Incidental Mutation 'R8826:Ttc3'
| ID |
673501 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ttc3
|
| Ensembl Gene |
ENSMUSG00000040785 |
| Gene Name |
tetratricopeptide repeat domain 3 |
| Synonyms |
D16Ium21e, TPRD, 2610202A04Rik, D16Ium21 |
| MMRRC Submission |
068729-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.574)
|
| Stock # |
R8826 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
16 |
| Chromosomal Location |
94171479-94270081 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 94232829 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Phenylalanine
at position 957
(L957F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000116097
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000117648]
[ENSMUST00000122895]
[ENSMUST00000143145]
[ENSMUST00000147046]
[ENSMUST00000147352]
[ENSMUST00000150346]
[ENSMUST00000151770]
[ENSMUST00000152117]
[ENSMUST00000153988]
[ENSMUST00000155692]
[ENSMUST00000231569]
[ENSMUST00000231850]
[ENSMUST00000231915]
[ENSMUST00000232395]
[ENSMUST00000232660]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000117648
AA Change: L975F
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000112801
Gene: ENSMUSG00000040785
AA Change: L975F
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
231 |
264 |
3.61e-2 |
SMART |
|
TPR
|
265 |
298 |
3.32e-1 |
SMART |
|
Blast:TPR
|
300 |
332 |
2e-12 |
BLAST |
|
low complexity region
|
444 |
459 |
N/A |
INTRINSIC |
|
TPR
|
576 |
609 |
2.55e-2 |
SMART |
|
low complexity region
|
720 |
732 |
N/A |
INTRINSIC |
|
coiled coil region
|
765 |
796 |
N/A |
INTRINSIC |
|
low complexity region
|
1018 |
1032 |
N/A |
INTRINSIC |
|
low complexity region
|
1036 |
1050 |
N/A |
INTRINSIC |
|
low complexity region
|
1170 |
1190 |
N/A |
INTRINSIC |
|
low complexity region
|
1248 |
1260 |
N/A |
INTRINSIC |
|
low complexity region
|
1278 |
1291 |
N/A |
INTRINSIC |
|
coiled coil region
|
1472 |
1570 |
N/A |
INTRINSIC |
|
low complexity region
|
1876 |
1887 |
N/A |
INTRINSIC |
|
RING
|
1931 |
1970 |
7e-9 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000122895
AA Change: L957F
PolyPhen 2
Score 0.851 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000123037
Gene: ENSMUSG00000040785
AA Change: L957F
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
213 |
246 |
3.61e-2 |
SMART |
|
TPR
|
247 |
280 |
3.32e-1 |
SMART |
|
Blast:TPR
|
282 |
314 |
3e-12 |
BLAST |
|
low complexity region
|
426 |
441 |
N/A |
INTRINSIC |
|
TPR
|
558 |
591 |
2.55e-2 |
SMART |
|
low complexity region
|
702 |
714 |
N/A |
INTRINSIC |
|
coiled coil region
|
747 |
778 |
N/A |
INTRINSIC |
|
low complexity region
|
1000 |
1014 |
N/A |
INTRINSIC |
|
low complexity region
|
1018 |
1032 |
N/A |
INTRINSIC |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000114483
Gene: ENSMUSG00000040785
AA Change: L173F
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
28 |
40 |
N/A |
INTRINSIC |
|
coiled coil region
|
72 |
103 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000143145
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000147046
|
| SMART Domains |
Protein: ENSMUSP00000119265
Gene: ENSMUSG00000040785
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
43 |
