Incidental Mutation 'R8827:Vmn2r106'
| ID |
673573 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r106
|
| Ensembl Gene |
ENSMUSG00000091656 |
| Gene Name |
vomeronasal 2, receptor 106 |
| Synonyms |
EG224576 |
| MMRRC Submission |
068658-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.166)
|
| Stock # |
R8827 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
20487809-20505692 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 20487868 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Threonine
at position 844
(S844T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126534
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167464]
|
| AlphaFold |
E9PY92 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000167464
AA Change: S844T
PolyPhen 2
Score 0.051 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000126534
Gene: ENSMUSG00000091656
AA Change: S844T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
83 |
471 |
3.8e-37 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
5.7e-22 |
PFAM |
|
Pfam:7tm_3
|
596 |
835 |
1.3e-49 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
100% (75/75) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 75 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adamts3 |
T |
C |
5: 89,839,324 (GRCm39) |
I810V |
probably benign |
Het |
| Adcy7 |
T |
C |
8: 89,036,327 (GRCm39) |
F128S |
possibly damaging |
Het |
| Ankhd1 |
C |
T |
18: 36,757,633 (GRCm39) |
Q188* |
probably null |
Het |
| Asxl2 |
A |
T |
12: 3,550,501 (GRCm39) |
I748L |
probably benign |
Het |
| Atp8b2 |
T |
C |
3: 89,853,307 (GRCm39) |
N70S |
|
Het |
| Bmp1 |
A |
G |
14: 70,728,082 (GRCm39) |
Y616H |
probably damaging |
Het |
| Brap |
T |
A |
5: 121,810,261 (GRCm39) |
D248E |
probably benign |
Het |
| Ccdc13 |
G |
A |
9: 121,645,765 (GRCm39) |
S294L |
probably benign |
Het |
| Cdkl1 |
T |
C |
12: 69,794,123 (GRCm39) |
Y338C |
probably benign |
Het |
| Cfap54 |
A |
T |
10: 92,774,110 (GRCm39) |
S1993T |
unknown |
Het |
| Chl1 |
G |
T |
6: 103,670,111 (GRCm39) |
M500I |
probably benign |
Het |
| Cntn3 |
G |
C |
6: 102,246,094 (GRCm39) |
L352V |
probably benign |
Het |
| Cog6 |
T |
C |
3: 52,890,535 (GRCm39) |
D635G |
probably benign |
Het |
| Col22a1 |
C |
A |
15: 71,774,665 (GRCm39) |
|
probably null |
Het |
| Cyp3a16 |
A |
T |
5: 145,387,008 (GRCm39) |
D327E |
probably benign |
Het |
| D6Ertd527e |
A |
T |
6: 87,088,226 (GRCm39) |
S130C |
unknown |
Het |
| Dhodh |
T |
C |
8: 110,334,928 (GRCm39) |
|
probably benign |
Het |
| Dync2li1 |
C |
T |
17: 84,955,079 (GRCm39) |
S246L |
possibly damaging |
Het |
| Eif3c |
A |
T |
7: 126,157,894 (GRCm39) |
F316Y |
probably damaging |
Het |
| Esp34 |
A |
T |
17: 38,865,091 (GRCm39) |
|
probably benign |
Het |
| Fam98a |
T |
C |
17: 75,851,824 (GRCm39) |
M86V |
possibly damaging |
Het |
| Gm29394 |
G |
T |
15: 57,932,717 (GRCm39) |
Q7K |
probably damaging |
Het |
| Gtf2i |
C |
T |
5: 134,269,096 (GRCm39) |
|
probably null |
Het |
| H2bc27 |
C |
T |
11: 58,839,917 (GRCm39) |
P51L |
probably benign |
Het |
| Hecw1 |
A |
G |
13: 14,438,720 (GRCm39) |
Y888H |
probably damaging |
Het |
| Kcnma1 |
A |
T |
14: 23,417,548 (GRCm39) |
W894R |
probably damaging |
Het |
| Klhl25 |
C |
A |
7: 75,516,391 (GRCm39) |
D432E |
possibly damaging |
Het |
| Klhl7 |
G |
A |
5: 24,363,635 (GRCm39) |
|
probably null |
Het |
| Lamc1 |
A |
T |
1: 153,097,424 (GRCm39) |
L1540Q |
