Incidental Mutation 'R8865:Zeb2'
ID |
675842 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Zeb2
|
Ensembl Gene |
ENSMUSG00000026872 |
Gene Name |
zinc finger E-box binding homeobox 2 |
Synonyms |
SIP1, D130016B08Rik, 9130203F04Rik, Zfhx1b, Zfx1b |
MMRRC Submission |
068681-MU
|
Accession Numbers |
|
Essential gene? |
Essential
(E-score: 1.000)
|
Stock # |
R8865 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
2 |
Chromosomal Location |
44873644-45007407 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 44886139 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Methionine to Leucine
at position 973
(M973L)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000028229
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000028229]
[ENSMUST00000068415]
[ENSMUST00000076836]
[ENSMUST00000176438]
[ENSMUST00000176732]
[ENSMUST00000177302]
[ENSMUST00000200844]
[ENSMUST00000201804]
|
AlphaFold |
Q9R0G7 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000028229
AA Change: M973L
PolyPhen 2
Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)
|
SMART Domains |
Protein: ENSMUSP00000028229 Gene: ENSMUSG00000026872 AA Change: M973L
Domain | Start | End | E-Value | Type |
low complexity region
|
78 |
90 |
N/A |
INTRINSIC |
ZnF_C2H2
|
211 |
234 |
2.09e-3 |
SMART |
ZnF_C2H2
|
241 |
263 |
9.88e-5 |
SMART |
ZnF_C2H2
|
282 |
304 |
4.87e-4 |
SMART |
ZnF_C2H2
|
310 |
330 |
1.86e1 |
SMART |
low complexity region
|
352 |
364 |
N/A |
INTRINSIC |
ZnF_C2H2
|
581 |
601 |
5.54e1 |
SMART |
HOX
|
644 |
706 |
2.05e-3 |
SMART |
low complexity region
|
778 |
808 |
N/A |
INTRINSIC |
low complexity region
|
841 |
856 |
N/A |
INTRINSIC |
low complexity region
|
870 |
881 |
N/A |
INTRINSIC |
ZnF_C2H2
|
999 |
1021 |
4.47e-3 |
SMART |
ZnF_C2H2
|
1027 |
1049 |
2.17e-1 |
SMART |
ZnF_C2H2
|
1055 |
1076 |
1.89e-1 |
SMART |
low complexity region
|
1083 |
1097 |
N/A |
INTRINSIC |
low complexity region
|
1134 |
1150 |
N/A |
INTRINSIC |
low complexity region
|
1158 |
1168 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000068415
AA Change: M929L
PolyPhen 2
Score 0.210 (Sensitivity: 0.92; Specificity: 0.88)
|
SMART Domains |
Protein: ENSMUSP00000069685 Gene: ENSMUSG00000026872 AA Change: M929L
Domain | Start | End | E-Value | Type |
low complexity region
|
78 |
90 |
N/A |
INTRINSIC |
ZnF_C2H2
|
211 |
234 |
2.09e-3 |
SMART |
ZnF_C2H2
|
241 |
263 |
9.88e-5 |
SMART |
ZnF_C2H2
|
282 |
304 |
4.87e-4 |
SMART |
ZnF_C2H2
|
310 |
330 |
1.86e1 |
SMART |
low complexity region
|
352 |
364 |
N/A |
INTRINSIC |
ZnF_C2H2
|
581 |
601 |
5.54e1 |
SMART |
HOX
|
644 |
706 |
2.05e-3 |
SMART |
low complexity region
