Incidental Mutation 'R8829:Dennd2c'
ID 673661
Institutional Source Beutler Lab
Gene Symbol Dennd2c
Ensembl Gene ENSMUSG00000007379
Gene Name DENN domain containing 2C
Synonyms A930010I20Rik
MMRRC Submission 068731-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8829 (G1)
Quality Score 225.009
Status Not validated
Chromosome 3
Chromosomal Location 103009954-103077054 bp(+) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to A at 103059720 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000127187 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000172288] [ENSMUST00000173206]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000172288
SMART Domains Protein: ENSMUSP00000127187
Gene: ENSMUSG00000007379

DomainStartEndE-ValueType
uDENN 481 571 1.01e-25 SMART
DENN 578 762 3.36e-77 SMART
dDENN 806 873 1.15e-20 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000173206
SMART Domains Protein: ENSMUSP00000134008
Gene: ENSMUSG00000007379

DomainStartEndE-ValueType
uDENN 424 514 1.01e-25 SMART
DENN 521 705 3.36e-77 SMART
dDENN 749 816 1.15e-20 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadac A T 3: 59,939,240 (GRCm39) I5F probably benign Het
Abca13 A T 11: 9,571,881 (GRCm39) D4814V probably damaging Het
Adgrl1 A G 8: 84,665,458 (GRCm39) N1382D Het
Adh6b T C 3: 138,055,463 (GRCm39) V71A probably benign Het
Aox4 A T 1: 58,294,649 (GRCm39) M953L probably benign Het
B3galt9 T A 2: 34,728,634 (GRCm39) N144K probably benign Het
Bach2 A T 4: 32,562,028 (GRCm39) E165V probably damaging Het
Bltp2 A G 11: 78,158,064 (GRCm39) K409E probably benign Het
Catsperg2 A G 7: 29,397,269 (GRCm39) V1078A probably benign Het
Ccno A G 13: 113,126,239 (GRCm39) N236S probably benign Het
Ccpg1 A T 9: 72,917,633 (GRCm39) D255V probably benign Het
Cdhr2 A T 13: 54,865,930 (GRCm39) Y278F probably damaging Het
Cdk17 C T 10: 93,042,920 (GRCm39) probably benign Het
Celsr3 A G 9: 108,717,582 (GRCm39) D2216G probably benign Het
Cenpu T C 8: 47,026,496 (GRCm39) L294P probably damaging Het
Chct1 A G 11: 85,062,037 (GRCm39) D12G probably damaging Het
Ctif CGGGGCACACTTTGCTCTTACCTCCCGGAGGCACGTGTAGATGGGGCACACTTTGCTCTTACCTCCCGGAGGCACGTGTAGATGGGGCACAC CGGGGCACACTTTGCTCTTACCTCCCGGAGGCACGTGTAGATGGGGCACAC 18: 75,604,874 (GRCm39) probably benign Het
Ctnna2 G A 6: 77,582,205 (GRCm39) R352* probably null Het
D630003M21Rik C A 2: 158,058,856 (GRCm39) C348F probably damaging Het
Dcdc2a C T 13: 25,294,051 (GRCm39) Q236* probably null Het
Ddx60 T G 8: 62,393,695 (GRCm39) S44A probably damaging Het
Drd5 G A 5: 38,477,078 (GRCm39) V24M probably benign Het
Dthd1 T C 5: 62,971,608 (GRCm39) S144P probably benign Het
Fcna C A 2: 25,516,145 (GRCm39) R124L possibly damaging Het
Frem1 T C 4: 82,918,431 (GRCm39) R504G probably damaging Het
Gldc C G 19: 30,078,212 (GRCm39) M928I probably benign Het
Gprc6a A C 10: 51,491,295 (GRCm39) I818R probably damaging Het
Hcfc2 T C 10: 82,574,179 (GRCm39) Y118H probably damaging Het
