Incidental Mutation 'R8853:Plcl2'
ID 675146
Institutional Source Beutler Lab
Gene Symbol Plcl2
Ensembl Gene ENSMUSG00000038910
Gene Name phospholipase C-like 2
Synonyms Plce2, PRIP-2
MMRRC Submission 068675-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.221) question?
Stock # R8853 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 50816431-50995512 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 50913884 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Stop codon at position 298 (R298*)
Ref Sequence ENSEMBL: ENSMUSP00000046584 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043938]
AlphaFold Q8K394
Predicted Effect probably null
Transcript: ENSMUST00000043938
AA Change: R298*
SMART Domains Protein: ENSMUSP00000046584
Gene: ENSMUSG00000038910
AA Change: R298*

DomainStartEndE-ValueType
low complexity region 20 49 N/A INTRINSIC
PH 143 254 2.88e-5 SMART
Pfam:EF-hand_like 344 426 3.7e-29 PFAM
PLCXc 427 571 2.19e-84 SMART
PLCYc 619 735 4.37e-61 SMART
C2 756 862 3.45e-19 SMART
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency 98% (56/57)
MGI Phenotype PHENOTYPE: Inactivation of this gene is compatible with normal immune cell development, though the B cell response is dysregulated. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aoc1 A T 6: 48,882,994 (GRCm39) Y290F probably benign Het
Ap5m1 T A 14: 49,311,337 (GRCm39) L136M possibly damaging Het
Arpp21 T G 9: 111,976,516 (GRCm39) T322P probably damaging Het
Atp6v1c2 C T 12: 17,351,148 (GRCm39) V128M possibly damaging Het
C4b A G 17: 34,948,879 (GRCm39) V1523A possibly damaging Het
Copg2 G C 6: 30,803,115 (GRCm39) L277V probably benign Het
Cyp2b19 A G 7: 26,456,645 (GRCm39) T12A possibly damaging Het
D5Ertd579e A T 5: 36,787,024 (GRCm39) C115S probably damaging Het
Defb35 G A 8: 22,430,806 (GRCm39) R60Q unknown Het
Dlgap3 T A 4: 127,088,810 (GRCm39) D135E probably damaging Het
Dync2h1 A T 9: 7,117,645 (GRCm39) W2215R possibly damaging Het
Eea1 G C 10: 95,857,517 (GRCm39) A660P Het
Egfr A G 11: 16,858,885 (GRCm39) I955V possibly damaging Het
Eif3b G A 5: 140,425,774 (GRCm39) V655M probably damaging Het
Elp3 T A 14: 65,815,390 (GRCm39) I220F probably benign Het
Ern2 A G 7: 121,772,967 (GRCm39) V550A probably damaging Het
Evc G A 5: 37,460,647 (GRCm39) S857L possibly damaging Het
Glt28d2 T A 3: 85,779,087 (GRCm39) M129L probably benign Het
Hcn1 ACAGCAGCAGCAGCAGCAGCAGCAACAGCAACAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGC ACAGCAGCAGCAGCAGCAGCAACAGCAACAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGC 13: 118,112,269 (GRCm39) probably benign Het
Hmcn1 A T 1: 150,547,726 (GRCm39) Y2742N probably damaging Het
Klhl6 T A 16: 19,765,979 (GRCm39) Q541L possibly damaging Het
Myh14 G A 7: 44,265,678 (GRCm39) T1559I probably benign Het
Myo7b A G 18: 32,119,744 (GRCm39) F783L possibly damaging Het
Myrip C T 9: 120,290,487 (GRCm39) A702V probably damaging Het
Ndnf C A 6: 65,680,161 (GRCm39) Q147K probably benign Het
Necab2 C G 8: 120,189,339 (GRCm39) R170G possibly damaging Het
Nfatc4 T C 14: 56,063,690 (GRCm39) I59T probably damaging Het
Nfix A G 8: 85,454,276 (GRCm39) S211P probably damaging Het
Nlrp5 A T 7: 23,117,725 (GRCm39) Q483L possibly damaging Het
Or6k14 T C 1: 173,927,861 (GRCm39) V279A probably damaging Het
