Incidental Mutation 'R8861:Steap4'
ID 675651
Institutional Source Beutler Lab
Gene Symbol Steap4
Ensembl Gene ENSMUSG00000012428
Gene Name STEAP family member 4
Synonyms Tnfaip9, Tiarp
MMRRC Submission 068740-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.115) question?
Stock # R8861 (G1)
Quality Score 225.009
Status Validated
Chromosome 5
Chromosomal Location 8010472-8032213 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 8025672 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 78 (I78V)
Ref Sequence ENSEMBL: ENSMUSP00000111081 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000115421]
AlphaFold Q923B6
Predicted Effect probably benign
Transcript: ENSMUST00000115421
AA Change: I78V

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000111081
Gene: ENSMUSG00000012428
AA Change: I78V

DomainStartEndE-ValueType
Pfam:F420_oxidored 21 107 2.3e-16 PFAM
transmembrane domain 203 225 N/A INTRINSIC
Pfam:Ferric_reduct 247 395 2.6e-14 PFAM
transmembrane domain 416 438 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 100% (59/59)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit adipose accumulation, oxidative stress, increased liver weight, lower metabolic rate, hypoactivity, insulin resistance, glucose intolerance, mild hyperglycemia and dyslipidemia. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3110082I17Rik T C 5: 139,396,642 (GRCm39) probably benign Het
Acly A G 11: 100,375,424 (GRCm39) probably null Het
Agap2 T G 10: 126,926,383 (GRCm39) V896G unknown Het
Agtpbp1 T C 13: 59,643,287 (GRCm39) Y724C probably damaging Het
Angpt4 A G 2: 151,767,373 (GRCm39) N135D probably damaging Het
Aox3 T A 1: 58,189,460 (GRCm39) I387K probably benign Het
Bysl T C 17: 47,917,884 (GRCm39) E103G probably benign Het
Cdcp3 A T 7: 130,861,690 (GRCm39) K1168* probably null Het
Chmp5 T A 4: 40,964,608 (GRCm39) V208E probably damaging Het
Chst9 T G 18: 15,585,630 (GRCm39) H311P possibly damaging Het
Cilk1 T A 9: 78,071,844 (GRCm39) N505K probably benign Het
Dcaf11 C A 14: 55,801,955 (GRCm39) Y235* probably null Het
Dlx5 A C 6: 6,878,233 (GRCm39) S266A probably benign Het
Dnah7b T A 1: 46,280,236 (GRCm39) S2722T possibly damaging Het
Drc1 G A 5: 30,521,839 (GRCm39) probably benign Het
En2 T A 5: 28,371,733 (GRCm39) I70N probably damaging Het
Fam72a T C 1: 131,466,656 (GRCm39) Y147H possibly damaging Het
Fermt2 A T 14: 45,697,466 (GRCm39) F628L possibly damaging Het
Fkrp T A 7: 16,544,749 (GRCm39) D371V probably damaging Het
Fmn1 T C 2: 113,195,149 (GRCm39) L283P unknown Het
Gm13271 G A 4: 88,673,366 (GRCm39) V88I probably benign Het
Gnmt G A 17: 47,037,618 (GRCm39) T120M probably damaging Het
H2-T22 A T 17: 36,353,290 (GRCm39) V10D possibly damaging Het
Hbs1l T A 10: 21,220,963 (GRCm39) probably benign Het
Igf2bp3 A C 6: 49,082,550 (GRCm39) M344R possibly damaging Het
Kdm1b T C 13: 47,217,582 (GRCm39) V347A probably benign Het
Klra17 A T 6: 129,851,865 (GRCm39) S2R probably damaging Het
Klri1 A G 6: 129,675,164 (GRCm39) S199P probably benign Het
Ltk T A 2: 119,590,094 (GRCm39) Q44L probably benign Het
Map3k20 C A 2: 72,219,811 (GRCm39) probably benign Het
Matn4 A T 2: 164,234,825 (GRCm39) Y549N Het
Mcoln3 T A 3: 145,845,159 (GRCm39) F452I probably damaging Het
Mipol1 T C 12: 57,352,802 (GRCm39) V47A probably benign Het
Msh4 A G 3: 153,607,105 (GRCm39) L145S probably benign Het
Myh11 A T 16: 14,064,646 (GRCm39) I224N Het
Nat8f1 A G 6: 85,887,444 (GRCm39) L172P probably damaging Het
Ncoa7 T A 10: 30,567,364 (GRCm39) K438I probably benign Het
Nr1h3 T G 2: 91,024,026 (GRCm39) probably benign Het
Nuggc T C 14: 65,847,484 (GRCm39) probably null Het
Or4b12 T C 2: 90,096,803 (GRCm39) probably benign Het
Or5m9b A G 2: 85,905,960 (GRCm39) N292S probably damaging Het
Or7h8 A T 9: 20,124,377 (GRCm39) H244L probably damaging Het
Pfn4 T A 12: 4,825,456 (GRCm39) Y98N probably benign Het
