Mutagenetix > Incidental Mutation

Incidental Mutation 'R8851:Tenm4'

675005

Institutional Source

Beutler Lab

Gene Symbol

Tenm4

Ensembl Gene

ENSMUSG00000048078

Gene Name

teneurin transmembrane protein 4

Synonyms

Doc4, l7Rn3, Ten-m4, ELM2, l(7)-3Rn, Odz4

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R8851 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

96171246-96911093 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to C at 96852503 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glycine to Arginine at position 1305 (G1305R)

Ref Sequence

ENSEMBL: ENSMUSP00000102783 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000107162] [ENSMUST00000107165] [ENSMUST00000107166]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000107162
AA Change: G1304R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000102780
Gene: ENSMUSG00000048078
AA Change: G1304R

Domain	Start	End	E-Value	Type
Pfam:Ten_N	10	410	5.6e-195	PFAM
transmembrane domain	411	433	N/A	INTRINSIC
EGF_like	637	665	3.43e1	SMART
EGF	668	696	2.29e1	SMART
EGF	701	730	1.88e-1	SMART
EGF	733	762	1.13e1	SMART
EGF	767	797	2.39e1	SMART
EGF	800	828	4.32e-1	SMART
EGF	831	859	6.02e0	SMART
EGF	862	894	9.93e-1	SMART
low complexity region	900	914	N/A	INTRINSIC
Pfam:RHS_repeat	2327	2380	5.5e-7	PFAM
Pfam:Tox-GHH	2740	2818	5.2e-34	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000107165
AA Change: G1305R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000102783
Gene: ENSMUSG00000048078
AA Change: G1305R

Domain	Start	End	E-Value	Type
Pfam:Ten_N	36	402	1.1e-171	PFAM
transmembrane domain	403	425	N/A	INTRINSIC
EGF_like	629	657	3.43e1	SMART
EGF	660	688	2.29e1	SMART
EGF	693	722	1.88e-1	SMART
EGF	725	754	1.13e1	SMART
EGF	759	789	2.39e1	SMART
EGF	792	820	4.32e-1	SMART
EGF	823	851	6.02e0	SMART
EGF	863	895	9.93e-1	SMART
low complexity region	901	915	N/A	INTRINSIC
Pfam:RHS_repeat	2335	2368	1.6e-7	PFAM
Pfam:Tox-GHH	2749	2826	1.8e-32	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000107166
AA Change: G1268R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000102784
Gene: ENSMUSG00000048078
AA Change: G1268R

