Incidental Mutation 'R0729:Myo10'
ID 67416
Institutional Source Beutler Lab
Gene Symbol Myo10
Ensembl Gene ENSMUSG00000022272
Gene Name myosin X
Synonyms myosin-X, D15Ertd600e
MMRRC Submission 038910-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0729 (G1)
Quality Score 165
Status Validated
Chromosome 15
Chromosomal Location 25622636-25813759 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to C at 25722243 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000118280 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000110457] [ENSMUST00000137601]
AlphaFold F8VQB6
Predicted Effect probably benign
Transcript: ENSMUST00000110457
SMART Domains Protein: ENSMUSP00000106087
Gene: ENSMUSG00000022272

DomainStartEndE-ValueType
MYSc 57 740 N/A SMART
IQ 741 763 1.27e-3 SMART
IQ 764 786 1.06e0 SMART
IQ 787 809 7.07e-2 SMART
Pfam:MYO10_CC 881 932 4.2e-22 PFAM
low complexity region 959 981 N/A INTRINSIC
low complexity region 1090 1102 N/A INTRINSIC
low complexity region 1147 1165 N/A INTRINSIC
PH 1217 1316 1.39e-21 SMART
PH 1397 1503 6.76e-11 SMART
MyTH4 1551 1699 4.12e-37 SMART
B41 1700 1962 1.72e-44 SMART
low complexity region 2050 2062 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126076
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130517
Predicted Effect probably benign
Transcript: ENSMUST00000137601
SMART Domains Protein: ENSMUSP00000118280
Gene: ENSMUSG00000022272

DomainStartEndE-ValueType
MYSc 24 707 N/A SMART
IQ 708 730 1.27e-3 SMART
IQ 731 753 1.06e0 SMART
IQ 754 776 7.07e-2 SMART
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.8%
  • 20x: 96.0%
Validation Efficiency 97% (74/76)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-10 (MYH10). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. This gene functions as an actin-based molecular motor and plays a role in integration of F-actin and microtubule cytoskeletons during meiosis. [provided by RefSeq, Dec 2011]
PHENOTYPE: Homozygous null mutations are semi-lethal with over half of homozygous embryos exhibiting exencephaly. Surviving mutants show decreased body weight, white spotting, syndactyly, persistence of hyaloid vascular system and other eye defects. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933427D14Rik C A 11: 72,050,281 (GRCm39) A828S probably benign Het
Acsm3 T C 7: 119,383,207 (GRCm39) probably benign Het
Adamts12 G A 15: 11,255,769 (GRCm39) R446H possibly damaging Het
Adgrb1 A G 15: 74,420,398 (GRCm39) N849S probably damaging Het
Ankra2 A G 13: 98,408,235 (GRCm39) D228G probably damaging Het
Bicd1 T C 6: 149,414,412 (GRCm39) V375A probably damaging Het
Blvrb A G 7: 27,147,555 (GRCm39) K5E possibly damaging Het
Cacna2d2 A G 9: 107,394,456 (GRCm39) N573D probably benign Het
Calhm2 C A 19: 47,121,356 (GRCm39) G271V possibly damaging Het
Capn13 C T 17: 73,629,064 (GRCm39) G581E probably damaging Het
Capzb T C 4: 139,016,288 (GRCm39) probably benign Het
Casd1 T C 6: 4,619,753 (GRCm39) probably benign Het
Clca4b A G 3: 144,634,111 (GRCm39) probably benign Het
Col1a2 G A 6: 4,518,822 (GRCm39) probably benign Het
Crx A G 7: 15,605,058 (GRCm39) probably benign Het
Cyp2c68 T C 19: 39,727,994 (GRCm39) probably benign Het
Dcaf8 T A 1: 172,000,221 (GRCm39) D126E probably benign Het