Ppp6r2 T G 15: 89,143,368 (GRCm39) C172G probably damaging Het
Ptprk A G 10: 28,446,186 (GRCm39) D979G probably damaging Het
Rbm28 A G 6: 29,152,284 (GRCm39) I329T probably damaging Het
Rnf144a T C 12: 26,389,343 (GRCm39) T33A probably damaging Het
Rnf145 A G 11: 44,445,984 (GRCm39) T273A probably damaging Het
Rnf213 G A 11: 119,333,062 (GRCm39) R2758H Het
Slc22a19 A T 19: 7,660,324 (GRCm39) M362K possibly damaging Het
Slc29a4 G C 5: 142,704,580 (GRCm39) R374P probably damaging Het
Slc43a1 A G 2: 84,691,748 (GRCm39) T528A possibly damaging Het
Sp3 A T 2: 72,801,630 (GRCm39) Y172N probably damaging Het
Srpra T A 9: 35,127,045 (GRCm39) M573K probably benign Het
Sulf2 A G 2: 165,974,606 (GRCm39) L26P possibly damaging Het
Taok2 T C 7: 126,470,615 (GRCm39) K738E probably damaging Het
Tcea3 G A 4: 135,981,810 (GRCm39) R56H probably damaging Het
Tcf20 A G 15: 82,736,726 (GRCm39) V1575A probably damaging Het
Togaram1 T G 12: 65,027,406 (GRCm39) S798R possibly damaging Het
Other mutations in Steap4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00596:Steap4 APN 5 8,026,979 (GRCm39) missense probably damaging 1.00
IGL00827:Steap4 APN 5 8,026,712 (GRCm39) missense probably damaging 1.00
IGL01481:Steap4 APN 5 8,026,858 (GRCm39) missense probably damaging 0.98
IGL02378:Steap4 APN 5 8,026,741 (GRCm39) missense probably benign 0.00
IGL03058:Steap4 APN 5 8,025,664 (GRCm39) missense probably benign 0.00
PIT4362001:Steap4 UTSW 5 8,030,337 (GRCm39) missense probably benign 0.03
R0329:Steap4 UTSW 5 8,025,829 (GRCm39) missense possibly damaging 0.92
R0546:Steap4 UTSW 5 8,025,870 (GRCm39) missense probably damaging 0.99
R0637:Steap4 UTSW 5 8,028,398 (GRCm39) splice site probably benign
R0638:Steap4 UTSW 5 8,027,030 (GRCm39) splice site probably benign
R0651:Steap4 UTSW 5 8,030,348 (GRCm39) nonsense probably null
R0881:Steap4 UTSW 5 8,030,388 (GRCm39) missense probably benign
R1167:Steap4 UTSW 5 8,026,520 (GRCm39) missense probably benign 0.34
R1543:Steap4 UTSW 5 8,025,902 (GRCm39) splice site probably benign
R1889:Steap4 UTSW 5 8,025,892 (GRCm39) missense probably damaging 1.00
R3803:Steap4 UTSW 5 8,026,979 (GRCm39) missense probably damaging 1.00
R3811:Steap4 UTSW 5 8,027,017 (GRCm39) missense probably benign 0.18
R3885:Steap4 UTSW 5 8,030,494 (GRCm39) missense probably damaging 1.00
R3887:Steap4 UTSW 5 8,030,494 (GRCm39) missense probably damaging 1.00
R4051:Steap4 UTSW 5 8,030,404 (GRCm39) missense probably damaging 1.00
R4208:Steap4 UTSW 5 8,030,404 (GRCm39) missense probably damaging 1.00
R5016:Steap4 UTSW 5 8,026,699 (GRCm39) nonsense probably null
R5302:Steap4 UTSW 5 8,025,547 (GRCm39) nonsense probably null
R5951:Steap4 UTSW 5 8,025,769 (GRCm39) missense probably benign 0.00
R6136:Steap4 UTSW 5 8,028,562 (GRCm39) missense probably damaging 0.99
R6527:Steap4 UTSW 5 8,028,502 (GRCm39) missense probably damaging 0.99
R6631:Steap4 UTSW 5 8,026,995 (GRCm39) nonsense probably null
R6964:Steap4 UTSW 5 8,025,568 (GRCm39) missense probably damaging 1.00
R7055:Steap4 UTSW 5 8,026,858 (GRCm39) missense probably damaging 1.00
R7408:Steap4 UTSW 5 8,028,453 (GRCm39) missense probably benign 0.07
R7692:Steap4 UTSW 5 8,026,976 (GRCm39) missense probably benign 0.32
R8205:Steap4 UTSW 5 8,026,795 (GRCm39) missense possibly damaging 0.65
R9287:Steap4 UTSW 5 8,026,683 (GRCm39) missense probably benign 0.05
R9423:Steap4 UTSW 5 8,026,720 (GRCm39) missense probably damaging 0.99
R9504:Steap4 UTSW 5 8,030,538 (GRCm39) missense probably benign 0.00
R9531:Steap4 UTSW 5 8,028,424 (GRCm39) missense probably benign 0.20
R9566:Steap4 UTSW 5 8,025,646 (GRCm39) missense possibly damaging 0.51
Predicted Primers PCR Primer
(F):5'- AAAGCAAGGGGTTGTCTGC -3'
(R):5'- GCTTGCATCTAGTGTTCCTGAC -3'

Sequencing Primer
(F):5'- CTGCATTTTCGGAACAGGAG -3'
(R):5'- GAGATGGTGTTAAATGCTTTGACCAC -3'
Posted On 2021-07-15