|
778 |
808 |
N/A |
INTRINSIC |
low complexity region
|
841 |
856 |
N/A |
INTRINSIC |
low complexity region
|
870 |
881 |
N/A |
INTRINSIC |
ZnF_C2H2
|
999 |
1021 |
4.47e-3 |
SMART |
ZnF_C2H2
|
1027 |
1049 |
2.17e-1 |
SMART |
ZnF_C2H2
|
1055 |
1076 |
1.89e-1 |
SMART |
low complexity region
|
1083 |
1097 |
N/A |
INTRINSIC |
low complexity region
|
1134 |
1150 |
N/A |
INTRINSIC |
low complexity region
|
1158 |
1168 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000076836
AA Change: M928L
PolyPhen 2
Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)
|
SMART Domains |
Protein: ENSMUSP00000076111 Gene: ENSMUSG00000026872 AA Change: M928L
Domain | Start | End | E-Value | Type |
low complexity region
|
78 |
90 |
N/A |
INTRINSIC |
ZnF_C2H2
|
210 |
233 |
2.09e-3 |
SMART |
ZnF_C2H2
|
240 |
262 |
9.88e-5 |
SMART |
ZnF_C2H2
|
281 |
303 |
4.87e-4 |
SMART |
ZnF_C2H2
|
309 |
329 |
1.86e1 |
SMART |
low complexity region
|
351 |
363 |
N/A |
INTRINSIC |
ZnF_C2H2
|
580 |
600 |
5.54e1 |
SMART |
HOX
|
643 |
705 |
2.05e-3 |
SMART |
low complexity region
|
777 |
807 |
N/A |
INTRINSIC |
low complexity region
|
840 |
855 |
N/A |
INTRINSIC |
low complexity region
|
869 |
880 |
N/A |
INTRINSIC |
ZnF_C2H2
|
998 |
1020 |
4.47e-3 |
SMART |
ZnF_C2H2
|
1026 |
1048 |
2.17e-1 |
SMART |
ZnF_C2H2
|
1054 |
1075 |
1.89e-1 |
SMART |
low complexity region
|
1082 |
1096 |
N/A |
INTRINSIC |
low complexity region
|
1133 |
1149 |
N/A |
INTRINSIC |
low complexity region
|
1157 |
1167 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000176438
AA Change: M929L
PolyPhen 2
Score 0.210 (Sensitivity: 0.92; Specificity: 0.88)
|
SMART Domains |
Protein: ENSMUSP00000134849 Gene: ENSMUSG00000026872 AA Change: M929L
Domain | Start | End | E-Value | Type |
low complexity region
|
78 |
90 |
N/A |
INTRINSIC |
ZnF_C2H2
|
211 |
234 |
2.09e-3 |
SMART |
ZnF_C2H2
|
241 |
263 |
9.88e-5 |
SMART |
ZnF_C2H2
|
282 |
304 |
4.87e-4 |
SMART |
ZnF_C2H2
|
310 |
330 |
1.86e1 |
SMART |
low complexity region
|
352 |
364 |
N/A |
INTRINSIC |
ZnF_C2H2
|
581 |
601 |
5.54e1 |
SMART |
HOX
|
644 |
706 |
2.05e-3 |
SMART |
low complexity region
|
778 |
808 |
N/A |
INTRINSIC |
low complexity region
|
841 |
856 |
N/A |
INTRINSIC |
low complexity region
|
870 |
881 |
N/A |
INTRINSIC |
ZnF_C2H2
|
999 |
1021 |
4.47e-3 |
SMART |
ZnF_C2H2
|
1027 |
1049 |
2.17e-1 |
SMART |
ZnF_C2H2
|
1055 |
1076 |
1.89e-1 |
SMART |
low complexity region
|
1083 |
1097 |
N/A |
INTRINSIC |
low complexity region
|
1134 |
1150 |
N/A |
INTRINSIC |
low complexity region
|
1158 |
1168 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000176732
|
SMART Domains |