probably damaging |
Het |
| Map3k5 |
T |
A |
10: 19,902,003 (GRCm39) |
V358E |
probably damaging |
Het |
| Map4k5 |
C |
T |
12: 69,903,635 (GRCm39) |
D57N |
possibly damaging |
Het |
| Mpped2 |
T |
C |
2: 106,691,928 (GRCm39) |
M211T |
possibly damaging |
Het |
| Nat9 |
T |
C |
11: 115,075,339 (GRCm39) |
T101A |
probably benign |
Het |
| Nprl3 |
A |
T |
11: 32,184,742 (GRCm39) |
F447L |
probably benign |
Het |
| Nup50l |
G |
T |
6: 96,142,293 (GRCm39) |
N250K |
probably benign |
Het |
| Or4p22 |
T |
C |
2: 88,317,165 (GRCm39) |
S30P |
probably damaging |
Het |
| Or5h24 |
G |
A |
16: 58,919,061 (GRCm39) |
T98I |
unknown |
Het |
| Or5w16 |
C |
T |
2: 87,576,777 (GRCm39) |
P79L |
possibly damaging |
Het |
| Orc3 |
A |
T |
4: 34,605,569 (GRCm39) |
F104Y |
probably benign |
Het |
| Pcdha6 |
T |
A |
18: 37,102,802 (GRCm39) |
V665E |
probably damaging |
Het |
| Pdpk1 |
T |
C |
17: 24,307,191 (GRCm39) |
D380G |
probably benign |
Het |
| Phkg1 |
T |
A |
5: 129,893,894 (GRCm39) |
E280D |
probably benign |
Het |
| Pkdrej |
T |
A |
15: 85,699,732 (GRCm39) |
Y2068F |
possibly damaging |
Het |
| Plekhg5 |
A |
G |
4: 152,191,462 (GRCm39) |
|
probably benign |
Het |
| Plekhh3 |
G |
A |
11: 101,058,380 (GRCm39) |
P222L |
probably damaging |
Het |
| Prdm1 |
A |
T |
10: 44,334,476 (GRCm39) |
V10E |
probably benign |
Het |
| Prdm6 |
G |
T |
18: 53,701,267 (GRCm39) |
Q513H |
probably damaging |
Het |
| Pros1 |
T |
C |
16: 62,746,827 (GRCm39) |
V593A |
probably benign |
Het |
| Radil |
T |
C |
5: 142,493,859 (GRCm39) |
H250R |
probably damaging |
Het |
| Rasa2 |
C |
T |
9: 96,434,403 (GRCm39) |
R628Q |
probably damaging |
Het |
| Ryr2 |
T |
C |
13: 11,572,934 (GRCm39) |
E4884G |
possibly damaging |
Het |
| Shh |
A |
G |
5: 28,663,125 (GRCm39) |
S348P |
probably damaging |
Het |
| Slc1a4 |
A |
T |
11: 20,270,237 (GRCm39) |
|
probably benign |
Het |
| Slc32a1 |
A |
C |
2: 158,453,274 (GRCm39) |
D38A |
probably damaging |
Het |
| Slc35f3 |
TCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC |
TCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC |
8: 127,115,780 (GRCm39) |
|
probably benign |
Het |
| Slc45a4 |
A |
T |
15: 73,458,316 (GRCm39) |
I411N |
probably benign |
Het |
| Slc49a4 |
A |
T |
16: 35,554,320 (GRCm39) |
C274S |
probably benign |
Het |
| Slc7a10 |
C |
A |
7: 34,897,313 (GRCm39) |
S248Y |
probably damaging |
Het |
| Smc3 |
T |
A |
19: 53,611,085 (GRCm39) |
D258E |
probably benign |
Het |
| Spata31h1 |
T |
A |
10: 82,129,617 (GRCm39) |
Q1131L |
probably benign |
Het |
| Sphk1 |
A |
G |
11: 116,426,590 (GRCm39) |
D182G |
probably damaging |
Het |
| Srgap3 |
A |
G |
6: 112,716,302 (GRCm39) |
Y633H |
probably damaging |
Het |
| Sspo |
T |
G |
6: 48,434,606 (GRCm39) |
F1033V |
possibly damaging |
Het |
| Syne2 |
T |
C |
12: 76,095,357 (GRCm39) |
V488A |
probably benign |
Het |
| Tead1 |
A |
C |
7: 112,475,449 (GRCm39) |
K299N |
probably damaging |
Het |
| Tmem150c |
A |
C |
5: 100,240,654 (GRCm39) |
S69R |
probably damaging |
Het |
| Tnfaip3 |
T |
A |
10: 18,880,795 (GRCm39) |
K424M |
probably damaging |
Het |
| Trib3 |
A |
G |
2: 152,180,188 (GRCm39) |
V335A |
possibly damaging |
Het |
| Ttc39c |
G |
A |
18: 12,828,436 (GRCm39) |
V199I |
probably benign |
Het |
| Vangl1 |
A |
T |
3: 102,070,736 (GRCm39) |
F400Y |
probably damaging |
Het |
| Wwtr1 |
A |
G |
3: 57,482,616 (GRCm39) |
V77A |
probably damaging |
Het |
| Yju2b |
T |
A |