Domain	Start	End	E-Value	Type
Pfam:Ten_N	35	193	1.4e-83	PFAM
Pfam:Ten_N	187	365	5e-78	PFAM
transmembrane domain	366	388	N/A	INTRINSIC
EGF_like	592	620	3.43e1	SMART
EGF	623	651	2.29e1	SMART
EGF	656	685	1.88e-1	SMART
EGF	688	717	1.13e1	SMART
EGF	722	752	2.39e1	SMART
EGF	755	783	4.32e-1	SMART
EGF	786	814	6.02e0	SMART
EGF	826	858	9.93e-1	SMART
low complexity region	864	878	N/A	INTRINSIC
Pfam:RHS_repeat	2298	2351	3.8e-7	PFAM
Pfam:Tox-GHH	2711	2789	3.9e-34	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 98.9%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene plays a role in establishing proper neuronal connectivity during development. Defects in this gene have been associated with hereditary essential tremor-5. [provided by RefSeq, Oct 2016]
PHENOTYPE: Various ENU-induced alleles cause prenatal lethality associated with impaired mesoderm development and lead to pleiotropic phenotypes. The most severe alleles cause failure of gastrulation and somitogenesis while the least severe one allows survival to adulthood with runting of variable penetrance. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ackr1	T	A	1: 173,332,116 (GRCm38)	I279F	probably benign	Het
Adamts7	A	G	9: 90,193,110 (GRCm38)	N965S	probably benign	Het
Adgrl3	A	G	5: 81,465,272 (GRCm38)	Y184C	probably damaging	Het
Ankar	T	C	1: 72,652,376 (GRCm38)	Y1142C	probably damaging	Het
Apoa4	A	G	9: 46,242,608 (GRCm38)	K169R	probably benign	Het
AY761184	T	A	8: 21,703,539 (GRCm38)	I22F	possibly damaging	Het
Cd22	T	A	7: 30,877,659 (GRCm38)	K74N	probably benign	Het
Dgcr2	G	A	16: 17,872,643 (GRCm38)	T41I	possibly damaging	Het
Dicer1	A	G	12: 104,724,041 (GRCm38)	V245A	possibly damaging	Het
Dopey2	T	A	16: 93,762,510 (GRCm38)	S715T	probably benign	Het
Epb41l1	A	T	2: 156,522,511 (GRCm38)	H980L	probably benign	Het
Erc2	A	T	14: 28,317,259 (GRCm38)	E973V	probably null	Het
Fam124b	T	A	1: 80,213,165 (GRCm38)	Q167L	probably damaging	Het
Frmpd2	A	G	14: 33,495,686 (GRCm38)	E46G	probably damaging	Het
Gabrb2	G	A	11: 42,421,359 (GRCm38)	V4I	probably benign	Het
Gbf1	T	A	19: 46,268,483 (GRCm38)	N841K	probably damaging	Het
Gnpat	A	G	8: 124,874,265 (GRCm38)	H161R	probably damaging	Het
Gpd2	A	T	2: 57,307,050 (GRCm38)	M206L	possibly damaging	Het
Grid2ip	T	C	5: 143,362,597 (GRCm38)	F148L	possibly damaging	Het
Hemk1	A	G	9: 107,336,213 (GRCm38)	V128A	probably benign	Het