Protein: ENSMUSP00000135393 Gene: ENSMUSG00000026872
Domain | Start | End | E-Value | Type |
low complexity region
|
14 |
26 |
N/A |
INTRINSIC |
ZnF_C2H2
|
60 |
83 |
2.09e-3 |
SMART |
ZnF_C2H2
|
90 |
112 |
9.88e-5 |
SMART |
ZnF_C2H2
|
131 |
153 |
4.87e-4 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000177302
AA Change: M929L
PolyPhen 2
Score 0.210 (Sensitivity: 0.92; Specificity: 0.88)
|
SMART Domains |
Protein: ENSMUSP00000134747 Gene: ENSMUSG00000026872 AA Change: M929L
Domain | Start | End | E-Value | Type |
low complexity region
|
78 |
90 |
N/A |
INTRINSIC |
ZnF_C2H2
|
211 |
234 |
2.09e-3 |
SMART |
ZnF_C2H2
|
241 |
263 |
9.88e-5 |
SMART |
ZnF_C2H2
|
282 |
304 |
4.87e-4 |
SMART |
ZnF_C2H2
|
310 |
330 |
1.86e1 |
SMART |
low complexity region
|
352 |
364 |
N/A |
INTRINSIC |
ZnF_C2H2
|
581 |
601 |
5.54e1 |
SMART |
HOX
|
644 |
706 |
2.05e-3 |
SMART |
low complexity region
|
778 |
808 |
N/A |
INTRINSIC |
low complexity region
|
841 |
856 |
N/A |
INTRINSIC |
low complexity region
|
870 |
881 |
N/A |
INTRINSIC |
ZnF_C2H2
|
999 |
1021 |
4.47e-3 |
SMART |
ZnF_C2H2
|
1027 |
1049 |
2.17e-1 |
SMART |
ZnF_C2H2
|
1055 |
1076 |
1.89e-1 |
SMART |
low complexity region
|
1083 |
1097 |
N/A |
INTRINSIC |
low complexity region
|
1134 |
1150 |
N/A |
INTRINSIC |
low complexity region
|
1158 |
1168 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000200844
AA Change: M905L
PolyPhen 2
Score 0.112 (Sensitivity: 0.93; Specificity: 0.86)
|
SMART Domains |
Protein: ENSMUSP00000144421 Gene: ENSMUSG00000026872 AA Change: M905L
Domain | Start | End | E-Value | Type |
low complexity region
|
78 |
90 |
N/A |
INTRINSIC |
ZnF_C2H2
|
187 |
210 |
9.2e-6 |
SMART |
ZnF_C2H2
|
217 |
239 |
4.2e-7 |
SMART |
ZnF_C2H2
|
258 |
280 |
2e-6 |
SMART |
ZnF_C2H2
|
286 |
306 |
8e-2 |
SMART |
low complexity region
|
328 |
340 |
N/A |
INTRINSIC |
ZnF_C2H2
|
557 |
577 |
2.4e-1 |
SMART |
HOX
|
620 |
682 |
1.1e-5 |
SMART |
low complexity region
|
754 |
784 |
N/A |
INTRINSIC |
low complexity region
|
817 |
832 |
N/A |
INTRINSIC |
low complexity region
|
846 |
857 |
N/A |
INTRINSIC |
ZnF_C2H2
|
975 |
997 |
1.9e-5 |
SMART |
ZnF_C2H2
|
1003 |
1025 |
9.6e-4 |
SMART |
ZnF_C2H2
|
1031 |
1052 |
7.9e-4 |
SMART |
low complexity region
|
1059 |
1073 |
N/A |
INTRINSIC |
low complexity region
|
1110 |
1126 |
N/A |
INTRINSIC |
low complexity region
|
1134 |
1144 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000201804
|
SMART Domains |
Protein: ENSMUSP00000144637 Gene: ENSMUSG00000026872
Domain | Start | End | E-Value | Type |
low complexity region
|
107 |
119 |
N/A |
INTRINSIC |
ZnF_C2H2
|
240 |
263 |
9.2e-6 |
SMART |
