Mutagenetix > Incidental Mutation

Incidental Mutation 'R8847:Vmn2r120'

674787

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r120

Ensembl Gene

ENSMUSG00000090655

Gene Name

vomeronasal 2, receptor 120

Synonyms

EG224916

MMRRC Submission

068735-MU

Accession Numbers

Genbank: NM_001104591; MGI: 3644483

Essential gene?

Probably non essential (E-score: 0.115) question?

Stock #

R8847 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

57508783-57545314 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 57509217 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Leucine at position 713 (M713L)

Ref Sequence

ENSEMBL: ENSMUSP00000129296 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165781]

AlphaFold

A0A3Q4EG79

Predicted Effect

probably benign
Transcript: ENSMUST00000165781
AA Change: M713L

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000129296
Gene: ENSMUSG00000090655
AA Change: M713L

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	80	474	5.9e-42	PFAM
Pfam:NCD3G	517	570	7.5e-22	PFAM
Pfam:7tm_3	598	836	1.3e-54	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.4%
20x: 97.9%

Validation Efficiency

100% (64/64)

Allele List at MGI

Other mutations in this stock

Total: 65 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam25	G	C	8: 40,753,709	R4T	probably benign	Het
Alk	T	A	17: 71,949,825	I680F	probably benign	Het
Best3	A	G	10: 116,988,667	T13A	possibly damaging	Het
Ccdc7b	A	G	8: 129,145,601	D59G		Het
Cd300ld2	CGAACTGTGGATGGCAGAACTGTGGATGTCAGAACTGTGGATGGCAGAACTGTGGATGTCAGAACTGTGGATGGCAGAACTGTGGATGTCAGAACTGTGGATGTCAGAACTGTGGATGGCACAACTGTGCATGGCAGAACTGTGGATGGCACAACTGTGGATGGCAGAACTGTGG	CGAACTGTGGATGGCAGAACTGTGGATGTCAGAACTGTGGATGGCAGAACTGTGGATGTCAGAACTGTGGATGTCAGAACTGTGGATGGCACAACTGTGCATGGCAGAACTGTGGATGGCACAACTGTGGATGGCAGAACTGTGG	11: 115,012,431		probably benign	Het
Cic	G	A	7: 25,271,206	V121M	probably damaging	Het
Clasp1	C	G	1: 118,578,975	P1280R	probably damaging	Het
Col6a5	A	T	9: 105,864,273	N2482K	possibly damaging	Het
Crebbp	A	G	16: 4,085,027	M2116T	probably benign	Het
Ddn	T	C	15: 98,806,913	E166G	possibly damaging	Het
Dennd6a	C	T	14: 26,605,931	T249I	probably benign	Het
Diaph1	A	T	18: 37,854,537	D1055E	possibly damaging	Het
Dnajc13	C	A	9: 104,180,161	G1547*	probably null	Het
Dvl1	C	T	4: 155,858,154	R626C	possibly damaging	Het
Fam126b	G	T	1: 58,556,554	P55Q	probably damaging	Het
Fam129a	A	G	1: 151,700,178	E351G	probably damaging	Het