Ism1	G	T	2: 139,749,545 (GRCm38)	S273I	probably damaging	Het
Kcnab3	G	T	11: 69,328,164 (GRCm38)		probably null	Het
Kdm6b	A	G	11: 69,401,167 (GRCm38)	Y1430H	unknown	Het
Lama2	A	G	10: 27,366,123 (GRCm38)	V279A	possibly damaging	Het
Lmf1	G	A	17: 25,585,706 (GRCm38)	W119*	probably null	Het
Lrrc42	A	G	4: 107,239,178 (GRCm38)	V276A	probably benign	Het
Magi2	T	C	5: 20,065,620 (GRCm38)	F163L	probably damaging	Het
Map2k2	A	G	10: 81,119,263 (GRCm38)	K196R	probably damaging	Het
Mfsd11	C	A	11: 116,861,653 (GRCm38)	D209E	probably benign	Het
Muc1	C	A	3: 89,231,118 (GRCm38)	F422L	probably benign	Het
Muc13	A	G	16: 33,810,903 (GRCm38)	H391R	probably benign	Het
Mxi1	G	A	19: 53,371,695 (GRCm38)	G283S	probably damaging	Het
Nfatc2ip	T	C	7: 126,387,445 (GRCm38)	Q346R	probably damaging	Het
Olfr971	A	G	9: 39,840,304 (GRCm38)	Y290C	probably damaging	Het
Otol1	T	A	3: 70,027,966 (GRCm38)	D430E	probably damaging	Het
Pcdh1	T	C	18: 38,192,102 (GRCm38)	E929G	probably damaging	Het
Plekhf1	C	T	7: 38,222,042 (GRCm38)	R34H	probably damaging	Het
Plekhm2	A	T	4: 141,631,328 (GRCm38)	V622E	probably benign	Het
Pomt2	G	A	12: 87,138,064 (GRCm38)	T196I	probably damaging	Het
Ppp1r12c	C	T	7: 4,484,704 (GRCm38)	G436D	probably damaging	Het
Prss50	A	G	9: 110,858,013 (GRCm38)		probably benign	Het
Slc29a1	A	G	17: 45,589,476 (GRCm38)	I176T	probably damaging	Het
Slc5a9	A	T	4: 111,898,593 (GRCm38)	V36E	probably damaging	Het
Slc7a1	A	C	5: 148,348,283 (GRCm38)	S133R	probably damaging	Het
Sox17	A	G	1: 4,491,850 (GRCm38)	Y376H	probably benign	Het
Spata4	T	C	8: 54,609,900 (GRCm38)	I280T	probably benign	Het
Svop	T	A	5: 114,054,496 (GRCm38)	I187F	probably damaging	Het
Tas2r103	T	A	6: 133,036,933 (GRCm38)	I57F		Het
Tead3	A	G	17: 28,332,730 (GRCm38)	V463A	probably damaging	Het
Tmem55a	T	C	4: 14,912,491 (GRCm38)	M200T	possibly damaging	Het
Top2a	A	T	11: 99,009,851 (GRCm38)	F594L	probably damaging	Het
Trim23	A	G	13: 104,198,065 (GRCm38)	T419A	possibly damaging	Het
Ttn	T	C	2: 76,798,893 (GRCm38)	E12621G	probably damaging	Het
Ttyh2	A	G	11: 114,702,264 (GRCm38)	I254V	probably benign	Het
Vmn2r58	T	C	7: 41,837,795 (GRCm38)	M559V	probably benign	Het
Wwp1	A	T	4: 19,643,437 (GRCm38)	H358Q	probably null	Het
Zcwpw1	A	C	5: 137,822,364 (GRCm38)	D597A	probably damaging	Het
Zfp318	A	T	17: 46,399,835 (GRCm38)	Y828F	probably damaging	Het
Zfp608	T	A	18: 54,899,122 (GRCm38)	N582I	possibly damaging	Het