Pde4a A G 9: 21,106,119 (GRCm39) T245A possibly damaging Het
Peli2 C T 14: 48,493,945 (GRCm39) T389M probably damaging Het
Pfas T C 11: 68,883,744 (GRCm39) K638E probably damaging Het
Pkhd1 A G 1: 20,143,679 (GRCm39) probably null Het
Plch1 T C 3: 63,688,967 (GRCm39) D67G probably damaging Het
Ppp1r13l A G 7: 19,103,893 (GRCm39) I125V probably benign Het
Ppp2r3d A G 9: 101,090,110 (GRCm39) V71A probably benign Het
Pvr A G 7: 19,650,897 (GRCm39) V209A possibly damaging Het
Rap1gap2 A G 11: 74,298,198 (GRCm39) L414P probably damaging Het
Rasgrp2 A G 19: 6,464,855 (GRCm39) D601G probably damaging Het
Reck T A 4: 43,912,089 (GRCm39) N199K probably benign Het
Rin2 G T 2: 145,718,475 (GRCm39) A652S possibly damaging Het
Rnf34 T C 5: 123,002,087 (GRCm39) L88P possibly damaging Het
Serpina3m A G 12: 104,355,914 (GRCm39) I194V probably benign Het
Spred3 A G 7: 28,861,415 (GRCm39) S255P probably benign Het
Sult2a7 A G 7: 14,225,641 (GRCm39) probably null Het
Synpo2l C A 14: 20,711,442 (GRCm39) G622C probably damaging Het
Tenm3 A G 8: 48,795,382 (GRCm39) C582R probably damaging Het
Tex261 A T 6: 83,750,727 (GRCm39) I90N probably damaging Het
Trappc11 A G 8: 47,982,439 (GRCm39) F100S probably damaging Het
Trhde G A 10: 114,636,830 (GRCm39) P126S probably benign Het
Vmn2r53 A T 7: 12,315,737 (GRCm39) V694E probably damaging Het
Vmn2r54 A T 7: 12,349,782 (GRCm39) L600Q probably damaging Het
Vwf G A 6: 125,634,227 (GRCm39) C2174Y Het
Wee2 A G 6: 40,441,200 (GRCm39) T502A probably benign Het
Zfp112 A T 7: 23,823,390 (GRCm39) silent Het
Zfp40 T A 17: 23,394,691 (GRCm39) H632L possibly damaging Het
Zmynd11 T C 13: 9,740,965 (GRCm39) S378G probably damaging Het
Other mutations in Plcl2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00927:Plcl2 APN 17 50,913,948 (GRCm39) missense probably benign 0.01
IGL01746:Plcl2 APN 17 50,914,724 (GRCm39) missense probably benign 0.00
IGL02227:Plcl2 APN 17 50,913,425 (GRCm39) missense probably damaging 0.97
IGL02232:Plcl2 APN 17 50,913,669 (GRCm39) missense possibly damaging 0.66
IGL02878:Plcl2 APN 17 50,914,383 (GRCm39) missense probably damaging 1.00
IGL02985:Plcl2 APN 17 50,994,842 (GRCm39) nonsense probably null
acerbic UTSW 17 50,915,141 (GRCm39) missense probably damaging 1.00
Balsamic UTSW 17 50,914,689 (GRCm39) missense probably damaging 1.00
Bastante UTSW 17 50,913,389 (GRCm39) nonsense probably null
italietta UTSW 17 50,915,790 (GRCm39) missense probably damaging 1.00
Oxalic UTSW 17 50,915,127 (GRCm39) missense probably damaging 1.00
Parece UTSW 17 50,914,874 (GRCm39) missense probably damaging 0.99
picolinic UTSW 17 50,975,188 (GRCm39) splice site probably null
ranch UTSW 17 50,816,957 (GRCm39) missense probably benign 0.00
verdad UTSW 17 50,915,109 (GRCm39) missense probably damaging 1.00
vinagrette UTSW 17 50,913,884 (GRCm39) nonsense probably null
BB007:Plcl2 UTSW 17 50,913,831 (GRCm39) missense probably benign
BB017:Plcl2 UTSW 17 50,913,831 (GRCm39) missense probably benign
IGL03014:Plcl2 UTSW 17 50,918,029 (GRCm39) missense possibly damaging 0.65
R0110:Plcl2 UTSW 17 50,915,010 (GRCm39) missense probably damaging 1.00
R0190:Plcl2 UTSW 17 50,914,671 (GRCm39) missense probably benign
R0280:Plcl2 UTSW 17 50,914,062 (GRCm39) missense probably damaging 1.00