ZnF_C2H2
|
270 |
292 |
4.2e-7 |
SMART |
ZnF_C2H2
|
311 |
333 |
2e-6 |
SMART |
ZnF_C2H2
|
339 |
359 |
8e-2 |
SMART |
low complexity region
|
381 |
393 |
N/A |
INTRINSIC |
ZnF_C2H2
|
610 |
630 |
2.4e-1 |
SMART |
HOX
|
673 |
731 |
1.2e-3 |
SMART |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.9%
|
Validation Efficiency |
100% (72/72) |
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jan 2010] PHENOTYPE: Homozygous null mutants exhibit a variety of defects at embryonic day 8.5 and die between embryonic days 9.5 and 10.5. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 74 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Adamts2 |
T |
A |
11: 50,672,571 (GRCm39) |
Y606* |
probably null |
Het |
Adgrb1 |
A |
G |
15: 74,415,507 (GRCm39) |
I696V |
possibly damaging |
Het |
Ass1 |
A |
G |
2: 31,410,407 (GRCm39) |
Q406R |
probably benign |
Het |
Calcoco2 |
GGGCCTTCTCTTTCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTTCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTTCTCCCAGGAGGCCTTCTCTTCC |
GGGCCTTCTCTTTCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTTCTCCCAGGAGGCCTTCTCTTCC |
11: 95,990,808 (GRCm39) |
|
probably benign |
Het |
Ccdc148 |
T |
C |
2: 58,719,832 (GRCm39) |
K409R |
possibly damaging |
Het |
Ccnl1 |
A |
T |
3: 65,854,269 (GRCm39) |
S451T |
probably benign |
Het |
Cdc123 |
T |
C |
2: 5,800,235 (GRCm39) |
|
probably benign |
Het |
Cep192 |
T |
C |
18: 67,967,703 (GRCm39) |
V729A |
probably benign |
Het |
Chd6 |
G |
A |
2: 160,862,989 (GRCm39) |
A444V |
probably benign |
Het |
Chl1 |
A |
G |
6: 103,685,822 (GRCm39) |
K898E |
probably damaging |
Het |
Chrng |
T |
C |
1: 87,135,219 (GRCm39) |
V154A |
probably damaging |
Het |
Cog1 |
T |
G |
11: 113,549,324 (GRCm39) |
M799R |
probably benign |
Het |
Col4a3 |
G |
A |
1: 82,647,483 (GRCm39) |
|
probably null |
Het |
Coro6 |
C |
A |
11: 77,359,917 (GRCm39) |
T366K |
probably damaging |
Het |
Cwh43 |
G |
A |
5: 73,598,702 (GRCm39) |
M640I |
probably benign |
Het |
Cyp2c55 |
A |
G |
19: 39,019,878 (GRCm39) |
E272G |
probably benign |
Het |
Cyp4f39 |
A |
G |
17: 32,702,271 (GRCm39) |
Y256C |
probably damaging |
Het |
Dbx2 |
G |
A |
15: 95,530,281 (GRCm39) |
R229* |
probably null |
Het |
Dcdc2a |
C |
T |
13: 25,386,266 (GRCm39) |
A380V |
probably benign |
Het |
En1 |
G |
T |
1: 120,530,729 (GRCm39) |
|
probably benign |
Het |
F3 |
T |
A |
3: 121,523,060 (GRCm39) |
V90E |
probably damaging |
Het |
Fam171a1 |
A |
G |
2: 3,226,940 (GRCm39) |
K691R |
probably damaging |
Het |
Foxp2 |
C |
T |
6: 15,415,093 (GRCm39) |
A609V |
unknown |
Het |
Hemgn |
A |
T |
4: 46,396,682 (GRCm39) |
S185T |
possibly damaging |