Hmmr G A 11: 40,612,499 (GRCm39) S206F probably damaging Het
Htr1d A T 4: 136,170,554 (GRCm39) H261L probably benign Het
Hycc2 A T 1: 58,587,832 (GRCm39) I127N possibly damaging Het
Igf1r T A 7: 67,875,769 (GRCm39) F1244I probably damaging Het
Ighv1-63 A G 12: 115,459,534 (GRCm39) V21A probably benign Het
Kit A G 5: 75,799,791 (GRCm39) N508D probably benign Het
Klk1b22 A T 7: 43,764,277 (GRCm39) E68D probably benign Het
Knstrn C T 2: 118,654,222 (GRCm39) Q211* probably null Het
Krtap2-4 A T 11: 99,505,246 (GRCm39) C122S unknown Het
Map3k1 T G 13: 111,889,015 (GRCm39) H1314P possibly damaging Het
Mgat4c A T 10: 102,214,084 (GRCm39) K22N probably damaging Het
Mpo T A 11: 87,694,250 (GRCm39) F660Y probably damaging Het
Myb A T 10: 21,021,130 (GRCm39) L433H probably damaging Het
Myo1c G A 11: 75,561,072 (GRCm39) V793I probably benign Het
Nckap1l T A 15: 103,387,242 (GRCm39) S706T probably benign Het
Ncoa3 A G 2: 165,892,068 (GRCm39) Y148C probably damaging Het
Nktr T A 9: 121,583,330 (GRCm39) S1432T unknown Het
Odf2l C T 3: 144,833,820 (GRCm39) S160L probably benign Het
Or10j7 C T 1: 173,011,458 (GRCm39) R181H probably benign Het
Or56b34 T C 7: 104,937,435 (GRCm39) L45P possibly damaging Het
Or6x1 T A 9: 40,099,209 (GRCm39) F266Y probably benign Het
Or8d23 G T 9: 38,842,190 (GRCm39) C241F probably damaging Het
Pclo T C 5: 14,838,464 (GRCm39) W1424R Het
Pcx A G 19: 4,651,968 (GRCm39) D72G probably damaging Het
Pebp4 A G 14: 70,285,916 (GRCm39) D193G probably benign Het
Pi4kb C T 3: 94,900,344 (GRCm39) T326M probably damaging Het
Piezo1 A C 8: 123,217,753 (GRCm39) M1265R Het
Pip4k2c A T 10: 127,037,037 (GRCm39) H177Q probably damaging Het
Pramel48 G T 5: 95,630,939 (GRCm39) C272F possibly damaging Het
Prpf40a T C 2: 53,047,927 (GRCm39) M197V probably benign Het
Ptger3 A G 3: 157,273,423 (GRCm39) T257A probably damaging Het
Relt T A 7: 100,499,479 (GRCm39) S147C probably damaging Het
Scap A G 9: 110,209,271 (GRCm39) Y648C probably damaging Het
Scn9a T A 2: 66,313,961 (GRCm39) D1919V probably benign Het
Septin8 G A 11: 53,422,865 (GRCm39) V25I probably damaging Het
Serpinb2 A G 1: 107,443,257 (GRCm39) I19V probably benign Het
Slc16a6 A G 11: 109,345,932 (GRCm39) Y444H probably benign Het
Syne1 T C 10: 5,058,685 (GRCm39) E7276G probably benign Het
Syt1 C A 10: 108,478,193 (GRCm39) C77F probably benign Het
Tcf20 T A 15: 82,739,915 (GRCm39) K512M probably damaging Het
Tomm7 T C 5: 24,049,047 (GRCm39) K9E possibly damaging Het
Trank1 T C 9: 111,176,591 (GRCm39) S288P probably benign Het
Trem3 T C 17: 48,556,865 (GRCm39) V112A probably benign Het
Ttbk1 C A 17: 46,757,821 (GRCm39) G938W probably damaging Het
Vmn1r178 G A 7: 23,593,264 (GRCm39) C104Y probably damaging Het
Zpr1 T A 9: 46,192,344 (GRCm39) Y418* probably null Het
Other mutations in Dennd2c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01763:Dennd2c APN 3 103,064,224 (GRCm39) missense probably damaging 1.00
