Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00488:Adgrl4'

6735

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Adgrl4

Ensembl Gene

ENSMUSG00000039167

Gene Name

adhesion G protein-coupled receptor L4

Synonyms

EGF-TM7 receptor, Eltd1, 1110033N21Rik, Etl

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00488

Quality Score

Status

Chromosome

Chromosomal Location

151143519-151250718 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 151248478 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Threonine at position 717 (S717T)

Ref Sequence

ENSEMBL: ENSMUSP00000041939 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000046977]

AlphaFold

Q923X1

Predicted Effect

probably damaging
Transcript: ENSMUST00000046977
AA Change: S717T

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000041939
Gene: ENSMUSG00000039167
AA Change: S717T

Domain	Start	End	E-Value	Type
EGF	21	57	9.13e0	SMART
EGF_CA	58	107	4.88e-9	SMART
EGF_CA	108	157	4.88e-9	SMART
Pfam:GAIN	182	390	6.8e-38	PFAM
GPS	414	467	1.25e-17	SMART
Pfam:7tm_2	473	709	2.5e-58	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: For a targeted mutation, no significant differences were detected between homozygous mice and controls in a high-throughput screen. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 21 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Bcorl1	T	G	X: 47,494,919 (GRCm39)	V1730G	probably damaging	Het
Cchcr1	A	G	17: 35,839,469 (GRCm39)	D585G	possibly damaging	Het
Dnah6	A	T	6: 73,063,190 (GRCm39)	N2637K	possibly damaging	Het
Erg	C	A	16: 95,170,848 (GRCm39)		probably benign	Het
Mak	C	T	13: 41,209,165 (GRCm39)		probably benign	Het
Max	T	C	12: 76,985,404 (GRCm39)	S132G	probably damaging	Het
Nfam1	T	C	15: 82,907,185 (GRCm39)	Y4C	probably benign	Het
Orc5	G	T	5: 22,721,771 (GRCm39)	D360E	probably damaging	Het
Prkdc	T	A	16: 15,593,711 (GRCm39)		probably null	Het
Ptpn18	G	A	1: 34,502,200 (GRCm39)	R72K	probably damaging	Het
R3hcc1l	A	G	19: 42,552,391 (GRCm39)	I463V	probably benign	Het
Rapgef2	T	C	3: 78,999,332 (GRCm39)	E480G	possibly damaging	Het
Rictor	T	A	15: 6,816,071 (GRCm39)	D1114E	probably damaging	Het
Sestd1	A	G	2: 77,042,796 (GRCm39)	S253P	possibly damaging	Het
Slk	C	T	19: 47,608,148 (GRCm39)	T367I	probably benign	Het
Tasl	T	A	X: 84,931,985 (GRCm39)	Y184N	possibly damaging	Het
Tcirg1	T	G	19: 3,949,108 (GRCm39)	I394L	possibly damaging	Het
Ubn1	T	C	16: 4,899,778 (GRCm39)	S1097P	probably benign	Het
Ugt2b34	T	A	5: 87,040,818 (GRCm39)	H368L	probably damaging	Het
Wdr20rt	T	C	12: 65,272,744 (GRCm39)	V69A	possibly damaging	Het
Wnt16	T	C	6: 22,291,012 (GRCm39)	S147P	probably damaging	Het

