Incidental Mutation 'R8831:Gm10308'
ID 673871
Institutional Source Beutler Lab
Gene Symbol Gm10308
Ensembl Gene ENSMUSG00000071033
Gene Name predicted gene 10308
Synonyms
MMRRC Submission 068659-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.610) question?
Stock # R8831 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 91395921-91396819 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 91396431 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 118 (R118G)
Ref Sequence ENSEMBL: ENSMUSP00000092806 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054059] [ENSMUST00000072671] [ENSMUST00000095183] [ENSMUST00000160800] [ENSMUST00000160844] [ENSMUST00000161402] [ENSMUST00000174331]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000054059
SMART Domains Protein: ENSMUSP00000057294
Gene: ENSMUSG00000024109

DomainStartEndE-ValueType
low complexity region 9 23 N/A INTRINSIC
LamG 50 192 2.29e-31 SMART
EGF 216 256 4.26e0 SMART
LamG 304 438 2.3e-36 SMART
LamG 492 644 2.74e-43 SMART
EGF 671 705 1.58e-3 SMART
LamG 730 869 7.27e-25 SMART
LamG 917 1053 8.46e-35 SMART
EGF 1078 1112 1.87e1 SMART
LamG 1140 1297 7.74e-20 SMART
low complexity region 1324 1355 N/A INTRINSIC
low complexity region 1426 1441 N/A INTRINSIC
4.1m 1444 1462 1.19e-6 SMART
low complexity region 1481 1493 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000072671
SMART Domains Protein: ENSMUSP00000072458
Gene: ENSMUSG00000024109

DomainStartEndE-ValueType
low complexity region 9 23 N/A INTRINSIC
LamG 50 192 2.29e-31 SMART
EGF 216 256 4.26e0 SMART
LamG 304 438 2.3e-36 SMART
LamG 492 644 2.74e-43 SMART
EGF 671 705 1.58e-3 SMART
LamG 730 869 7.27e-25 SMART
LamG 917 1053 8.46e-35 SMART
EGF 1078 1112 1.87e1 SMART
LamG 1140 1297 7.74e-20 SMART
low complexity region 1324 1355 N/A INTRINSIC
low complexity region 1423 1438 N/A INTRINSIC
4.1m 1441 1459 1.19e-6 SMART
low complexity region 1478 1490 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000095183
AA Change: R118G
SMART Domains Protein: ENSMUSP00000092806
Gene: ENSMUSG00000071033
AA Change: R118G

DomainStartEndE-ValueType
low complexity region 1 40 N/A INTRINSIC
low complexity region 47 61 N/A INTRINSIC
low complexity region 75 93 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000160800
SMART Domains Protein: ENSMUSP00000124561
Gene: ENSMUSG00000024109

DomainStartEndE-ValueType
low complexity region 9 23 N/A INTRINSIC
LamG 50 192 2.29e-31 SMART
EGF 216 256 4.26e0 SMART
LamG 300 434 2.3e-36 SMART
LamG 488 640 2.74e-43 SMART
EGF 667 701 1.58e-3 SMART
LamG 726 865 7.27e-25 SMART
LamG 913 1049 8.46e-35 SMART
EGF 1074 1108 1.87e1 SMART
LamG 1136 1293 7.74e-20 SMART
low complexity region 1320 1351 N/A INTRINSIC
low complexity region 1422 1437 N/A INTRINSIC
4.1m 1440 1458 1.19e-6 SMART
low complexity region 1477 1489 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000160844
SMART Domains Protein: ENSMUSP00000125407
Gene: ENSMUSG00000024109

DomainStartEndE-ValueType
low complexity region 9 23 N/A INTRINSIC
LamG 50 192 2.29e-31 SMART
EGF 216 256 4.26e0 SMART
LamG 304 446 1.24e-32 SMART
LamG 500 652 2.74e-43 SMART
EGF 679 713 1.58e-3 SMART
LamG 738 877 7.27e-25 SMART
LamG 925 1061 8.46e-35 SMART
EGF 1086 1120 1.87e1 SMART
LamG 1148 1305 7.74e-20 SMART
low complexity region 1332 1363 N/A INTRINSIC
low complexity region 1434 1449 N/A INTRINSIC
4.1m 1452 1470 1.19e-6 SMART
low complexity region 1489 1501 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000161402
SMART Domains Protein: ENSMUSP00000124116
Gene: ENSMUSG00000024109