Ddx31 T C 2: 28,764,186 (GRCm39) I464T probably damaging Het
Dhx32 G A 7: 133,339,150 (GRCm39) T155I probably benign Het
Elac2 C A 11: 64,889,349 (GRCm39) P567T possibly damaging Het
Fat4 A G 3: 39,054,444 (GRCm39) probably benign Het
Fh1 T G 1: 175,442,383 (GRCm39) N156H probably damaging Het
Gm10064 T C 5: 122,835,584 (GRCm39) noncoding transcript Het
Gm14137 A G 2: 119,005,834 (GRCm39) E131G probably benign Het
Gpr22 T A 12: 31,759,312 (GRCm39) K233M probably damaging Het
Gpr63 A G 4: 25,007,480 (GRCm39) N68S probably benign Het
Gypa C T 8: 81,223,421 (GRCm39) P66S unknown Het
Htr2a A T 14: 74,879,587 (GRCm39) Q72L probably benign Het
Klhdc7b C T 15: 89,271,598 (GRCm39) R827* probably null Het
Leo1 G A 9: 75,364,420 (GRCm39) R520Q possibly damaging Het
Lrrc66 T C 5: 73,765,757 (GRCm39) M429V probably benign Het
Lrrc74a C T 12: 86,792,353 (GRCm39) Q225* probably null Het
Mamdc4 T A 2: 25,460,048 (GRCm39) N68Y probably damaging Het
Map3k10 G A 7: 27,360,992 (GRCm39) P507L probably damaging Het
Methig1 T A 15: 100,272,870 (GRCm39) C68S probably benign Het
Metrn C T 17: 26,015,202 (GRCm39) probably benign Het
Mmp12 C T 9: 7,358,290 (GRCm39) T392I possibly damaging Het
Mss51 A T 14: 20,533,160 (GRCm39) I437N probably damaging Het
Mtus2 A G 5: 148,014,097 (GRCm39) T297A probably benign Het
Ncoa7 G A 10: 30,567,575 (GRCm39) P319S probably benign Het
Nlrp4d A T 7: 10,111,612 (GRCm39) probably benign Het
Obscn A G 11: 58,923,535 (GRCm39) S6455P probably damaging Het
Or5b97 T C 19: 12,878,259 (GRCm39) N295S probably damaging Het
Or8b37 G T 9: 37,959,123 (GRCm39) V202L probably benign Het
Pcdh12 A G 18: 38,415,517 (GRCm39) I536T probably benign Het
Pex5l G T 3: 33,008,685 (GRCm39) probably benign Het
Pla2g2e A C 4: 138,608,046 (GRCm39) K43Q possibly damaging Het
Rasa4 T C 5: 136,130,924 (GRCm39) probably benign Het
Rsf1 C T 7: 97,328,234 (GRCm39) R1079W probably damaging Het
Sez6 A G 11: 77,867,411 (GRCm39) T803A probably benign Het
Shcbp1 T A 8: 4,786,297 (GRCm39) N602Y probably benign Het
Slc16a13 G A 11: 70,109,857 (GRCm39) P215S probably damaging Het
Slc39a6 T C 18: 24,734,527 (GRCm39) Q54R probably benign Het
Smg1 C A 7: 117,745,512 (GRCm39) probably benign Het
Spg7 A G 8: 123,797,156 (GRCm39) N110D probably damaging Het
Sptbn1 A T 11: 30,060,902 (GRCm39) S2010T probably damaging Het
Sun1 T A 5: 139,223,619 (GRCm39) probably benign Het
Sytl5 A G X: 9,860,736 (GRCm39) E717G probably damaging Het
Tle1 A T 4: 72,044,679 (GRCm39) probably benign Het
Tm9sf4 T A 2: 153,033,065 (GRCm39) V290E probably damaging Het
Tmem63b A G 17: 45,985,060 (GRCm39) S179P probably damaging Het
Trpm3 T A 19: 22,965,153 (GRCm39) F1549L probably benign Het
Ubr4 A T 4: 139,212,631 (GRCm39) Y5063F possibly damaging Het
Uroc1 T A 6: 90,313,937 (GRCm39) Y75N probably damaging Het
Vmn2r70 T C 7: 85,215,112 (GRCm39) T141A probably benign Het
Vps13c A G 9: 67,868,931 (GRCm39) K3128E probably damaging Het
Wdr26 T C 1: 181,013,470 (GRCm39) probably null Het
Wrn T A 8: 33,738,946 (GRCm39) probably null Het
Zfp106 C T 2: 120,385,729 (GRCm39) V13M probably damaging Het
Zfp456 G A 13: 67,514,663 (GRCm39) H348Y probably damaging Het
Zfpm1 G A 8: 123,063,398 (GRCm39) R819H probably benign Het