Other mutations in Adgrl4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00694:Adgrl4	APN	3	151,145,033 (GRCm39)	splice site	probably benign
IGL01143:Adgrl4	APN	3	151,205,866 (GRCm39)	splice site	probably null
IGL01359:Adgrl4	APN	3	151,248,923 (GRCm39)	missense	probably damaging	1.00
IGL01947:Adgrl4	APN	3	151,216,428 (GRCm39)	critical splice donor site	probably null
IGL02149:Adgrl4	APN	3	151,205,991 (GRCm39)	missense	possibly damaging	0.95
IGL02324:Adgrl4	APN	3	151,203,511 (GRCm39)	missense	probably damaging	1.00
IGL02562:Adgrl4	APN	3	151,144,949 (GRCm39)	missense	probably damaging	1.00
IGL02644:Adgrl4	APN	3	151,198,007 (GRCm39)	missense	probably benign	0.00
trivial	UTSW	3	151,223,247 (GRCm39)	missense	probably benign	0.07
R0077:Adgrl4	UTSW	3	151,223,418 (GRCm39)	missense	probably damaging	1.00
R0116:Adgrl4	UTSW	3	151,223,247 (GRCm39)	missense	probably benign	0.07
R0331:Adgrl4	UTSW	3	151,203,577 (GRCm39)	missense	probably benign	0.00
R0601:Adgrl4	UTSW	3	151,204,066 (GRCm39)	splice site	probably benign
R0613:Adgrl4	UTSW	3	151,248,859 (GRCm39)	splice site	probably benign
R1293:Adgrl4	UTSW	3	151,213,081 (GRCm39)	missense	probably benign	0.00
R1463:Adgrl4	UTSW	3	151,216,233 (GRCm39)	missense	probably damaging	0.98
R1697:Adgrl4	UTSW	3	151,223,248 (GRCm39)	missense	probably damaging	1.00
R1731:Adgrl4	UTSW	3	151,246,623 (GRCm39)	missense	possibly damaging	0.64
R1765:Adgrl4	UTSW	3	151,248,872 (GRCm39)	missense	probably damaging	1.00
R1782:Adgrl4	UTSW	3	151,248,442 (GRCm39)	nonsense	probably null
R1888:Adgrl4	UTSW	3	151,144,914 (GRCm39)	missense	probably benign	0.11
R1888:Adgrl4	UTSW	3	151,144,914 (GRCm39)	missense	probably benign	0.11
R1957:Adgrl4	UTSW	3	151,216,416 (GRCm39)	missense	possibly damaging	0.94
R2128:Adgrl4	UTSW	3	151,205,838 (GRCm39)	missense	probably benign	0.00
R2180:Adgrl4	UTSW	3	151,205,779 (GRCm39)	missense	probably damaging	0.96
R2238:Adgrl4	UTSW	3	151,205,779 (GRCm39)	missense	probably damaging	0.96
R2474:Adgrl4	UTSW	3	151,248,361 (GRCm39)	missense	probably benign	0.01
R2697:Adgrl4	UTSW	3	151,216,260 (GRCm39)	missense	probably damaging	1.00
R3835:Adgrl4	UTSW	3	151,216,254 (GRCm39)	missense	probably damaging	1.00
R4499:Adgrl4	UTSW	3	151,216,422 (GRCm39)	missense	possibly damaging	0.81
R4640:Adgrl4	UTSW	3	151,205,947 (GRCm39)	unclassified	probably benign
R4747:Adgrl4	UTSW	3	151,213,077 (GRCm39)	missense	probably benign	0.01
R5428:Adgrl4	UTSW	3	151,248,323 (GRCm39)	missense	probably damaging	1.00
R5510:Adgrl4	UTSW	3	151,203,467 (GRCm39)	missense	possibly damaging	0.89
R5717:Adgrl4	UTSW	3	151,197,971 (GRCm39)	missense	probably benign	0.01
R6106:Adgrl4	UTSW	3	151,246,622 (GRCm39)	missense	possibly damaging	0.67
R6343:Adgrl4	UTSW	3	151,223,443 (GRCm39)	missense	probably damaging	1.00
R6419:Adgrl4	UTSW	3	151,144,953 (GRCm39)	missense	probably damaging	1.00
R6468:Adgrl4	UTSW	3	151,198,012 (GRCm39)	missense	probably benign
R6636:Adgrl4	UTSW	3	151,223,410 (GRCm39)	nonsense	probably null
R6637:Adgrl4	UTSW	3	151,223,410 (GRCm39)	nonsense	probably null
R6687:Adgrl4	UTSW	3	151,248,392 (GRCm39)	missense	probably benign	0.00
R6856:Adgrl4	UTSW	3	151,205,755 (GRCm39)	missense	probably benign	0.00
R6887:Adgrl4	UTSW	3	151,248,370 (GRCm39)	missense	possibly damaging	0.46
R7041:Adgrl4	UTSW	3	151,144,959 (GRCm39)	missense	probably benign	0.00
R7527:Adgrl4	UTSW	3	151,144,887 (GRCm39)	missense	probably benign	0.08
R7597:Adgrl4	UTSW	3	151,248,895 (GRCm39)	missense	probably damaging	1.00
R7751:Adgrl4	UTSW	3	151,197,946 (GRCm39)	missense	probably damaging	0.99
R8556:Adgrl4	UTSW	3	151,216,302 (GRCm39)	missense	probably damaging	0.98
R8696:Adgrl4	UTSW	3	151,248,344 (GRCm39)	missense	probably damaging	1.00
R8698:Adgrl4	UTSW	3	151,203,512 (GRCm39)	missense	probably damaging	1.00
R8795:Adgrl4	UTSW	3	151,216,416 (GRCm39)	missense	probably benign	0.03
R9226:Adgrl4	UTSW	3	151,198,064 (GRCm39)	critical splice donor site	probably null
R9655:Adgrl4	UTSW	3	151,248,450 (GRCm39)	missense	probably damaging	0.96
R9755:Adgrl4	UTSW	3	151,216,418 (GRCm39)	missense	probably benign	0.01
R9767:Adgrl4	UTSW	3	151,207,394 (GRCm39)	missense	probably benign	0.16
R9784:Adgrl4	UTSW	3	151,214,948 (GRCm39)	missense	probably damaging	1.00
X0053:Adgrl4	UTSW	3	151,203,470 (GRCm39)	missense	probably damaging	1.00
Z1088:Adgrl4	UTSW	3	151,205,812 (GRCm39)	missense	probably benign	0.00

Posted On

2012-04-20