Incidental Mutation 'R8837:Vmn2r96'
| ID |
674246 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r96
|
| Ensembl Gene |
ENSMUSG00000091679 |
| Gene Name |
vomeronasal 2, receptor 96 |
| Synonyms |
EG433070 |
| MMRRC Submission |
068665-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.157)
|
| Stock # |
R8837 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
18793282-18818419 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 18802888 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 266
(D266G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000135095
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000165692]
[ENSMUST00000177244]
[ENSMUST00000231261]
[ENSMUST00000231286]
|
| AlphaFold |
E9PZU5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000165692
AA Change: D74G
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000131564
Gene: ENSMUSG00000091679
AA Change: D74G
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ANF_receptor
|
1 |
257 |
8.6e-20 |
PFAM |
|
Pfam:NCD3G
|
317 |
370 |
3.7e-22 |
PFAM |
|
Pfam:7tm_3
|
402 |
638 |
3.9e-53 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177244
AA Change: D266G
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000135095
Gene: ENSMUSG00000091679
AA Change: D266G
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ANF_receptor
|
1 |
245 |
4.2e-19 |
PFAM |
|
Pfam:NCD3G
|
317 |
370 |
6.9e-21 |
PFAM |
|
Pfam:7tm_3
|
400 |
639 |
3.4e-75 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000231261
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000231286
AA Change: D266G
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.9%
|
| Validation Efficiency |
100% (59/59) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 59 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcb4 |
T |
G |
5: 8,986,873 (GRCm39) |
F764C |
probably damaging |
Het |
| Aff1 |
A |
G |
5: 103,982,078 (GRCm39) |
D739G |
possibly damaging |
Het |
| Atosb |
A |
G |
4: 43,034,531 (GRCm39) |
S355P |
probably damaging |
Het |
| Atp1a3 |
T |
C |
7: 24,677,980 (GRCm39) |
Y1012C |
probably damaging |
Het |
| Btbd10 |
T |
C |
7: 112,929,133 (GRCm39) |
T206A |
probably benign |
Het |
| Capn8 |
G |
T |
1: 182,456,199 (GRCm39) |
A650S |
possibly damaging |
Het |
| Catsper1 |
A |
C |
19: 5,386,070 (GRCm39) |
N101T |
probably damaging |
Het |
| Cdh23 |
A |
C |
10: 60,160,755 (GRCm39) |
S2070R |
probably benign |
Het |
| Cep350 |
A |
G |
1: 155,737,518 (GRCm39) |
V2775A |
probably benign |
Het |
| Clybl |
G |
A |
14: 122,419,194 (GRCm39) |
|
probably null |
Het |
| Cog4 |
T |
A |
8: 111,579,004 (GRCm39) |
N148K |
probably benign |
Het |
| Dbnl |
G |
A |
11: 5,741,839 (GRCm39) |
G44D |
possibly damaging |
Het |
| Dgcr2 |
A |
T |
16: 17,667,630 (GRCm39) |
N276K |
possibly damaging |
Het |
| Dnah9 |
T |
A |
11: 65,746,060 (GRCm39) |
T4018S |
possibly damaging |
Het |
| Dock3 |
A |
G |
9: 106,774,539 (GRCm39) |
L72P |
probably benign |
Het |
| Dync2i2 |
T |
C |
2: 29,928,374 (GRCm39) |
D84G |
probably benign |
Het |
| Fabp4 |
T |
C |
3: 10,271,105 (GRCm39) |
T51A |
probably benign |
Het |
| Fars2 |
T |
A |
13: 36,430,409 (GRCm39) |
I279N |
probably damaging |
Het |
| Fas |
A |
T |
19: 34,296,049 (GRCm39) |
Q164L |
probably benign |
Het |
| Focad |
A |
G |
4: 88,072,905 (GRCm39) |
K107E |
probably damaging |
Het |
| Gga3 |
G |
A |
11: 115,479,305 (GRCm39) |
S338L |
probably benign |
Het |
| Grip1 |
A |
G |
10: 119,765,940 (GRCm39) |
R91G |
probably damaging |
Het |
| Igkv3-7 |
A |
G |
6: 70,584,942 (GRCm39) |
D94G |
possibly damaging |
Het |
| Kank3 |
G |
C |
17: 34,036,627 (GRCm39) |
R165P |
probably damaging |
Het |
| Kmt2d |
A |
T |
15: 98,762,048 (GRCm39) |
L434Q |
unknown |
Het |
| Krt18 |
A |
G |
15: 101,938,265 (GRCm39) |
T163A |
possibly damaging |
Het |
| Lcn10 |
T |
A |
2: 25,575,298 (GRCm39) |
|
probably benign |
Het |
| Lrrc37a |
G |
T |
11: 103,394,795 (GRCm39) |
P210Q |
probably benign |
Het |
| Lyst |
T |
A |
13: 13,852,548 (GRCm39) |
S2183T |
probably benign |
Het |
| Mga |
G |
A |
2: 119,769,272 (GRCm39) |
|
probably benign |
Het |
| Myh9 |
G |
A |
15: 77,661,137 (GRCm39) |
A818V |
possibly damaging |
Het |
| Or1j15 |
T |
C |
2: 36,458,703 (GRCm39) |
I31T |
probably benign |
Het |
| Or1o3 |
G |
T |