58 |
N/A |
INTRINSIC |
|
Pfam:TPR_1
|
175 |
206 |
5.3e-6 |
PFAM |
|
low complexity region
|
319 |
331 |
N/A |
INTRINSIC |
|
low complexity region
|
359 |
382 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000147352
AA Change: L957F
PolyPhen 2
Score 0.851 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000116097
Gene: ENSMUSG00000040785
AA Change: L957F
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
213 |
246 |
3.61e-2 |
SMART |
|
TPR
|
247 |
280 |
3.32e-1 |
SMART |
|
Blast:TPR
|
282 |
314 |
3e-12 |
BLAST |
|
low complexity region
|
426 |
441 |
N/A |
INTRINSIC |
|
TPR
|
558 |
591 |
2.55e-2 |
SMART |
|
low complexity region
|
702 |
714 |
N/A |
INTRINSIC |
|
coiled coil region
|
747 |
778 |
N/A |
INTRINSIC |
|
low complexity region
|
1000 |
1014 |
N/A |
INTRINSIC |
|
low complexity region
|
1018 |
1032 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000150346
AA Change: L574F
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000122726
Gene: ENSMUSG00000040785
AA Change: L574F
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
43 |
58 |
N/A |
INTRINSIC |
|
Pfam:TPR_1
|
175 |
206 |
9.6e-6 |
PFAM |
|
low complexity region
|
319 |
331 |
N/A |
INTRINSIC |
|
coiled coil region
|
364 |
395 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000151770
AA Change: L975F
PolyPhen 2
Score 0.851 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000121349
Gene: ENSMUSG00000040785
AA Change: L975F
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
231 |
264 |
3.61e-2 |
SMART |
|
TPR
|
265 |
298 |
3.32e-1 |
SMART |
|
Blast:TPR
|
300 |
332 |
3e-12 |
BLAST |
|
low complexity region
|
444 |
459 |
N/A |
INTRINSIC |
|
TPR
|
576 |
609 |
2.55e-2 |
SMART |
|
low complexity region
|
720 |
732 |
N/A |
INTRINSIC |
|
coiled coil region
|
765 |
796 |
N/A |
INTRINSIC |
|
low complexity region
|
1018 |
1032 |
N/A |
INTRINSIC |
|
low complexity region
|
1036 |
1050 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000152117
AA Change: L574F
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000116896
Gene: ENSMUSG00000040785
AA Change: L574F
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
43 |
58 |
N/A |
INTRINSIC |
|
SCOP:d1ihga1
|
69 |
201 |
6e-8 |
SMART |
|
Blast:TPR
|
175 |
208 |
1e-14 |
BLAST |
|
low complexity region
|
319 |
331 |
N/A |
INTRINSIC |
|
coiled coil region
|
364 |
395 |
N/A |
INTRINSIC |
|
low complexity region
|
617 |
631 |
N/A |
INTRINSIC |
|
low complexity region
|
635 |
649 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000153988
|
| SMART Domains |
Protein: ENSMUSP00000118763
Gene: ENSMUSG00000040785
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:TPR
|
1 |
22 |
3e-6 |
BLAST |
|
low complexity region
|
134 |
149 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000155692
AA Change: L994F
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000122724
Gene: ENSMUSG00000040785
AA Change: L994F
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
250 |
283 |
3.61e-2 |
SMART |
|
TPR
|
284 |
317 |
3.32e-1 |
SMART |
|
Blast:TPR
|
319 |
351 |
3e-12 |
BLAST |
|
low complexity region
|
463 |
478 |
N/A |
INTRINSIC |
|
TPR
|
595 |
628 |
2.55e-2 |
SMART |
|
low complexity region
|
739 |
