Incidental Mutation 'R8827:Adamts3'
| ID |
673523 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Adamts3
|
| Ensembl Gene |
ENSMUSG00000043635 |
| Gene Name |
ADAM metallopeptidase with thrombospondin type 1 motif 3 |
| Synonyms |
1100001H14Rik, 6330442E02Rik |
| MMRRC Submission |
068658-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R8827 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
89824946-90031193 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 89839324 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Valine
at position 810
(I810V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132219
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000061427]
[ENSMUST00000163159]
|
| AlphaFold |
E9Q287 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000061427
AA Change: I809V
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000058552
Gene: ENSMUSG00000043635
AA Change: I809V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:Pep_M12B_propep
|
42 |
201 |
5.1e-40 |
PFAM |
|
Pfam:Reprolysin_5
|
254 |
439 |
5.4e-15 |
PFAM |
|
Pfam:Reprolysin_4
|
256 |
454 |
1.9e-10 |
PFAM |
|
Pfam:Reprolysin
|
257 |
460 |
3.6e-22 |
PFAM |
|
Pfam:Reprolysin_2
|
274 |
451 |
7.7e-13 |
PFAM |
|
Pfam:Reprolysin_3
|
278 |
409 |
1.5e-12 |
PFAM |
|
TSP1
|
554 |
606 |
1.26e-15 |
SMART |
|
Pfam:ADAM_spacer1
|
713 |
827 |
3e-34 |
PFAM |
|
TSP1
|
848 |
905 |
4.35e-2 |
SMART |
|
TSP1
|
908 |
967 |
4.95e-2 |
SMART |
|
TSP1
|
969 |
1016 |
6.58e-5 |
SMART |
|
low complexity region
|
1114 |
1128 |
N/A |
INTRINSIC |
|
low complexity region
|
1157 |
1177 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000163159
AA Change: I810V
PolyPhen 2
Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000132219
Gene: ENSMUSG00000043635
AA Change: I810V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:Pep_M12B_propep
|
43 |
201 |
1.5e-40 |
PFAM |
|
Pfam:Reprolysin_5
|
254 |
439 |
2.2e-15 |
PFAM |
|
Pfam:Reprolysin_4
|
256 |
454 |
7.7e-11 |
PFAM |
|
Pfam:Reprolysin
|
257 |
460 |
3.7e-21 |
PFAM |
|
Pfam:Reprolysin_2
|
274 |
451 |
4.3e-14 |
PFAM |
|
Pfam:Reprolysin_3
|
278 |
409 |
1.3e-12 |
PFAM |
|
TSP1
|
554 |
606 |
1.26e-15 |
SMART |
|
Pfam:ADAM_spacer1
|
713 |
828 |
3.6e-28 |
PFAM |
|
TSP1
|
849 |
906 |
4.35e-2 |
SMART |
|
TSP1
|
909 |
968 |
4.95e-2 |
SMART |
|
TSP1
|
970 |
1017 |
6.58e-5 |
SMART |
|
low complexity region
|
1115 |
1129 |
N/A |
INTRINSIC |
|
low complexity region
|
1158 |
1178 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
100% (75/75) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease, a member of the procollagen aminopropeptidase subfamily of proteins, may play a role in the processing of type II fibrillar collagen in articular cartilage. [provided by RefSeq, Feb 2016]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 75 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adcy7 |
T |
C |
8: 89,036,327 (GRCm39) |
F128S |
possibly damaging |
Het |
| Ankhd1 |
C |
T |
18: 36,757,633 (GRCm39) |
Q188* |
probably null |
Het |
| Asxl2 |
A |
T |
12: 3,550,501 (GRCm39) |
I748L |
probably benign |
Het |
| Atp8b2 |
T |
C |
3: 89,853,307 (GRCm39) |
N70S |
|
Het |
| Bmp1 |
A |
G |
14: 70,728,082 (GRCm39) |
Y616H |
probably damaging |
Het |
| Brap |
T |
