Incidental Mutation 'R8858:Wdr77'
ID 675457
Institutional Source Beutler Lab
Gene Symbol Wdr77
Ensembl Gene ENSMUSG00000000561
Gene Name WD repeat domain 77
Synonyms 2610312E17Rik, 2610003I18Rik, p44/MEP50
MMRRC Submission 068738-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R8858 (G1)
Quality Score 225.009
Status Validated
Chromosome 3
Chromosomal Location 105866814-105877076 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 105868978 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 116 (V116A)
Ref Sequence ENSEMBL: ENSMUSP00000010278 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000010278] [ENSMUST00000118209] [ENSMUST00000128005] [ENSMUST00000130994] [ENSMUST00000133320]
AlphaFold Q99J09
Predicted Effect probably damaging
Transcript: ENSMUST00000010278
AA Change: V116A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000010278
Gene: ENSMUSG00000000561
AA Change: V116A

DomainStartEndE-ValueType
low complexity region 40 51 N/A INTRINSIC
WD40 70 107 5.11e1 SMART
WD40 115 153 1.06e-3 SMART
WD40 156 196 4.51e-7 SMART
WD40 201 241 2.75e1 SMART
WD40 244 284 9.94e-1 SMART
WD40 286 326 1.99e0 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000118209
SMART Domains Protein: ENSMUSP00000113022
Gene: ENSMUSG00000000563

DomainStartEndE-ValueType
Pfam:Mt_ATP-synt_B 83 244 2.5e-45 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000128005
AA Change: V14A

PolyPhen 2 Score 0.922 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000122465
Gene: ENSMUSG00000000561
AA Change: V14A

DomainStartEndE-ValueType
WD40 13 51 1.06e-3 SMART
WD40 54 94 4.51e-7 SMART
WD40 99 139 2.75e1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000130994
SMART Domains Protein: ENSMUSP00000120517
Gene: ENSMUSG00000000561