751 |
N/A |
INTRINSIC |
|
coiled coil region
|
784 |
815 |
N/A |
INTRINSIC |
|
low complexity region
|
1037 |
1051 |
N/A |
INTRINSIC |
|
low complexity region
|
1055 |
1069 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000231569
AA Change: L620F
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000231850
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000231915
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000232395
AA Change: L975F
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000232660
AA Change: L975F
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Meta Mutation Damage Score |
0.1712 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.9%
|
| Validation Efficiency |
100% (91/91) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 90 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acta1 |
T |
C |
8: 124,619,978 (GRCm39) |
M121V |
probably damaging |
Het |
| AI987944 |
A |
T |
7: 41,024,627 (GRCm39) |
H120Q |
possibly damaging |
Het |
| Aldh9a1 |
C |
G |
1: 167,184,119 (GRCm39) |
P205A |
probably damaging |
Het |
| Ank2 |
A |
T |
3: 126,740,951 (GRCm39) |
N1644K |
unknown |
Het |
| Arfgef2 |
A |
T |
2: 166,677,386 (GRCm39) |
|
probably benign |
Het |
| Bpifb4 |
G |
T |
2: 153,783,817 (GRCm39) |
V54L |
probably benign |
Het |
| Cacna1c |
T |
A |
6: 118,711,836 (GRCm39) |
M456L |
|
Het |
| Cbln1 |
T |
C |
8: 88,198,420 (GRCm39) |
N95S |
probably benign |
Het |
| Ccl11 |
G |
T |
11: 81,953,044 (GRCm39) |
R67S |
possibly damaging |
Het |
| Cd200 |
G |
A |
16: 45,215,157 (GRCm39) |
R165C |
probably benign |
Het |
| Cd2bp2 |
A |
T |
7: 126,793,257 (GRCm39) |
M283K |
probably damaging |
Het |
| Cd86 |
G |
T |
16: 36,435,650 (GRCm39) |
L256I |
possibly damaging |
Het |
| Ces2f |
T |
A |
8: 105,679,734 (GRCm39) |
F409Y |
probably benign |
Het |
| Cisd3 |
A |
T |
11: 97,579,158 (GRCm39) |
Q100L |
probably damaging |
Het |
| Cntnap1 |
C |
T |
11: 101,077,655 (GRCm39) |
R1106C |
probably damaging |
Het |
| Col6a2 |
A |
T |
10: 76,439,433 (GRCm39) |
M777K |
probably damaging |
Het |
| Cp |
A |
G |
3: 20,039,739 (GRCm39) |
Y852C |
probably damaging |
Het |
| Ddx1 |
T |
C |
12: 13,277,332 (GRCm39) |
E523G |
probably damaging |
Het |
| Ddx60 |
T |
A |
8: 62,398,990 (GRCm39) |
D236E |
probably benign |
Het |
| Dnah9 |
A |
T |
11: 65,740,742 (GRCm39) |
F4148Y |
probably benign |
Het |
| Dusp6 |
G |
T |
10: 99,099,469 (GRCm39) |
|
probably benign |
Het |
| Eif2a |
C |
A |
3: 58,456,049 (GRCm39) |
Y349* |
probably null |
Het |
| Enpep |
G |
A |
3: 129,065,067 (GRCm39) |
T874I |
probably damaging |
Het |
| Eps15 |
A |
G |
4: 109,169,505 (GRCm39) |
D105G |
possibly damaging |
Het |
| Ess2 |
A |
T |
16: 17,722,954 (GRCm39) |
M320K |
probably damaging |
Het |
| Exosc10 |
G |
A |
4: 148,653,159 (GRCm39) |
|
probably null |
Het |
| Fam13b |
A |
T |
18: 34,631,070 (GRCm39) |
N36K |
probably damaging |
Het |
| Fanca |
T |
C |
8: 123,995,209 (GRCm39) |
D1431G |
probably benign |
Het |
| Fgg |
A |
G |
3: 82,921,625 (GRCm39) |
D436G |
probably benign |
Het |
| Fip1l1 |
C |
T |
5: 74,725,188 (GRCm39) |
T251I |
probably benign |
Het |
| Galnt2 |
A |
G |
8: 125,032,347 (GRCm39) |
N104S |
probably damaging |
Het |
| Gmip |