A |
5: 121,810,261 (GRCm39) |
D248E |
probably benign |
Het |
| Ccdc13 |
G |
A |
9: 121,645,765 (GRCm39) |
S294L |
probably benign |
Het |
| Cdkl1 |
T |
C |
12: 69,794,123 (GRCm39) |
Y338C |
probably benign |
Het |
| Cfap54 |
A |
T |
10: 92,774,110 (GRCm39) |
S1993T |
unknown |
Het |
| Chl1 |
G |
T |
6: 103,670,111 (GRCm39) |
M500I |
probably benign |
Het |
| Cntn3 |
G |
C |
6: 102,246,094 (GRCm39) |
L352V |
probably benign |
Het |
| Cog6 |
T |
C |
3: 52,890,535 (GRCm39) |
D635G |
probably benign |
Het |
| Col22a1 |
C |
A |
15: 71,774,665 (GRCm39) |
|
probably null |
Het |
| Cyp3a16 |
A |
T |
5: 145,387,008 (GRCm39) |
D327E |
probably benign |
Het |
| D6Ertd527e |
A |
T |
6: 87,088,226 (GRCm39) |
S130C |
unknown |
Het |
| Dhodh |
T |
C |
8: 110,334,928 (GRCm39) |
|
probably benign |
Het |
| Dync2li1 |
C |
T |
17: 84,955,079 (GRCm39) |
S246L |
possibly damaging |
Het |
| Eif3c |
A |
T |
7: 126,157,894 (GRCm39) |
F316Y |
probably damaging |
Het |
| Esp34 |
A |
T |
17: 38,865,091 (GRCm39) |
|
probably benign |
Het |
| Fam98a |
T |
C |
17: 75,851,824 (GRCm39) |
M86V |
possibly damaging |
Het |
| Gm29394 |
G |
T |
15: 57,932,717 (GRCm39) |
Q7K |
probably damaging |
Het |
| Gtf2i |
C |
T |
5: 134,269,096 (GRCm39) |
|
probably null |
Het |
| H2bc27 |
C |
T |
11: 58,839,917 (GRCm39) |
P51L |
probably benign |
Het |
| Hecw1 |
A |
G |
13: 14,438,720 (GRCm39) |
Y888H |
probably damaging |
Het |
| Kcnma1 |
A |
T |
14: 23,417,548 (GRCm39) |
W894R |
probably damaging |
Het |
| Klhl25 |
C |
A |
7: 75,516,391 (GRCm39) |
D432E |
possibly damaging |
Het |
| Klhl7 |
G |
A |
5: 24,363,635 (GRCm39) |
|
probably null |
Het |
| Lamc1 |
A |
T |
1: 153,097,424 (GRCm39) |
L1540Q |
probably damaging |
Het |
| Map3k5 |
T |
A |
10: 19,902,003 (GRCm39) |
V358E |
probably damaging |
Het |
| Map4k5 |
C |
T |
12: 69,903,635 (GRCm39) |
D57N |
possibly damaging |
Het |
| Mpped2 |
T |
C |
2: 106,691,928 (GRCm39) |
M211T |
possibly damaging |
Het |
| Nat9 |
T |
C |
11: 115,075,339 (GRCm39) |
T101A |
probably benign |
Het |
| Nprl3 |
A |
T |
11: 32,184,742 (GRCm39) |
F447L |
probably benign |
Het |
| Nup50l |
G |
T |
6: 96,142,293 (GRCm39) |
N250K |
probably benign |
Het |
| Or4p22 |
T |
C |
2: 88,317,165 (GRCm39) |
S30P |
probably damaging |
Het |
| Or5h24 |
G |
A |
16: 58,919,061 (GRCm39) |
T98I |
unknown |
Het |
| Or5w16 |
C |
T |
2: 87,576,777 (GRCm39) |
P79L |
possibly damaging |
Het |
| Orc3 |
A |
T |
4: 34,605,569 (GRCm39) |
F104Y |
probably benign |
Het |
| Pcdha6 |
T |
A |
18: 37,102,802 (GRCm39) |
V665E |
probably damaging |
Het |
| Pdpk1 |
T |
C |
17: 24,307,191 (GRCm39) |
D380G |
probably benign |
Het |
| Phkg1 |
T |
A |
5: 129,893,894 (GRCm39) |
E280D |
probably benign |
Het |
| Pkdrej |
T |
A |
15: 85,699,732 (GRCm39) |
Y2068F |
possibly damaging |
Het |
| Plekhg5 |
A |
G |
4: 152,191,462 (GRCm39) |
|
probably benign |
Het |
| Plekhh3 |
G |
A |
11: 101,058,380 (GRCm39) |
P222L |
probably damaging |
Het |
| Prdm1 |
A |
T |
10: 44,334,476 (GRCm39) |
V10E |
probably benign |
Het |
| Prdm6 |
G |
T |
18: 53,701,267 (GRCm39) |
Q513H |
probably damaging |
Het |
| Pros1 |
T |
C |
16: 62,746,827 (GRCm39) |
V593A |
probably benign |
Het |
| Radil |
T |
C |
5: 142,493,859 (GRCm39) |
H250R |
probably damaging |
