Incidental Mutation 'R8828:Zfp658'
ID 673610
Institutional Source Beutler Lab
Gene Symbol Zfp658
Ensembl Gene ENSMUSG00000056592
Gene Name zinc finger protein 658
Synonyms
MMRRC Submission 068730-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8828 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 43211680-43224885 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 43222240 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tryptophan to Arginine at position 172 (W172R)
Ref Sequence ENSEMBL: ENSMUSP00000005597 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000005597] [ENSMUST00000107972]
AlphaFold Q5PPQ4
Predicted Effect probably benign
Transcript: ENSMUST00000005597
AA Change: W172R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000005597
Gene: ENSMUSG00000056592
AA Change: W172R

DomainStartEndE-ValueType
KRAB 23 83 3.7e-27 SMART
ZnF_C2H2 276 295 8.84e1 SMART
ZnF_C2H2 301 323 5.81e-2 SMART
ZnF_C2H2 328 350 1.5e-4 SMART
ZnF_C2H2 356 378 1.84e-4 SMART
ZnF_C2H2 384 406 3.16e-3 SMART
ZnF_C2H2 412 434 1.45e-2 SMART
ZnF_C2H2 440 462 4.87e-4 SMART
ZnF_C2H2 468 490 4.87e-4 SMART
ZnF_C2H2 496 518 6.88e-4 SMART
ZnF_C2H2 524 546 1.69e-3 SMART
ZnF_C2H2 552 574 9.73e-4 SMART
ZnF_C2H2 580 602 1.82e-3 SMART
ZnF_C2H2 608 630 3.16e-3 SMART
ZnF_C2H2 636 658 8.94e-3 SMART
ZnF_C2H2 664 686 3.74e-5 SMART
ZnF_C2H2 692 714 2.99e-4 SMART
ZnF_C2H2 720 742 5.21e-4 SMART
ZnF_C2H2 748 770 2.79e-4 SMART
ZnF_C2H2 776 798 1.58e-3 SMART
ZnF_C2H2 804 826 3.44e-4 SMART
ZnF_C2H2 832 854 5.59e-4 SMART
ZnF_C2H2 860 882 5.81e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000107972
AA Change: W172R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000103606
Gene: ENSMUSG00000056592
AA Change: W172R

DomainStartEndE-ValueType
KRAB 23 83 3.7e-27 SMART
ZnF_C2H2 276 295 8.84e1 SMART
ZnF_C2H2 301 323 5.81e-2 SMART
ZnF_C2H2 328 350 1.5e-4 SMART
ZnF_C2H2 356 378 1.84e-4 SMART
ZnF_C2H2 384 406 3.16e-3 SMART
ZnF_C2H2 412 434 1.45e-2 SMART
ZnF_C2H2 440 462 4.87e-4 SMART
ZnF_C2H2 468 490 4.87e-4 SMART
ZnF_C2H2 496 518 6.88e-4 SMART
ZnF_C2H2 524 546 1.69e-3 SMART
ZnF_C2H2 552 574 9.73e-4 SMART
ZnF_C2H2 580 602 1.82e-3 SMART
ZnF_C2H2 608 630 3.16e-3 SMART
ZnF_C2H2 636 658 8.94e-3 SMART
ZnF_C2H2 664 686 3.74e-5 SMART
ZnF_C2H2 692 714 2.99e-4 SMART
ZnF_C2H2 720 742 5.21e-4 SMART
ZnF_C2H2 748 770 2.79e-4 SMART
ZnF_C2H2 776 798 1.58e-3 SMART
ZnF_C2H2 804 826 3.44e-4 SMART
ZnF_C2H2 832 854 5.59e-4 SMART
ZnF_C2H2 860 882 5.81e-2 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abi3bp A T 16: 56,507,455 (GRCm39) Y1091F probably damaging Het
Arl8b A G 6: 108,792,250 (GRCm39) I104V probably benign Het
Asb2 C A 12: 103,304,457 (GRCm39) G16C probably benign Het
Bptf T C 11: 106,945,836 (GRCm39) S2468G probably damaging Het
Capns1 T A 7: 29,889,963 (GRCm39) D182V probably damaging Het
Cct5 T C 15: 31,594,658 (GRCm39) H182R possibly damaging Het
