Incidental Mutation 'R8866:Lrrc10'
ID 675941
Institutional Source Beutler Lab
Gene Symbol Lrrc10
Ensembl Gene ENSMUSG00000060187
Gene Name leucine rich repeat containing 10
Synonyms D330003I11Rik, Hrlrrp, Serdin1
MMRRC Submission 068742-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8866 (G1)
Quality Score 225.009
Status Not validated
Chromosome 10
Chromosomal Location 116881246-116882673 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 116881858 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 177 (N177K)
Ref Sequence ENSEMBL: ENSMUSP00000073502 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073834]
AlphaFold Q8K3W2
Predicted Effect probably damaging
Transcript: ENSMUST00000073834
AA Change: N177K

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000073502
Gene: ENSMUSG00000060187
AA Change: N177K

DomainStartEndE-ValueType
LRR 51 73 3.75e0 SMART
LRR 74 95 2.2e1 SMART
LRR 97 119 2.76e1 SMART
LRR_TYP 120 143 1.92e-2 SMART
LRR 166 189 1.62e0 SMART
low complexity region 265 274 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null mutation are viable and fertile. They show prenatal systolic dysfunction and development of dilated cardiomyopathy in postnatal life. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl2 C T 3: 59,914,511 (GRCm39) T38I probably benign Het
Arhgap1 G T 2: 91,499,744 (GRCm39) S293I probably benign Het
Arhgap45 C A 10: 79,853,750 (GRCm39) P88Q probably damaging Het
Atg9a A C 1: 75,161,867 (GRCm39) F560V probably damaging Het
Btaf1 T A 19: 36,935,901 (GRCm39) N230K probably benign Het
Ccne1 A C 7: 37,800,046 (GRCm39) H179Q probably benign Het
Dbr1 T A 9: 99,460,497 (GRCm39) L109* probably null Het
Dchs1 G T 7: 105,404,597 (GRCm39) N2648K probably benign Het
Ddx47 A G 6: 135,000,356 (GRCm39) K451E probably benign Het
Dlgap1 A T 17: 70,823,435 (GRCm39) H140L probably damaging Het
Dnah11 T A 12: 118,156,107 (GRCm39) H181L probably benign Het
Dync1h1 T C 12: 110,602,333 (GRCm39) C2074R probably damaging Het
Ell2 A T 13: 75,917,793 (GRCm39) Q574H probably damaging Het
Eloa A C 4: 135,737,538 (GRCm39) probably null Het
Epha7 A G 4: 28,821,614 (GRCm39) I260V probably benign Het
Fbp2 T C 13: 62,989,709 (GRCm39) K199R probably benign Het
Fetub A T 16: 22,758,321 (GRCm39) E368V possibly damaging Het
Fsip2 A G 2: 82,810,521 (GRCm39) Q2280R probably benign Het
Fstl4 A G 11: 52,963,233 (GRCm39) E205G possibly damaging Het
Gm5592 A T 7: 40,938,246 (GRCm39) R509S possibly damaging Het
Gpld1 A G 13: 25,170,890 (GRCm39) T794A probably benign Het
Gsk3b A G 16: 38,004,900 (GRCm39) Y157C probably damaging Het
Hgs A G 11: 120,360,464 (GRCm39) N54S probably benign Het
Hydin G A 8: 111,308,779 (GRCm39) V4022M possibly damaging Het
Kank1 T C 19: 25,388,702 (GRCm39) S792P possibly damaging Het
Kctd4 A G 14: 76,200,465 (GRCm39) I145M probably benign Het
Klra5 A T 6: 129,880,533 (GRCm39) W212R probably damaging Het
Lrp6 A T 6: 134,445,785 (GRCm39) N1009K probably benign Het
Lrrc39 T A 3: 116,363,790 (GRCm39) I121N probably damaging Het
Mov10l1 A T 15: 88,896,169 (GRCm39) D671V probably benign Het
Ndel1 A G 11: 68,734,645 (GRCm39) probably null Het
Or10g3 A T 14: 52,610,196 (GRCm39) Y105N probably damaging Het
Or1e27-ps1 A G 11: 73,555,825 (GRCm39) Y130C probably damaging Het
Or1e32 A T 11: 73,705,237 (GRCm39) S224T probably damaging Het