R0414:Plcl2 UTSW 17 50,914,983 (GRCm39) missense possibly damaging 0.90
R0450:Plcl2 UTSW 17 50,915,010 (GRCm39) missense probably damaging 1.00
R0760:Plcl2 UTSW 17 50,915,802 (GRCm39) missense possibly damaging 0.82
R1134:Plcl2 UTSW 17 50,915,138 (GRCm39) missense probably benign
R1168:Plcl2 UTSW 17 50,914,100 (GRCm39) missense possibly damaging 0.49
R1381:Plcl2 UTSW 17 50,914,757 (GRCm39) missense probably damaging 0.99
R1748:Plcl2 UTSW 17 50,913,826 (GRCm39) missense probably benign
R1856:Plcl2 UTSW 17 50,914,878 (GRCm39) missense probably benign 0.13
R1958:Plcl2 UTSW 17 50,915,109 (GRCm39) missense probably damaging 1.00
R2016:Plcl2 UTSW 17 50,913,722 (GRCm39) missense probably damaging 1.00
R2057:Plcl2 UTSW 17 50,975,139 (GRCm39) splice site probably null
R2077:Plcl2 UTSW 17 50,913,857 (GRCm39) missense probably benign
R2247:Plcl2 UTSW 17 50,913,873 (GRCm39) missense probably damaging 0.96
R3083:Plcl2 UTSW 17 50,994,772 (GRCm39) missense probably benign 0.06
R4153:Plcl2 UTSW 17 50,913,389 (GRCm39) nonsense probably null
R4574:Plcl2 UTSW 17 50,914,874 (GRCm39) missense probably damaging 0.99
R4870:Plcl2 UTSW 17 50,914,254 (GRCm39) missense possibly damaging 0.46
R5030:Plcl2 UTSW 17 50,914,347 (GRCm39) missense possibly damaging 0.92
R5330:Plcl2 UTSW 17 50,816,876 (GRCm39) missense probably benign 0.01
R5331:Plcl2 UTSW 17 50,816,876 (GRCm39) missense probably benign 0.01
R5503:Plcl2 UTSW 17 50,816,957 (GRCm39) missense probably benign 0.00
R5920:Plcl2 UTSW 17 50,915,703 (GRCm39) missense probably damaging 0.99
R6238:Plcl2 UTSW 17 50,913,873 (GRCm39) missense probably damaging 0.96
R6378:Plcl2 UTSW 17 50,975,188 (GRCm39) splice site probably null
R6603:Plcl2 UTSW 17 50,914,145 (GRCm39) missense probably benign 0.03
R6633:Plcl2 UTSW 17 50,947,168 (GRCm39) missense probably benign 0.00
R7113:Plcl2 UTSW 17 50,913,492 (GRCm39) missense probably damaging 1.00
R7466:Plcl2 UTSW 17 50,915,496 (GRCm39) missense probably damaging 1.00
R7665:Plcl2 UTSW 17 50,914,185 (GRCm39) missense probably benign 0.00
R7930:Plcl2 UTSW 17 50,913,831 (GRCm39) missense probably benign
R8114:Plcl2 UTSW 17 50,994,815 (GRCm39) missense probably damaging 0.97
R8152:Plcl2 UTSW 17 50,914,689 (GRCm39) missense probably damaging 1.00
R8208:Plcl2 UTSW 17 50,915,343 (GRCm39) missense probably damaging 1.00
R8911:Plcl2 UTSW 17 50,915,141 (GRCm39) missense probably damaging 1.00
R8940:Plcl2 UTSW 17 50,915,790 (GRCm39) missense probably damaging 1.00
R8979:Plcl2 UTSW 17 50,947,145 (GRCm39) missense possibly damaging 0.64
R9127:Plcl2 UTSW 17 50,918,032 (GRCm39) missense probably benign 0.05
R9253:Plcl2 UTSW 17 50,915,127 (GRCm39) missense probably damaging 1.00
R9453:Plcl2 UTSW 17 50,915,391 (GRCm39) missense probably damaging 1.00
R9469:Plcl2 UTSW 17 50,913,953 (GRCm39) missense probably benign 0.05
R9630:Plcl2 UTSW 17 50,947,147 (GRCm39) missense probably benign
X0026:Plcl2 UTSW 17 50,914,588 (GRCm39) missense probably benign 0.03
Z1088:Plcl2 UTSW 17 50,914,020 (GRCm39) missense probably damaging 1.00
Z1176:Plcl2 UTSW 17 50,915,484 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGTTGCAAACATCTGGGTGAC -3'
(R):5'- CCCTGTTCTGCCTCAAGAAAC -3'

Sequencing Primer
(F):5'- TGACAGGACTCCGCTACC -3'
(R):5'- CTCAAGAAACATCATAAGGTCCTTGG -3'
Posted On 2021-07-15