Het |
Hk1 |
C |
T |
10: 62,151,294 (GRCm39) |
D33N |
probably benign |
Het |
Igfbp1 |
T |
A |
11: 7,151,929 (GRCm39) |
V244D |
probably damaging |
Het |
Insr |
A |
T |
8: 3,211,358 (GRCm39) |
D1160E |
probably damaging |
Het |
Irs1 |
A |
T |
1: 82,265,830 (GRCm39) |
Y795* |
probably null |
Het |
Krtap28-10 |
T |
C |
1: 83,019,808 (GRCm39) |
K111E |
unknown |
Het |
Lbx1 |
T |
G |
19: 45,223,605 (GRCm39) |
D21A |
probably benign |
Het |
Map6 |
G |
T |
7: 98,918,192 (GRCm39) |
A322S |
probably benign |
Het |
Mat1a |
T |
C |
14: 40,843,788 (GRCm39) |
Y336H |
probably damaging |
Het |
Mcf2l |
A |
G |
8: 12,930,003 (GRCm39) |
I8V |
probably benign |
Het |
Med12l |
T |
C |
3: 58,979,303 (GRCm39) |
V276A |
probably benign |
Het |
Mettl17 |
A |
G |
14: 52,122,308 (GRCm39) |
|
probably benign |
Het |
Mllt1 |
T |
C |
17: 57,207,295 (GRCm39) |
D183G |
possibly damaging |
Het |
Msmb |
T |
A |
14: 31,872,217 (GRCm39) |
C69* |
probably null |
Het |
Mterf1a |
A |
G |
5: 3,941,425 (GRCm39) |
S148P |
probably damaging |
Het |
Mybl2 |
A |
G |
2: 162,922,653 (GRCm39) |
I583V |
probably benign |
Het |
Nbr1 |
T |
A |
11: 101,455,520 (GRCm39) |
D91E |
probably benign |
Het |
Notch3 |
A |
G |
17: 32,341,090 (GRCm39) |
Y2221H |
probably benign |
Het |
Npat |
C |
A |
9: 53,481,940 (GRCm39) |
T1216N |
probably benign |
Het |
Or14j6 |
T |
C |
17: 38,215,115 (GRCm39) |
L226P |
probably damaging |
Het |
Or2j3 |
T |
A |
17: 38,615,872 (GRCm39) |
H160L |
probably damaging |
Het |
Or8k35 |
C |
A |
2: 86,424,744 (GRCm39) |
V143F |
possibly damaging |
Het |
Pawr |
T |
A |
10: 108,218,603 (GRCm39) |
Y170N |
probably damaging |
Het |
Pde12 |
T |
C |
14: 26,390,280 (GRCm39) |
D143G |
possibly damaging |
Het |
Phactr2 |
A |
G |
10: 13,129,476 (GRCm39) |
I264T |
probably benign |
Het |
Pip5k1b |
A |
G |
19: 24,374,422 (GRCm39) |
L53P |
probably damaging |
Het |
Pknox1 |
T |
C |
17: 31,818,520 (GRCm39) |
I251T |
probably benign |
Het |
Plcxd1 |
A |
T |
5: 110,249,841 (GRCm39) |
|
probably benign |
Het |
Polr3c |
C |
T |
3: 96,622,517 (GRCm39) |
|
probably benign |
Het |
Pramel4 |
G |
C |
4: 143,795,052 (GRCm39) |
G483R |
probably damaging |
Het |
Prdm10 |
T |
C |
9: 31,238,693 (GRCm39) |
L195P |
probably damaging |
Het |
Prss16 |
A |
T |
13: 22,187,175 (GRCm39) |
L465Q |
possibly damaging |
Het |
Psg25 |
G |
T |
7: 18,263,519 (GRCm39) |
H101Q |
possibly damaging |
Het |
Pstpip2 |
A |
G |
18: 77,934,108 (GRCm39) |
D55G |
possibly damaging |
Het |
Rfc1 |
A |
T |
5: 65,436,135 (GRCm39) |
D636E |
possibly damaging |
Het |
Scarf2 |
G |
T |
16: 17,620,974 (GRCm39) |
C214F |
probably damaging |
Het |
Sirt4 |