17: 37,573,807 (GRCm39) |
Y249* |
probably null |
Het |
| Or8b1 |
A |
T |
9: 38,399,597 (GRCm39) |
I91F |
probably benign |
Het |
| Pde7b |
A |
G |
10: 20,314,469 (GRCm39) |
|
probably null |
Het |
| Pik3cb |
A |
T |
9: 98,936,117 (GRCm39) |
Y772N |
possibly damaging |
Het |
| Ppl |
C |
G |
16: 4,906,854 (GRCm39) |
R1147P |
probably damaging |
Het |
| Prl3d2 |
A |
T |
13: 27,307,926 (GRCm39) |
D69V |
probably benign |
Het |
| Psd3 |
A |
G |
8: 68,172,596 (GRCm39) |
F871L |
probably damaging |
Het |
| Rlf |
G |
A |
4: 121,045,432 (GRCm39) |
P152S |
probably benign |
Het |
| Rpa1 |
T |
C |
11: 75,204,167 (GRCm39) |
E270G |
possibly damaging |
Het |
| Scfd2 |
T |
C |
5: 74,691,656 (GRCm39) |
T209A |
probably benign |
Het |
| Scn11a |
A |
G |
9: 119,621,410 (GRCm39) |
L669P |
probably damaging |
Het |
| Sec31b |
A |
T |
19: 44,506,106 (GRCm39) |
C933* |
probably null |
Het |
| Serpina3k |
G |
T |
12: 104,309,292 (GRCm39) |
M245I |
probably benign |
Het |
| Slc9a3 |
T |
A |
13: 74,305,823 (GRCm39) |
I280N |
probably damaging |
Het |
| Soat1 |
A |
G |
1: 156,261,772 (GRCm39) |
V412A |
probably damaging |
Het |
| Spata31d1a |
A |
T |
13: 59,850,596 (GRCm39) |
S511T |
possibly damaging |
Het |
| Sphkap |
A |
T |
1: 83,253,384 (GRCm39) |
V1455E |
possibly damaging |
Het |
| Spns1 |
G |
A |
7: 125,971,593 (GRCm39) |
S319F |
possibly damaging |
Het |
| Tbxas1 |
G |
T |
6: 39,048,364 (GRCm39) |
M403I |
|
Het |
| Tln2 |
A |
T |
9: 67,157,866 (GRCm39) |
C1158S |
probably damaging |
Het |
| Tnrc18 |
T |
C |
5: 142,778,811 (GRCm39) |
T98A |
possibly damaging |
Het |
| Ttc23 |
T |
C |
7: 67,319,494 (GRCm39) |
L118P |
probably damaging |
Het |
| Tyr |
T |
A |
7: 87,087,223 (GRCm39) |
I430L |
probably damaging |
Het |
| Uck2 |
A |
G |
1: 167,070,715 (GRCm39) |
F5L |
probably benign |
Het |
| Ush2a |
G |
A |
1: 188,485,847 (GRCm39) |
V2986I |
probably benign |
Het |
| Yrdc |
A |
G |
4: 124,747,677 (GRCm39) |
D213G |
probably benign |
Het |
| Zfp612 |
C |
A |
8: 110,815,603 (GRCm39) |
T270K |
probably damaging |
Het |
|
| Other mutations in Vmn2r96 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00562:Vmn2r96
|
APN |
17 |
18,804,077 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00563:Vmn2r96
|
APN |
17 |
18,804,077 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00769:Vmn2r96
|
APN |
17 |
18,804,081 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01314:Vmn2r96
|
APN |
17 |
18,803,226 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01983:Vmn2r96
|
APN |
17 |
18,817,527 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02314:Vmn2r96
|
APN |
17 |
18,804,221 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02600:Vmn2r96
|
APN |
17 |
18,817,829 (GRCm39) |
missense |
probably benign |
|
|
IGL02672:Vmn2r96
|
APN |
17 |
18,818,376 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02750:Vmn2r96
|
APN |
17 |
18,802,851 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03068:Vmn2r96
|
APN |
17 |
18,803,137 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03411:Vmn2r96
|
APN |
17 |
18,806,634 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0316:Vmn2r96
|
UTSW |
17 |
18,802,827 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0502:Vmn2r96
|
UTSW |
17 |
18,804,262 (GRCm39) |
missense |
probably benign |
|
|
R0580:Vmn2r96
|
UTSW |
17 |
18,802,900 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0652:Vmn2r96
|
UTSW |
17 |
18,817,830 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0789:Vmn2r96
|
UTSW |
17 |
18,802,738 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R1462:Vmn2r96
|
UTSW |
17 |
18,817,660 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1462:Vmn2r96
|
UTSW |
17 |
18,817,660 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1660:Vmn2r96
|
UTSW |
17 |
18,817,988 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1755:Vmn2r96
|
UTSW |
17 |
18,802,915 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R1843:Vmn2r96
|
UTSW |
17 |
18,818,183 (GRCm39) |
missense |
probably benign |
0.14 |
|
R1943:Vmn2r96
|
UTSW |
17 |
18,806,664 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1993:Vmn2r96
|
UTSW |
17 |
18,804,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2018:Vmn2r96
|
UTSW |
17 |
18,804,263 (GRCm39) |
