably benign |
0.06 |
R6874:Vmn2r77
|
UTSW |
7 |
86,451,286 (GRCm39) |
missense |
probably benign |
0.00 |
R6972:Vmn2r77
|
UTSW |
7 |
86,452,202 (GRCm39) |
missense |
probably damaging |
1.00 |
R7056:Vmn2r77
|
UTSW |
7 |
86,451,023 (GRCm39) |
missense |
probably benign |
0.06 |
R7185:Vmn2r77
|
UTSW |
7 |
86,451,035 (GRCm39) |
missense |
probably benign |
0.00 |
R7261:Vmn2r77
|
UTSW |
7 |
86,460,518 (GRCm39) |
nonsense |
probably null |
|
R7298:Vmn2r77
|
UTSW |
7 |
86,449,979 (GRCm39) |
missense |
probably benign |
0.00 |
R7662:Vmn2r77
|
UTSW |
7 |
86,460,492 (GRCm39) |
nonsense |
probably null |
|
R8182:Vmn2r77
|
UTSW |
7 |
86,460,801 (GRCm39) |
missense |
probably damaging |
1.00 |
R8327:Vmn2r77
|
UTSW |
7 |
86,450,680 (GRCm39) |
missense |
probably benign |
0.08 |
R8387:Vmn2r77
|
UTSW |
7 |
86,450,947 (GRCm39) |
missense |
probably benign |
0.00 |
R8898:Vmn2r77
|
UTSW |
7 |
86,444,430 (GRCm39) |
missense |
probably damaging |
1.00 |
R8973:Vmn2r77
|
UTSW |
7 |
86,452,150 (GRCm39) |
missense |
possibly damaging |
0.93 |
R9258:Vmn2r77
|
UTSW |
7 |
86,452,302 (GRCm39) |
missense |
possibly damaging |
0.88 |
R9338:Vmn2r77
|
UTSW |
7 |
86,460,994 (GRCm39) |
missense |
probably damaging |
1.00 |
R9358:Vmn2r77
|
UTSW |
7 |
86,452,236 (GRCm39) |
missense |
probably benign |
0.00 |
R9377:Vmn2r77
|
UTSW |
7 |
86,444,442 (GRCm39) |
missense |
probably benign |
0.05 |
R9404:Vmn2r77
|
UTSW |
7 |
86,451,247 (GRCm39) |
missense |
probably benign |
|
R9673:Vmn2r77
|
UTSW |
7 |
86,450,171 (GRCm39) |
missense |
possibly damaging |
0.75 |
R9679:Vmn2r77
|
UTSW |
7 |
86,460,741 (GRCm39) |
missense |
probably benign |
0.07 |
|
Predicted Primers |
PCR Primer
(F):5'- AAGGGAAGTCTTTCAGTGGCA -3'
(R):5'- TCCAAAATTCTCAACTCACAAGTTAT -3'
Sequencing Primer
(F):5'- AAGGGAAGTCTTTCAGTGGCATTTTC -3'
(R):5'- TTCAATAAACCATTTGGGCAGAG -3'
|
Posted On |
2021-07-15 |