Other mutations in Tenm4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00228:Tenm4	APN	7	96,868,009 (GRCm38)	missense	probably benign	0.00
IGL00468:Tenm4	APN	7	96,874,472 (GRCm38)	missense	probably damaging	0.98
IGL00519:Tenm4	APN	7	96,805,138 (GRCm38)	splice site	probably benign
IGL00979:Tenm4	APN	7	96,729,391 (GRCm38)	missense	probably damaging	0.96
IGL01401:Tenm4	APN	7	96,874,267 (GRCm38)	missense	probably damaging	1.00
IGL01459:Tenm4	APN	7	96,729,385 (GRCm38)	missense	probably damaging	1.00
IGL01519:Tenm4	APN	7	96,895,177 (GRCm38)	missense	probably damaging	1.00
IGL01545:Tenm4	APN	7	96,874,303 (GRCm38)	missense	probably benign	0.00
IGL01579:Tenm4	APN	7	96,863,502 (GRCm38)	missense	probably benign	0.00
IGL01587:Tenm4	APN	7	96,863,502 (GRCm38)	missense	probably benign	0.00
IGL01625:Tenm4	APN	7	96,885,358 (GRCm38)	missense	probably damaging	1.00
IGL01655:Tenm4	APN	7	96,553,724 (GRCm38)	missense	probably damaging	1.00
IGL01683:Tenm4	APN	7	96,885,404 (GRCm38)	missense	possibly damaging	0.84
IGL01728:Tenm4	APN	7	96,896,064 (GRCm38)	missense	probably damaging	1.00
IGL01732:Tenm4	APN	7	96,895,509 (GRCm38)	missense	probably damaging	1.00
IGL01924:Tenm4	APN	7	96,895,212 (GRCm38)	missense	probably damaging	1.00
IGL01966:Tenm4	APN	7	96,553,550 (GRCm38)	missense	probably damaging	1.00
IGL02177:Tenm4	APN	7	96,895,662 (GRCm38)	missense	probably benign	0.40
IGL02207:Tenm4	APN	7	96,874,116 (GRCm38)	missense	possibly damaging	0.85
IGL02269:Tenm4	APN	7	96,823,822 (GRCm38)	missense	probably damaging	1.00
IGL02274:Tenm4	APN	7	96,854,734 (GRCm38)	missense	probably damaging	1.00
IGL02375:Tenm4	APN	7	96,704,137 (GRCm38)	missense	possibly damaging	0.52
IGL02415:Tenm4	APN	7	96,874,074 (GRCm38)	missense	probably damaging	0.98
IGL02472:Tenm4	APN	7	96,774,176 (GRCm38)	unclassified	probably benign
IGL02656:Tenm4	APN	7	96,885,433 (GRCm38)	missense	probably damaging	1.00
IGL02678:Tenm4	APN	7	96,896,219 (GRCm38)	missense	probably damaging	1.00
IGL02829:Tenm4	APN	7	96,894,998 (GRCm38)	nonsense	probably null
IGL02863:Tenm4	APN	7	96,873,706 (GRCm38)	missense	probably damaging	1.00
IGL03145:Tenm4	APN	7	96,842,968 (GRCm38)	missense	probably damaging	0.98
IGL03153:Tenm4	APN	7	96,873,762 (GRCm38)	missense	probably damaging	1.00
principium	UTSW	7	96,797,481 (GRCm38)	missense	probably damaging	0.98
toccata	UTSW	7	96,902,989 (GRCm38)	critical splice donor site	probably null
P0026:Tenm4	UTSW	7	96,874,527 (GRCm38)	missense	probably damaging	1.00
R0097:Tenm4	UTSW	7	96,892,926 (GRCm38)	missense	probably damaging	1.00
R0097:Tenm4	UTSW	7	96,892,926 (GRCm38)	missense	probably damaging	1.00
R0140:Tenm4	UTSW	7	96,896,052 (GRCm38)	missense	possibly damaging	0.78
R0164:Tenm4	UTSW	7	96,729,340 (GRCm38)	splice site	probably benign
R0277:Tenm4	UTSW	7	96,694,950 (GRCm38)	missense	possibly damaging	0.54
R0323:Tenm4	UTSW	7	96,694,950 (GRCm38)	missense	possibly damaging	0.54
R0362:Tenm4	UTSW	7	96,772,035 (GRCm38)	nonsense	probably null
R0381:Tenm4	UTSW	7	96,905,881 (GRCm38)	missense	probably damaging	1.00