Cd200 G A 16: 45,215,157 (GRCm39) R165C probably benign Het
Chd3 C T 11: 69,247,097 (GRCm39) V1024I probably damaging Het
Chd8 CAGGGTCTGCCCTCATGGTATTGTATTTCTCATAGCCTAAAAGAACAAGGG C 14: 52,448,037 (GRCm39) probably null Het
Csmd1 T C 8: 16,048,794 (GRCm39) S2303G probably benign Het
Ctsl A G 13: 64,514,314 (GRCm39) S255P probably damaging Het
Dclre1c T G 2: 3,444,714 (GRCm39) N268K possibly damaging Het
Dock10 T C 1: 80,521,134 (GRCm39) D1158G probably damaging Het
Dock6 A T 9: 21,757,797 (GRCm39) D102E probably benign Het
Dvl3 T A 16: 20,344,495 (GRCm39) D290E probably damaging Het
Fam72a T A 1: 131,458,461 (GRCm39) C74* probably null Het
Gnrh1 T A 14: 67,985,334 (GRCm39) L73Q probably damaging Het
Grina T A 15: 76,132,497 (GRCm39) S115T probably damaging Het
Grm3 A T 5: 9,554,725 (GRCm39) S856T probably benign Het
Hars1 C A 18: 36,899,996 (GRCm39) R490L possibly damaging Het
Ide T A 19: 37,292,241 (GRCm39) K318I Het
Immt C A 6: 71,829,762 (GRCm39) S156* probably null Het
Iqcd A G 5: 120,738,232 (GRCm39) I17V possibly damaging Het
Klhdc1 T C 12: 69,298,808 (GRCm39) V131A probably damaging Het
Klk6 C A 7: 43,478,061 (GRCm39) N144K Het
Klk6 T C 7: 43,478,062 (GRCm39) C145R probably damaging Het
Lrfn2 A T 17: 49,404,132 (GRCm39) T752S probably damaging Het
Lrguk A C 6: 34,080,572 (GRCm39) Q1269P unknown Het
Lrwd1 G T 5: 136,164,787 (GRCm39) Q7K probably benign Het
Macf1 A T 4: 123,302,204 (GRCm39) M766K probably benign Het
Myo3a A T 2: 22,245,864 (GRCm39) T4S probably benign Het
Neb T C 2: 52,084,438 (GRCm39) Y5587C probably damaging Het
Nf1 A T 11: 79,286,679 (GRCm39) probably null Het
Npepps G T 11: 97,131,823 (GRCm39) R344S probably damaging Het
Nudt16l2 C T 9: 105,021,648 (GRCm39) D133N probably damaging Het
Or52p1 A T 7: 104,267,486 (GRCm39) Y200F probably damaging Het
Or5v1b A G 17: 37,841,333 (GRCm39) N155S probably damaging Het
Pcnx1 T A 12: 82,042,597 (GRCm39) W2286R probably damaging Het
Ppm1g A T 5: 31,365,768 (GRCm39) N51K probably benign Het
Ppp1r13b T C 12: 111,799,981 (GRCm39) K722E probably damaging Het
Prim1 A G 10: 127,859,761 (GRCm39) S318G probably damaging Het
Prl4a1 T C 13: 28,207,307 (GRCm39) Y194H probably damaging Het
Prl7c1 A T 13: 27,957,854 (GRCm39) D195E probably benign Het
Psmb2 A G 4: 126,603,330 (GRCm39) D186G probably benign Het
Ptprq A G 10: 107,482,513 (GRCm39) V1020A probably benign Het
Scgb2b20 T C 7: 33,065,689 (GRCm39) T13A unknown Het
Scly C A 1: 91,244,830 (GRCm39) H310Q possibly damaging Het
Sdccag8 G A 1: 176,783,473 (GRCm39) E661K probably damaging Het
Sema4f G A 6: 82,894,873 (GRCm39) L441F probably benign Het
Sema4f A C 6: 82,894,874 (GRCm39) Y440* probably null Het
Tmem262 C T 19: 6,130,118 (GRCm39) probably benign Het
Trim33 A G 3: 103,236,392 (GRCm39) T501A probably damaging Het
Trio C A 15: 27,741,150 (GRCm39) V2692F possibly damaging Het
