Incidental Mutation 'R8863:Lysmd4'
ID 675767
Institutional Source Beutler Lab
Gene Symbol Lysmd4
Ensembl Gene ENSMUSG00000043831
Gene Name LysM, putative peptidoglycan-binding, domain containing 4
Synonyms 4930506D23Rik
MMRRC Submission 068679-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R8863 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 66872292-66878216 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 66873493 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 43 (S43P)
Ref Sequence ENSEMBL: ENSMUSP00000053341 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058771] [ENSMUST00000179106] [ENSMUST00000207757] [ENSMUST00000207823] [ENSMUST00000208213] [ENSMUST00000208512] [ENSMUST00000208698] [ENSMUST00000208998]
AlphaFold Q8CC84
Predicted Effect probably damaging
Transcript: ENSMUST00000058771
AA Change: S43P

PolyPhen 2 Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000053341
Gene: ENSMUSG00000043831
AA Change: S43P

DomainStartEndE-ValueType
low complexity region 31 43 N/A INTRINSIC
LysM 72 116 3.73e-4 SMART
transmembrane domain 215 237 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000179106
AA Change: S43P

PolyPhen 2 Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000136151
Gene: ENSMUSG00000043831
AA Change: S43P

DomainStartEndE-ValueType
low complexity region 31 43 N/A INTRINSIC
LysM 72 116 3.73e-4 SMART
transmembrane domain 215 237 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000207757
AA Change: S43P

PolyPhen 2 Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)
Predicted Effect probably damaging
Transcript: ENSMUST00000207823
AA Change: S43P

PolyPhen 2 Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)
Predicted Effect possibly damaging
Transcript: ENSMUST00000208213
AA Change: S43P

PolyPhen 2 Score 0.931 (Sensitivity: 0.81; Specificity: 0.94)
Predicted Effect probably damaging
Transcript: ENSMUST00000208512
AA Change: S43P

PolyPhen 2 Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)
Predicted Effect probably damaging
Transcript: ENSMUST00000208698
AA Change: S43P

PolyPhen 2 Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)
Predicted Effect probably damaging
Transcript: ENSMUST00000208998
AA Change: S43P