R0420:Tenm4	UTSW	7	96,873,766 (GRCm38)	missense	possibly damaging	0.85
R0426:Tenm4	UTSW	7	96,777,851 (GRCm38)	missense	probably damaging	1.00
R0513:Tenm4	UTSW	7	96,895,623 (GRCm38)	missense	probably benign	0.35
R0624:Tenm4	UTSW	7	96,774,020 (GRCm38)	missense	probably damaging	1.00
R0837:Tenm4	UTSW	7	96,896,275 (GRCm38)	splice site	probably benign
R1037:Tenm4	UTSW	7	96,797,481 (GRCm38)	missense	probably damaging	0.98
R1172:Tenm4	UTSW	7	96,848,044 (GRCm38)	missense	probably damaging	1.00
R1422:Tenm4	UTSW	7	96,550,051 (GRCm38)	missense	probably damaging	0.99
R1427:Tenm4	UTSW	7	96,843,048 (GRCm38)	missense	probably benign	0.42
R1462:Tenm4	UTSW	7	96,704,153 (GRCm38)	missense	probably damaging	1.00
R1462:Tenm4	UTSW	7	96,704,153 (GRCm38)	missense	probably damaging	1.00
R1597:Tenm4	UTSW	7	96,902,989 (GRCm38)	critical splice donor site	probably null
R1701:Tenm4	UTSW	7	96,902,889 (GRCm38)	missense	probably damaging	1.00
R1707:Tenm4	UTSW	7	96,888,685 (GRCm38)	missense	probably damaging	1.00
R1809:Tenm4	UTSW	7	96,873,780 (GRCm38)	missense	probably benign	0.17
R1812:Tenm4	UTSW	7	96,895,940 (GRCm38)	missense	probably damaging	1.00
R1895:Tenm4	UTSW	7	96,735,808 (GRCm38)	missense	probably damaging	1.00
R1933:Tenm4	UTSW	7	96,895,326 (GRCm38)	missense	probably damaging	1.00
R1946:Tenm4	UTSW	7	96,735,808 (GRCm38)	missense	probably damaging	1.00
R2108:Tenm4	UTSW	7	96,906,290 (GRCm38)	missense	probably damaging	1.00
R2151:Tenm4	UTSW	7	96,902,847 (GRCm38)	missense	probably damaging	1.00
R2247:Tenm4	UTSW	7	96,906,009 (GRCm38)	missense	probably benign	0.03
R2329:Tenm4	UTSW	7	96,895,862 (GRCm38)	missense	probably benign	0.00
R2893:Tenm4	UTSW	7	96,894,990 (GRCm38)	missense	probably damaging	1.00
R2990:Tenm4	UTSW	7	96,893,125 (GRCm38)	splice site	probably null
R3409:Tenm4	UTSW	7	96,895,160 (GRCm38)	missense	probably damaging	1.00
R3410:Tenm4	UTSW	7	96,852,530 (GRCm38)	missense	probably damaging	0.99
R3411:Tenm4	UTSW	7	96,852,530 (GRCm38)	missense	probably damaging	0.99
R3440:Tenm4	UTSW	7	96,553,516 (GRCm38)	missense	probably benign	0.00
R3441:Tenm4	UTSW	7	96,553,516 (GRCm38)	missense	probably benign	0.00
R3719:Tenm4	UTSW	7	96,863,563 (GRCm38)	missense	possibly damaging	0.92
R3772:Tenm4	UTSW	7	96,694,880 (GRCm38)	missense	probably damaging	1.00
R3773:Tenm4	UTSW	7	96,694,880 (GRCm38)	missense	probably damaging	1.00
R4093:Tenm4	UTSW	7	96,895,772 (GRCm38)	missense	probably damaging	1.00
R4439:Tenm4	UTSW	7	96,895,815 (GRCm38)	missense	probably benign	0.01
R4441:Tenm4	UTSW	7	96,895,815 (GRCm38)	missense	probably benign	0.01
R4510:Tenm4	UTSW	7	96,894,863 (GRCm38)	missense	probably benign
R4511:Tenm4	UTSW	7	96,894,863 (GRCm38)	missense	probably benign
R4543:Tenm4	UTSW	7	96,895,815 (GRCm38)	missense	probably benign	0.01
R4645:Tenm4	UTSW	7	96,895,742 (GRCm38)	missense	probably damaging	1.00
R4701:Tenm4	UTSW	7	96,895,349 (GRCm38)	missense	probably damaging	1.00
R4707:Tenm4	UTSW	7	96,774,046 (GRCm38)	missense	probably damaging	0.99
R4714:Tenm4	UTSW	7	96,894,924 (GRCm38)	missense	probably damaging	1.00
