Incidental Mutation 'R8865:Tnfrsf21'
ID 675899
Institutional Source Beutler Lab
Gene Symbol Tnfrsf21
Ensembl Gene ENSMUSG00000023915
Gene Name tumor necrosis factor receptor superfamily, member 21
Synonyms TR7, Death receptor 6, DR6
MMRRC Submission 068681-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.175) question?
Stock # R8865 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 43327446-43400079 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 43396372 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 552 (D552G)
Ref Sequence ENSEMBL: ENSMUSP00000024708 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000024708]
AlphaFold Q9EPU5
Predicted Effect probably damaging
Transcript: ENSMUST00000024708
AA Change: D552G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000024708
Gene: ENSMUSG00000023915
AA Change: D552G

DomainStartEndE-ValueType
TNFR 50 88 1.58e1 SMART
TNFR 91 131 3.42e-3 SMART
TNFR 133 168 9.31e-5 SMART
TNFR 171 211 1.1e-1 SMART
transmembrane domain 351 370 N/A INTRINSIC
DEATH 393 498 1.41e-22 SMART
low complexity region 511 526 N/A INTRINSIC
low complexity region 562 575 N/A INTRINSIC
PDB:2DBH|A 576 655 5e-48 PDB
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency 100% (72/72)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired T cell differentiation and an enhanced Th2 response. Mice homozygous for a different knock-out allele show increased CD4+ T cell proliferation and Th2 cytokine production, and enhanced B cell proliferation, survival, and humoral responses. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts2 T A 11: 50,672,571 (GRCm39) Y606* probably null Het
Adgrb1 A G 15: 74,415,507 (GRCm39) I696V possibly damaging Het
Ass1 A G 2: 31,410,407 (GRCm39) Q406R probably benign Het
Calcoco2 GGGCCTTCTCTTTCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTTCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTTCTCCCAGGAGGCCTTCTCTTCC GGGCCTTCTCTTTCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTTCTCCCAGGAGGCCTTCTCTTCC 11: 95,990,808 (GRCm39) probably benign Het
Ccdc148 T C 2: 58,719,832 (GRCm39) K409R possibly damaging Het
Ccnl1 A T 3: 65,854,269 (GRCm39) S451T probably benign Het
Cdc123 T C 2: 5,800,235 (GRCm39) probably benign Het
Cep192 T C 18: 67,967,703 (GRCm39) V729A probably benign Het
Chd6 G A 2: 160,862,989 (GRCm39) A444V probably benign Het
Chl1 A G 6: 103,685,822 (GRCm39) K898E probably damaging Het
Chrng T C 1: 87,135,219 (GRCm39) V154A probably damaging Het
Cog1 T G 11: 113,549,324 (GRCm39) M799R probably benign Het
Col4a3 G A 1: 82,647,483 (GRCm39) probably null Het
Coro6 C A 11: 77,359,917 (GRCm39) T366K probably damaging Het
Cwh43 G A 5: 73,598,702 (GRCm39) M640I probably benign Het
Cyp2c55 A G 19: 39,019,878 (GRCm39) E272G probably benign Het
Cyp4f39 A G 17: 32,702,271 (GRCm39) Y256C probably damaging Het
Dbx2 G A 15: 95,530,281 (GRCm39) R229* probably null Het
Dcdc2a C T 13: 25,386,266 (GRCm39) A380V probably benign Het
En1 G T 1: 120,530,729 (GRCm39) probably benign Het
F3 T A 3: 121,523,060 (GRCm39) V90E probably damaging Het
Fam171a1 A G 2: 3,226,940 (GRCm39) K691R probably damaging Het
Foxp2 C T 6: 15,415,093 (GRCm39) A609V unknown Het
Hemgn A T 4: 46,396,682 (GRCm39) S185T possibly damaging Het
Hk1 C T 10: 62,151,294 (GRCm39) D33N probably benign Het
Igfbp1 T A 11: 7,151,929 (GRCm39) V244D probably damaging Het
Insr A T 8: 3,211,358 (GRCm39) D1160E probably damaging Het
Irs1 A T 1: 82,265,830 (GRCm39) Y795* probably null Het
Krtap28-10 T C 1: 83,019,808 (GRCm39) K111E unknown Het
Lbx1 T G 19: 45,223,605 (GRCm39) D21A probably benign Het
Map6 G T 7: 98,918,192 (GRCm39) A322S probably benign Het
Mat1a T C 14: 40,843,788 (GRCm39) Y336H probably damaging Het