DomainStartEndE-ValueType
low complexity region 9 23 N/A INTRINSIC
LamG 50 192 2.29e-31 SMART
EGF 216 256 4.26e0 SMART
LamG 304 453 3.46e-31 SMART
LamG 507 659 2.74e-43 SMART
EGF 686 720 1.58e-3 SMART
LamG 745 884 7.27e-25 SMART
LamG 932 1068 8.46e-35 SMART
EGF 1093 1127 1.87e1 SMART
LamG 1155 1312 7.74e-20 SMART
low complexity region 1339 1370 N/A INTRINSIC
low complexity region 1441 1456 N/A INTRINSIC
4.1m 1459 1477 1.19e-6 SMART
low complexity region 1496 1508 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000174331
SMART Domains Protein: ENSMUSP00000133491
Gene: ENSMUSG00000024109

DomainStartEndE-ValueType
signal peptide 1 30 N/A INTRINSIC
LamG 50 192 2.29e-31 SMART
EGF 216 256 4.26e0 SMART
LamG 304 446 1.24e-32 SMART
LamG 500 652 2.74e-43 SMART
EGF 679 713 1.58e-3 SMART
LamG 738 877 7.27e-25 SMART
LamG 925 1061 8.46e-35 SMART
EGF 1086 1120 1.87e1 SMART
LamG 1148 1275 3.29e-23 SMART
low complexity region 1302 1333 N/A INTRINSIC
low complexity region 1404 1419 N/A INTRINSIC
4.1m 1422 1440 1.19e-6 SMART
low complexity region 1459 1471 N/A INTRINSIC
Meta Mutation Damage Score 0.0852 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency 99% (81/82)
Allele List at MGI
Other mutations in this stock
Total: 86 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A230072I06Rik A T 8: 12,329,688 (GRCm39) I48L unknown Het
Abcc3 A C 11: 94,241,787 (GRCm39) C1415G probably damaging Het
Abcf3 C T 16: 20,369,214 (GRCm39) R205C probably damaging Het
Abcg5 G T 17: 84,976,423 (GRCm39) H471Q probably damaging Het
Actl6b G A 5: 137,565,305 (GRCm39) R363Q probably damaging Het
Adcy1 T A 11: 7,111,362 (GRCm39) D884E probably benign Het
Aldh3a1 A G 11: 61,107,142 (GRCm39) Y282C probably damaging Het
Amdhd2 A G 17: 24,376,712 (GRCm39) probably null Het
Arfgef3 A G 10: 18,528,491 (GRCm39) S299P possibly damaging Het
Asic2 A T 11: 81,858,726 (GRCm39) N95K probably damaging Het
Atp2c2 A G 8: 120,476,033 (GRCm39) probably null Het
Atrn T C 2: 130,748,521 (GRCm39) L14P probably benign Het
C8b A G 4: 104,647,874 (GRCm39) Y355C probably damaging Het
Carm1 A G 9: 21,491,663 (GRCm39) E244G probably damaging Het
Cd300c2 A T 11: 114,891,844 (GRCm39) C39* probably null Het
Cish T A 9: 107,177,671 (GRCm39) F116I probably damaging Het
Clstn1 G A 4: 149,730,780 (GRCm39) R837Q probably benign Het
Cox10 A G 11: 63,855,306 (GRCm39) F325S probably damaging Het
Cplane1 T C 15: 8,211,620 (GRCm39) I320T probably benign Het
Ctps1 A T 4: 120,424,507 (GRCm39) S36T possibly damaging Het
Dchs2 T C 3: 83,192,670 (GRCm39) L1705P probably benign Het
Defb25 C A 2: 152,464,899 (GRCm39) V17L probably benign Het
Dhx16 A G 17: 36,199,000 (GRCm39) D782G probably damaging Het
Dhx30 A G 9: 109,917,319 (GRCm39) S399P probably benign Het
Dhx58 T A 11: 100,594,806 (GRCm39) K30M probably damaging Het
Drc7 G A 8: 95,788,845 (GRCm39) R301Q probably damaging Het
Dsg1a T C 18: 20,453,365 (GRCm39) V21A probably damaging Het
Ercc6 T A 14: 32,282,784 (GRCm39) probably null Het
Fam193a A G 5: 34,616,374 (GRCm39) T850A probably benign Het
Fgf10 A G 13: 118,925,671 (GRCm39) D150G probably damaging Het
Flii A T 11: 60,616,074 (GRCm39) N28K probably benign Het
Gfi1 G A 5: 107,868,138 (GRCm39) R377C probably damaging Het
Gfra2 A T 14: 71,204,503 (GRCm39) N324I probably benign Het
Gm10801 T A 2: 98,494,334 (GRCm39) V137E probably damaging Het
Hmmr G A 11: 40,612,499 (GRCm39) S206F probably damaging Het
Hsd3b9 A T 3: 98,354,047 (GRCm39) W151R probably benign Het
