Incidental Mutation 'R8841:Or7e168'
ID 674425
Institutional Source Beutler Lab
Gene Symbol Or7e168
Ensembl Gene ENSMUSG00000095448
Gene Name olfactory receptor family 7 subfamily E member 168
Synonyms Olfr859, GA_x6K02T2PVTD-13548326-13549255, MOR146-3, MOR146-10_p
MMRRC Submission 068732-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.095) question?
Stock # R8841 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 19719616-19720545 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 19719885 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Serine at position 90 (R90S)
Ref Sequence ENSEMBL: ENSMUSP00000148298 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086480] [ENSMUST00000212540] [ENSMUST00000217280]
AlphaFold Q7TRF5
Predicted Effect probably benign
Transcript: ENSMUST00000086480
AA Change: R90S

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000083669
Gene: ENSMUSG00000095448
AA Change: R90S

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 6.2e-54 PFAM
Pfam:7TM_GPCR_Srsx 35 304 2e-7 PFAM
Pfam:7tm_1 41 290 3.9e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000212540
AA Change: R90S

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)
Predicted Effect probably benign
Transcript: ENSMUST00000217280
AA Change: R90S

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 100% (63/63)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca1 C T 4: 53,143,925 (GRCm39) probably benign Het
Chaf1b C T 16: 93,701,908 (GRCm39) T510I probably benign Het
Chrd T A 16: 20,554,487 (GRCm39) probably benign Het
Dennd2d A G 3: 106,393,580 (GRCm39) Q11R probably benign Het
Dmrta1 A C 4: 89,579,950 (GRCm39) R303S probably benign Het
Emsy A G 7: 98,264,768 (GRCm39) I543T possibly damaging Het
Fbxw2 G A 2: 34,712,844 (GRCm39) probably benign Het
Fndc1 A G 17: 7,992,181 (GRCm39) V505A unknown Het
Foxf1 T C 8: 121,811,919 (GRCm39) V261A probably damaging Het
Fyb1 T C 15: 6,681,972 (GRCm39) V773A probably damaging Het
Gask1b A G 3: 79,794,426 (GRCm39) E298G probably benign Het
Glp2r G T 11: 67,653,555 (GRCm39) P77T probably damaging Het
Gpam C A 19: 55,066,950 (GRCm39) D522Y probably damaging Het
Hpgd T A 8: 56,760,709 (GRCm39) N135K probably damaging Het
Hsph1 T A 5: 149,550,789 (GRCm39) R437W probably damaging Het
Kif1c G A 11: 70,615,659 (GRCm39) V588I probably benign Het
Klhdc4 T A 8: 122,523,380 (GRCm39) E554V possibly damaging Het
Krt33a A G 11: 99,904,961 (GRCm39) S182P probably damaging Het
Lad1 A G 1: 135,754,970 (GRCm39) D82G probably benign Het
Lin7a A G 10: 107,218,524 (GRCm39) R145G possibly damaging Het
Lmna A G 3: 88,391,920 (GRCm39) probably null Het
Lrrc8b T C 5: 105,628,188 (GRCm39) V178A probably benign Het
Lrwd1 T C 5: 136,152,037 (GRCm39) R647G possibly damaging Het
Mapt A G 11: 104,201,203 (GRCm39) E153G probably damaging Het
Mefv C T 16: 3,528,842 (GRCm39) C563Y probably benign Het
Myo7b T C 18: 32,097,490 (GRCm39) N1792S probably benign Het
Nkx6-3 C T 8: 23,646,274 (GRCm39) T148M probably damaging Het
Nomo1 T A 7: 45,707,911 (GRCm39) S573T probably benign Het
Ntrk3 G T 7: 78,005,841 (GRCm39) R507S probably damaging Het
Or2v2 A C 11: 49,003,938 (GRCm39) I205S probably benign Het
Or4k15 T A 14: 50,364,666 (GRCm39) F211I probably damaging Het
Or52e5 T A 7: 104,719,479 (GRCm39) N268K possibly damaging Het
Or6c200-ps1 A G 10: 128,870,042 (GRCm39) V223A probably benign Het
Or8g21 A G 9: 38,905,879 (GRCm39) M284T possibly damaging Het
Pcdhb8 A G 18: 37,488,699 (GRCm39) I126V probably benign Het
Phactr4 A G 4: 132,092,884 (GRCm39) probably null Het
Pign T C 1: 105,485,634 (GRCm39) probably benign Het