Het |
| Rasa2 |
C |
T |
9: 96,434,403 (GRCm39) |
R628Q |
probably damaging |
Het |
| Ryr2 |
T |
C |
13: 11,572,934 (GRCm39) |
E4884G |
possibly damaging |
Het |
| Shh |
A |
G |
5: 28,663,125 (GRCm39) |
S348P |
probably damaging |
Het |
| Slc1a4 |
A |
T |
11: 20,270,237 (GRCm39) |
|
probably benign |
Het |
| Slc32a1 |
A |
C |
2: 158,453,274 (GRCm39) |
D38A |
probably damaging |
Het |
| Slc35f3 |
TCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC |
TCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC |
8: 127,115,780 (GRCm39) |
|
probably benign |
Het |
| Slc45a4 |
A |
T |
15: 73,458,316 (GRCm39) |
I411N |
probably benign |
Het |
| Slc49a4 |
A |
T |
16: 35,554,320 (GRCm39) |
C274S |
probably benign |
Het |
| Slc7a10 |
C |
A |
7: 34,897,313 (GRCm39) |
S248Y |
probably damaging |
Het |
| Smc3 |
T |
A |
19: 53,611,085 (GRCm39) |
D258E |
probably benign |
Het |
| Spata31h1 |
T |
A |
10: 82,129,617 (GRCm39) |
Q1131L |
probably benign |
Het |
| Sphk1 |
A |
G |
11: 116,426,590 (GRCm39) |
D182G |
probably damaging |
Het |
| Srgap3 |
A |
G |
6: 112,716,302 (GRCm39) |
Y633H |
probably damaging |
Het |
| Sspo |
T |
G |
6: 48,434,606 (GRCm39) |
F1033V |
possibly damaging |
Het |
| Syne2 |
T |
C |
12: 76,095,357 (GRCm39) |
V488A |
probably benign |
Het |
| Tead1 |
A |
C |
7: 112,475,449 (GRCm39) |
K299N |
probably damaging |
Het |
| Tmem150c |
A |
C |
5: 100,240,654 (GRCm39) |
S69R |
probably damaging |
Het |
| Tnfaip3 |
T |
A |
10: 18,880,795 (GRCm39) |
K424M |
probably damaging |
Het |
| Trib3 |
A |
G |
2: 152,180,188 (GRCm39) |
V335A |
possibly damaging |
Het |
| Ttc39c |
G |
A |
18: 12,828,436 (GRCm39) |
V199I |
probably benign |
Het |
| Vangl1 |
A |
T |
3: 102,070,736 (GRCm39) |
F400Y |
probably damaging |
Het |
| Vmn2r106 |
A |
T |
17: 20,487,868 (GRCm39) |
S844T |
probably benign |
Het |
| Wwtr1 |
A |
G |
3: 57,482,616 (GRCm39) |
V77A |
probably damaging |
Het |
| Yju2b |
T |
A |
8: 84,986,987 (GRCm39) |
Q170L |
possibly damaging |
Het |
| Zc3h4 |
C |
A |
7: 16,163,123 (GRCm39) |
P500T |
unknown |
Het |
| Zfand2a |
C |
T |
5: 139,460,607 (GRCm39) |
|
probably null |
Het |
| Zfr2 |
A |
G |
10: 81,078,619 (GRCm39) |
T284A |
probably benign |
Het |
|
| Other mutations in Adamts3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00160:Adamts3
|
APN |
5 |
90,009,184 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00340:Adamts3
|
APN |
5 |
89,849,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00923:Adamts3
|
APN |
5 |
89,832,235 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01420:Adamts3
|
APN |
5 |
89,850,916 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
IGL01522:Adamts3
|
APN |
5 |
89,850,802 (GRCm39) |
missense |
probably benign |
0.14 |
|
IGL01676:Adamts3
|
APN |
5 |
90,029,402 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
IGL01676:Adamts3
|
APN |
5 |
89,825,613 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01678:Adamts3
|
APN |
5 |
89,855,715 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01936:Adamts3
|
APN |
5 |
90,009,282 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01956:Adamts3
|
APN |
5 |
89,825,770 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02342:Adamts3
|
APN |
5 |
89,839,332 (GRCm39) |