R4742:Tenm4	UTSW	7	96,797,484 (GRCm38)	missense	probably damaging	0.99
R4784:Tenm4	UTSW	7	96,774,046 (GRCm38)	missense	probably damaging	0.99
R4785:Tenm4	UTSW	7	96,774,046 (GRCm38)	missense	probably damaging	0.99
R4801:Tenm4	UTSW	7	96,906,245 (GRCm38)	missense	probably damaging	0.97
R4802:Tenm4	UTSW	7	96,906,245 (GRCm38)	missense	probably damaging	0.97
R4880:Tenm4	UTSW	7	96,905,818 (GRCm38)	splice site	probably null
R5036:Tenm4	UTSW	7	96,852,561 (GRCm38)	missense	probably damaging	1.00
R5036:Tenm4	UTSW	7	96,694,790 (GRCm38)	missense	probably damaging	1.00
R5050:Tenm4	UTSW	7	96,895,788 (GRCm38)	missense	probably damaging	1.00
R5103:Tenm4	UTSW	7	96,842,957 (GRCm38)	missense	probably damaging	1.00
R5106:Tenm4	UTSW	7	96,843,149 (GRCm38)	missense	probably damaging	0.99
R5118:Tenm4	UTSW	7	96,893,086 (GRCm38)	missense	probably damaging	1.00
R5272:Tenm4	UTSW	7	96,874,203 (GRCm38)	missense	probably damaging	0.98
R5282:Tenm4	UTSW	7	96,837,331 (GRCm38)	missense	possibly damaging	0.90
R5403:Tenm4	UTSW	7	96,888,827 (GRCm38)	missense	probably damaging	1.00
R5404:Tenm4	UTSW	7	96,894,680 (GRCm38)	missense	probably damaging	1.00
R5567:Tenm4	UTSW	7	96,896,209 (GRCm38)	nonsense	probably null
R5590:Tenm4	UTSW	7	96,797,401 (GRCm38)	missense	possibly damaging	0.93
R5590:Tenm4	UTSW	7	96,797,400 (GRCm38)	missense	possibly damaging	0.73
R5597:Tenm4	UTSW	7	96,553,517 (GRCm38)	missense	probably benign	0.00
R5782:Tenm4	UTSW	7	96,893,039 (GRCm38)	missense	probably benign	0.00
R5861:Tenm4	UTSW	7	96,843,217 (GRCm38)	intron	probably benign
R5890:Tenm4	UTSW	7	96,902,860 (GRCm38)	missense	probably damaging	1.00
R5930:Tenm4	UTSW	7	96,854,719 (GRCm38)	missense	probably damaging	1.00
R5940:Tenm4	UTSW	7	96,845,895 (GRCm38)	missense	probably damaging	1.00
R6012:Tenm4	UTSW	7	96,522,433 (GRCm38)	intron	probably benign
R6060:Tenm4	UTSW	7	96,873,711 (GRCm38)	missense	probably damaging	1.00
R6104:Tenm4	UTSW	7	96,837,289 (GRCm38)	missense	probably damaging	0.97
R6283:Tenm4	UTSW	7	96,874,494 (GRCm38)	missense	probably benign	0.33
R6333:Tenm4	UTSW	7	96,774,124 (GRCm38)	missense	probably damaging	1.00
R6522:Tenm4	UTSW	7	96,843,044 (GRCm38)	missense	possibly damaging	0.88
R6616:Tenm4	UTSW	7	96,553,496 (GRCm38)	missense	probably benign	0.01
R6746:Tenm4	UTSW	7	96,892,860 (GRCm38)	missense	probably damaging	1.00
R6751:Tenm4	UTSW	7	96,845,712 (GRCm38)	missense	possibly damaging	0.95
R6806:Tenm4	UTSW	7	96,811,959 (GRCm38)	missense	possibly damaging	0.95
R6807:Tenm4	UTSW	7	96,895,271 (GRCm38)	missense	probably damaging	1.00
R6807:Tenm4	UTSW	7	96,553,496 (GRCm38)	missense	probably benign	0.01
R6809:Tenm4	UTSW	7	96,553,496 (GRCm38)	missense	probably benign	0.01
R6810:Tenm4	UTSW	7	96,553,496 (GRCm38)	missense	probably benign	0.01
R6811:Tenm4	UTSW	7	96,553,496 (GRCm38)	missense	probably benign	0.01
R6853:Tenm4	UTSW	7	96,837,295 (GRCm38)	missense	possibly damaging	0.94
R6886:Tenm4	UTSW	7	96,797,392 (GRCm38)	missense	possibly damaging	0.85
R6920:Tenm4	UTSW	7	96,895,550 (GRCm38)	missense	probably damaging	1.00
R6937:Tenm4	UTSW	7	96,553,496 (GRCm38)	missense	probably benign	0.01