Mcf2l A G 8: 12,930,003 (GRCm39) I8V probably benign Het
Med12l T C 3: 58,979,303 (GRCm39) V276A probably benign Het
Mettl17 A G 14: 52,122,308 (GRCm39) probably benign Het
Mllt1 T C 17: 57,207,295 (GRCm39) D183G possibly damaging Het
Msmb T A 14: 31,872,217 (GRCm39) C69* probably null Het
Mterf1a A G 5: 3,941,425 (GRCm39) S148P probably damaging Het
Mybl2 A G 2: 162,922,653 (GRCm39) I583V probably benign Het
Nbr1 T A 11: 101,455,520 (GRCm39) D91E probably benign Het
Notch3 A G 17: 32,341,090 (GRCm39) Y2221H probably benign Het
Npat C A 9: 53,481,940 (GRCm39) T1216N probably benign Het
Or14j6 T C 17: 38,215,115 (GRCm39) L226P probably damaging Het
Or2j3 T A 17: 38,615,872 (GRCm39) H160L probably damaging Het
Or8k35 C A 2: 86,424,744 (GRCm39) V143F possibly damaging Het
Pawr T A 10: 108,218,603 (GRCm39) Y170N probably damaging Het
Pde12 T C 14: 26,390,280 (GRCm39) D143G possibly damaging Het
Phactr2 A G 10: 13,129,476 (GRCm39) I264T probably benign Het
Pip5k1b A G 19: 24,374,422 (GRCm39) L53P probably damaging Het
Pknox1 T C 17: 31,818,520 (GRCm39) I251T probably benign Het
Plcxd1 A T 5: 110,249,841 (GRCm39) probably benign Het
Polr3c C T 3: 96,622,517 (GRCm39) probably benign Het
Pramel4 G C 4: 143,795,052 (GRCm39) G483R probably damaging Het
Prdm10 T C 9: 31,238,693 (GRCm39) L195P probably damaging Het
Prss16 A T 13: 22,187,175 (GRCm39) L465Q possibly damaging Het
Psg25 G T 7: 18,263,519 (GRCm39) H101Q possibly damaging Het
Pstpip2 A G 18: 77,934,108 (GRCm39) D55G possibly damaging Het
Rfc1 A T 5: 65,436,135 (GRCm39) D636E possibly damaging Het
Scarf2 G T 16: 17,620,974 (GRCm39) C214F probably damaging Het
Sirt4 T C 5: 115,620,704 (GRCm39) E156G probably damaging Het
Spag6 C T 2: 18,738,928 (GRCm39) S286L probably benign Het
Stx17 T A 4: 48,183,444 (GRCm39) H267Q unknown Het
Tekt3 T C 11: 62,961,058 (GRCm39) C76R probably benign Het
Tln1 A T 4: 43,538,281 (GRCm39) V1807E possibly damaging Het
Ttn C A 2: 76,560,664 (GRCm39) V29246L possibly damaging Het
Usp43 C A 11: 67,789,788 (GRCm39) C252F probably damaging Het
Vmn2r16 T C 5: 109,487,910 (GRCm39) I261T probably benign Het
Vwa5b1 T C 4: 138,308,530 (GRCm39) E769G probably benign Het
Xrn1 T A 9: 95,873,246 (GRCm39) F670Y probably benign Het
Ypel1 T C 16: 16,915,269 (GRCm39) N113S probably benign Het
Zc3h7b G A 15: 81,656,681 (GRCm39) R166Q probably benign Het
Zdhhc14 A T 17: 5,775,570 (GRCm39) Y274F possibly damaging Het
Zeb2 T A 2: 44,886,139 (GRCm39) M973L probably benign Het
Zfp638 T C 6: 83,954,035 (GRCm39) V1380A possibly damaging Het
Other mutations in Tnfrsf21
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01406:Tnfrsf21 APN 17 43,348,837 (GRCm39) missense probably damaging 1.00
IGL01663:Tnfrsf21 APN 17 43,398,702 (GRCm39) missense probably benign 0.13
IGL01811:Tnfrsf21 APN 17 43,348,504 (GRCm39) missense probably benign
IGL01916:Tnfrsf21 APN 17 43,350,694 (GRCm39) missense probably benign 0.00
IGL01934:Tnfrsf21 APN 17 43,376,078 (GRCm39) missense probably benign 0.15
IGL02184:Tnfrsf21 APN 17 43,396,354 (GRCm39) missense probably benign 0.37
IGL02292:Tnfrsf21 APN 17 43,350,802 (GRCm39) missense probably benign
IGL02385:Tnfrsf21 APN 17 43,350,942 (GRCm39) missense probably damaging 1.00
IGL02710:Tnfrsf21 APN 17 43,398,820 (GRCm39) missense probably damaging 0.97
IGL03001:Tnfrsf21 APN 17 43,398,786 (GRCm39) missense probably damaging 0.99
IGL03003:Tnfrsf21 APN 17 43,350,834 (GRCm39) missense probably damaging 1.00
PIT4480001:Tnfrsf21 UTSW 17 43,348,802 (GRCm39) missense probably benign 0.00
