Incidental Mutation 'R8830:Micalcl'
ID 673750
Institutional Source Beutler Lab
Gene Symbol Micalcl
Ensembl Gene ENSMUSG00000030771
Gene Name MICAL C-terminal like
Synonyms Ebitein1, 4921517J23Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8830 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 112368308-112413106 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 112381196 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 126 (T126A)
Ref Sequence ENSEMBL: ENSMUSP00000062443 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033033] [ENSMUST00000051308] [ENSMUST00000106645]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000033033
AA Change: T192A

PolyPhen 2 Score 0.048 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000033033
Gene: ENSMUSG00000030771
AA Change: T192A

DomainStartEndE-ValueType
low complexity region 8 18 N/A INTRINSIC
low complexity region 72 100 N/A INTRINSIC
low complexity region 393 404 N/A INTRINSIC
low complexity region 415 432 N/A INTRINSIC
low complexity region 545 562 N/A INTRINSIC
coiled coil region 569 597 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000051308
AA Change: T126A

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000062443
Gene: ENSMUSG00000030771
AA Change: T126A

DomainStartEndE-ValueType
low complexity region 6 34 N/A INTRINSIC
low complexity region 327 338 N/A INTRINSIC
low complexity region 349 366 N/A INTRINSIC
low complexity region 479 496 N/A INTRINSIC
low complexity region 500 515 N/A INTRINSIC
DUF3585 526 668 6.86e-56 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000106645
AA Change: T126A

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000102256
Gene: ENSMUSG00000030771
AA Change: T126A