splice site |
probably null |
|
|
IGL02415:Adamts3
|
APN |
5 |
89,854,506 (GRCm39) |
splice site |
probably null |
|
|
IGL03261:Adamts3
|
APN |
5 |
90,030,756 (GRCm39) |
utr 5 prime |
probably benign |
|
|
IGL03301:Adamts3
|
APN |
5 |
89,855,263 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0041:Adamts3
|
UTSW |
5 |
89,832,326 (GRCm39) |
missense |
probably benign |
|
|
R0079:Adamts3
|
UTSW |
5 |
89,840,912 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0096:Adamts3
|
UTSW |
5 |
89,849,576 (GRCm39) |
nonsense |
probably null |
|
|
R0096:Adamts3
|
UTSW |
5 |
89,849,576 (GRCm39) |
nonsense |
probably null |
|
|
R0477:Adamts3
|
UTSW |
5 |
89,832,366 (GRCm39) |
missense |
probably benign |
|
|
R0605:Adamts3
|
UTSW |
5 |
90,009,334 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R1036:Adamts3
|
UTSW |
5 |
89,843,952 (GRCm39) |
splice site |
probably benign |
|
|
R1462:Adamts3
|
UTSW |
5 |
90,009,208 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1462:Adamts3
|
UTSW |
5 |
90,009,208 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1621:Adamts3
|
UTSW |
5 |
89,869,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1799:Adamts3
|
UTSW |
5 |
89,923,280 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2163:Adamts3
|
UTSW |
5 |
89,856,577 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2412:Adamts3
|
UTSW |
5 |
89,849,630 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2420:Adamts3
|
UTSW |
5 |
89,831,034 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2421:Adamts3
|
UTSW |
5 |
89,831,034 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2422:Adamts3
|
UTSW |
5 |
89,831,034 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2921:Adamts3
|
UTSW |
5 |
90,009,393 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R2922:Adamts3
|
UTSW |
5 |
90,009,393 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R2923:Adamts3
|
UTSW |
5 |
90,009,393 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3402:Adamts3
|
UTSW |
5 |
89,849,592 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3431:Adamts3
|
UTSW |
5 |
89,855,312 (GRCm39) |
splice site |
probably benign |
|
|
R3432:Adamts3
|
UTSW |
5 |
89,855,312 (GRCm39) |
splice site |
probably benign |
|
|
R3813:Adamts3
|
UTSW |
5 |
89,825,785 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R3816:Adamts3
|
UTSW |
5 |
89,853,123 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3905:Adamts3
|
UTSW |
5 |
90,009,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3906:Adamts3
|
UTSW |
5 |
90,009,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3907:Adamts3
|
UTSW |
5 |
90,009,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3908:Adamts3
|
UTSW |
5 |
90,009,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4557:Adamts3
|
UTSW |
5 |
89,848,346 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4684:Adamts3
|
UTSW |
5 |
89,850,866 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4844:Adamts3
|
UTSW |
5 |
89,825,675 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4925:Adamts3
|
UTSW |
5 |
89,832,182 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5097:Adamts3
|
UTSW |
5 |
89,840,909 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5100:Adamts3
|
UTSW |
5 |