R6939:Tenm4	UTSW	7	96,553,496 (GRCm38)	missense	probably benign	0.01
R7011:Tenm4	UTSW	7	96,896,135 (GRCm38)	nonsense	probably null
R7033:Tenm4	UTSW	7	96,895,223 (GRCm38)	nonsense	probably null
R7040:Tenm4	UTSW	7	96,553,496 (GRCm38)	missense	probably benign	0.01
R7083:Tenm4	UTSW	7	96,895,349 (GRCm38)	missense	probably damaging	1.00
R7238:Tenm4	UTSW	7	96,553,496 (GRCm38)	missense	probably benign	0.01
R7239:Tenm4	UTSW	7	96,735,813 (GRCm38)	missense	possibly damaging	0.47
R7239:Tenm4	UTSW	7	96,553,496 (GRCm38)	missense	probably benign	0.01
R7337:Tenm4	UTSW	7	96,874,126 (GRCm38)	missense	probably benign	0.44
R7400:Tenm4	UTSW	7	96,694,803 (GRCm38)	missense	probably damaging	0.97
R7407:Tenm4	UTSW	7	96,773,987 (GRCm38)	missense	possibly damaging	0.89
R7449:Tenm4	UTSW	7	96,874,213 (GRCm38)	missense	possibly damaging	0.65
R7473:Tenm4	UTSW	7	96,774,146 (GRCm38)	missense	probably damaging	1.00
R7477:Tenm4	UTSW	7	96,845,808 (GRCm38)	missense	probably damaging	0.99
R7489:Tenm4	UTSW	7	96,837,314 (GRCm38)	missense	possibly damaging	0.90
R7498:Tenm4	UTSW	7	96,848,017 (GRCm38)	missense	probably damaging	1.00
R7562:Tenm4	UTSW	7	96,888,814 (GRCm38)	missense	probably damaging	1.00
R7615:Tenm4	UTSW	7	96,845,926 (GRCm38)	missense	probably damaging	1.00
R7624:Tenm4	UTSW	7	96,895,985 (GRCm38)	missense	possibly damaging	0.95
R7626:Tenm4	UTSW	7	96,893,014 (GRCm38)	missense	probably damaging	1.00
R7690:Tenm4	UTSW	7	96,863,533 (GRCm38)	missense	probably benign	0.00
R7692:Tenm4	UTSW	7	96,895,403 (GRCm38)	missense	probably damaging	1.00
R7748:Tenm4	UTSW	7	96,894,702 (GRCm38)	missense	probably damaging	1.00
R7763:Tenm4	UTSW	7	96,895,692 (GRCm38)	missense	probably benign	0.38
R7792:Tenm4	UTSW	7	96,774,014 (GRCm38)	missense	possibly damaging	0.54
R7855:Tenm4	UTSW	7	96,873,874 (GRCm38)	missense	probably damaging	1.00
R7868:Tenm4	UTSW	7	96,906,380 (GRCm38)	missense	possibly damaging	0.79
R7878:Tenm4	UTSW	7	96,852,357 (GRCm38)	missense	probably damaging	1.00
R7997:Tenm4	UTSW	7	96,874,305 (GRCm38)	missense	probably benign	0.44
R8017:Tenm4	UTSW	7	96,704,041 (GRCm38)	missense	probably damaging	1.00
R8019:Tenm4	UTSW	7	96,704,041 (GRCm38)	missense	probably damaging	1.00
R8054:Tenm4	UTSW	7	96,729,346 (GRCm38)	splice site	probably benign
R8061:Tenm4	UTSW	7	96,852,456 (GRCm38)	missense	probably damaging	1.00
R8108:Tenm4	UTSW	7	96,854,728 (GRCm38)	missense	probably benign	0.39
R8140:Tenm4	UTSW	7	96,895,176 (GRCm38)	missense	probably damaging	1.00
R8214:Tenm4	UTSW	7	96,895,407 (GRCm38)	missense	probably damaging	1.00
R8258:Tenm4	UTSW	7	96,867,991 (GRCm38)	missense	probably damaging	1.00
R8259:Tenm4	UTSW	7	96,867,991 (GRCm38)	missense	probably damaging	1.00
R8364:Tenm4	UTSW	7	96,772,106 (GRCm38)	critical splice donor site	probably null
R8542:Tenm4	UTSW	7	96,811,932 (GRCm38)	missense	probably damaging	0.99
R8669:Tenm4	UTSW	7	96,905,941 (GRCm38)	missense	probably benign
R8670:Tenm4	UTSW	7	96,905,941 (GRCm38)	missense	probably benign
R8683:Tenm4	UTSW	7	96,902,857 (GRCm38)	missense	probably damaging	0.99