PolyPhen 2 Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)
Meta Mutation Damage Score 0.1045 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.3%
Validation Efficiency 100% (44/44)
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9130023H24Rik A G 7: 127,836,123 (GRCm39) S157P possibly damaging Het
Aasdhppt C A 9: 4,309,424 (GRCm39) A5S possibly damaging Het
Aoc1l2 T C 6: 48,907,042 (GRCm39) L14P probably benign Het
Asb16 T C 11: 102,168,058 (GRCm39) Y373H probably damaging Het
Axin1 T C 17: 26,362,375 (GRCm39) S240P probably benign Het
C2cd5 T C 6: 142,987,088 (GRCm39) I505V possibly damaging Het
Camk2g A G 14: 20,810,244 (GRCm39) L305P probably damaging Het
Ccm2 A G 11: 6,535,211 (GRCm39) K156E probably damaging Het
Cdh23 G T 10: 60,212,613 (GRCm39) Y1600* probably null Het
Cyp2c29 A G 19: 39,261,810 (GRCm39) Q16R probably benign Het
Ebf1 T A 11: 44,774,666 (GRCm39) V221E probably damaging Het
Fcgbpl1 A G 7: 27,831,006 (GRCm39) D73G probably damaging Het
Gtpbp1 A G 15: 79,591,262 (GRCm39) E125G possibly damaging Het
Idh2 TCCCAGG T 7: 79,748,079 (GRCm39) probably benign Het
Igfbp3 A G 11: 7,163,568 (GRCm39) C75R probably damaging Het
Itgb4 T A 11: 115,875,898 (GRCm39) C478* probably null Het
L3mbtl4 T A 17: 68,986,419 (GRCm39) C488S probably benign Het
Mocs2 A G 13: 114,962,815 (GRCm39) K167E probably damaging Het
Mpl C A 4: 118,314,602 (GRCm39) V23F Het
Muc4 A T 16: 32,570,280 (GRCm39) I447F possibly damaging Het
Mxi1 G A 19: 53,360,126 (GRCm39) G283S probably damaging Het
Ncf2 A G 1: 152,711,864 (GRCm39) *526W probably null Het
Oas1a C T 5: 121,043,943 (GRCm39) G63D probably damaging Het
Or2q1 A T 6: 42,794,780 (GRCm39) Y125F probably damaging Het
Or5ac15 G T 16: 58,939,712 (GRCm39) C240* probably null Het
Or8c17 T C 9: 38,180,655 (GRCm39) V274A probably damaging Het
Piwil4 T C 9: 14,631,383 (GRCm39) N409S probably benign Het
Pkhd1l1 C T 15: 44,433,382 (GRCm39) Q3421* probably null Het
Plekha7 T A 7: 115,753,875 (GRCm39) D664V probably damaging Het
Pole T C 5: 110,437,233 (GRCm39) M66T possibly damaging Het
Pon2 C T 6: 5,265,480 (GRCm39) probably null Het
Pop4 G A 7: 37,962,649 (GRCm39) A205V possibly damaging Het
Ppp6r3 T A 19: 3,521,030 (GRCm39) E590D probably damaging Het
Ptpn6 T A 6: 124,709,309 (GRCm39) I96F probably damaging Het
Rfk T A 19: 17,372,590 (GRCm39) N37K probably benign Het
Syne1 G T 10: 5,049,527 (GRCm39) Q7535K probably damaging Het
Tcf15 A T 2: 151,986,023 (GRCm39) I160F probably damaging Het
Thap1 CAGCATCTGCTCGGAGCA CAGCA 8: 26,650,884 (GRCm39) probably null Het
Tmem160 T C 7: 16,186,889 (GRCm39) M1T probably null Het
Tpp1 C T 7: 105,398,814 (GRCm39) R205H probably benign Het
Trnt1 T C 6: 106,751,443 (GRCm39) F140S probably damaging Het
Ttf1 T C 2: 28,969,492 (GRCm39) probably null Het
Vmn1r172 A T 7: 23,359,210 (GRCm39) I32F probably benign Het
Vwc2l T A 1: 70,768,063 (GRCm39) N42K possibly damaging Het
Other mutations in Lysmd4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02244:Lysmd4 APN 7 66,875,672 (GRCm39) missense probably damaging 1.00
R0024:Lysmd4 UTSW 7 66,875,828 (GRCm39) missense probably benign 0.03
R0317:Lysmd4 UTSW 7 66,876,045 (GRCm39) missense probably damaging 1.00
R0563:Lysmd4 UTSW 7 66,875,925 (GRCm39) missense probably benign 0.01
R0653:Lysmd4 UTSW 7 66,875,788 (GRCm39) missense probably benign 0.09
R1856:Lysmd4 UTSW 7 66,875,979 (GRCm39) missense probably benign 0.07
R7012:Lysmd4 UTSW 7 66,875,765 (GRCm39) missense probably benign 0.08
R7578:Lysmd4 UTSW 7 66,876,037 (GRCm39) nonsense probably null
R7777:Lysmd4 UTSW 7 66,873,446 (GRCm39) missense possibly damaging 0.92
R8064:Lysmd4 UTSW 7 66,873,398 (GRCm39) missense probably damaging 1.00
R8751:Lysmd4 UTSW 7 66,875,787 (GRCm39) missense probably benign 0.09
Predicted Primers PCR Primer
(F):5'- ATTTGTGTGGAATTAACTCCAGGTC -3'
(R):5'- AGGACTCTAGTCGCCTATGG -3'

Sequencing Primer
(F):5'- CTCCAGGTCTGATTTTCAGTTAAGAG -3'
(R):5'- TGCAGCAGAACCATGGT -3'
Posted On 2021-07-15