Incidental Mutation 'R8854:Vmn2r10'
| ID |
675169 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r10
|
| Ensembl Gene |
ENSMUSG00000067010 |
| Gene Name |
vomeronasal 2, receptor 10 |
| Synonyms |
VR16, V2r16 |
| MMRRC Submission |
068676-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.085)
|
| Stock # |
R8854 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
109141278-109154337 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 109144126 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 608
(D608G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000078162
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000079163]
[ENSMUST00000176594]
|
| AlphaFold |
K7N621 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000079163
AA Change: D608G
PolyPhen 2
Score 0.196 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000078162
Gene: ENSMUSG00000067010
AA Change: D608G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
75 |
464 |
8.5e-29 |
PFAM |
|
Pfam:NCD3G
|
506 |
560 |
3.8e-17 |
PFAM |
|
Pfam:7tm_3
|
593 |
828 |
4e-55 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176594
|
| SMART Domains |
Protein: ENSMUSP00000135274
Gene: ENSMUSG00000067010
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.0846 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.4%
|
| Validation Efficiency |
100% (64/64) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 63 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aldh1a1 |
G |
A |
19: 20,588,297 (GRCm39) |
W29* |
probably null |
Het |
| Ankib1 |
C |
A |
5: 3,777,489 (GRCm39) |
W467L |
probably null |
Het |
| Arhgef10 |
A |
G |
8: 15,029,798 (GRCm39) |
|
probably null |
Het |
| Arpc1b |
C |
A |
5: 145,060,405 (GRCm39) |
R66S |
probably benign |
Het |
| Atoh1 |
A |
T |
6: 64,706,189 (GRCm39) |
|
probably benign |
Het |
| Bach2 |
T |
A |
4: 32,575,263 (GRCm39) |
D619E |
possibly damaging |
Het |
| Bbs9 |
T |
C |
9: 22,490,060 (GRCm39) |
I277T |
probably damaging |
Het |
| Cadps2 |
G |
A |
6: 23,385,507 (GRCm39) |
P772S |
probably damaging |
Het |
| Cd1d1 |
T |
A |
3: 86,905,480 (GRCm39) |
D171V |
probably damaging |
Het |
| Cfap20dc |
A |
T |
14: 8,518,638 (GRCm38) |
S273T |
probably damaging |
Het |
| Clca3a2 |
C |
T |
3: 144,783,852 (GRCm39) |
A588T |
possibly damaging |
Het |
| Cps1 |
A |
G |
1: 67,200,048 (GRCm39) |
K399E |
probably damaging |
Het |
| Cpt1a |
T |
C |
19: 3,406,327 (GRCm39) |
S98P |
probably benign |
Het |
| Cryzl2 |
A |
G |
1: 157,286,370 (GRCm39) |
K36R |
possibly damaging |
Het |
| Cxcl13 |
T |
C |
5: 96,104,861 (GRCm39) |
L11P |
unknown |
Het |
| Dbf4 |
T |
A |
5: 8,458,562 (GRCm39) |
D151V |
probably damaging |
Het |
| Eogt |
A |
T |
6: 97,108,359 (GRCm39) |
C227* |
probably null |
Het |
| Fermt3 |
T |
A |
19: 6,991,310 (GRCm39) |
D231V |
probably damaging |
Het |
| Il2rb |
T |
C |
15: 78,369,953 (GRCm39) |
T229A |
probably benign |
Het |
| Ildr1 |
T |
A |
16: 36,535,910 (GRCm39) |
Y142N |
probably damaging |
Het |
| Kcnv2 |
A |
T |
19: 27,311,258 (GRCm39) |
T542S |
probably benign |
Het |
| Kif26b |
G |
A |
1: 178,743,948 (GRCm39) |
G1348E |
possibly damaging |
Het |
| Lancl1 |
C |
T |
1: 67,073,358 (GRCm39) |
E42K |
possibly damaging |
Het |
| Lrp1 |
T |
A |
10: 127,378,968 (GRCm39) |
D4010V |
probably damaging |
Het |
| Mark2 |
A |
G |
19: 7,258,369 (GRCm39) |
V640A |
probably benign |
Het |
| Megf6 |
C |
T |
4: 154,352,469 (GRCm39) |
T1276M |
probably damaging |
Het |
| Meioc |
T |
C |
11: 102,566,589 (GRCm39) |
M735T |
probably damaging |
Het |
| Mfsd4b5 |
C |
A |
10: 39,846,735 (GRCm39) |
V282L |
probably damaging |
Het |
| Mlx |
T |
A |
11: 100,981,951 (GRCm39) |
V286E |
|
Het |
| Ms4a18 |
G |
A |
19: 10,990,887 (GRCm39) |
T69I |
probably benign |
Het |
| Muc1 |
C |
T |
3: 89,139,412 (GRCm39) |
P604L |
probably damaging |
Het |
| Net1 |
G |
T |
13: 3,934,214 (GRCm39) |
D548E |
probably benign |