Ift80 G A 3: 68,869,583 (GRCm39) A236V probably damaging Het
Il1rn A T 2: 24,239,505 (GRCm39) T134S possibly damaging Het
Il6st G T 13: 112,640,914 (GRCm39) D897Y probably damaging Het
Imp4 T C 1: 34,483,445 (GRCm39) M257T probably benign Het
Impdh2 T C 9: 108,441,957 (GRCm39) L377S probably damaging Het
Kdm1b C A 13: 47,217,617 (GRCm39) L359I possibly damaging Het
Kidins220 A T 12: 25,086,454 (GRCm39) I963L possibly damaging Het
Mdm4 T C 1: 132,931,601 (GRCm39) R148G probably benign Het
Myl10 G C 5: 136,726,825 (GRCm39) V70L probably benign Het
Ncor1 A T 11: 62,260,234 (GRCm39) D505E probably benign Het
Necab3 A T 2: 154,396,607 (GRCm39) L107Q probably damaging Het
Nkx2-4 G A 2: 146,927,114 (GRCm39) P51L probably benign Het
Nol11 T C 11: 107,067,662 (GRCm39) T388A probably benign Het
Npc1 T A 18: 12,333,877 (GRCm39) M735L probably benign Het
Nr1h3 C A 2: 91,021,091 (GRCm39) R232L probably benign Het
Nrcam T A 12: 44,591,680 (GRCm39) probably null Het
Or1j13 G A 2: 36,369,794 (GRCm39) T116I possibly damaging Het
Or52s1b T A 7: 102,822,203 (GRCm39) I214L probably benign Het
Pabpn1 T C 14: 55,131,914 (GRCm39) V101A probably damaging Het
Pcare A T 17: 72,059,305 (GRCm39) V124E probably benign Het
Pcbp2 A G 15: 102,394,453 (GRCm39) D217G probably benign Het
Pcdhb12 A G 18: 37,570,386 (GRCm39) M511V probably benign Het
Phf3 T A 1: 30,860,347 (GRCm39) K828* probably null Het
Plcg1 G C 2: 160,589,732 (GRCm39) K85N probably benign Het
Prag1 A T 8: 36,613,891 (GRCm39) T1148S probably benign Het
Prmt3 A G 7: 49,478,729 (GRCm39) E430G probably null Het
Prx G T 7: 27,217,538 (GRCm39) V819F probably damaging Het
Ptpn18 A T 1: 34,511,271 (GRCm39) R338W probably null Het
Rab6a T C 7: 100,283,931 (GRCm39) Y128H probably benign Het
Rgs2 T C 1: 143,877,497 (GRCm39) Y186C probably damaging Het
Rhbdl1 C T 17: 26,053,857 (GRCm39) V342M probably damaging Het
Rpn1 A G 6: 88,061,775 (GRCm39) Q88R probably benign Het
Slc19a2 C T 1: 164,084,443 (GRCm39) T111M probably damaging Het
Slc35e4 G A 11: 3,863,087 (GRCm39) P34L possibly damaging Het
Slc7a6os A T 8: 106,937,189 (GRCm39) D90E probably benign Het
Ssh3 A G 19: 4,319,053 (GRCm39) V19A possibly damaging Het
Susd1 C T 4: 59,379,594 (GRCm39) probably benign Het
Tcf19 A T 17: 35,825,794 (GRCm39) M121K possibly damaging Het
Tcp11 G A 17: 28,299,193 (GRCm39) R21C probably damaging Het
Tcp11l2 A G 10: 84,449,522 (GRCm39) I496V probably damaging Het
Tenm3 C T 8: 48,729,417 (GRCm39) A1530T Het
Tmem127 T A 2: 127,098,979 (GRCm39) V171D probably damaging Het
Tyrp1 G A 4: 80,753,399 (GRCm39) C30Y probably damaging Het
Usp48 A T 4: 137,341,080 (GRCm39) D360V probably damaging Het
Vamp4 T A 1: 162,401,952 (GRCm39) D11E possibly damaging Het
Vmn1r14 T C 6: 57,210,505 (GRCm39) F28L probably benign Het
Vmn2r69 G T 7: 85,059,018 (GRCm39) C514* probably null Het
Vmn2r84 G A 10: 130,226,968 (GRCm39) A290V probably benign Het
Zfp1007 A T 5: 109,824,174 (GRCm39) S425R probably benign Het
Zhx3 T A 2: 160,622,691 (GRCm39) Y492F probably benign Het
Other mutations in Gm10308
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1756:Gm10308 UTSW 17 91,396,385 (GRCm39) nonsense probably null
R7194:Gm10308 UTSW 17 91,396,389 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- ACACCTTCACAGAGAAATGGGG -3'
(R):5'- CCGAGAAAAGTGTGTTTCTTCCG -3'

Sequencing Primer
(F):5'- TTCACAGAGAAATGGGGGTCCG -3'
(R):5'- AAAAGTGTGTTTCTTCCGATTCTGC -3'
Posted On 2021-07-15