T |
C |
5: 115,620,704 (GRCm39) |
E156G |
probably damaging |
Het |
Spag6 |
C |
T |
2: 18,738,928 (GRCm39) |
S286L |
probably benign |
Het |
Stx17 |
T |
A |
4: 48,183,444 (GRCm39) |
H267Q |
unknown |
Het |
Tekt3 |
T |
C |
11: 62,961,058 (GRCm39) |
C76R |
probably benign |
Het |
Tln1 |
A |
T |
4: 43,538,281 (GRCm39) |
V1807E |
possibly damaging |
Het |
Tnfrsf21 |
A |
G |
17: 43,396,372 (GRCm39) |
D552G |
probably damaging |
Het |
Ttn |
C |
A |
2: 76,560,664 (GRCm39) |
V29246L |
possibly damaging |
Het |
Usp43 |
C |
A |
11: 67,789,788 (GRCm39) |
C252F |
probably damaging |
Het |
Vmn2r16 |
T |
C |
5: 109,487,910 (GRCm39) |
I261T |
probably benign |
Het |
Vwa5b1 |
T |
C |
4: 138,308,530 (GRCm39) |
E769G |
probably benign |
Het |
Xrn1 |
T |
A |
9: 95,873,246 (GRCm39) |
F670Y |
probably benign |
Het |
Ypel1 |
T |
C |
16: 16,915,269 (GRCm39) |
N113S |
probably benign |
Het |
Zc3h7b |
G |
A |
15: 81,656,681 (GRCm39) |
R166Q |
probably benign |
Het |
Zdhhc14 |
A |
T |
17: 5,775,570 (GRCm39) |
Y274F |
possibly damaging |
Het |
Zfp638 |
T |
C |
6: 83,954,035 (GRCm39) |
V1380A |
possibly damaging |
Het |
|
Other mutations in Zeb2 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00900:Zeb2
|
APN |
2 |
44,887,287 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01639:Zeb2
|
APN |
2 |
44,887,269 (GRCm39) |
missense |
probably benign |
|
IGL02016:Zeb2
|
APN |
2 |
44,878,886 (GRCm39) |
missense |
possibly damaging |
0.71 |
IGL02337:Zeb2
|
APN |
2 |
44,887,242 (GRCm39) |
missense |
probably damaging |
0.96 |
IGL02745:Zeb2
|
APN |
2 |
44,884,487 (GRCm39) |
unclassified |
probably benign |
|
IGL02893:Zeb2
|
APN |
2 |
44,886,619 (GRCm39) |
missense |
probably benign |
0.03 |
IGL03412:Zeb2
|
APN |
2 |
44,892,720 (GRCm39) |
intron |
probably benign |
|
Blight
|
UTSW |
2 |
45,000,040 (GRCm39) |
missense |
possibly damaging |
0.95 |
Dropped
|
UTSW |
2 |
45,000,053 (GRCm39) |
missense |
possibly damaging |
0.66 |
Okapi
|
UTSW |
2 |
44,887,168 (GRCm39) |
missense |
probably damaging |
1.00 |
sable
|
UTSW |
2 |
44,887,330 (GRCm39) |
missense |
probably damaging |
1.00 |
R0514:Zeb2
|
UTSW |
2 |
44,892,659 (GRCm39) |
missense |
possibly damaging |
0.52 |
R0603:Zeb2
|
UTSW |
2 |
44,907,438 (GRCm39) |
missense |
probably benign |
0.45 |
R0608:Zeb2
|
UTSW |
2 |
44,886,138 (GRCm39) |
missense |
possibly damaging |
0.87 |
R1236:Zeb2
|
UTSW |
2 |
44,884,658 (GRCm39) |
missense |
probably damaging |
1.00 |
R1529:Zeb2
|
UTSW |
2 |
44,887,206 (GRCm39) |
missense |
probably damaging |
1.00 |
R1581:Zeb2
|
UTSW |
2 |
44,887,012 (GRCm39) |
missense |
probably damaging |
0.99 |
R1636:Zeb2
|
UTSW |
2 |