8: 84,986,987 (GRCm39) |
Q170L |
possibly damaging |
Het |
| Zc3h4 |
C |
A |
7: 16,163,123 (GRCm39) |
P500T |
unknown |
Het |
| Zfand2a |
C |
T |
5: 139,460,607 (GRCm39) |
|
probably null |
Het |
| Zfr2 |
A |
G |
10: 81,078,619 (GRCm39) |
T284A |
probably benign |
Het |
|
| Other mutations in Vmn2r106 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00979:Vmn2r106
|
APN |
17 |
20,497,837 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01313:Vmn2r106
|
APN |
17 |
20,498,651 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01419:Vmn2r106
|
APN |
17 |
20,499,807 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01574:Vmn2r106
|
APN |
17 |
20,488,572 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL01796:Vmn2r106
|
APN |
17 |
20,488,314 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL01893:Vmn2r106
|
APN |
17 |
20,497,730 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01895:Vmn2r106
|
APN |
17 |
20,499,227 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02378:Vmn2r106
|
APN |
17 |
20,497,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02430:Vmn2r106
|
APN |
17 |
20,499,158 (GRCm39) |
missense |
probably benign |
0.38 |
|
IGL02664:Vmn2r106
|
APN |
17 |
20,488,344 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL03308:Vmn2r106
|
APN |
17 |
20,498,785 (GRCm39) |
nonsense |
probably null |
|
|
IGL03384:Vmn2r106
|
APN |
17 |
20,488,405 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0401:Vmn2r106
|
UTSW |
17 |
20,499,281 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R0842:Vmn2r106
|
UTSW |
17 |
20,488,465 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0964:Vmn2r106
|
UTSW |
17 |
20,487,859 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1235:Vmn2r106
|
UTSW |
17 |
20,499,741 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1709:Vmn2r106
|
UTSW |
17 |
20,499,373 (GRCm39) |
missense |
probably benign |
0.12 |
|
R1712:Vmn2r106
|
UTSW |
17 |
20,498,997 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1770:Vmn2r106
|
UTSW |
17 |
20,488,560 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2049:Vmn2r106
|
UTSW |
17 |
20,488,566 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R2245:Vmn2r106
|
UTSW |
17 |
20,488,423 (GRCm39) |
missense |
probably benign |
0.13 |
|
R2336:Vmn2r106
|
UTSW |
17 |
20,488,470 (GRCm39) |
missense |
probably benign |
0.18 |
|
R2910:Vmn2r106
|
UTSW |
17 |
20,498,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3025:Vmn2r106
|
UTSW |
17 |
20,499,147 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3944:Vmn2r106
|
UTSW |
17 |
20,487,913 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4081:Vmn2r106
|
UTSW |
17 |
20,487,818 (GRCm39) |
nonsense |
probably null |
|
|
R4153:Vmn2r106
|
UTSW |
17 |
20,488,080 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4356:Vmn2r106
|
UTSW |
17 |
20,499,910 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4426:Vmn2r106
|
UTSW |
17 |
20,505,641 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4590:Vmn2r106
|
UTSW |
17 |
20,497,728 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4661:Vmn2r106
|
UTSW |
17 |
20,487,885 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5106:Vmn2r106
|
UTSW |
17 |
20,499,395 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5341:Vmn2r106
|
UTSW |
17 |
20,497,788 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5509:Vmn2r106
|
UTSW |
17 |