Fer1l6	A	C	15: 58,542,163	K13Q	possibly damaging	Het
Fry	G	A	5: 150,386,007	E639K		Het
Gm6408	G	T	5: 146,483,792	V161L	probably benign	Het
Gpatch8	A	T	11: 102,481,184	N509K	unknown	Het
Ints13	T	C	6: 146,556,133	T416A	probably benign	Het
Iqcf6	A	T	9: 106,627,451	M105L	probably damaging	Het
Magi3	C	A	3: 104,015,018	R1461L	probably benign	Het
Map3k8	A	T	18: 4,333,889	L401Q		Het
Miga2	G	T	2: 30,383,978	R542L	probably damaging	Het
Mphosph9	A	T	5: 124,316,146	V96E	possibly damaging	Het
Nek5	T	C	8: 22,123,579	S28G	probably benign	Het
Notch4	A	G	17: 34,584,988		probably benign	Het
Npc1	A	G	18: 12,190,930	L1275P	probably damaging	Het
Nphp4	C	T	4: 152,506,406	R287C	probably damaging	Het
Olfr1333	T	C	4: 118,829,624	D271G	probably damaging	Het
Olfr341	G	A	2: 36,479,471	R220*	probably null	Het
Olfr406	C	T	11: 74,269,617	T76I	probably damaging	Het
Olfr53	G	C	7: 140,652,413	A145P	possibly damaging	Het
Parn	A	T	16: 13,628,406	L343*	probably null	Het
Pax5	T	A	4: 44,691,865	D127V	probably benign	Het
Peak1	C	A	9: 56,207,143	D1505Y	probably damaging	Het
Perm1	C	T	4: 156,217,611	T204I	probably benign	Het
Pid1	A	T	1: 84,115,973	S65T	unknown	Het
Pkn2	A	G	3: 142,820,640	V392A	probably benign	Het
Plekhh2	A	G	17: 84,571,051	D578G	probably benign	Het
Ppp4r4	T	A	12: 103,596,488	L572Q	probably damaging	Het
Pum3	G	A	19: 27,421,313	T279M	probably damaging	Het
Rasa2	A	G	9: 96,576,349	V266A	possibly damaging	Het
Sirpb1c	C	T	3: 15,832,420	W264*	probably null	Het
Slc35g3	A	T	11: 69,760,573	Y195*	probably null	Het
Slk	T	A	19: 47,619,193	H289Q		Het
Spef2	T	C	15: 9,668,827	S758G	probably benign	Het
Spon2	C	T	5: 33,214,497	A322T	probably benign	Het
Spred2	T	C	11: 20,001,064	L87P	probably benign	Het
Stk10	A	G	11: 32,589,427	D269G		Het
Tex48	T	A	4: 63,612,535		probably benign	Het
Themis2	T	A	4: 132,786,198	H239L	probably damaging	Het
Tle4	T	A	19: 14,516,373	R199*	probably null	Het
Tlr11	C	T	14: 50,362,725	H723Y	possibly damaging	Het
Trdj2	T	A	14: 54,136,780	S1T		Het
Vdac1	T	G	11: 52,376,403	S44A		Het
Vill	C	T	9: 119,068,446	T647I	probably damaging	Het
Vmn1r61	A	G	7: 5,610,818	C166R	probably damaging	Het
Vmn2r114	T	A	17: 23,310,012	N372I	probably damaging	Het
Vmn2r61	T	C	7: 42,300,586	V810A	probably damaging	Het
Vmn2r65	A	T	7: 84,941,004	L568Q	probably damaging	Het
Wdr7	T	C	18: 63,739,222	V409A	probably damaging	Het
Ylpm1	C	A	12: 85,014,898	N524K	unknown	Het
Zfp958	A	C	8: 4,628,434	H153P	probably damaging	Het