R0007:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0046:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0088:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0091:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0102:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0102:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0103:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0105:Tnfrsf21 UTSW 17 43,351,082 (GRCm39) critical splice donor site probably null
R0105:Tnfrsf21 UTSW 17 43,351,082 (GRCm39) critical splice donor site probably null
R0206:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0211:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0240:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0243:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0308:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0363:Tnfrsf21 UTSW 17 43,348,768 (GRCm39) missense probably benign 0.01
R0456:Tnfrsf21 UTSW 17 43,348,982 (GRCm39) missense probably benign 0.01
R0522:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0523:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0525:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0528:Tnfrsf21 UTSW 17 43,348,505 (GRCm39) missense probably benign
R0543:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0549:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0550:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0699:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0724:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0734:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0847:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0880:Tnfrsf21 UTSW 17 43,348,733 (GRCm39) nonsense probably null
R1591:Tnfrsf21 UTSW 17 43,396,265 (GRCm39) missense probably benign 0.01
R2069:Tnfrsf21 UTSW 17 43,348,829 (GRCm39) missense possibly damaging 0.67
R2153:Tnfrsf21 UTSW 17 43,398,763 (GRCm39) missense probably damaging 1.00
R2323:Tnfrsf21 UTSW 17 43,396,420 (GRCm39) nonsense probably null
R3941:Tnfrsf21 UTSW 17 43,348,901 (GRCm39) missense probably damaging 1.00
R4438:Tnfrsf21 UTSW 17 43,398,733 (GRCm39) missense possibly damaging 0.49
R4509:Tnfrsf21 UTSW 17 43,396,279 (GRCm39) missense probably benign 0.00
R4510:Tnfrsf21 UTSW 17 43,375,910 (GRCm39) missense probably damaging 0.98
R4511:Tnfrsf21 UTSW 17 43,375,910 (GRCm39) missense probably damaging 0.98
R4708:Tnfrsf21 UTSW 17 43,349,123 (GRCm39) missense possibly damaging 0.66
R4721:Tnfrsf21 UTSW 17 43,396,395 (GRCm39) missense probably damaging 1.00
R4811:Tnfrsf21 UTSW 17 43,348,621 (GRCm39) missense probably benign 0.00
R5437:Tnfrsf21 UTSW 17 43,348,753 (GRCm39) missense possibly damaging 0.55
R5767:Tnfrsf21 UTSW 17 43,348,550 (GRCm39) missense probably damaging 0.98
R6057:Tnfrsf21 UTSW 17 43,350,606 (GRCm39) missense possibly damaging 0.86
R6392:Tnfrsf21 UTSW 17 43,327,979 (GRCm39) missense probably benign 0.00
R6860:Tnfrsf21 UTSW 17 43,327,957 (GRCm39) missense probably benign
R7253:Tnfrsf21 UTSW 17 43,348,558 (GRCm39) missense probably benign 0.00
R7288:Tnfrsf21 UTSW 17 43,348,709 (GRCm39) missense possibly damaging 0.86
R7643:Tnfrsf21 UTSW 17 43,348,807 (GRCm39) missense probably benign 0.00
R7937:Tnfrsf21 UTSW 17 43,348,816 (GRCm39) missense probably benign 0.01
R8098:Tnfrsf21 UTSW 17 43,350,790 (GRCm39) missense probably benign
R8495:Tnfrsf21 UTSW 17 43,349,128 (GRCm39) missense probably benign
R8991:Tnfrsf21 UTSW 17 43,396,299 (GRCm39) missense probably benign 0.03
R9088:Tnfrsf21 UTSW 17 43,348,607 (GRCm39) missense probably damaging 1.00
R9150:Tnfrsf21 UTSW 17 43,398,691 (GRCm39) missense probably damaging 1.00
R9220:Tnfrsf21 UTSW 17 43,398,801 (GRCm39) missense probably damaging 1.00
V3553:Tnfrsf21 UTSW 17 43,348,822 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TAAAGGAGGAGGGTTTAGCTTC -3'
(R):5'- GGACACTTTCATCTTGGAGGTC -3'

Sequencing Primer
(F):5'- AAGGAGGAGGGTTTAGCTTCATTTTG -3'
(R):5'- GGAGGTCTCCCTAAACAGCTCAG -3'
Posted On 2021-07-15