44,892,623 (GRCm39) |
missense |
probably damaging |
1.00 |
R1924:Zeb2
|
UTSW |
2 |
44,892,624 (GRCm39) |
missense |
probably damaging |
1.00 |
R2012:Zeb2
|
UTSW |
2 |
44,887,962 (GRCm39) |
missense |
probably damaging |
1.00 |
R2097:Zeb2
|
UTSW |
2 |
44,887,168 (GRCm39) |
missense |
probably damaging |
1.00 |
R2156:Zeb2
|
UTSW |
2 |
44,878,821 (GRCm39) |
missense |
probably benign |
0.20 |
R4385:Zeb2
|
UTSW |
2 |
44,913,074 (GRCm39) |
missense |
probably damaging |
1.00 |
R4472:Zeb2
|
UTSW |
2 |
44,913,023 (GRCm39) |
missense |
probably damaging |
1.00 |
R4678:Zeb2
|
UTSW |
2 |
44,886,353 (GRCm39) |
missense |
probably damaging |
0.99 |
R4769:Zeb2
|
UTSW |
2 |
44,886,447 (GRCm39) |
missense |
probably damaging |
1.00 |
R4816:Zeb2
|
UTSW |
2 |
44,887,780 (GRCm39) |
missense |
probably damaging |
0.99 |
R4918:Zeb2
|
UTSW |
2 |
44,886,894 (GRCm39) |
missense |
probably damaging |
1.00 |
R4969:Zeb2
|
UTSW |
2 |
44,888,931 (GRCm39) |
missense |
probably damaging |
1.00 |
R5191:Zeb2
|
UTSW |
2 |
44,892,612 (GRCm39) |
missense |
probably benign |
0.00 |
R5195:Zeb2
|
UTSW |
2 |
44,891,647 (GRCm39) |
missense |
probably damaging |
1.00 |
R5322:Zeb2
|
UTSW |
2 |
44,887,107 (GRCm39) |
missense |
probably damaging |
1.00 |
R5699:Zeb2
|
UTSW |
2 |
44,887,800 (GRCm39) |
missense |
probably damaging |
1.00 |
R5750:Zeb2
|
UTSW |
2 |
44,887,530 (GRCm39) |
missense |
probably damaging |
0.96 |
R5764:Zeb2
|
UTSW |
2 |
44,886,931 (GRCm39) |
missense |
possibly damaging |
0.89 |
R5914:Zeb2
|
UTSW |
2 |
44,887,064 (GRCm39) |
missense |
probably benign |
0.00 |
R5918:Zeb2
|
UTSW |
2 |
45,001,271 (GRCm39) |
intron |
probably benign |
|
R6037:Zeb2
|
UTSW |
2 |
44,878,652 (GRCm39) |
nonsense |
probably null |
|
R6037:Zeb2
|
UTSW |
2 |
44,878,652 (GRCm39) |
nonsense |
probably null |
|
R6302:Zeb2
|
UTSW |
2 |
44,887,771 (GRCm39) |
missense |
probably benign |
0.18 |
R6372:Zeb2
|
UTSW |
2 |
44,892,551 (GRCm39) |
missense |
probably damaging |
1.00 |
R6402:Zeb2
|
UTSW |
2 |
44,886,987 (GRCm39) |
missense |
probably damaging |
1.00 |
R6492:Zeb2
|
UTSW |
2 |
45,000,508 (GRCm39) |
intron |
probably benign |
|
R6554:Zeb2
|
UTSW |
2 |
44,887,524 (GRCm39) |
missense |
probably damaging |
1.00 |
R6675:Zeb2
|
UTSW |
2 |
44,887,457 (GRCm39) |
nonsense |
probably null |
|
R6735:Zeb2
|
UTSW |
2 |
45,000,028 (GRCm39) |
missense |
probably null |
0.99 |
R6870:Zeb2
|
UTSW |
2 |
44,878,922 (GRCm39) |
missense |
probably damaging |
0.98 |
R6925:Zeb2
|
UTSW |
2 |
44,884,541 (GRCm39) |
missense |
probably damaging |
1.00 |
R6963:Zeb2
|
UTSW |
2 |
44,878,811 (GRCm39) |
missense |
probably damaging |
0.97 |
R6972:Zeb2