T |
C |
8: 70,268,748 (GRCm39) |
S458P |
possibly damaging |
Het |
| Herc2 |
A |
G |
7: 55,756,144 (GRCm39) |
D728G |
probably benign |
Het |
| Hif3a |
A |
G |
7: 16,788,671 (GRCm39) |
L100P |
probably damaging |
Het |
| Hmox2 |
C |
G |
16: 4,583,866 (GRCm39) |
P282R |
possibly damaging |
Het |
| Hook1 |
A |
T |
4: 95,880,432 (GRCm39) |
H90L |
probably benign |
Het |
| Igf2bp2 |
C |
A |
16: 21,883,866 (GRCm39) |
G473C |
probably damaging |
Het |
| Ip6k2 |
T |
C |
9: 108,675,379 (GRCm39) |
|
probably null |
Het |
| Ipo5 |
G |
T |
14: 121,157,366 (GRCm39) |
R68L |
probably damaging |
Het |
| Kif19b |
A |
G |
5: 140,455,434 (GRCm39) |
M347V |
probably damaging |
Het |
| Klhdc1 |
G |
T |
12: 69,305,392 (GRCm39) |
W234L |
probably damaging |
Het |
| Krt8 |
A |
G |
15: 101,909,870 (GRCm39) |
V178A |
possibly damaging |
Het |
| Lgi3 |
T |
A |
14: 70,768,712 (GRCm39) |
|
probably null |
Het |
| Litaf |
T |
G |
16: 10,784,421 (GRCm39) |
N30H |
probably benign |
Het |
| Lman2 |
C |
A |
13: 55,510,368 (GRCm39) |
W12L |
unknown |
Het |
| Macf1 |
A |
G |
4: 123,276,022 (GRCm39) |
L6182P |
probably damaging |
Het |
| Magi3 |
A |
T |
3: 103,992,662 (GRCm39) |
M270K |
probably benign |
Het |
| Mapre2 |
A |
T |
18: 23,886,888 (GRCm39) |
|
probably benign |
Het |
| Minar1 |
T |
A |
9: 89,483,234 (GRCm39) |
E721V |
probably damaging |
Het |
| Mllt10 |
T |
A |
2: 18,167,353 (GRCm39) |
V426D |
probably benign |
Het |
| Mrgprf |
A |
G |
7: 144,862,046 (GRCm39) |
I203V |
probably benign |
Het |
| Mrnip |
G |
A |
11: 50,067,688 (GRCm39) |
C27Y |
probably damaging |
Het |
| Mrpl24 |
C |
T |
3: 87,829,701 (GRCm39) |
R96* |
probably null |
Het |
| Nbas |
T |
A |
12: 13,402,875 (GRCm39) |
|
probably benign |
Het |
| Nipal4 |
G |
A |
11: 46,045,470 (GRCm39) |
T131M |
possibly damaging |
Het |
| Nlrp12 |
T |
C |
7: 3,289,621 (GRCm39) |
D297G |
possibly damaging |
Het |
| Nol6 |
A |
C |
4: 41,121,823 (GRCm39) |
M237R |
probably benign |
Het |
| Olig1 |
A |
G |
16: 91,067,027 (GRCm39) |
E88G |
probably benign |
Het |
| Or1j19 |
T |
A |
2: 36,676,855 (GRCm39) |
L106* |
probably null |
Het |
| Parg |
A |
G |
14: 31,931,175 (GRCm39) |
D265G |
possibly damaging |
Het |
| Pcdhgb8 |
A |
T |
18: 37,895,301 (GRCm39) |
I124L |
probably damaging |
Het |
| Pign |
A |
G |
1: 105,481,827 (GRCm39) |
F822L |
probably damaging |
Het |
| Plch2 |
T |
C |
4: 155,071,140 (GRCm39) |
T1080A |
probably benign |
Het |
| Pld4 |
A |
T |
12: 112,733,210 (GRCm39) |
Y262F |
possibly damaging |
Het |
| Ppp1r12b |
A |
G |
1: 134,693,730 (GRCm39) |
V977A |
probably benign |
Het |
| Ppp6r3 |
C |
T |
19: 3,521,984 (GRCm39) |
E565K |
|
Het |
| Psmg2 |
A |
G |
18: 67,787,158 (GRCm39) |
|
probably benign |
Het |
| Ptcd3 |
C |
T |
6: 71,885,645 (GRCm39) |
G27D |
probably benign |
Het |
| Retreg2 |
G |
T |
1: 75,119,525 (GRCm39) |
G7C |
unknown |
Het |
| Rlbp1 |
A |
T |
7: 79,027,114 (GRCm39) |
F182Y |
probably benign |
Het |
| Rnf148 |
G |
C |
6: 23,654,378 (GRCm39) |
S206C |
probably benign |
Het |
| Sash1 |
A |
G |
10: 8,637,869 (GRCm39) |
M1T |
probably null |
Het |
| Shank3 |
A |
T |
15: 89,433,598 (GRCm39) |
T1448S |
probably damaging |
Het |
| Sipa1l1 |
A |
G |
12: 82,389,207 (GRCm39) |