missense |
probably benign |
|
|
R2405:Vmn2r96
|
UTSW |
17 |
18,818,102 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3977:Vmn2r96
|
UTSW |
17 |
18,817,941 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3979:Vmn2r96
|
UTSW |
17 |
18,817,941 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4059:Vmn2r96
|
UTSW |
17 |
18,818,339 (GRCm39) |
missense |
probably benign |
0.20 |
|
R4693:Vmn2r96
|
UTSW |
17 |
18,803,270 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4709:Vmn2r96
|
UTSW |
17 |
18,803,088 (GRCm39) |
missense |
probably benign |
0.36 |
|
R4776:Vmn2r96
|
UTSW |
17 |
18,817,770 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4882:Vmn2r96
|
UTSW |
17 |
18,817,866 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4920:Vmn2r96
|
UTSW |
17 |
18,802,918 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5143:Vmn2r96
|
UTSW |
17 |
18,804,120 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R5301:Vmn2r96
|
UTSW |
17 |
18,817,950 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5507:Vmn2r96
|
UTSW |
17 |
18,818,091 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6151:Vmn2r96
|
UTSW |
17 |
18,804,221 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6181:Vmn2r96
|
UTSW |
17 |
18,804,126 (GRCm39) |
missense |
probably benign |
|
|
R6339:Vmn2r96
|
UTSW |
17 |
18,804,124 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6404:Vmn2r96
|
UTSW |
17 |
18,817,793 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6452:Vmn2r96
|
UTSW |
17 |
18,804,117 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6749:Vmn2r96
|
UTSW |
17 |
18,818,352 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6813:Vmn2r96
|
UTSW |
17 |
18,802,116 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6851:Vmn2r96
|
UTSW |
17 |
18,802,800 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6944:Vmn2r96
|
UTSW |
17 |
18,817,891 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6949:Vmn2r96
|
UTSW |
17 |
18,818,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6962:Vmn2r96
|
UTSW |
17 |
18,818,283 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6990:Vmn2r96
|
UTSW |
17 |
18,804,082 (GRCm39) |
missense |
probably benign |
|
|
R7149:Vmn2r96
|
UTSW |
17 |
18,817,989 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7346:Vmn2r96
|
UTSW |
17 |
18,803,029 (GRCm39) |
missense |
probably benign |
0.15 |
|
R7385:Vmn2r96
|
UTSW |
17 |
18,803,302 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7442:Vmn2r96
|
UTSW |
17 |
18,793,662 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7509:Vmn2r96
|
UTSW |
17 |
18,802,995 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7652:Vmn2r96
|
UTSW |
17 |
18,793,832 (GRCm39) |
missense |
probably benign |
|
|
R7659:Vmn2r96
|
UTSW |
17 |
18,793,749 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7753:Vmn2r96
|
UTSW |
17 |
18,806,663 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7855:Vmn2r96
|
UTSW |
17 |
18,818,130 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R8166:Vmn2r96
|
UTSW |
17 |
18,802,744 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8260:Vmn2r96
|
UTSW |
17 |
18,804,243 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8323:Vmn2r96
|
UTSW |
17 |
18,803,023 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8787:Vmn2r96
|
UTSW |
17 |
18,818,250 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8933:Vmn2r96
|
UTSW |
17 |
18,804,241 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9306:Vmn2r96
|
UTSW |
17 |
18,803,226 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9481:Vmn2r96
|
UTSW |
17 |
18,793,621 (GRCm39) |
start gained |
probably benign |
|
|
R9626:Vmn2r96
|
UTSW |
17 |
18,793,758 (GRCm39) |
missense |
probably benign |
0.14 |
|
R9629:Vmn2r96
|
UTSW |
17 |
18,803,257 (GRCm39) |
missense |
probably benign |
0.15 |
|
Z1088:Vmn2r96
|
UTSW |
17 |
18,817,628 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
Z1177:Vmn2r96
|
UTSW |
17 |
18,818,376 (GRCm39) |
missense |
probably benign |
0.02 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGTATCCTTCTCTCTACCAGATGGC -3'
(R):5'- ATGAGGCTCCCATGGAATGAG -3'
Sequencing Primer
(F):5'- AAAGACACATCTCTTTCACTTGC -3'
(R):5'- GCTCCCATGGAATGAGTCTAACATG -3'
|
| Posted On |
2021-07-15 |
Incidental Mutation