R8691:Tenm4	UTSW	7	96,905,941 (GRCm38)	missense	probably benign
R8692:Tenm4	UTSW	7	96,905,941 (GRCm38)	missense	probably benign
R8714:Tenm4	UTSW	7	96,905,941 (GRCm38)	missense	probably benign
R8716:Tenm4	UTSW	7	96,905,941 (GRCm38)	missense	probably benign
R8735:Tenm4	UTSW	7	96,905,941 (GRCm38)	missense	probably benign
R8736:Tenm4	UTSW	7	96,905,941 (GRCm38)	missense	probably benign
R8737:Tenm4	UTSW	7	96,905,941 (GRCm38)	missense	probably benign
R8738:Tenm4	UTSW	7	96,905,941 (GRCm38)	missense	probably benign
R8738:Tenm4	UTSW	7	96,873,840 (GRCm38)	missense	probably damaging	1.00
R8739:Tenm4	UTSW	7	96,905,941 (GRCm38)	missense	probably benign
R8776:Tenm4	UTSW	7	96,895,032 (GRCm38)	missense	probably damaging	1.00
R8776-TAIL:Tenm4	UTSW	7	96,895,032 (GRCm38)	missense	probably damaging	1.00
R8777:Tenm4	UTSW	7	96,896,037 (GRCm38)	missense	probably damaging	1.00
R8777-TAIL:Tenm4	UTSW	7	96,896,037 (GRCm38)	missense	probably damaging	1.00
R8817:Tenm4	UTSW	7	96,874,128 (GRCm38)	missense	probably benign	0.01
R8913:Tenm4	UTSW	7	96,702,745 (GRCm38)	splice site	probably benign
R8977:Tenm4	UTSW	7	96,811,970 (GRCm38)	missense	probably damaging	1.00
R9100:Tenm4	UTSW	7	96,845,854 (GRCm38)	missense	probably damaging	1.00
R9136:Tenm4	UTSW	7	96,823,918 (GRCm38)	missense	possibly damaging	0.69
R9163:Tenm4	UTSW	7	96,823,873 (GRCm38)	missense	probably damaging	1.00
R9188:Tenm4	UTSW	7	96,772,027 (GRCm38)	missense	probably damaging	1.00
R9195:Tenm4	UTSW	7	96,892,919 (GRCm38)	missense	probably damaging	1.00
R9217:Tenm4	UTSW	7	96,885,439 (GRCm38)	missense	probably damaging	1.00
R9344:Tenm4	UTSW	7	96,896,145 (GRCm38)	missense	probably damaging	1.00
R9414:Tenm4	UTSW	7	96,896,160 (GRCm38)	missense	probably benign
R9466:Tenm4	UTSW	7	96,550,045 (GRCm38)	missense	possibly damaging	0.79
R9559:Tenm4	UTSW	7	96,823,849 (GRCm38)	missense	probably benign
R9626:Tenm4	UTSW	7	96,896,138 (GRCm38)	missense	probably damaging	1.00
R9673:Tenm4	UTSW	7	96,867,989 (GRCm38)	missense	probably damaging	1.00
R9676:Tenm4	UTSW	7	96,895,431 (GRCm38)	missense	probably damaging	1.00
R9678:Tenm4	UTSW	7	96,737,412 (GRCm38)	missense	possibly damaging	0.94
R9775:Tenm4	UTSW	7	96,906,554 (GRCm38)	missense	possibly damaging	0.92
R9790:Tenm4	UTSW	7	96,888,839 (GRCm38)	missense	probably damaging	1.00
R9791:Tenm4	UTSW	7	96,888,839 (GRCm38)	missense	probably damaging	1.00
R9803:Tenm4	UTSW	7	96,553,478 (GRCm38)	missense	probably damaging	1.00
X0021:Tenm4	UTSW	7	96,873,909 (GRCm38)	nonsense	probably null
X0026:Tenm4	UTSW	7	96,868,087 (GRCm38)	missense	probably damaging	0.98
X0066:Tenm4	UTSW	7	96,894,794 (GRCm38)	missense	probably damaging	1.00
X0066:Tenm4	UTSW	7	96,848,030 (GRCm38)	missense	probably damaging	1.00
Z1176:Tenm4	UTSW	7	96,905,914 (GRCm38)	missense	probably benign	0.00
Z1177:Tenm4	UTSW	7	96,863,585 (GRCm38)	missense	probably damaging	0.96

Predicted Primers

PCR Primer
(F):5'- TCAAGATAACATTGGCCAGCC -3'
(R):5'- ACTTCTCTGGTCCCTATGGG -3'

Sequencing Primer
(F):5'- AAAAGGACCCGGCCTCTGTTC -3'
(R):5'- CCTATGGGTAGGGCTGTTGG -3'

Posted On

2021-07-15