Incidental Mutation 'R8855:Taar1'
ID 675260
Institutional Source Beutler Lab
Gene Symbol Taar1
Ensembl Gene ENSMUSG00000056379
Gene Name trace amine-associated receptor 1
Synonyms Trar1, Tar1
MMRRC Submission 068736-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.101) question?
Stock # R8855 (G1)
Quality Score 225.009
Status Not validated
Chromosome 10
Chromosomal Location 23796304-23797302 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 23796976 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Cysteine at position 225 (R225C)
Ref Sequence ENSEMBL: ENSMUSP00000049527 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051532]
AlphaFold Q923Y8
Predicted Effect possibly damaging
Transcript: ENSMUST00000051532
AA Change: R225C

PolyPhen 2 Score 0.500 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000049527
Gene: ENSMUSG00000056379
AA Change: R225C

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 33 316 1.4e-11 PFAM
Pfam:7tm_1 39 301 2.4e-62 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a G-protein coupled receptor activated by trace amines. The encoded protein responds little or not at all to dopamine, serotonin, epinephrine, or histamine, but responds well to beta-phenylethylamine, p-tyramine, octopamine, and tryptamine. While primarily functioning in neurologic systems, there is evidence that this gene is involved in blood cell and immunologic functions as well. This gene is thought to be intronless. [provided by RefSeq, Nov 2015]
PHENOTYPE: Mice homozygous for a null mutation display decreased prepulse inhibition and increased sensitivity to amphetamines. Mice homozygous for another knock-out allele exhibit increased sensitivity to MDMA-induced hyperthermia, brain dopamine and serotonin levels, and induced hyperactivity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 79 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl2 C T 3: 59,914,511 (GRCm39) T38I probably benign Het
Ace T A 11: 105,861,424 (GRCm39) L191* probably null Het
Ahctf1 G A 1: 179,614,341 (GRCm39) H451Y probably damaging Het
Amotl1 C A 9: 14,466,869 (GRCm39) probably null Het
Angptl6 T A 9: 20,786,940 (GRCm39) Y261F probably damaging Het
Arhgap1 G T 2: 91,499,744 (GRCm39) S293I probably benign Het
Atg9a A C 1: 75,161,867 (GRCm39) F560V probably damaging Het
B4galnt4 G A 7: 140,648,488 (GRCm39) G668D possibly damaging Het
Btaf1 T A 19: 36,935,901 (GRCm39) N230K probably benign Het
Ccne1 A C 7: 37,800,046 (GRCm39) H179Q probably benign Het
Cdk5rap2 A T 4: 70,218,887 (GRCm39) D623E probably damaging Het
Cenpf C A 1: 189,385,430 (GRCm39) K2283N probably benign Het
Clec16a A T 16: 10,462,731 (GRCm39) D683V probably damaging Het
Clvs2 T C 10: 33,404,400 (GRCm39) D272G probably benign Het
Cnksr1 A G 4: 133,959,494 (GRCm39) V380A probably damaging Het
Col20a1 C A 2: 180,655,684 (GRCm39) P42T Het
Ddx47 A G 6: 135,000,356 (GRCm39) K451E probably benign Het
Dennd4a G A 9: 64,819,672 (GRCm39) G1761D probably benign Het
Dnah11 T A 12: 118,156,107 (GRCm39) H181L probably benign Het
Dync1h1 T C 12: 110,602,333 (GRCm39) C2074R probably damaging Het
Ell2 A T 13: 75,917,793 (GRCm39) Q574H probably damaging Het
Enpp7 A G 11: 118,879,191 (GRCm39) N50S possibly damaging Het
Fbp2 T C 13: 62,989,709 (GRCm39) K199R probably benign Het
Fetub A T 16: 22,758,321 (GRCm39) E368V possibly damaging Het
Flt1 A T 5: 147,507,682 (GRCm39) D1209E probably benign Het
Flt1 A T 5: 147,618,460 (GRCm39) N260K probably damaging Het
Fras1 A G 5: 96,917,465 (GRCm39) H3495R Het
Fsip2 A G 2: 82,810,521 (GRCm39) Q2280R probably benign Het
Gja10 A T 4: 32,601,573 (GRCm39) C270* probably null Het
Gpld1 A G 13: 25,170,890 (GRCm39) T794A probably benign Het
Gsk3b A G 16: 38,004,900 (GRCm39) Y157C probably damaging Het
Gsta2 T C 9: 78,244,880 (GRCm39) K78R probably damaging Het
Gtf3a A G 5: 146,885,721 (GRCm39) D44G probably benign Het
Hap1 C A 11: 100,246,864 (GRCm39) G14W probably damaging Het
Hcn4 T A 9: 58,765,387 (GRCm39) I623N unknown Het
Kank1 T C 19: 25,388,702 (GRCm39) S792P possibly damaging Het
Klra5 A T 6: 129,880,533 (GRCm39) W212R probably damaging Het
Kmt2d A T 15: 98,754,237 (GRCm39) L1622Q unknown Het
Lipi T A 16: 75,355,481 (GRCm39) D343V probably damaging Het