DomainStartEndE-ValueType
low complexity region 6 34 N/A INTRINSIC
low complexity region 327 338 N/A INTRINSIC
low complexity region 349 366 N/A INTRINSIC
low complexity region 479 496 N/A INTRINSIC
low complexity region 500 515 N/A INTRINSIC
DUF3585 526 668 6.86e-56 SMART
Predicted Effect
Predicted Effect probably benign
Transcript: ENSMUST00000215412
Predicted Effect
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 100% (68/68)
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aaed1 G A 13: 64,297,300 (GRCm38) Q170* probably null Het
Abca7 T A 10: 80,008,971 (GRCm38) V1509E probably damaging Het
Abraxas2 A G 7: 132,883,356 (GRCm38) D376G probably damaging Het
Agbl1 A G 7: 76,335,311 (GRCm38) T159A Het
Ahnak2 G A 12: 112,787,036 (GRCm38) R89W Het
Arhgef40 A C 14: 52,003,708 (GRCm38) D1396A probably damaging Het
Atp13a5 A T 16: 29,248,176 (GRCm38) F1060I probably damaging Het
Atp6v1c1 T A 15: 38,677,545 (GRCm38) F105I probably damaging Het
Atp9b C T 18: 80,765,800 (GRCm38) E635K Het
BC017643 C T 11: 121,228,723 (GRCm38) probably benign Het
Brix1 T A 15: 10,479,596 (GRCm38) Q124L possibly damaging Het
Cep68 A G 11: 20,230,418 (GRCm38) probably benign Het
Cfap46 A G 7: 139,615,649 (GRCm38) S2208P unknown Het
Crisp1 T A 17: 40,294,419 (GRCm38) K234* probably null Het
Cryzl1 C T 16: 91,712,204 (GRCm38) V70I probably benign Het
Dnah7b T C 1: 46,191,793 (GRCm38) Y1404H probably damaging Het
Dot1l A G 10: 80,771,199 (GRCm38) H109R possibly damaging Het
E330034G19Rik A C 14: 24,309,508 (GRCm38) H329P unknown Het
Erbb4 A T 1: 68,075,468 (GRCm38) L939Q probably damaging Het
Fst A T 13: 114,455,828 (GRCm38) C118S probably damaging Het
Gfra3 A G 18: 34,711,136 (GRCm38) V117A possibly damaging Het
Gldc C G 19: 30,100,812 (GRCm38) M928I probably benign Het
Gm5538 A T 3: 59,747,323 (GRCm38) T193S probably benign Het
Gm996 T G 2: 25,577,250 (GRCm38) D883A Het
Greb1 A G 12: 16,688,519 (GRCm38) M1481T probably benign Het
Hecw2 G A 1: 53,891,146 (GRCm38) R1045C probably damaging Het
Hexb C T 13: 97,194,254 (GRCm38) V84I probably benign Het
Hpse T C 5: 100,695,586 (GRCm38) E240G probably benign Het
Hspa12a T C 19: 58,805,463 (GRCm38) D322G possibly damaging Het
Hspa9 A T 18: 34,948,104 (GRCm38) probably null Het
Kif9 A G 9: 110,524,930 (GRCm38) K790R probably damaging Het
Klc2 C T 19: 5,110,366 (GRCm38) probably null Het
Ldha C G 7: 46,850,278 (GRCm38) N144K probably benign Het
Mrpl15 A T 1: 4,782,584 (GRCm38) V137D probably damaging Het
Muc16 G A 9: 18,646,069 (GRCm38) T2976I unknown Het
Mybpc2 A T 7: 44,512,541 (GRCm38) V495D probably damaging Het
Olfr597 A G 7: 103,321,005 (GRCm38) K198R Het
Olfr713 A G 7: 107,036,682 (GRCm38) N176D probably benign Het
Olfr772 A T 10: 129,174,846 (GRCm38) Y58* probably null Het
Pcnt G A 10: 76,382,174 (GRCm38) T2089I probably benign Het
Pdzd7 T C 19: 45,033,073 (GRCm38) D563G probably damaging Het
Phlpp1 T G 1: 106,350,603 (GRCm38) L915R probably damaging Het
Plekhh2 T A 17: 84,521,803 (GRCm38) I34N probably damaging Het
Pou6f2 T A 13: 18,378,498 (GRCm38) T84S Het
Ptprq A G 10: 107,586,695 (GRCm38) V1612A possibly damaging Het
Pvrig T G 5: 138,342,148 (GRCm38) probably benign Het
Rasl10b A T 11: 83,412,676 (GRCm38) I20F probably damaging Het
Rimbp3 T A 16: 17,209,006 (GRCm38) V98E probably damaging Het
Rims2 T C 15: 39,437,362 (GRCm38) I355T possibly damaging Het
Slc1a2 A G 2: 102,736,015 (GRCm38) H30R probably benign Het
Slc28a1 G A 7: 81,161,046 (GRCm38) V389M possibly damaging Het
Slc7a13 T C 4: 19,819,189 (GRCm38) S130P probably benign Het
Sp140 TTTTTTTT TTTTTTTTTTTTT 1: 85,644,574 (GRCm38) probably benign Het
Spag17 T A 3: 100,125,435 (GRCm38) H2320Q possibly damaging Het
Speer4a T C 5: 26,036,795 (GRCm38) E111G possibly damaging Het