DomainStartEndE-ValueType
PDB:4GQB|B 1 52 8e-18 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000133320
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 100% (47/47)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an androgen receptor coactivator that forms a complex with protein arginine methyltransferase 5, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. The encoded protein may be involved in the early stages of prostate cancer, with most of the protein being nuclear-localized in benign cells but cytoplasmic in cancer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
PHENOTYPE: Mice homozygous for a knock-out allele die prior to E8.5 for unknown reasons. Heterozygotes develop multifocal hyperplasia in the dorsal prostate; however, no prostate tumors are detected up to 12 months of age. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A430033K04Rik A G 5: 138,638,338 (GRCm39) Q91R probably benign Het
Abca16 G T 7: 120,052,327 (GRCm39) C465F probably benign Het
Amfr A G 8: 94,714,070 (GRCm39) Y254H probably damaging Het
Arl6ip6 A G 2: 53,093,018 (GRCm39) E181G probably damaging Het
Atp10a A G 7: 58,465,971 (GRCm39) E1066G probably damaging Het
BC034090 A G 1: 155,101,964 (GRCm39) V100A probably benign Het
Cep126 T C 9: 8,130,270 (GRCm39) M54V probably benign Het
Ciao2a T C 9: 66,039,824 (GRCm39) I47T probably damaging Het
Csmd1 A G 8: 16,120,318 (GRCm39) V1829A probably benign Het
Cyp2c54 G A 19: 40,062,227 (GRCm39) T10I probably benign Het
Dennd11 T C 6: 40,399,669 (GRCm39) N173S probably benign Het
Disc1 A G 8: 125,977,781 (GRCm39) Y799C probably damaging Het
Dnajc17 T C 2: 119,011,445 (GRCm39) T162A probably benign Het
Fhad1 T C 4: 141,666,339 (GRCm39) E695G possibly damaging Het
Gadl1 A T 9: 115,835,669 (GRCm39) S366C probably damaging Het
Gbp11 C A 5: 105,473,392 (GRCm39) E454* probably null Het
Gm32742 T A 9: 51,062,256 (GRCm39) T691S probably benign Het
Gsdma3 C A 11: 98,520,695 (GRCm39) Q109K probably benign Het
Hsph1 A T 5: 149,548,576 (GRCm39) V482E probably damaging Het
Ighv1-23 T A 12: 114,728,083 (GRCm39) Y113F probably benign Het
Lactb G T 9: 66,863,182 (GRCm39) Y477* probably null Het
Lgr6 T C 1: 134,923,849 (GRCm39) probably null Het
Lrp1b T C 2: 41,560,827 (GRCm39) probably benign Het
Map3k4 A C 17: 12,490,759 (GRCm39) L224R probably damaging Het
Mex3d A T 10: 80,217,217 (GRCm39) C667S unknown Het
Myh8 A G 11: 67,192,820 (GRCm39) E1537G possibly damaging Het
Myo5a T C 9: 75,091,965 (GRCm39) S1205P probably damaging Het
Nfic A T 10: 81,262,965 (GRCm39) probably benign Het
Nrcam T A 12: 44,644,554 (GRCm39) probably benign Het
Or2aj6 A G 16: 19,443,109 (GRCm39) V247A probably damaging Het
Or4f54 G A 2: 111,123,503 (GRCm39) V297M probably benign Het
Orc2 A T 1: 58,532,857 (GRCm39) D127E probably benign Het
Ppp2r5c T A 12: 110,519,329 (GRCm39) probably null Het
Ptpn18 A G 1: 34,502,196 (GRCm39) T71A possibly damaging Het
Ptpru T C 4: 131,526,825 (GRCm39) probably benign Het
Ralgapa2 C A 2: 146,102,285 (GRCm39) probably null Het
Rnase9 G A 14: 51,276,766 (GRCm39) P71S Het
Ryr1 A G 7: 28,808,638 (GRCm39) L485P probably benign Het
Sardh T C 2: 27,118,302 (GRCm39) D476G probably null Het
Sorbs3 T C 14: 70,438,850 (GRCm39) Y170C probably damaging Het
Spata31e4 T C 13: 50,855,423 (GRCm39) S354P probably benign Het
St8sia5 C T 18: 77,320,511 (GRCm39) P88S probably benign Het
Tmprss15 A G 16: 78,854,497 (GRCm39) probably null Het
Tnfrsf13b A G 11: 61,038,363 (GRCm39) I215M possibly damaging Het
Unc13d G T 11: 115,953,618 (GRCm39) L1052M probably damaging Het
Vasn A G 16: 4,466,833 (GRCm39) D260G probably benign Het
Zfp560 A G 9: 20,260,403 (GRCm39) I153T probably benign Het
Zfp672 G A 11: 58,208,145 (GRCm39) R59C possibly damaging Het
Other mutations in Wdr77
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01626:Wdr77 APN 3 105,867,002 (GRCm39) nonsense probably null
R0368:Wdr77 UTSW 3 105,869,382 (GRCm39) critical splice donor site probably null
R0436:Wdr77 UTSW 3 105,867,342 (GRCm39) missense probably damaging 1.00
R1403:Wdr77 UTSW 3 105,874,573 (GRCm39) missense possibly damaging 0.76
R1403:Wdr77 UTSW 3 105,874,573 (GRCm39) missense possibly damaging 0.76
R1928:Wdr77 UTSW 3 105,874,618 (GRCm39) missense probably benign 0.00
R2422:Wdr77 UTSW 3 105,867,337 (GRCm39) nonsense probably null
R8749:Wdr77 UTSW 3 105,866,975 (GRCm39) missense probably damaging 1.00
R9484:Wdr77 UTSW 3 105,872,404 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- GACGTGGACTTTGCTTTTACAG -3'
(R):5'- GGAAACAGACATGCCATTACTC -3'

Sequencing Primer
(F):5'- ACTTTGCTTTTACAGTTGGCTCAG -3'
(R):5'- ACAGACATGCCATTACTCACTAG -3'
Posted On 2021-07-15