K478E |
probably damaging |
Het |
| Slitrk6 |
A |
G |
14: 110,988,801 (GRCm39) |
I302T |
probably benign |
Het |
| Smc1b |
A |
G |
15: 84,950,529 (GRCm39) |
V1165A |
probably damaging |
Het |
| Sncaip |
A |
T |
18: 53,048,381 (GRCm39) |
H939L |
probably benign |
Het |
| Stn1 |
T |
C |
19: 47,524,709 (GRCm39) |
D27G |
probably damaging |
Het |
| Sugct |
T |
G |
13: 17,427,180 (GRCm39) |
|
probably null |
Het |
| Tmem259 |
A |
G |
10: 79,814,983 (GRCm39) |
S214P |
probably damaging |
Het |
| Trdv4 |
G |
A |
14: 54,312,946 (GRCm39) |
G107S |
probably damaging |
Het |
| Ttn |
A |
G |
2: 76,711,471 (GRCm39) |
Y8357H |
unknown |
Het |
| Twnk |
T |
C |
19: 44,996,434 (GRCm39) |
V289A |
probably benign |
Het |
| Umodl1 |
A |
G |
17: 31,202,958 (GRCm39) |
D437G |
possibly damaging |
Het |
| Upf1 |
T |
C |
8: 70,790,930 (GRCm39) |
T590A |
probably benign |
Het |
| Vmn2r63 |
A |
T |
7: 42,576,441 (GRCm39) |
D457E |
probably benign |
Het |
| Wdr82 |
A |
T |
9: 106,061,975 (GRCm39) |
T213S |
probably benign |
Het |
| Zfp267 |
T |
C |
3: 36,218,255 (GRCm39) |
Y93H |
possibly damaging |
Het |
| Zfp672 |
A |
T |
11: 58,220,590 (GRCm39) |
M3K |
unknown |
Het |
| Zfyve26 |
A |
G |
12: 79,285,742 (GRCm39) |
V2345A |
probably benign |
Het |
|
| Other mutations in Ttc3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00944:Ttc3
|
APN |
16 |
94,227,620 (GRCm39) |
splice site |
probably null |
|
|
IGL00979:Ttc3
|
APN |
16 |
94,257,577 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01520:Ttc3
|
APN |
16 |
94,191,066 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01663:Ttc3
|
APN |
16 |
94,210,590 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01720:Ttc3
|
APN |
16 |
94,186,228 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01736:Ttc3
|
APN |
16 |
94,243,386 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02045:Ttc3
|
APN |
16 |
94,210,540 (GRCm39) |
splice site |
probably benign |
|
|
IGL02203:Ttc3
|
APN |
16 |
94,219,457 (GRCm39) |
splice site |
probably benign |
|
|
IGL02327:Ttc3
|
APN |
16 |
94,248,967 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02794:Ttc3
|
APN |
16 |
94,268,785 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02898:Ttc3
|
APN |
16 |
94,220,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4378001:Ttc3
|
UTSW |
16 |
94,211,765 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0064:Ttc3
|
UTSW |
16 |
94,223,106 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R0098:Ttc3
|
UTSW |
16 |
94,191,124 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0112:Ttc3
|
UTSW |
16 |
94,186,181 (GRCm39) |
splice site |
probably benign |
|
|
R0135:Ttc3
|
UTSW |
16 |
94,263,127 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0480:Ttc3
|
UTSW |
16 |
94,232,863 (GRCm39) |
nonsense |
probably null |
|
|
R0513:Ttc3
|
UTSW |
16 |
94,227,071 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0532:Ttc3
|
UTSW |
16 |
94,188,189 (GRCm39) |
splice site |
probably benign |
|
|
R0607:Ttc3
|
UTSW |
16 |
94,257,644 (GRCm39) |
nonsense |
probably null |
|
|
R0742:Ttc3
|
UTSW |
16 |
94,260,739 (GRCm39) |
missense |
probably benign |
0.23 |
|
R0905:Ttc3
|
UTSW |
16 |
94,257,648 (GRCm39) |
nonsense |