Ss18l1 T C 2: 180,067,338 (GRCm38) Y397H unknown Het
Tbck T C 3: 132,838,057 (GRCm38) S890P probably damaging Het
Tcp11 T C 17: 28,080,230 (GRCm38) E17G probably benign Het
Tesk2 C T 4: 116,802,287 (GRCm38) R315C probably benign Het
Tln1 T C 4: 43,556,383 (GRCm38) N45S probably benign Het
Trim10 C T 17: 36,869,954 (GRCm38) P26S probably damaging Het
Vmac C A 17: 56,715,573 (GRCm38) G146C probably damaging Het
Vmn1r14 G A 6: 57,234,032 (GRCm38) M198I probably damaging Het
Vmn1r194 T C 13: 22,244,836 (GRCm38) Y208H possibly damaging Het
Vmn1r78 G A 7: 12,153,191 (GRCm38) C243Y probably damaging Het
Wasf3 C T 5: 146,466,862 (GRCm38) Q261* probably null Het
Ybx2 A G 11: 69,936,237 (GRCm38) K88R probably benign Het
Zfhx4 G A 3: 5,398,889 (GRCm38) R1394H probably damaging Het
Zfp871 T C 17: 32,774,927 (GRCm38) T425A probably benign Het
Zfy2 C T Y: 2,106,600 (GRCm38) S678N possibly damaging Het
Zswim4 T C 8: 84,223,316 (GRCm38) E650G possibly damaging Het
Other mutations in Micalcl
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00504:Micalcl APN 7 112,382,145 (GRCm38) missense possibly damaging 0.94
IGL01775:Micalcl APN 7 112,382,062 (GRCm38) missense possibly damaging 0.89
IGL02051:Micalcl APN 7 112,381,390 (GRCm38) missense probably benign 0.30
IGL03114:Micalcl APN 7 112,397,557 (GRCm38) missense probably damaging 1.00
R0091:Micalcl UTSW 7 112,381,296 (GRCm38) missense probably benign 0.05
R0415:Micalcl UTSW 7 112,381,028 (GRCm38) missense probably damaging 1.00
R0962:Micalcl UTSW 7 112,380,417 (GRCm38) missense probably damaging 0.99
R1521:Micalcl UTSW 7 112,381,610 (GRCm38) missense probably damaging 1.00
R1611:Micalcl UTSW 7 112,381,464 (GRCm38) missense probably damaging 0.99
R1815:Micalcl UTSW 7 112,412,902 (GRCm38) missense probably damaging 1.00
R1958:Micalcl UTSW 7 112,381,104 (GRCm38) missense probably benign 0.00
R1962:Micalcl UTSW 7 112,412,844 (GRCm38) missense probably benign 0.14
R2439:Micalcl UTSW 7 112,394,795 (GRCm38) missense probably damaging 0.99
R3979:Micalcl UTSW 7 112,407,678 (GRCm38) splice site probably null
R4551:Micalcl UTSW 7 112,381,916 (GRCm38) missense possibly damaging 0.87
R4583:Micalcl UTSW 7 112,412,947 (GRCm38) missense probably benign 0.02
R5459:Micalcl UTSW 7 112,382,237 (GRCm38) missense probably benign 0.00
R5763:Micalcl UTSW 7 112,374,654 (GRCm38) critical splice donor site probably null
R6042:Micalcl UTSW 7 112,380,412 (GRCm38) missense probably benign 0.40
R6189:Micalcl UTSW 7 112,412,880 (GRCm38) missense probably damaging 1.00
R6750:Micalcl UTSW 7 112,381,839 (GRCm38) missense probably damaging 0.98
R6798:Micalcl UTSW 7 112,376,059 (GRCm38) utr 3 prime probably benign
R7347:Micalcl UTSW 7 112,382,151 (GRCm38) missense probably benign 0.01
R7783:Micalcl UTSW 7 112,412,976 (GRCm38) missense probably damaging 1.00
R7824:Micalcl UTSW 7 112,407,637 (GRCm38) missense probably damaging 1.00
R7995:Micalcl UTSW 7 112,381,768 (GRCm38) missense probably benign 0.31
R8906:Micalcl UTSW 7 112,381,464 (GRCm38) missense probably damaging 0.99
R9006:Micalcl UTSW 7 112,382,116 (GRCm38) missense probably benign 0.13
R9140:Micalcl UTSW 7 112,407,619 (GRCm38) missense probably damaging 1.00
R9233:Micalcl UTSW 7 112,382,192 (GRCm38) missense probably benign 0.05
R9304:Micalcl UTSW 7 112,381,767 (GRCm38) missense probably damaging 0.97
R9377:Micalcl UTSW 7 112,382,039 (GRCm38) missense probably benign 0.10
R9457:Micalcl UTSW 7 112,411,458 (GRCm38) missense probably damaging 0.96
R9620:Micalcl UTSW 7 112,381,196 (GRCm38) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CCAATCTACCTCAGACGTGC -3'
(R):5'- GTGCAGTCACTCCAGTCTAG -3'

Sequencing Primer
(F):5'- CCAGGGCTCAAGGGATTGTG -3'
(R):5'- AGTCACTCCAGTCTAGCAACTTG -3'
Posted On 2021-07-15