Lrp6 A T 6: 134,445,785 (GRCm39) N1009K probably benign Het
Lrrc39 T A 3: 116,363,790 (GRCm39) I121N probably damaging Het
Mamstr A T 7: 45,294,403 (GRCm39) D419V probably benign Het
Map2k7 C T 8: 4,293,594 (GRCm39) T119I probably damaging Het
Mov10l1 A T 15: 88,896,169 (GRCm39) D671V probably benign Het
Mrps24 A T 11: 5,654,642 (GRCm39) L104Q probably damaging Het
Myh1 T A 11: 67,102,247 (GRCm39) L846H probably damaging Het
Ndufaf5 T A 2: 140,025,840 (GRCm39) I133N possibly damaging Het
Ndufs5 A G 4: 123,609,655 (GRCm39) probably null Het
Numa1 G C 7: 101,639,835 (GRCm39) D62H possibly damaging Het
Or10g3 A T 14: 52,610,196 (GRCm39) Y105N probably damaging Het
Or52e19 T A 7: 102,959,168 (GRCm39) I80N probably damaging Het
Or52p2 G T 7: 102,237,945 (GRCm39) Q2K probably benign Het
Or8b12c C G 9: 37,715,709 (GRCm39) F167L probably damaging Het
Pag1 T C 3: 9,764,529 (GRCm39) K208R probably benign Het
Pkd1 T C 17: 24,792,051 (GRCm39) V1246A probably damaging Het
Plekhg2 T C 7: 28,069,526 (GRCm39) T144A probably benign Het
Plekhm2 A T 4: 141,361,658 (GRCm39) S262T probably benign Het
Pramel14 A T 4: 143,720,905 (GRCm39) L12Q probably damaging Het
Prpf4 A G 4: 62,334,235 (GRCm39) D230G probably benign Het
Rbm15b C T 9: 106,763,595 (GRCm39) R191Q probably benign Het
Sec16a G A 2: 26,329,852 (GRCm39) T721I probably benign Het
Serpinb6c A T 13: 34,083,309 (GRCm39) I35N probably damaging Het
Sgk1 T G 10: 21,871,726 (GRCm39) S181A probably benign Het
Slc25a10 T C 11: 120,385,795 (GRCm39) S74P probably damaging Het
Slc30a3 C A 5: 31,245,325 (GRCm39) V332F possibly damaging Het
Smg1 A G 7: 117,806,122 (GRCm39) S240P unknown Het
Snapc4 G A 2: 26,264,545 (GRCm39) R265W probably damaging Het
Tmem74 A G 15: 43,730,231 (GRCm39) S271P probably damaging Het
Trank1 T C 9: 111,141,289 (GRCm39) V127A unknown Het
Trim66 G T 7: 109,081,188 (GRCm39) H244N probably damaging Het
Tshz2 T A 2: 169,728,425 (GRCm39) L1007H probably damaging Het
Ttc39c A T 18: 12,831,003 (GRCm39) S288C probably benign Het
Twnk C T 19: 45,000,272 (GRCm39) Q663* probably null Het
Ucn T A 5: 31,295,857 (GRCm39) Q3L probably benign Het
Usp9y C T Y: 1,395,758 (GRCm39) R492H probably damaging Het
Vars1 T C 17: 35,234,620 (GRCm39) S1150P probably benign Het
Zc3h7b G A 15: 81,656,681 (GRCm39) R166Q probably benign Het
Zfand1 T C 3: 10,405,811 (GRCm39) D264G probably benign Het
Zfp839 A G 12: 110,834,848 (GRCm39) E701G probably benign Het
Other mutations in Taar1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00782:Taar1 APN 10 23,796,344 (GRCm39) missense probably benign 0.00
R0022:Taar1 UTSW 10 23,796,625 (GRCm39) missense probably benign 0.45
R0126:Taar1 UTSW 10 23,796,445 (GRCm39) missense probably benign 0.00
R0442:Taar1 UTSW 10 23,796,380 (GRCm39) missense possibly damaging 0.80
R0720:Taar1 UTSW 10 23,796,971 (GRCm39) missense probably damaging 1.00
R0931:Taar1 UTSW 10 23,797,181 (GRCm39) missense probably damaging 1.00
R1270:Taar1 UTSW 10 23,796,431 (GRCm39) missense probably damaging 1.00
R1834:Taar1 UTSW 10 23,797,087 (GRCm39) missense probably benign 0.04
R2137:Taar1 UTSW 10 23,797,168 (GRCm39) missense probably benign
R3765:Taar1 UTSW 10 23,797,205 (GRCm39) missense probably damaging 1.00
R3873:Taar1 UTSW 10 23,796,482 (GRCm39) missense probably damaging 1.00
R5334:Taar1 UTSW 10 23,796,443 (GRCm39) missense probably damaging 1.00
R5418:Taar1 UTSW 10 23,797,214 (GRCm39) missense possibly damaging 0.91
R5578:Taar1 UTSW 10 23,796,718 (GRCm39) missense possibly damaging 0.71
R7048:Taar1 UTSW 10 23,796,722 (GRCm39) missense probably benign 0.40
R7096:Taar1 UTSW 10 23,796,809 (GRCm39) missense possibly damaging 0.48
R7163:Taar1 UTSW 10 23,796,918 (GRCm39) missense probably benign 0.38
R7707:Taar1 UTSW 10 23,797,135 (GRCm39) missense possibly damaging 0.69
R7854:Taar1 UTSW 10 23,796,680 (GRCm39) missense probably benign 0.00
R8036:Taar1 UTSW 10 23,797,033 (GRCm39) missense probably benign 0.01
R8442:Taar1 UTSW 10 23,796,522 (GRCm39) nonsense probably null
R9777:Taar1 UTSW 10 23,796,676 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GAGTGGAAGAGCTGTATCGC -3'
(R):5'- ATCGGATTGAGGGCAGAATTC -3'

Sequencing Primer
(F):5'- AGAGCTGTATCGCAGTCAGGTC -3'
(R):5'- CAATACAGTGCGTCATTCAGAG -3'
Posted On 2021-07-15