Het |
| Ngly1 |
T |
C |
14: 16,281,769 (GRCm38) |
S342P |
probably damaging |
Het |
| Niban1 |
A |
G |
1: 151,584,950 (GRCm39) |
K516E |
probably damaging |
Het |
| Nipbl |
A |
T |
15: 8,330,210 (GRCm39) |
I2405N |
probably damaging |
Het |
| Nkx2-1 |
A |
T |
12: 56,580,206 (GRCm39) |
C245S |
probably benign |
Het |
| Or52ab7 |
T |
C |
7: 102,978,023 (GRCm39) |
I110T |
probably damaging |
Het |
| Or5p76 |
T |
A |
7: 108,122,936 (GRCm39) |
I74L |
probably benign |
Het |
| Pcare |
T |
C |
17: 72,056,326 (GRCm39) |
Y1117C |
probably benign |
Het |
| Pcdhgb5 |
C |
T |
18: 37,865,501 (GRCm39) |
T432I |
probably benign |
Het |
| Plpp4 |
T |
A |
7: 128,909,362 (GRCm39) |
L24* |
probably null |
Het |
| Pnma8a |
T |
C |
7: 16,695,104 (GRCm39) |
S320P |
possibly damaging |
Het |
| Sass6 |
C |
A |
3: 116,399,384 (GRCm39) |
Q93K |
possibly damaging |
Het |
| Sirpb1c |
T |
C |
3: 15,887,308 (GRCm39) |
N177S |
possibly damaging |
Het |
| Slc22a30 |
A |
G |
19: 8,363,754 (GRCm39) |
|
probably null |
Het |
| Snd1 |
A |
G |
6: 28,526,968 (GRCm39) |
H217R |
probably benign |
Het |
| Spata31d1c |
C |
A |
13: 65,183,804 (GRCm39) |
Q449K |
possibly damaging |
Het |
| Spidr |
A |
G |
16: 15,707,630 (GRCm39) |
V889A |
probably damaging |
Het |
| Suclg2 |
A |
T |
6: 95,572,650 (GRCm39) |
V105D |
probably damaging |
Het |
| Syne1 |
A |
T |
10: 5,078,503 (GRCm39) |
M974K |
probably benign |
Het |
| Tbrg4 |
A |
T |
11: 6,566,691 (GRCm39) |
D605E |
probably benign |
Het |
| Tcn2 |
A |
G |
11: 3,876,074 (GRCm39) |
F118S |
possibly damaging |
Het |
| Tcstv2b |
T |
A |
13: 120,377,825 (GRCm39) |
|
probably benign |
Het |
| Tfap4 |
T |
C |
16: 4,367,238 (GRCm39) |
H208R |
probably benign |
Het |
| Trf |
A |
G |
9: 103,107,529 (GRCm39) |
|
probably benign |
Het |
| Trpc4 |
A |
T |
3: 54,102,122 (GRCm39) |
K7* |
probably null |
Het |
| Uap1 |
G |
T |
1: 169,976,984 (GRCm39) |
P405Q |
probably damaging |
Het |
| Usp33 |
C |
A |
3: 152,073,967 (GRCm39) |
T271N |
probably benign |
Het |
| Usp42 |
T |
C |
5: 143,702,632 (GRCm39) |
D663G |
possibly damaging |
Het |
| Wfdc16 |
G |
A |
2: 164,480,486 (GRCm39) |
P3L |
probably benign |
Het |
| Zfp28 |
T |
C |
7: 6,397,938 (GRCm39) |
I791T |
probably benign |
Het |
| Zfp970 |
A |
T |
2: 177,165,088 (GRCm39) |
T5S |
probably damaging |
Het |
| Zfy1 |
A |
T |
Y: 726,501 (GRCm39) |
H421Q |
possibly damaging |
Het |
|
| Other mutations in Vmn2r10 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00816:Vmn2r10
|
APN |
5 |
109,150,451 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL01618:Vmn2r10
|
APN |
5 |
109,150,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01624:Vmn2r10
|
APN |
5 |
109,154,112 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
IGL01941:Vmn2r10
|
APN |
5 |
109,143,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01959:Vmn2r10
|
APN |
5 |
109,145,571 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01973:Vmn2r10
|
APN |
5 |
109,143,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01985:Vmn2r10
|
APN |
5 |
109,154,125 (GRCm39) |
missense |
probably benign |
0.21 |
|
IGL02451:Vmn2r10
|
APN |
5 |
109,143,788 (GRCm39) |
nonsense |
probably null |
|
|
IGL02503:Vmn2r10
|
APN |
5 |
109,151,341 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03275:Vmn2r10
|
APN |
5 |
109,151,243 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0035:Vmn2r10
|
UTSW |
5 |
109,145,467 (GRCm39) |
splice site |
probably benign |
|
|
R0395:Vmn2r10
|
UTSW |
5 |
109,149,859 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0454:Vmn2r10
|
UTSW |
5 |
109,151,327 (GRCm39) |
missense |
probably benign |
0.25 |
|
R0648:Vmn2r10
|
UTSW |
5 |
109,143,782 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1251:Vmn2r10
|
UTSW |
5 |
109,143,890 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1580:Vmn2r10
|
UTSW |
5 |
109,154,117 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1845:Vmn2r10