Ttn A T 2: 76,772,774 (GRCm39) V2453E unknown Het
Ttn G T 2: 76,541,956 (GRCm39) R33677S probably benign Het
Uaca T A 9: 60,778,852 (GRCm39) S1080T probably benign Het
Vav3 T A 3: 109,555,051 (GRCm39) C660S probably benign Het
Vmn1r229 T A 17: 21,034,990 (GRCm39) D78E probably damaging Het
Vmn2r73 A G 7: 85,521,179 (GRCm39) V263A probably damaging Het
Yeats2 A T 16: 19,969,260 (GRCm39) D17V probably benign Het
Zfp804a A C 2: 82,089,459 (GRCm39) H1096P possibly damaging Het
Zkscan14 C T 5: 145,138,375 (GRCm39) W37* probably null Het
Zmynd15 A T 11: 70,355,017 (GRCm39) D468V probably damaging Het
Zmynd8 A T 2: 165,654,466 (GRCm39) V682E probably benign Het
Other mutations in Zfp658
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00465:Zfp658 APN 7 43,216,780 (GRCm39) missense probably benign 0.03
IGL00475:Zfp658 APN 7 43,223,500 (GRCm39) missense possibly damaging 0.68
IGL01972:Zfp658 APN 7 43,222,134 (GRCm39) nonsense probably null
IGL03223:Zfp658 APN 7 43,216,735 (GRCm39) missense possibly damaging 0.85
R0135:Zfp658 UTSW 7 43,223,019 (GRCm39) nonsense probably null
R1863:Zfp658 UTSW 7 43,223,323 (GRCm39) missense possibly damaging 0.78
R1962:Zfp658 UTSW 7 43,223,245 (GRCm39) missense possibly damaging 0.93
R2698:Zfp658 UTSW 7 43,222,969 (GRCm39) missense possibly damaging 0.53
R3781:Zfp658 UTSW 7 43,223,270 (GRCm39) missense probably benign
R4791:Zfp658 UTSW 7 43,223,890 (GRCm39) missense possibly damaging 0.93
R5392:Zfp658 UTSW 7 43,222,355 (GRCm39) missense probably benign 0.07
R6092:Zfp658 UTSW 7 43,223,951 (GRCm39) missense possibly damaging 0.73
R6594:Zfp658 UTSW 7 43,216,701 (GRCm39) missense possibly damaging 0.86
R7003:Zfp658 UTSW 7 43,224,172 (GRCm39) missense possibly damaging 0.85
R7008:Zfp658 UTSW 7 43,223,336 (GRCm39) missense possibly damaging 0.95
R7077:Zfp658 UTSW 7 43,223,413 (GRCm39) missense probably benign 0.32
R7689:Zfp658 UTSW 7 43,224,102 (GRCm39) missense probably benign 0.00
R7793:Zfp658 UTSW 7 43,224,108 (GRCm39) missense possibly damaging 0.74
R7939:Zfp658 UTSW 7 43,224,301 (GRCm39) missense possibly damaging 0.73
R8672:Zfp658 UTSW 7 43,222,919 (GRCm39) missense possibly damaging 0.52
R8995:Zfp658 UTSW 7 43,222,798 (GRCm39) missense possibly damaging 0.93
R9021:Zfp658 UTSW 7 43,223,381 (GRCm39) missense possibly damaging 0.71
R9259:Zfp658 UTSW 7 43,224,280 (GRCm39) missense probably benign 0.02
R9551:Zfp658 UTSW 7 43,222,567 (GRCm39) missense probably benign 0.00
R9552:Zfp658 UTSW 7 43,222,567 (GRCm39) missense probably benign 0.00
R9571:Zfp658 UTSW 7 43,222,139 (GRCm39) missense possibly damaging 0.85
Z1176:Zfp658 UTSW 7 43,222,641 (GRCm39) missense possibly damaging 0.72
Predicted Primers PCR Primer
(F):5'- TACAGGCCTCAGCAGAAAGC -3'
(R):5'- CATTAGAAGAGTCTTGCGGGAG -3'

Sequencing Primer
(F):5'- ATCTGAGGAGGCAGCATTCC -3'
(R):5'- CTTGCGGGAGGAGGTGAGC -3'
Posted On 2021-07-15