Incidental Mutation 'R8828:Vmn2r73'
| ID |
673613 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r73
|
| Ensembl Gene |
ENSMUSG00000070458 |
| Gene Name |
vomeronasal 2, receptor 73 |
| Synonyms |
EG620928 |
| MMRRC Submission |
068730-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.172)
|
| Stock # |
R8828 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
85506755-85525146 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 85521179 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 263
(V263A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000076687
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000077478]
|
| AlphaFold |
D3Z7M3 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000077478
AA Change: V263A
PolyPhen 2
Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000076687
Gene: ENSMUSG00000070458
AA Change: V263A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
465 |
1.4e-30 |
PFAM |
|
Pfam:NCD3G
|
508 |
560 |
5.9e-21 |
PFAM |
|
Pfam:7tm_3
|
590 |
827 |
4.4e-51 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 64 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abi3bp |
A |
T |
16: 56,507,455 (GRCm39) |
Y1091F |
probably damaging |
Het |
| Arl8b |
A |
G |
6: 108,792,250 (GRCm39) |
I104V |
probably benign |
Het |
| Asb2 |
C |
A |
12: 103,304,457 (GRCm39) |
G16C |
probably benign |
Het |
| Bptf |
T |
C |
11: 106,945,836 (GRCm39) |
S2468G |
probably damaging |
Het |
| Capns1 |
T |
A |
7: 29,889,963 (GRCm39) |
D182V |
probably damaging |
Het |
| Cct5 |
T |
C |
15: 31,594,658 (GRCm39) |
H182R |
possibly damaging |
Het |
| Cd200 |
G |
A |
16: 45,215,157 (GRCm39) |
R165C |
probably benign |
Het |
| Chd3 |
C |
T |
11: 69,247,097 (GRCm39) |
V1024I |
probably damaging |
Het |
| Chd8 |
CAGGGTCTGCCCTCATGGTATTGTATTTCTCATAGCCTAAAAGAACAAGGG |
C |
14: 52,448,037 (GRCm39) |
|
probably null |
Het |
| Csmd1 |
T |
C |
8: 16,048,794 (GRCm39) |
S2303G |
probably benign |
Het |
| Ctsl |
A |
G |
13: 64,514,314 (GRCm39) |
S255P |
probably damaging |
Het |
| Dclre1c |
T |
G |
2: 3,444,714 (GRCm39) |
N268K |
possibly damaging |
Het |
| Dock10 |
T |
C |
1: 80,521,134 (GRCm39) |
D1158G |
probably damaging |
Het |
| Dock6 |
A |
T |
9: 21,757,797 (GRCm39) |
D102E |
probably benign |
Het |
| Dvl3 |
T |
A |
16: 20,344,495 (GRCm39) |
D290E |
probably damaging |
Het |
| Fam72a |
T |
A |
1: 131,458,461 (GRCm39) |
C74* |
probably null |
Het |
| Gnrh1 |
T |
A |
14: 67,985,334 (GRCm39) |
L73Q |
probably damaging |
Het |
| Grina |
T |
A |
15: 76,132,497 (GRCm39) |
S115T |
probably damaging |
Het |
| Grm3 |
A |
T |
5: 9,554,725 (GRCm39) |
S856T |
probably benign |
Het |
| Hars1 |
C |
A |
18: 36,899,996 (GRCm39) |
R490L |
possibly damaging |
Het |
| Ide |
T |
A |
19: 37,292,241 (GRCm39) |
K318I |
|
Het |
| Immt |
C |
A |
6: 71,829,762 (GRCm39) |
S156* |
probably null |
Het |
| Iqcd |
A |
G |
5: 120,738,232 (GRCm39) |
I17V |
possibly damaging |
Het |
| Klhdc1 |
T |
C |
12: 69,298,808 (GRCm39) |
V131A |
probably damaging |
Het |
| Klk6 |
C |
A |
7: 43,478,061 (GRCm39) |
N144K |
|
Het |
| Klk6 |
T |
C |
7: 43,478,062 (GRCm39) |
C145R |
probably damaging |
Het |
| Lrfn2 |
A |
T |
17: 49,404,132 (GRCm39) |
T752S |
probably damaging |
Het |
| Lrguk |
A |
C |
6: 34,080,572 (GRCm39) |
Q1269P |
unknown |
Het |
| Lrwd1 |
G |
T |
5: 136,164,787 (GRCm39) |
Q7K |
probably benign |
Het |
| Macf1 |
A |
T |
4: 123,302,204 (GRCm39) |
M766K |
probably benign |
Het |
| Myo3a |
A |
T |
