|Institutional Source||Beutler Lab|
|Gene Name||regulator of G-protein signaling 5|
|Essential gene?||Non essential (E-score: 0.000)|
|Stock #||R8864 (G1)|
|Chromosomal Location||169655501-169695813 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to A at 169690421 bp (GRCm38)|
|Amino Acid Change||Phenylalanine to Isoleucine at position 75 (F75I)|
|Ref Sequence||ENSEMBL: ENSMUSP00000027997 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000027997]|
AA Change: F75I
PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
AA Change: F75I
|Coding Region Coverage||
|Validation Efficiency||100% (41/41)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2011]
PHENOTYPE: Mice homozygous for a targeted mutation appear normal. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Rgs5||
(F):5'- CACACATCTCTTGAAAAGTATCTGAGG -3'
(R):5'- ACCTGGGAATGTGATGATCTGG -3'
(F):5'- GACTGCAGAATCATATAGCCTGATGC -3'
(R):5'- GATGATCTGGCTCTTAAATAGCTGC -3'