Incidental Mutation 'R8839:Olfr629'
ID 674320
Institutional Source Beutler Lab
Gene Symbol Olfr629
Ensembl Gene ENSMUSG00000047545
Gene Name olfactory receptor 629
Synonyms MOR26-2, GA_x6K02T2PBJ9-6466772-6465828
MMRRC Submission 068667-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.066) question?
Stock # R8839 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 103739775-103744943 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 103740814 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 142 (I142T)
Ref Sequence ENSEMBL: ENSMUSP00000149272 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051346] [ENSMUST00000213906] [ENSMUST00000216300]
AlphaFold Q0VBH3
Predicted Effect probably benign
Transcript: ENSMUST00000051346
AA Change: I142T

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000052662
Gene: ENSMUSG00000047545
AA Change: I142T

DomainStartEndE-ValueType
Pfam:7tm_4 31 311 4.9e-103 PFAM
Pfam:7TM_GPCR_Srsx 35 307 1.6e-6 PFAM
Pfam:7tm_1 41 292 5.7e-15 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213906
AA Change: I142T

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Predicted Effect probably benign
Transcript: ENSMUST00000216300
AA Change: I142T

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency 100% (51/51)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1600015I10Rik T C 6: 48,931,040 Y325H probably damaging Het
Ace3 T C 11: 105,998,368 Y475H probably damaging Het
Ankfy1 T C 11: 72,730,566 I226T probably benign Het
Anln G A 9: 22,356,172 S825L probably benign Het
B3galt4 A G 17: 33,950,893 S124P possibly damaging Het
Cabin1 T C 10: 75,656,816 I1882V probably benign Het
Caprin2 A T 6: 148,873,027 S262R probably benign Het
Csmd2 A C 4: 128,442,888 I1420L Het
Cyp2b9 T G 7: 26,200,760 V331G probably damaging Het
Cyp3a59 A T 5: 146,109,086 M433L probably benign Het
Edrf1 A G 7: 133,653,915 D597G probably benign Het
Emc3 G A 6: 113,519,970 R147C possibly damaging Het
Fam172a A T 13: 77,999,662 H283L probably benign Het
Fkbp7 T C 2: 76,667,237 probably benign Het
Flii T C 11: 60,718,607 T665A possibly damaging Het
Fxr1 A G 3: 34,046,682 probably benign Het
Gpr37 T G 6: 25,669,370 I492L probably benign Het
Hmg20b A C 10: 81,348,915 W108G probably damaging Het
Ighv9-3 G A 12: 114,140,765 T93I possibly damaging Het
Inpp5a T C 7: 139,389,433 V15A probably benign Het
Inpp5d T A 1: 87,691,711 Y376N probably damaging Het
Ints6 A G 14: 62,693,673 F854L probably benign Het
Ipo7 A T 7: 110,042,016 K314N probably damaging Het
Ltn1 C A 16: 87,418,502 C415F probably damaging Het
Mfsd9 T C 1: 40,774,394 T254A probably benign Het
Musk A G 4: 58,286,151 T14A probably benign Het
Ncapd3 T C 9: 27,094,434 V1438A Het
Nnt A T 13: 119,357,637 V636D unknown Het
Olfr1338 A G 4: 118,754,214 L110P probably damaging Het
Olfr748 A T 14: 50,710,500 T57S possibly damaging Het
Ost4 T C 5: 30,907,591 probably benign Het
Pdzph1 T C 17: 58,950,242 T934A probably benign Het
Plekhn1 T A 4: 156,222,589 probably benign Het
Prkd1 T C 12: 50,342,833 probably benign Het
Ptch1 A T 13: 63,541,224 L413Q probably damaging Het
S100pbp A G 4: 129,182,207 probably null Het
Sec23a T C 12: 58,990,995 K361E possibly damaging Het
Sema3b C T 9: 107,601,353 probably benign Het
Serpina3g A G 12: 104,237,779 probably benign Het
Slc23a2 C T 2: 132,101,472 silent Het
Smug1 T C 15: 103,155,820 R225G possibly damaging Het
Srbd1 T A 17: 85,988,421 I854L probably benign Het
Tbc1d16 G A 11: 119,156,648 R417C probably damaging Het
Tiam1 A G 16: 89,884,939 Y384H probably damaging Het
Trappc9 T A 15: 73,058,238 K90* probably null Het
Tubgcp6 A T 15: 89,103,478 H1097Q possibly damaging Het
Ugt2b37 A G 5: 87,254,556 L72P probably damaging Het
Vmn2r20 A T 6: 123,396,556 H442Q possibly damaging Het
Vmn2r65 A T 7: 84,946,281 Y398* probably null Het
Zfhx4 A G 3: 5,401,855 T2383A probably benign Het
Other mutations in Olfr629
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00965:Olfr629 APN 7 103740965 missense probably benign 0.03
IGL01531:Olfr629 APN 7 103741114 missense probably damaging 1.00
IGL02263:Olfr629 APN 7 103741055 missense probably damaging 1.00
IGL02543:Olfr629 APN 7 103740503 missense possibly damaging 0.50
BB005:Olfr629 UTSW 7 103741190 missense probably damaging 1.00
BB015:Olfr629 UTSW 7 103741190 missense probably damaging 1.00
R0744:Olfr629 UTSW 7 103740925 missense probably damaging 1.00
R0836:Olfr629 UTSW 7 103740925 missense probably damaging 1.00
R1509:Olfr629 UTSW 7 103741036 missense probably benign 0.12
R1671:Olfr629 UTSW 7 103740410 missense possibly damaging 0.73
R1781:Olfr629 UTSW 7 103740821 missense probably benign 0.00
R1848:Olfr629 UTSW 7 103741174 missense probably benign 0.08
R3930:Olfr629 UTSW 7 103740587 missense probably damaging 1.00
R4125:Olfr629 UTSW 7 103741000 missense probably benign 0.22
R5321:Olfr629 UTSW 7 103740655 missense probably damaging 0.97
R6141:Olfr629 UTSW 7 103740787 missense probably damaging 1.00
R6232:Olfr629 UTSW 7 103740454 missense probably damaging 1.00
R6489:Olfr629 UTSW 7 103740668 missense probably benign 0.09
R6755:Olfr629 UTSW 7 103740500 missense probably damaging 0.99
R7526:Olfr629 UTSW 7 103740400 missense probably damaging 1.00
R7928:Olfr629 UTSW 7 103741190 missense probably damaging 1.00
R8890:Olfr629 UTSW 7 103740468 missense probably damaging 1.00
R9209:Olfr629 UTSW 7 103741112 missense probably benign 0.12
Z1177:Olfr629 UTSW 7 103741068 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TATTGTCACTGAAAGGGCCAC -3'
(R):5'- TTCTACAGCTCTGAAGATGCTTG -3'

Sequencing Primer
(F):5'- GGGCCACCAAGATTCCATATATTCTG -3'
(R):5'- CTACAGCTCTGAAGATGCTTGGTATC -3'
Posted On 2021-07-15