2: 22,245,864 (GRCm39) |
T4S |
probably benign |
Het |
| Neb |
T |
C |
2: 52,084,438 (GRCm39) |
Y5587C |
probably damaging |
Het |
| Nf1 |
A |
T |
11: 79,286,679 (GRCm39) |
|
probably null |
Het |
| Npepps |
G |
T |
11: 97,131,823 (GRCm39) |
R344S |
probably damaging |
Het |
| Nudt16l2 |
C |
T |
9: 105,021,648 (GRCm39) |
D133N |
probably damaging |
Het |
| Or52p1 |
A |
T |
7: 104,267,486 (GRCm39) |
Y200F |
probably damaging |
Het |
| Or5v1b |
A |
G |
17: 37,841,333 (GRCm39) |
N155S |
probably damaging |
Het |
| Pcnx1 |
T |
A |
12: 82,042,597 (GRCm39) |
W2286R |
probably damaging |
Het |
| Ppm1g |
A |
T |
5: 31,365,768 (GRCm39) |
N51K |
probably benign |
Het |
| Ppp1r13b |
T |
C |
12: 111,799,981 (GRCm39) |
K722E |
probably damaging |
Het |
| Prim1 |
A |
G |
10: 127,859,761 (GRCm39) |
S318G |
probably damaging |
Het |
| Prl4a1 |
T |
C |
13: 28,207,307 (GRCm39) |
Y194H |
probably damaging |
Het |
| Prl7c1 |
A |
T |
13: 27,957,854 (GRCm39) |
D195E |
probably benign |
Het |
| Psmb2 |
A |
G |
4: 126,603,330 (GRCm39) |
D186G |
probably benign |
Het |
| Ptprq |
A |
G |
10: 107,482,513 (GRCm39) |
V1020A |
probably benign |
Het |
| Scgb2b20 |
T |
C |
7: 33,065,689 (GRCm39) |
T13A |
unknown |
Het |
| Scly |
C |
A |
1: 91,244,830 (GRCm39) |
H310Q |
possibly damaging |
Het |
| Sdccag8 |
G |
A |
1: 176,783,473 (GRCm39) |
E661K |
probably damaging |
Het |
| Sema4f |
G |
A |
6: 82,894,873 (GRCm39) |
L441F |
probably benign |
Het |
| Sema4f |
A |
C |
6: 82,894,874 (GRCm39) |
Y440* |
probably null |
Het |
| Tmem262 |
C |
T |
19: 6,130,118 (GRCm39) |
|
probably benign |
Het |
| Trim33 |
A |
G |
3: 103,236,392 (GRCm39) |
T501A |
probably damaging |
Het |
| Trio |
C |
A |
15: 27,741,150 (GRCm39) |
V2692F |
possibly damaging |
Het |
| Ttn |
A |
T |
2: 76,772,774 (GRCm39) |
V2453E |
unknown |
Het |
| Ttn |
G |
T |
2: 76,541,956 (GRCm39) |
R33677S |
probably benign |
Het |
| Uaca |
T |
A |
9: 60,778,852 (GRCm39) |
S1080T |
probably benign |
Het |
| Vav3 |
T |
A |
3: 109,555,051 (GRCm39) |
C660S |
probably benign |
Het |
| Vmn1r229 |
T |
A |
17: 21,034,990 (GRCm39) |
D78E |
probably damaging |
Het |
| Yeats2 |
A |
T |
16: 19,969,260 (GRCm39) |
D17V |
probably benign |
Het |
| Zfp658 |
T |
A |
7: 43,222,240 (GRCm39) |
W172R |
probably benign |
Het |
| Zfp804a |
A |
C |
2: 82,089,459 (GRCm39) |
H1096P |
possibly damaging |
Het |
| Zkscan14 |
C |
T |
5: 145,138,375 (GRCm39) |
W37* |
probably null |
Het |
| Zmynd15 |
A |
T |
11: 70,355,017 (GRCm39) |
D468V |
probably damaging |
Het |
| Zmynd8 |
A |
T |
2: 165,654,466 (GRCm39) |
V682E |
probably benign |
Het |
|
| Other mutations in Vmn2r73 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00158:Vmn2r73
|
APN |
7 |
85,506,795 (GRCm39) |
missense |
|
|
|
IGL01151:Vmn2r73
|
APN |
7 |
85,507,086 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01408:Vmn2r73
|
APN |
7 |
85,521,455 (GRCm39) |
missense |
probably benign |
0.45 |
|
IGL01505:Vmn2r73
|
APN |
7 |
85,507,267 (GRCm39) |
nonsense |
probably null |
|
|
IGL01731:Vmn2r73
|
APN |
7 |
85,506,757 (GRCm39) |
makesense |
probably null |
|
|
IGL01818:Vmn2r73
|
APN |
7 |
85,519,109 (GRCm39) |
splice site |
probably benign |
|
|
IGL02236:Vmn2r73
|
APN |
7 |
85,521,902 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02265:Vmn2r73
|
APN |
7 |
85,520,847 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02266:Vmn2r73
|
APN |
7 |
85,525,007 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
IGL02276:Vmn2r73
|
APN |
7 |