Plekhn1 A G 4: 156,316,655 (GRCm39) L342P probably damaging Het
Pomk G A 8: 26,476,407 (GRCm39) A49V probably benign Het
Prss50 A G 9: 110,687,480 (GRCm39) D141G probably benign Het
Ralgps1 A C 2: 33,045,329 (GRCm39) F406L probably benign Het
Rexo5 G A 7: 119,448,011 (GRCm39) S752N probably benign Het
Rin3 A T 12: 102,335,537 (GRCm39) I483L probably benign Het
Scn1a T A 2: 66,156,466 (GRCm39) D481V probably benign Het
Scnn1a T C 6: 125,320,208 (GRCm39) I554T probably damaging Het
Shc2 A G 10: 79,458,150 (GRCm39) V511A probably damaging Het
Slc18a2 C T 19: 59,261,713 (GRCm39) S200F probably damaging Het
Slc25a38 A G 9: 119,949,845 (GRCm39) D208G probably damaging Het
Smok3c C A 5: 138,063,537 (GRCm39) D341E probably damaging Het
Tfcp2 A G 15: 100,410,989 (GRCm39) I373T probably damaging Het
Tnpo3 T A 6: 29,589,182 (GRCm39) D56V probably damaging Het
Trrap T A 5: 144,781,021 (GRCm39) Y3261N probably damaging Het
Ttll12 A T 15: 83,465,993 (GRCm39) probably benign Het
Ulk4 A G 9: 121,033,804 (GRCm39) C612R probably damaging Het
Ush1g G T 11: 115,210,007 (GRCm39) D62E probably damaging Het
Vmn2r124 A G 17: 18,283,299 (GRCm39) N331S Het
Vmn2r4 T C 3: 64,314,058 (GRCm39) I308V probably damaging Het
Vwa8 T A 14: 79,184,702 (GRCm39) V400E probably benign Het
Washc2 A G 6: 116,235,916 (GRCm39) D1129G probably benign Het
Washc5 G T 15: 59,206,971 (GRCm39) Q1101K probably damaging Het
Wfdc17 G T 11: 83,594,938 (GRCm39) L7F probably benign Het
Xpo4 T C 14: 57,835,413 (GRCm39) K636R probably damaging Het
Zan T A 5: 137,454,936 (GRCm39) T1367S unknown Het
Zfp691 A T 4: 119,027,861 (GRCm39) S124T probably damaging Het
Other mutations in Or7e168
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00156:Or7e168 APN 9 19,719,692 (GRCm39) missense probably benign 0.09
IGL00897:Or7e168 APN 9 19,719,917 (GRCm39) missense probably damaging 0.97
IGL01132:Or7e168 APN 9 19,719,950 (GRCm39) missense probably damaging 0.97
IGL01768:Or7e168 APN 9 19,720,456 (GRCm39) missense possibly damaging 0.57
IGL02302:Or7e168 APN 9 19,719,981 (GRCm39) missense probably damaging 0.97
IGL02377:Or7e168 APN 9 19,720,343 (GRCm39) missense probably damaging 0.99
IGL02972:Or7e168 APN 9 19,720,238 (GRCm39) missense probably damaging 0.97
R0139:Or7e168 UTSW 9 19,720,165 (GRCm39) missense probably damaging 0.99
R0367:Or7e168 UTSW 9 19,719,839 (GRCm39) missense probably damaging 0.99
R0521:Or7e168 UTSW 9 19,720,156 (GRCm39) missense probably benign 0.00
R1196:Or7e168 UTSW 9 19,719,928 (GRCm39) missense probably benign 0.00
R3742:Or7e168 UTSW 9 19,720,195 (GRCm39) missense probably benign 0.44
R5567:Or7e168 UTSW 9 19,719,674 (GRCm39) missense probably damaging 0.99
R6499:Or7e168 UTSW 9 19,719,847 (GRCm39) missense probably benign
R6501:Or7e168 UTSW 9 19,720,271 (GRCm39) missense possibly damaging 0.95
R6560:Or7e168 UTSW 9 19,720,412 (GRCm39) missense probably benign
R7291:Or7e168 UTSW 9 19,719,944 (GRCm39) missense possibly damaging 0.71
R7623:Or7e168 UTSW 9 19,720,225 (GRCm39) missense possibly damaging 0.93
R7627:Or7e168 UTSW 9 19,719,947 (GRCm39) missense probably damaging 0.99
R8680:Or7e168 UTSW 9 19,720,105 (GRCm39) missense possibly damaging 0.84
R8716:Or7e168 UTSW 9 19,720,165 (GRCm39) missense probably damaging 0.99
R9360:Or7e168 UTSW 9 19,720,529 (GRCm39) missense possibly damaging 0.82
Z1177:Or7e168 UTSW 9 19,719,830 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACTCTCAGAGGACCCTGAACTG -3'
(R):5'- GCACCTGTGAATCAATGAGAC -3'

Sequencing Primer
(F):5'- AACTGCAGTTCATCTTATTTGCAC -3'
(R):5'- CACCTGTGAATCAATGAGACTGATAC -3'
Posted On 2021-07-15