Other mutations in Vmn2r120

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01335:Vmn2r120	APN	17	57525732	missense	possibly damaging	0.86
IGL01346:Vmn2r120	APN	17	57545232	missense	probably benign	0.11
IGL01996:Vmn2r120	APN	17	57525222	missense	possibly damaging	0.92
IGL02503:Vmn2r120	APN	17	57509385	missense	probably benign	0.40
IGL02582:Vmn2r120	APN	17	57524724	missense	probably damaging	0.99
IGL02747:Vmn2r120	APN	17	57524719	missense	probably benign	0.19
IGL02896:Vmn2r120	APN	17	57509008	missense	probably damaging	1.00
IGL03139:Vmn2r120	APN	17	57524742	missense	probably benign	0.39
IGL03342:Vmn2r120	APN	17	57509372	missense	probably benign	0.03
A4554:Vmn2r120	UTSW	17	57525715	missense	probably benign	0.01
R0207:Vmn2r120	UTSW	17	57525052	missense	probably benign	0.17
R0472:Vmn2r120	UTSW	17	57524518	missense	probably benign	0.03
R0517:Vmn2r120	UTSW	17	57508949	missense	probably damaging	1.00
R1109:Vmn2r120	UTSW	17	57525829	missense	probably benign	0.09
R1316:Vmn2r120	UTSW	17	57525939	missense	probably benign	0.28
R1543:Vmn2r120	UTSW	17	57522374	missense	probably benign	0.09
R1795:Vmn2r120	UTSW	17	57525038	missense	probably benign	0.35
R1850:Vmn2r120	UTSW	17	57525826	missense	probably benign	0.19
R1920:Vmn2r120	UTSW	17	57524839	missense	probably benign	0.01
R1921:Vmn2r120	UTSW	17	57524839	missense	probably benign	0.01
R1922:Vmn2r120	UTSW	17	57524839	missense	probably benign	0.01
R2063:Vmn2r120	UTSW	17	57524553	missense	possibly damaging	0.88
R2064:Vmn2r120	UTSW	17	57524553	missense	possibly damaging	0.88
R2065:Vmn2r120	UTSW	17	57524553	missense	possibly damaging	0.88
R2067:Vmn2r120	UTSW	17	57524553	missense	possibly damaging	0.88
R2286:Vmn2r120	UTSW	17	57508958	missense	probably damaging	1.00
R2291:Vmn2r120	UTSW	17	57509479	missense	probably damaging	1.00
R3416:Vmn2r120	UTSW	17	57509241	missense	possibly damaging	0.89
R3874:Vmn2r120	UTSW	17	57524954	missense	probably benign	0.40
R4023:Vmn2r120	UTSW	17	57536718	missense	possibly damaging	0.92
R4024:Vmn2r120	UTSW	17	57536718	missense	possibly damaging	0.92
R4348:Vmn2r120	UTSW	17	57522466	missense	possibly damaging	0.47
R4409:Vmn2r120	UTSW	17	57509477	missense	probably damaging	1.00
R4610:Vmn2r120	UTSW	17	57509120	missense	probably damaging	1.00
R4771:Vmn2r120	UTSW	17	57524887	missense	probably damaging	1.00
R4786:Vmn2r120	UTSW	17	57522048	missense	probably benign	0.14
R4927:Vmn2r120	UTSW	17	57509125	missense	probably damaging	1.00
R5285:Vmn2r120	UTSW	17	57536703	missense	probably damaging	1.00
R5566:Vmn2r120	UTSW	17	57545290	missense	possibly damaging	0.95
R5578:Vmn2r120	UTSW	17	57522514	missense	probably benign	0.01
R5643:Vmn2r120	UTSW	17	57524977	missense	probably benign	0.01
R5644:Vmn2r120	UTSW	17	57524977	missense	probably benign	0.01
R5781:Vmn2r120	UTSW	17	57524938	missense	probably benign	0.00
R6084:Vmn2r120	UTSW	17	57525721	missense	probably benign	0.15
R6120:Vmn2r120	UTSW	17	57525973	missense	probably benign	0.02
R6160:Vmn2r120	UTSW	17	57509418	missense	probably benign	0.03
R6248:Vmn2r120	UTSW	17	57545287	missense	probably benign	0.03
R6256:Vmn2r120	UTSW	17	57524700	nonsense	probably null
R6730:Vmn2r120	UTSW	17	57525012	missense	probably benign	0.03
R6821:Vmn2r120	UTSW	17	57536659	missense	probably benign	0.00
R6868:Vmn2r120	UTSW	17	57545218	missense	probably benign	0.00
R6880:Vmn2r120	UTSW	17	57509187	missense	probably damaging	1.00
R6986:Vmn2r120	UTSW	17	57509340	missense	probably damaging	1.00
R7276:Vmn2r120	UTSW	17	57524881	missense	probably benign	0.11
R7373:Vmn2r120	UTSW	17	57509406	missense	probably benign	0.35
R7653:Vmn2r120	UTSW	17	57509258	missense	possibly damaging	0.93
R7667:Vmn2r120	UTSW	17	57536657	missense	probably benign	0.04
R7775:Vmn2r120	UTSW	17	57525942	missense	probably damaging	1.00
R7778:Vmn2r120	UTSW	17	57525942	missense	probably damaging	1.00
R7797:Vmn2r120	UTSW	17	57508874	missense	probably damaging	1.00
R7824:Vmn2r120	UTSW	17	57525942	missense	probably damaging	1.00
R7902:Vmn2r120	UTSW	17	57509244	missense	possibly damaging	0.87
R7922:Vmn2r120	UTSW	17	57524683	missense	probably damaging	0.99
R8508:Vmn2r120	UTSW	17	57525843	missense	probably benign	0.03
R8882:Vmn2r120	UTSW	17	57545229	missense	probably benign	0.01
R9134:Vmn2r120	UTSW	17	57525093	missense	probably damaging	1.00
R9161:Vmn2r120	UTSW	17	57524864	missense
R9336:Vmn2r120	UTSW	17	57525201	missense	possibly damaging	0.91
RF005:Vmn2r120	UTSW	17	57521991	missense	possibly damaging	0.65
Z1177:Vmn2r120	UTSW	17	57509245	missense	probably benign	0.00
Z1188:Vmn2r120	UTSW	17	57522436	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TGTCAGGAACTTGGCTTCATTG -3'
(R):5'- TCCCAACATGGCAACTTGC -3'

Sequencing Primer
(F):5'- AGGTTCCTGGCCCAAAATG -3'
(R):5'- GCAACTTGCATTCTACAGCAGATG -3'

Posted On

2021-07-15