probably null |
|
|
R1118:Ttc3
|
UTSW |
16 |
94,217,127 (GRCm39) |
splice site |
probably benign |
|
|
R1355:Ttc3
|
UTSW |
16 |
94,219,496 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1370:Ttc3
|
UTSW |
16 |
94,219,496 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1486:Ttc3
|
UTSW |
16 |
94,248,988 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1598:Ttc3
|
UTSW |
16 |
94,223,156 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1641:Ttc3
|
UTSW |
16 |
94,244,176 (GRCm39) |
missense |
probably benign |
0.19 |
|
R2092:Ttc3
|
UTSW |
16 |
94,243,691 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2232:Ttc3
|
UTSW |
16 |
94,260,831 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2339:Ttc3
|
UTSW |
16 |
94,232,857 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2342:Ttc3
|
UTSW |
16 |
94,232,857 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2842:Ttc3
|
UTSW |
16 |
94,232,857 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3117:Ttc3
|
UTSW |
16 |
94,243,422 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R4194:Ttc3
|
UTSW |
16 |
94,223,136 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4329:Ttc3
|
UTSW |
16 |
94,267,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4431:Ttc3
|
UTSW |
16 |
94,211,817 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4530:Ttc3
|
UTSW |
16 |
94,267,736 (GRCm39) |
intron |
probably benign |
|
|
R4531:Ttc3
|
UTSW |
16 |
94,267,736 (GRCm39) |
intron |
probably benign |
|
|
R4532:Ttc3
|
UTSW |
16 |
94,267,736 (GRCm39) |
intron |
probably benign |
|
|
R4533:Ttc3
|
UTSW |
16 |
94,267,736 (GRCm39) |
intron |
probably benign |
|
|
R4588:Ttc3
|
UTSW |
16 |
94,243,760 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4625:Ttc3
|
UTSW |
16 |
94,189,131 (GRCm39) |
nonsense |
probably null |
|
|
R4676:Ttc3
|
UTSW |
16 |
94,243,620 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4700:Ttc3
|
UTSW |
16 |
94,240,100 (GRCm39) |
splice site |
probably null |
|
|
R4856:Ttc3
|
UTSW |
16 |
94,191,142 (GRCm39) |
missense |
probably benign |
0.32 |
|
R4867:Ttc3
|
UTSW |
16 |
94,255,374 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4885:Ttc3
|
UTSW |
16 |
94,227,690 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4885:Ttc3
|
UTSW |
16 |
94,220,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4899:Ttc3
|
UTSW |
16 |
94,230,314 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4997:Ttc3
|
UTSW |
16 |
94,253,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5023:Ttc3
|
UTSW |
16 |
94,230,218 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5105:Ttc3
|
UTSW |
16 |
94,267,793 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5205:Ttc3
|
UTSW |
16 |
94,248,918 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5287:Ttc3
|
UTSW |
16 |
94,260,703 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5338:Ttc3
|
UTSW |
16 |
94,184,900 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5347:Ttc3
|
UTSW |
16 |
94,230,479 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5403:Ttc3
|
UTSW |
16 |
94,260,703 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5460:Ttc3
|
UTSW |
16 |
94,258,241 (GRCm39) |
missense |
probably benign |