85,518,980 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02284:Vmn2r73
|
APN |
7 |
85,507,123 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02380:Vmn2r73
|
APN |
7 |
85,507,383 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02466:Vmn2r73
|
APN |
7 |
85,522,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03172:Vmn2r73
|
APN |
7 |
85,507,495 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03179:Vmn2r73
|
APN |
7 |
85,519,468 (GRCm39) |
missense |
probably benign |
0.04 |
|
G1Funyon:Vmn2r73
|
UTSW |
7 |
85,507,510 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0077:Vmn2r73
|
UTSW |
7 |
85,525,075 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0311:Vmn2r73
|
UTSW |
7 |
85,520,997 (GRCm39) |
missense |
probably benign |
|
|
R0413:Vmn2r73
|
UTSW |
7 |
85,521,087 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R0494:Vmn2r73
|
UTSW |
7 |
85,522,140 (GRCm39) |
missense |
probably benign |
|
|
R1523:Vmn2r73
|
UTSW |
7 |
85,519,486 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1618:Vmn2r73
|
UTSW |
7 |
85,525,120 (GRCm39) |
nonsense |
probably null |
|
|
R1667:Vmn2r73
|
UTSW |
7 |
85,506,889 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1728:Vmn2r73
|
UTSW |
7 |
85,507,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1729:Vmn2r73
|
UTSW |
7 |
85,507,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1747:Vmn2r73
|
UTSW |
7 |
85,507,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1784:Vmn2r73
|
UTSW |
7 |
85,507,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2152:Vmn2r73
|
UTSW |
7 |
85,506,936 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2395:Vmn2r73
|
UTSW |
7 |
85,506,975 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2415:Vmn2r73
|
UTSW |
7 |
85,521,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2926:Vmn2r73
|
UTSW |
7 |
85,520,871 (GRCm39) |
missense |
probably benign |
0.17 |
|
R3719:Vmn2r73
|
UTSW |
7 |
85,519,582 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3766:Vmn2r73
|
UTSW |
7 |
85,521,198 (GRCm39) |
missense |
probably benign |
|
|
R3838:Vmn2r73
|
UTSW |
7 |
85,507,258 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3890:Vmn2r73
|
UTSW |
7 |
85,507,144 (GRCm39) |
missense |
probably benign |
|
|
R4030:Vmn2r73
|
UTSW |
7 |
85,521,044 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4247:Vmn2r73
|
UTSW |
7 |
85,521,883 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4409:Vmn2r73
|
UTSW |
7 |
85,520,768 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4427:Vmn2r73
|
UTSW |
7 |
85,506,981 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4430:Vmn2r73
|
UTSW |
7 |
85,519,449 (GRCm39) |
missense |
probably benign |
|
|
R4552:Vmn2r73
|
UTSW |
7 |
85,525,055 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4779:Vmn2r73
|
UTSW |
7 |
85,520,923 (GRCm39) |
nonsense |
probably null |
|
|
R4906:Vmn2r73
|
UTSW |
7 |
85,506,829 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4942:Vmn2r73
|
UTSW |
7 |
85,519,582 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5280:Vmn2r73
|
UTSW |
7 |
85,507,155 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5344:Vmn2r73
|
UTSW |
7 |
85,525,046 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5478:Vmn2r73
|
UTSW |
7 |
85,518,996 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5527:Vmn2r73
|
UTSW |
7 |
85,507,575 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R5691:Vmn2r73
|
UTSW |
7 |