Other mutations in Myo10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00557:Myo10 APN 15 25,776,466 (GRCm39) missense probably damaging 1.00
IGL01068:Myo10 APN 15 25,739,395 (GRCm39) missense possibly damaging 0.93
IGL01352:Myo10 APN 15 25,701,783 (GRCm39) missense probably damaging 1.00
IGL01388:Myo10 APN 15 25,736,703 (GRCm39) missense possibly damaging 0.55
IGL01460:Myo10 APN 15 25,714,194 (GRCm39) missense probably benign 0.00
IGL01553:Myo10 APN 15 25,776,415 (GRCm39) missense probably damaging 1.00
IGL01732:Myo10 APN 15 25,732,149 (GRCm39) missense probably benign 0.10
IGL01992:Myo10 APN 15 25,799,634 (GRCm39) missense possibly damaging 0.92
IGL02000:Myo10 APN 15 25,808,152 (GRCm39) missense probably damaging 1.00
IGL02045:Myo10 APN 15 25,726,574 (GRCm39) missense probably benign 0.03
IGL02307:Myo10 APN 15 25,776,401 (GRCm39) splice site probably benign
IGL02511:Myo10 APN 15 25,723,975 (GRCm39) missense probably damaging 0.97
IGL03240:Myo10 APN 15 25,701,688 (GRCm39) missense probably damaging 1.00
least UTSW 15 25,726,561 (GRCm39) nonsense probably null
R0037:Myo10 UTSW 15 25,666,618 (GRCm39) intron probably benign
R0153:Myo10 UTSW 15 25,781,324 (GRCm39) missense possibly damaging 0.84
R0282:Myo10 UTSW 15 25,793,253 (GRCm39) missense probably damaging 1.00
R0360:Myo10 UTSW 15 25,804,454 (GRCm39) missense probably damaging 1.00
R0585:Myo10 UTSW 15 25,736,541 (GRCm39) missense probably damaging 1.00
R0617:Myo10 UTSW 15 25,738,091 (GRCm39) missense probably damaging 1.00
R0771:Myo10 UTSW 15 25,778,264 (GRCm39) missense probably damaging 1.00
R0960:Myo10 UTSW 15 25,801,275 (GRCm39) missense probably damaging 1.00
R1562:Myo10 UTSW 15 25,780,497 (GRCm39) missense possibly damaging 0.81
R1651:Myo10 UTSW 15 25,742,455 (GRCm39) missense probably damaging 1.00
R1789:Myo10 UTSW 15 25,726,611 (GRCm39) critical splice donor site probably null
R1816:Myo10 UTSW 15 25,800,286 (GRCm39) missense probably damaging 1.00
R1835:Myo10 UTSW 15 25,805,673 (GRCm39) missense possibly damaging 0.53
R1908:Myo10 UTSW 15 25,801,308 (GRCm39) missense probably damaging 1.00
R2082:Myo10 UTSW 15 25,786,079 (GRCm39) missense probably damaging 1.00
R2101:Myo10 UTSW 15 25,722,345 (GRCm39) missense probably benign 0.26
R2129:Myo10 UTSW 15 25,781,885 (GRCm39) missense probably benign 0.09
R2141:Myo10 UTSW 15 25,714,194 (GRCm39) missense probably benign
R2142:Myo10 UTSW 15 25,714,194 (GRCm39) missense probably benign
R2920:Myo10 UTSW 15 25,801,226 (GRCm39) missense probably damaging 1.00
R2938:Myo10 UTSW 15 25,795,803 (GRCm39) missense probably damaging 0.99
R3723:Myo10 UTSW 15 25,803,374 (GRCm39) missense probably damaging 1.00
R3852:Myo10 UTSW 15 25,779,712 (GRCm39) missense probably damaging 1.00
R4162:Myo10 UTSW 15 25,726,501 (GRCm39) splice site probably null
R4163:Myo10 UTSW 15 25,726,501 (GRCm39) splice site probably null
R4164:Myo10 UTSW 15 25,726,501 (GRCm39) splice site probably null
R4177:Myo10 UTSW 15 25,734,137 (GRCm39) missense possibly damaging 0.81
R4409:Myo10 UTSW 15 25,807,955 (GRCm39) missense probably damaging 1.00
R4667:Myo10 UTSW 15 25,793,239 (GRCm39) missense possibly damaging 0.91
R4905:Myo10 UTSW 15 25,800,298 (GRCm39) missense probably damaging 0.99