IGL01791:Dennd2c APN 3 103,073,741 (GRCm39) missense probably benign 0.19
IGL02100:Dennd2c APN 3 103,060,991 (GRCm39) missense probably damaging 0.98
IGL02119:Dennd2c APN 3 103,044,559 (GRCm39) missense probably damaging 0.99
IGL02395:Dennd2c APN 3 103,065,081 (GRCm39) missense probably benign 0.00
IGL02631:Dennd2c APN 3 103,063,387 (GRCm39) missense possibly damaging 0.56
IGL02895:Dennd2c APN 3 103,044,519 (GRCm39) missense possibly damaging 0.76
convolution UTSW 3 103,063,423 (GRCm39) missense probably damaging 1.00
Resolution UTSW 3 103,040,661 (GRCm39) missense possibly damaging 0.51
R1749:Dennd2c UTSW 3 103,039,352 (GRCm39) missense possibly damaging 0.92
R1931:Dennd2c UTSW 3 103,040,568 (GRCm39) missense probably benign 0.32
R1964:Dennd2c UTSW 3 103,073,807 (GRCm39) missense probably damaging 1.00
R1972:Dennd2c UTSW 3 103,039,014 (GRCm39) missense probably benign 0.01
R1973:Dennd2c UTSW 3 103,039,014 (GRCm39) missense probably benign 0.01
R2025:Dennd2c UTSW 3 103,039,005 (GRCm39) missense possibly damaging 0.71
R2350:Dennd2c UTSW 3 103,039,317 (GRCm39) missense probably benign 0.00
R2373:Dennd2c UTSW 3 103,064,158 (GRCm39) missense probably damaging 0.99
R4555:Dennd2c UTSW 3 103,039,202 (GRCm39) missense probably benign 0.00
R4916:Dennd2c UTSW 3 103,039,140 (GRCm39) missense probably benign 0.00
R5560:Dennd2c UTSW 3 103,068,871 (GRCm39) missense probably damaging 1.00
R6291:Dennd2c UTSW 3 103,038,925 (GRCm39) nonsense probably null
R6395:Dennd2c UTSW 3 103,056,540 (GRCm39) critical splice donor site probably null
R6567:Dennd2c UTSW 3 103,039,335 (GRCm39) missense probably benign 0.02
R6681:Dennd2c UTSW 3 103,038,977 (GRCm39) missense probably benign 0.01
R7106:Dennd2c UTSW 3 103,038,893 (GRCm39) missense possibly damaging 0.82
R7162:Dennd2c UTSW 3 103,063,423 (GRCm39) missense probably damaging 1.00
R7514:Dennd2c UTSW 3 103,070,378 (GRCm39) missense probably benign 0.00
R7591:Dennd2c UTSW 3 103,040,661 (GRCm39) missense possibly damaging 0.51
R7698:Dennd2c UTSW 3 103,072,359 (GRCm39) missense possibly damaging 0.65
R8069:Dennd2c UTSW 3 103,072,446 (GRCm39) missense probably damaging 1.00
R8086:Dennd2c UTSW 3 103,040,661 (GRCm39) missense possibly damaging 0.51
R8247:Dennd2c UTSW 3 103,059,637 (GRCm39) missense probably damaging 0.99
R8347:Dennd2c UTSW 3 103,065,025 (GRCm39) missense probably damaging 0.99
R8832:Dennd2c UTSW 3 103,059,720 (GRCm39) critical splice donor site probably null
R9131:Dennd2c UTSW 3 103,065,031 (GRCm39) missense probably damaging 1.00
R9332:Dennd2c UTSW 3 103,038,877 (GRCm39) missense probably benign 0.01
R9350:Dennd2c UTSW 3 103,039,308 (GRCm39) missense possibly damaging 0.79
R9520:Dennd2c UTSW 3 103,044,484 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GTAAAGCAGCGCAAGTGTCC -3'
(R):5'- GCTTCTCCTTACACTGAAATCAATGC -3'

Sequencing Primer
(F):5'- GCAAGTGTCCCTGAGAGAAACTC -3'
(R):5'- GAAATCAATGCTTTTCTTTCCTGAGC -3'
Posted On 2021-07-15