85,507,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5826:Vmn2r73
|
UTSW |
7 |
85,524,956 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R6018:Vmn2r73
|
UTSW |
7 |
85,521,875 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R6082:Vmn2r73
|
UTSW |
7 |
85,507,429 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6111:Vmn2r73
|
UTSW |
7 |
85,520,997 (GRCm39) |
missense |
probably benign |
|
|
R6233:Vmn2r73
|
UTSW |
7 |
85,519,099 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6278:Vmn2r73
|
UTSW |
7 |
85,522,140 (GRCm39) |
missense |
probably benign |
|
|
R6283:Vmn2r73
|
UTSW |
7 |
85,521,049 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6307:Vmn2r73
|
UTSW |
7 |
85,506,828 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6413:Vmn2r73
|
UTSW |
7 |
85,519,544 (GRCm39) |
nonsense |
probably null |
|
|
R6782:Vmn2r73
|
UTSW |
7 |
85,519,563 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6884:Vmn2r73
|
UTSW |
7 |
85,507,213 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6921:Vmn2r73
|
UTSW |
7 |
85,507,446 (GRCm39) |
missense |
probably benign |
0.27 |
|
R7169:Vmn2r73
|
UTSW |
7 |
85,507,663 (GRCm39) |
nonsense |
probably null |
|
|
R7206:Vmn2r73
|
UTSW |
7 |
85,522,075 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7311:Vmn2r73
|
UTSW |
7 |
85,521,192 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R7650:Vmn2r73
|
UTSW |
7 |
85,521,147 (GRCm39) |
missense |
probably benign |
|
|
R7811:Vmn2r73
|
UTSW |
7 |
85,524,956 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R8263:Vmn2r73
|
UTSW |
7 |
85,507,619 (GRCm39) |
missense |
probably benign |
|
|
R8301:Vmn2r73
|
UTSW |
7 |
85,507,510 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8341:Vmn2r73
|
UTSW |
7 |
85,507,128 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8500:Vmn2r73
|
UTSW |
7 |
85,519,638 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8673:Vmn2r73
|
UTSW |
7 |
85,521,902 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8719:Vmn2r73
|
UTSW |
7 |
85,521,095 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8783:Vmn2r73
|
UTSW |
7 |
85,507,668 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8860:Vmn2r73
|
UTSW |
7 |
85,522,149 (GRCm39) |
splice site |
probably benign |
|
|
R9002:Vmn2r73
|
UTSW |
7 |
85,507,284 (GRCm39) |
missense |
probably benign |
0.32 |
|
R9008:Vmn2r73
|
UTSW |
7 |
85,521,904 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9159:Vmn2r73
|
UTSW |
7 |
85,521,931 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9180:Vmn2r73
|
UTSW |
7 |
85,507,123 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9198:Vmn2r73
|
UTSW |
7 |
85,518,987 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9329:Vmn2r73
|
UTSW |
7 |
85,519,073 (GRCm39) |
missense |
probably benign |
|
|
R9448:Vmn2r73
|
UTSW |
7 |
85,522,027 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9463:Vmn2r73
|
UTSW |
7 |
85,506,795 (GRCm39) |
missense |
|
|
|
R9589:Vmn2r73
|
UTSW |
7 |
85,519,659 (GRCm39) |
missense |
probably benign |
0.03 |
|
X0023:Vmn2r73
|
UTSW |
7 |
85,507,664 (GRCm39) |
missense |
probably benign |
0.31 |
|
Z1176:Vmn2r73
|
UTSW |
7 |
85,521,176 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Vmn2r73
|
UTSW |
7 |
85,521,480 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AACCAGACAGTTCAGATTGCTGG -3'
(R):5'- CATGGTGTCCTTAGTGGTCC -3'
Sequencing Primer
(F):5'- CCTAGAGGTGTGATCATGT -3'
(R):5'- TCCTTAGTGGTCCATTTCAGATG -3'
|
| Posted On |
2021-07-15 |
Incidental Mutation