20,498,684 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5826:Vmn2r106
|
UTSW |
17 |
20,499,133 (GRCm39) |
missense |
probably benign |
|
|
R5859:Vmn2r106
|
UTSW |
17 |
20,505,583 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R5937:Vmn2r106
|
UTSW |
17 |
20,505,667 (GRCm39) |
nonsense |
probably null |
|
|
R5972:Vmn2r106
|
UTSW |
17 |
20,498,738 (GRCm39) |
missense |
probably benign |
|
|
R6056:Vmn2r106
|
UTSW |
17 |
20,487,806 (GRCm39) |
splice site |
probably null |
|
|
R6108:Vmn2r106
|
UTSW |
17 |
20,488,638 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6114:Vmn2r106
|
UTSW |
17 |
20,488,638 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6115:Vmn2r106
|
UTSW |
17 |
20,488,638 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6132:Vmn2r106
|
UTSW |
17 |
20,488,666 (GRCm39) |
missense |
probably benign |
|
|
R6208:Vmn2r106
|
UTSW |
17 |
20,488,591 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6217:Vmn2r106
|
UTSW |
17 |
20,488,501 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6289:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6378:Vmn2r106
|
UTSW |
17 |
20,498,667 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6390:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6391:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6392:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6405:Vmn2r106
|
UTSW |
17 |
20,499,361 (GRCm39) |
missense |
probably benign |
0.22 |
|
R6427:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6428:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6435:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6436:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6437:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6511:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6512:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6587:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6703:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6730:Vmn2r106
|
UTSW |
17 |
20,499,096 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R6961:Vmn2r106
|
UTSW |
17 |
20,488,646 (GRCm39) |
nonsense |
probably null |
|
|
R7054:Vmn2r106
|
UTSW |
17 |
20,499,182 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7379:Vmn2r106
|
UTSW |
17 |
20,488,037 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R7402:Vmn2r106
|
UTSW |
17 |
20,487,883 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7497:Vmn2r106
|
UTSW |
17 |
20,488,201 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7692:Vmn2r106
|
UTSW |
17 |
20,505,490 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R8539:Vmn2r106
|
UTSW |
17 |
20,499,271 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8872:Vmn2r106
|
UTSW |
17 |
20,488,401 (GRCm39) |
missense |
probably benign |
0.19 |
|
R9118:Vmn2r106
|
UTSW |
17 |
20,505,667 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9254:Vmn2r106
|
UTSW |
17 |
20,496,066 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9379:Vmn2r106
|
UTSW |
17 |
20,496,066 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9571:Vmn2r106
|
UTSW |
17 |
20,505,641 (GRCm39) |
missense |
probably benign |
0.17 |
|
| Predicted Primers |
PCR Primer
(F):5'- CAGAAGGCAGATGTGGTTTTAATAC -3'
(R):5'- AGAAATCTACCTGGCACATTCAATG -3'
Sequencing Primer
(F):5'- TTAGGTGGCATGAAGAATG -3'
(R):5'- AAATTTCTGTCATTTAGCATGTTGG -3'
|
| Posted On |
2021-07-15 |
Incidental Mutation