89,856,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5237:Adamts3
|
UTSW |
5 |
89,923,236 (GRCm39) |
missense |
probably benign |
|
|
R5265:Adamts3
|
UTSW |
5 |
90,009,411 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R5322:Adamts3
|
UTSW |
5 |
89,855,159 (GRCm39) |
splice site |
probably null |
|
|
R5413:Adamts3
|
UTSW |
5 |
89,856,626 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5459:Adamts3
|
UTSW |
5 |
89,839,332 (GRCm39) |
splice site |
probably null |
|
|
R5738:Adamts3
|
UTSW |
5 |
89,856,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5979:Adamts3
|
UTSW |
5 |
90,009,528 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5992:Adamts3
|
UTSW |
5 |
89,839,194 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6364:Adamts3
|
UTSW |
5 |
89,869,673 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6572:Adamts3
|
UTSW |
5 |
90,009,468 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R7098:Adamts3
|
UTSW |
5 |
90,009,354 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7172:Adamts3
|
UTSW |
5 |
90,030,860 (GRCm39) |
start gained |
probably benign |
|
|
R7263:Adamts3
|
UTSW |
5 |
89,825,601 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7401:Adamts3
|
UTSW |
5 |
89,855,309 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7599:Adamts3
|
UTSW |
5 |
90,009,256 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7829:Adamts3
|
UTSW |
5 |
90,009,349 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7835:Adamts3
|
UTSW |
5 |
89,848,299 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R7892:Adamts3
|
UTSW |
5 |
90,009,288 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8021:Adamts3
|
UTSW |
5 |
89,831,043 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R8289:Adamts3
|
UTSW |
5 |
89,923,282 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8350:Adamts3
|
UTSW |
5 |
89,850,815 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8468:Adamts3
|
UTSW |
5 |
89,842,627 (GRCm39) |
missense |
probably benign |
0.19 |
|
R8864:Adamts3
|
UTSW |
5 |
89,854,981 (GRCm39) |
intron |
probably benign |
|
|
R8906:Adamts3
|
UTSW |
5 |
89,825,575 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9000:Adamts3
|
UTSW |
5 |
89,854,570 (GRCm39) |
missense |
probably benign |
0.17 |
|
R9005:Adamts3
|
UTSW |
5 |
89,825,693 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9378:Adamts3
|
UTSW |
5 |
89,848,269 (GRCm39) |
nonsense |
probably null |
|
|
R9505:Adamts3
|
UTSW |
5 |
89,855,751 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9516:Adamts3
|
UTSW |
5 |
89,834,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0064:Adamts3
|
UTSW |
5 |
89,850,901 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
Z1088:Adamts3
|
UTSW |
5 |
89,832,308 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Adamts3
|
UTSW |
5 |
89,923,210 (GRCm39) |
missense |
not run |
|
|
Z1177:Adamts3
|
UTSW |
5 |
89,923,210 (GRCm39) |
missense |
not run |
|
|
Z1177:Adamts3
|
UTSW |
5 |
89,855,723 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AATGCAGCTGTTACCTCCG -3'
(R):5'- AAGGTTTTGTTTCGGCTACAACTG -3'
Sequencing Primer
(F):5'- AGCTGTTACCTCCGCCACAG -3'
(R):5'- CCTGGTCTACAAAGTGAGTTCCAG -3'
|
| Posted On |
2021-07-15 |
Incidental Mutation