R4933:Myo10 UTSW 15 25,781,204 (GRCm39) missense probably damaging 0.96
R4968:Myo10 UTSW 15 25,808,270 (GRCm39) missense probably damaging 1.00
R5081:Myo10 UTSW 15 25,786,026 (GRCm39) missense probably damaging 1.00
R5123:Myo10 UTSW 15 25,726,569 (GRCm39) missense possibly damaging 0.94
R5310:Myo10 UTSW 15 25,778,164 (GRCm39) splice site probably null
R6073:Myo10 UTSW 15 25,736,728 (GRCm39) missense probably damaging 1.00
R6117:Myo10 UTSW 15 25,805,745 (GRCm39) missense probably benign 0.00
R6185:Myo10 UTSW 15 25,726,596 (GRCm39) missense probably damaging 0.99
R6749:Myo10 UTSW 15 25,714,196 (GRCm39) missense probably damaging 1.00
R6819:Myo10 UTSW 15 25,781,496 (GRCm39) missense possibly damaging 0.80
R6875:Myo10 UTSW 15 25,805,745 (GRCm39) missense probably benign 0.00
R6908:Myo10 UTSW 15 25,804,469 (GRCm39) missense probably damaging 1.00
R6963:Myo10 UTSW 15 25,734,149 (GRCm39) missense probably benign 0.31
R7144:Myo10 UTSW 15 25,724,011 (GRCm39) missense probably damaging 1.00
R7266:Myo10 UTSW 15 25,783,067 (GRCm39) missense probably damaging 1.00
R7380:Myo10 UTSW 15 25,779,706 (GRCm39) missense probably benign 0.01
R7460:Myo10 UTSW 15 25,807,913 (GRCm39) missense probably damaging 1.00
R7614:Myo10 UTSW 15 25,701,709 (GRCm39) missense probably benign 0.00
R7618:Myo10 UTSW 15 25,726,561 (GRCm39) nonsense probably null
R7717:Myo10 UTSW 15 25,732,056 (GRCm39) missense probably benign 0.01
R7811:Myo10 UTSW 15 25,804,610 (GRCm39) missense probably damaging 1.00
R7830:Myo10 UTSW 15 25,738,057 (GRCm39) nonsense probably null
R7862:Myo10 UTSW 15 25,666,522 (GRCm39) missense probably damaging 1.00
R8232:Myo10 UTSW 15 25,804,400 (GRCm39) missense possibly damaging 0.89
R8264:Myo10 UTSW 15 25,800,195 (GRCm39) missense probably damaging 0.99
R8377:Myo10 UTSW 15 25,804,481 (GRCm39) missense possibly damaging 0.94
R8385:Myo10 UTSW 15 25,804,484 (GRCm39) missense probably damaging 1.00
R8426:Myo10 UTSW 15 25,799,576 (GRCm39) missense probably damaging 0.99
R8439:Myo10 UTSW 15 25,725,158 (GRCm39) missense probably benign 0.00
R8696:Myo10 UTSW 15 25,799,572 (GRCm39) missense probably damaging 1.00
R8775:Myo10 UTSW 15 25,800,145 (GRCm39) missense probably damaging 0.97
R8775-TAIL:Myo10 UTSW 15 25,800,145 (GRCm39) missense probably damaging 0.97
R8970:Myo10 UTSW 15 25,803,467 (GRCm39) missense possibly damaging 0.82
R9024:Myo10 UTSW 15 25,793,295 (GRCm39) missense possibly damaging 0.53
R9196:Myo10 UTSW 15 25,805,716 (GRCm39) missense probably damaging 0.96
R9224:Myo10 UTSW 15 25,808,081 (GRCm39) missense probably benign 0.33
R9308:Myo10 UTSW 15 25,781,862 (GRCm39) missense probably damaging 0.99
R9358:Myo10 UTSW 15 25,781,520 (GRCm39) missense possibly damaging 0.69
R9606:Myo10 UTSW 15 25,776,401 (GRCm39) frame shift probably null
R9722:Myo10 UTSW 15 25,801,227 (GRCm39) missense probably damaging 1.00
RF013:Myo10 UTSW 15 25,799,565 (GRCm39) missense probably damaging 0.99
Z1177:Myo10 UTSW 15 25,799,640 (GRCm39) critical splice donor site probably null
Z1177:Myo10 UTSW 15 25,781,487 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGAACAGTGCGGTCTGTCTGTCTC -3'
(R):5'- AGAAAGGTGATGCGCTCGCTAC -3'

Sequencing Primer
(F):5'- acttgtggaggtcagaggg -3'
(R):5'- CGCTCGCTACCTGCTTTG -3'
Posted On 2013-09-03