|
UTSW |
5 |
109,149,861 (GRCm39) |
nonsense |
probably null |
|
|
R1986:Vmn2r10
|
UTSW |
5 |
109,154,120 (GRCm39) |
nonsense |
probably null |
|
|
R2137:Vmn2r10
|
UTSW |
5 |
109,151,410 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R2495:Vmn2r10
|
UTSW |
5 |
109,143,961 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3932:Vmn2r10
|
UTSW |
5 |
109,150,088 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R3933:Vmn2r10
|
UTSW |
5 |
109,150,088 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R4899:Vmn2r10
|
UTSW |
5 |
109,151,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4992:Vmn2r10
|
UTSW |
5 |
109,145,592 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5124:Vmn2r10
|
UTSW |
5 |
109,154,286 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5145:Vmn2r10
|
UTSW |
5 |
109,143,761 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R5156:Vmn2r10
|
UTSW |
5 |
109,143,466 (GRCm39) |
missense |
probably benign |
0.11 |
|
R5265:Vmn2r10
|
UTSW |
5 |
109,143,586 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5311:Vmn2r10
|
UTSW |
5 |
109,154,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5321:Vmn2r10
|
UTSW |
5 |
109,143,505 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5666:Vmn2r10
|
UTSW |
5 |
109,146,910 (GRCm39) |
nonsense |
probably null |
|
|
R5670:Vmn2r10
|
UTSW |
5 |
109,146,910 (GRCm39) |
nonsense |
probably null |
|
|
R5872:Vmn2r10
|
UTSW |
5 |
109,151,377 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6004:Vmn2r10
|
UTSW |
5 |
109,146,944 (GRCm39) |
missense |
probably benign |
0.30 |
|
R6108:Vmn2r10
|
UTSW |
5 |
109,143,667 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6332:Vmn2r10
|
UTSW |
5 |
109,151,328 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6599:Vmn2r10
|
UTSW |
5 |
109,143,944 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6651:Vmn2r10
|
UTSW |
5 |
109,143,488 (GRCm39) |
missense |
probably null |
0.22 |
|
R6891:Vmn2r10
|
UTSW |
5 |
109,149,845 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7023:Vmn2r10
|
UTSW |
5 |
109,149,894 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7146:Vmn2r10
|
UTSW |
5 |
109,151,200 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7941:Vmn2r10
|
UTSW |
5 |
109,144,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8058:Vmn2r10
|
UTSW |
5 |
109,149,955 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8478:Vmn2r10
|
UTSW |
5 |
109,143,636 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8526:Vmn2r10
|
UTSW |
5 |
109,145,572 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R8698:Vmn2r10
|
UTSW |
5 |
109,151,390 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8796:Vmn2r10
|
UTSW |
5 |
109,143,917 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R8871:Vmn2r10
|
UTSW |
5 |
109,146,899 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R8893:Vmn2r10
|
UTSW |
5 |
109,143,677 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8907:Vmn2r10
|
UTSW |
5 |
109,149,791 (GRCm39) |
missense |
probably benign |
|
|
R8957:Vmn2r10
|
UTSW |
5 |
109,149,780 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R8976:Vmn2r10
|
UTSW |
5 |
109,145,479 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9155:Vmn2r10
|
UTSW |
5 |
109,144,212 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9308:Vmn2r10
|
UTSW |
5 |
109,145,476 (GRCm39) |
nonsense |
probably null |
|
|
R9800:Vmn2r10
|
UTSW |
5 |
109,150,404 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1088:Vmn2r10
|
UTSW |
5 |
109,143,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Vmn2r10
|
UTSW |
5 |
109,149,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCCTTCTCCCTGGAGTAGTGAG -3'
(R):5'- CAGTGTATGAGGTGTCCAGATG -3'
Sequencing Primer
(F):5'- CTCCCTGGAGTAGTGAGCTTGAAAG -3'
(R):5'- GTGTCCAGATGATAAGTATGCCAAC -3'
|
| Posted On |
2021-07-15 |
Incidental Mutation