|
UTSW |
2 |
44,887,330 (GRCm39) |
missense |
probably damaging |
1.00 |
R7144:Zeb2
|
UTSW |
2 |
45,000,053 (GRCm39) |
missense |
possibly damaging |
0.66 |
R7178:Zeb2
|
UTSW |
2 |
44,887,006 (GRCm39) |
missense |
probably damaging |
0.97 |
R7379:Zeb2
|
UTSW |
2 |
44,891,829 (GRCm39) |
splice site |
probably null |
|
R7419:Zeb2
|
UTSW |
2 |
44,886,359 (GRCm39) |
missense |
probably benign |
0.20 |
R7580:Zeb2
|
UTSW |
2 |
44,884,544 (GRCm39) |
missense |
probably damaging |
1.00 |
R7599:Zeb2
|
UTSW |
2 |
44,884,625 (GRCm39) |
missense |
probably damaging |
1.00 |
R7625:Zeb2
|
UTSW |
2 |
44,892,584 (GRCm39) |
missense |
probably damaging |
1.00 |
R7917:Zeb2
|
UTSW |
2 |
44,886,421 (GRCm39) |
missense |
possibly damaging |
0.50 |
R8132:Zeb2
|
UTSW |
2 |
44,879,142 (GRCm39) |
missense |
probably damaging |
1.00 |
R8412:Zeb2
|
UTSW |
2 |
44,888,964 (GRCm39) |
missense |
probably damaging |
1.00 |
R8413:Zeb2
|
UTSW |
2 |
44,886,183 (GRCm39) |
missense |
probably damaging |
0.99 |
R8417:Zeb2
|
UTSW |
2 |
44,913,008 (GRCm39) |
missense |
probably damaging |
0.99 |
R8750:Zeb2
|
UTSW |
2 |
44,887,939 (GRCm39) |
missense |
probably damaging |
1.00 |
R8916:Zeb2
|
UTSW |
2 |
44,886,796 (GRCm39) |
missense |
probably damaging |
0.99 |
R9068:Zeb2
|
UTSW |
2 |
45,000,040 (GRCm39) |
missense |
possibly damaging |
0.95 |
R9094:Zeb2
|
UTSW |
2 |
45,003,136 (GRCm39) |
intron |
probably benign |
|
R9139:Zeb2
|
UTSW |
2 |
44,878,637 (GRCm39) |
missense |
possibly damaging |
0.52 |
R9187:Zeb2
|
UTSW |
2 |
45,000,040 (GRCm39) |
missense |
possibly damaging |
0.95 |
R9309:Zeb2
|
UTSW |
2 |
44,892,575 (GRCm39) |
missense |
probably damaging |
0.99 |
R9310:Zeb2
|
UTSW |
2 |
44,886,988 (GRCm39) |
missense |
probably benign |
0.01 |
R9337:Zeb2
|
UTSW |
2 |
44,912,912 (GRCm39) |
missense |
probably benign |
0.35 |
R9350:Zeb2
|
UTSW |
2 |
44,887,158 (GRCm39) |
missense |
possibly damaging |
0.79 |
R9371:Zeb2
|
UTSW |
2 |
44,888,912 (GRCm39) |
missense |
probably damaging |
1.00 |
R9389:Zeb2
|
UTSW |
2 |
44,887,920 (GRCm39) |
missense |
probably damaging |
1.00 |
R9509:Zeb2
|
UTSW |
2 |
44,887,876 (GRCm39) |
missense |
possibly damaging |
0.74 |
R9600:Zeb2
|
UTSW |
2 |
44,987,180 (GRCm39) |
missense |
unknown |
|
R9674:Zeb2
|
UTSW |
2 |
44,891,725 (GRCm39) |
missense |
probably damaging |
1.00 |
R9756:Zeb2
|
UTSW |
2 |
44,887,414 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
Predicted Primers |
PCR Primer
(F):5'- TTATTTAGGACTGGGCAGCC -3'
(R):5'- TTCAGATGAGCCTCTGAATTTGAC -3'
Sequencing Primer
(F):5'- GCCTGGGAATCACAACTAGGTTATC -3'
(R):5'- TGAGCCTCTGAATTTGACTTTTATC -3'
|
Posted On |
2021-07-15 |