0.32 |
|
R5739:Ttc3
|
UTSW |
16 |
94,240,183 (GRCm39) |
nonsense |
probably null |
|
|
R6242:Ttc3
|
UTSW |
16 |
94,243,554 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6253:Ttc3
|
UTSW |
16 |
94,258,272 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6455:Ttc3
|
UTSW |
16 |
94,219,482 (GRCm39) |
start codon destroyed |
probably null |
0.83 |
|
R6559:Ttc3
|
UTSW |
16 |
94,223,208 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6564:Ttc3
|
UTSW |
16 |
94,243,470 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6932:Ttc3
|
UTSW |
16 |
94,244,312 (GRCm39) |
missense |
probably benign |
|
|
R7331:Ttc3
|
UTSW |
16 |
94,195,218 (GRCm39) |
missense |
probably benign |
0.27 |
|
R7497:Ttc3
|
UTSW |
16 |
94,219,541 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7610:Ttc3
|
UTSW |
16 |
94,228,697 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7738:Ttc3
|
UTSW |
16 |
94,188,241 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7970:Ttc3
|
UTSW |
16 |
94,258,223 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8052:Ttc3
|
UTSW |
16 |
94,268,848 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8087:Ttc3
|
UTSW |
16 |
94,243,812 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8309:Ttc3
|
UTSW |
16 |
94,267,838 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8320:Ttc3
|
UTSW |
16 |
94,219,535 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8322:Ttc3
|
UTSW |
16 |
94,255,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8518:Ttc3
|
UTSW |
16 |
94,258,238 (GRCm39) |
missense |
probably benign |
0.21 |
|
R8670:Ttc3
|
UTSW |
16 |
94,191,067 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8868:Ttc3
|
UTSW |
16 |
94,252,002 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8873:Ttc3
|
UTSW |
16 |
94,243,842 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8940:Ttc3
|
UTSW |
16 |
94,230,358 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8993:Ttc3
|
UTSW |
16 |
94,228,667 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9068:Ttc3
|
UTSW |
16 |
94,204,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9119:Ttc3
|
UTSW |
16 |
94,192,950 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9124:Ttc3
|
UTSW |
16 |
94,236,389 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9129:Ttc3
|
UTSW |
16 |
94,185,208 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9189:Ttc3
|
UTSW |
16 |
94,268,831 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R9217:Ttc3
|
UTSW |
16 |
94,230,467 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R9490:Ttc3
|
UTSW |
16 |
94,245,360 (GRCm39) |
missense |
probably benign |
|
|
R9564:Ttc3
|
UTSW |
16 |
94,248,918 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9631:Ttc3
|
UTSW |
16 |
94,171,581 (GRCm39) |
intron |
probably benign |
|
|
X0022:Ttc3
|
UTSW |
16 |
94,243,384 (GRCm39) |
missense |
probably benign |
0.00 |
|
Y5378:Ttc3
|
UTSW |
16 |
94,212,988 (GRCm39) |
splice site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GCTTGGATGCCATAGGACCC -3'
(R):5'- GCTGGGACCTTTCTTTCAAGTC -3'
Sequencing Primer
(F):5'- GGATGCCATAGGACCCTTTTTCAC -3'
(R):5'- TTCTTCACCTCTGATCATCAAAAGAC -3'
|
| Posted On |
2021-07-15 |
Incidental Mutation