Incidental Mutation 'R8846:Gpr84'
ID 674724
Institutional Source Beutler Lab
Gene Symbol Gpr84
Ensembl Gene ENSMUSG00000063234
Gene Name G protein-coupled receptor 84
Synonyms EX33
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8846 (G1)
Quality Score 225.009
Status Not validated
Chromosome 15
Chromosomal Location 103216662-103219039 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 103218037 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Glutamine at position 13 (H13Q)
Ref Sequence ENSEMBL: ENSMUSP00000078753 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079824] [ENSMUST00000168828] [ENSMUST00000229373] [ENSMUST00000229551]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000079824
AA Change: H13Q

PolyPhen 2 Score 0.605 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000078753
Gene: ENSMUSG00000063234
AA Change: H13Q

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 28 175 5e-10 PFAM
Pfam:7TM_GPCR_Srsx 31 221 7.3e-8 PFAM
Pfam:7tm_1 37 370 7.1e-39 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000168828
SMART Domains Protein: ENSMUSP00000130176
Gene: ENSMUSG00000000552

DomainStartEndE-ValueType
ZnF_U1 71 105 1.05e-2 SMART
ZnF_C2H2 74 98 1.14e0 SMART
low complexity region 157 173 N/A INTRINSIC
ZnF_U1 198 232 2.29e-3 SMART
ZnF_C2H2 201 225 1.91e1 SMART
low complexity region 245 256 N/A INTRINSIC
ZnF_U1 258 292 5.26e-3 SMART
ZnF_C2H2 261 285 2.17e-1 SMART
low complexity region 319 361 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000229373
Predicted Effect probably benign
Transcript: ENSMUST00000229551
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 97.7%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced IL4 production in response to CD3 crosslinking. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc9 T A 6: 142,551,610 (GRCm39) I1198F possibly damaging Het
Adgrv1 C T 13: 81,637,025 (GRCm39) probably null Het
Adprh T C 16: 38,267,775 (GRCm39) H170R probably damaging Het
Arhgef10 T C 8: 15,025,956 (GRCm39) V820A probably benign Het
B3galt1 A G 2: 67,948,717 (GRCm39) D144G probably benign Het
Ccdc88a C T 11: 29,414,185 (GRCm39) R908C probably damaging Het
Ccs A G 19: 4,883,480 (GRCm39) L106P probably damaging Het
Dock10 T C 1: 80,545,786 (GRCm39) D820G possibly damaging Het
Gda A G 19: 21,389,889 (GRCm39) I298T probably damaging Het
Igdcc4 T C 9: 65,037,898 (GRCm39) S760P probably benign Het
Ighv1-53 A C 12: 115,122,165 (GRCm39) I70S probably damaging Het
Itpr3 T A 17: 27,330,996 (GRCm39) I1768N probably damaging Het
Kctd13 C A 7: 126,544,191 (GRCm39) D296E probably benign Het
Krt76 A G 15: 101,795,772 (GRCm39) I466T probably damaging Het
Lamb1 T C 12: 31,379,388 (GRCm39) Y1801H possibly damaging Het
Mapk10 A G 5: 103,144,521 (GRCm39) F129L probably damaging Het
Myo5b G A 18: 74,841,043 (GRCm39) E975K probably benign Het
Nrtn C T 17: 57,058,728 (GRCm39) R91H possibly damaging Het
Olfml2a A T 2: 38,850,255 (GRCm39) Y657F probably damaging Het
Or1j21 T A 2: 36,683,689 (GRCm39) V147E probably benign Het
Or4d10c T C 19: 12,065,433 (GRCm39) H241R probably damaging Het
Pfkfb2 T C 1: 130,625,648 (GRCm39) T511A probably benign Het
Pkd1l3 GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA 8: 110,350,827 (GRCm39) probably benign Het
Pkhd1l1 G T 15: 44,410,358 (GRCm39) G2622* probably null Het
Ppp6r3 A T 19: 3,564,654 (GRCm39) D206E probably damaging Het
Ptpn3 A G 4: 57,205,020 (GRCm39) Y714H probably damaging Het
Rfng C A 11: 120,674,972 (GRCm39) R6L unknown Het
Scrt1 A T 15: 76,405,808 (GRCm39) V33E possibly damaging Het
Siglecg A T 7: 43,061,942 (GRCm39) I563F probably benign Het
Slc1a6 G A 10: 78,637,781 (GRCm39) A436T probably damaging Het
Slc38a9 C A 13: 112,859,814 (GRCm39) S416* probably null Het
Sptbn1 A G 11: 30,075,009 (GRCm39) S1288P possibly damaging Het
Tbce A G 13: 14,194,285 (GRCm39) probably null Het
Tdpoz8 A T 3: 92,981,770 (GRCm39) I189F possibly damaging Het
Topors A G 4: 40,262,952 (GRCm39) F111L probably damaging Het
Vmn1r11 T C 6: 57,114,807 (GRCm39) M157T probably benign Het
Wdfy4 A G 14: 32,867,105 (GRCm39) L459P Het
Zfp738 T C 13: 67,818,155 (GRCm39) N612S probably benign Het
Other mutations in Gpr84
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00479:Gpr84 APN 15 103,217,834 (GRCm39) missense probably damaging 1.00
IGL02566:Gpr84 APN 15 103,217,150 (GRCm39) missense probably benign 0.00
IGL02943:Gpr84 APN 15 103,217,316 (GRCm39) missense probably benign 0.06
R1301:Gpr84 UTSW 15 103,217,646 (GRCm39) missense probably damaging 0.98
R1762:Gpr84 UTSW 15 103,217,754 (GRCm39) missense probably damaging 1.00
R4762:Gpr84 UTSW 15 103,217,027 (GRCm39) missense probably damaging 1.00
R6362:Gpr84 UTSW 15 103,216,937 (GRCm39) missense probably damaging 1.00
R6931:Gpr84 UTSW 15 103,217,441 (GRCm39) missense probably damaging 0.99
R8419:Gpr84 UTSW 15 103,217,963 (GRCm39) missense probably damaging 1.00
R8906:Gpr84 UTSW 15 103,217,625 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATTCTACAGAAGACCGCGC -3'
(R):5'- TCAAGTGCTTTCCAGCCAAG -3'

Sequencing Primer
(F):5'- TGTCCACGGAGAAAGGCTGC -3'
(R):5'- GCTTTCCAGCCAAGAATTAAAGTGAG -3'
Posted On 2021-07-15