Or51a43 A T 7: 103,718,119 (GRCm39) S40T probably damaging Het
Otop2 A G 11: 115,220,354 (GRCm39) D398G probably benign Het
Pkd1 T C 17: 24,792,051 (GRCm39) V1246A probably damaging Het
Polr3b T A 10: 84,531,555 (GRCm39) D810E probably benign Het
Ppl T A 16: 4,920,211 (GRCm39) T395S probably benign Het
Ptprm G A 17: 67,116,630 (GRCm39) A883V probably benign Het
Rapgef6 G A 11: 54,443,700 (GRCm39) probably null Het
Rbm12 A T 2: 155,938,693 (GRCm39) Y526* probably null Het
Rbm15b C T 9: 106,763,595 (GRCm39) R191Q probably benign Het
Rsf1 GCGGCGGCG GCGGCGGCGACGGCGGCG 7: 97,229,120 (GRCm39) probably benign Het
Rxylt1 A G 10: 121,924,953 (GRCm39) Y250H probably damaging Het
Serpinb6c A T 13: 34,083,309 (GRCm39) I35N probably damaging Het
Setd4 A G 16: 93,386,961 (GRCm39) F246L probably damaging Het
Shank2 A G 7: 143,964,986 (GRCm39) S865G probably benign Het
Skint6 T C 4: 112,711,650 (GRCm39) N956D probably benign Het
Slc30a3 C A 5: 31,245,325 (GRCm39) V332F possibly damaging Het
Smg1 A G 7: 117,806,122 (GRCm39) S240P unknown Het
Tank T A 2: 61,409,005 (GRCm39) S7R probably benign Het
Tecpr1 T C 5: 144,153,117 (GRCm39) E204G possibly damaging Het
Tmem74 A G 15: 43,730,231 (GRCm39) S271P probably damaging Het
Tor4a T C 2: 25,084,965 (GRCm39) M313V probably benign Het
Tpd52l2 A G 2: 181,154,861 (GRCm39) D192G probably damaging Het
Trim29 T C 9: 43,222,945 (GRCm39) V258A probably damaging Het
Ttc39c A T 18: 12,831,003 (GRCm39) S288C probably benign Het
Ttn T C 2: 76,592,675 (GRCm39) E20819G probably damaging Het
Twnk C T 19: 45,000,272 (GRCm39) Q663* probably null Het
Ucn T A 5: 31,295,857 (GRCm39) Q3L probably benign Het
Unc80 G A 1: 66,629,388 (GRCm39) G1295E probably benign Het
Usp9y C T Y: 1,395,758 (GRCm39) R492H probably damaging Het
Vars1 T C 17: 35,234,620 (GRCm39) S1150P probably benign Het
Vwa5b1 T G 4: 138,327,628 (GRCm39) E316A probably damaging Het
Zc3h7b G A 15: 81,656,681 (GRCm39) R166Q probably benign Het
Zfp839 A G 12: 110,834,848 (GRCm39) E701G probably benign Het
Zfp931 A T 2: 177,710,178 (GRCm39) C69* probably null Het
Other mutations in Lrrc10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01985:Lrrc10 APN 10 116,881,921 (GRCm39) missense probably damaging 1.00
R0077:Lrrc10 UTSW 10 116,881,419 (GRCm39) missense probably damaging 1.00
R0110:Lrrc10 UTSW 10 116,881,695 (GRCm39) missense probably damaging 1.00
R0469:Lrrc10 UTSW 10 116,881,695 (GRCm39) missense probably damaging 1.00
R0510:Lrrc10 UTSW 10 116,881,695 (GRCm39) missense probably damaging 1.00
R1293:Lrrc10 UTSW 10 116,881,838 (GRCm39) missense probably benign 0.02
R1642:Lrrc10 UTSW 10 116,881,788 (GRCm39) missense probably damaging 1.00
R3835:Lrrc10 UTSW 10 116,881,691 (GRCm39) missense possibly damaging 0.75
R4413:Lrrc10 UTSW 10 116,881,719 (GRCm39) missense probably damaging 1.00
R5165:Lrrc10 UTSW 10 116,881,965 (GRCm39) missense probably benign 0.02
R5289:Lrrc10 UTSW 10 116,881,392 (GRCm39) missense probably benign 0.01
R5605:Lrrc10 UTSW 10 116,881,805 (GRCm39) missense probably damaging 1.00
R6418:Lrrc10 UTSW 10 116,881,616 (GRCm39) missense probably damaging 1.00
R6827:Lrrc10 UTSW 10 116,881,545 (GRCm39) missense possibly damaging 0.79
R6916:Lrrc10 UTSW 10 116,881,454 (GRCm39) missense possibly damaging 0.80
R7678:Lrrc10 UTSW 10 116,881,662 (GRCm39) missense probably benign 0.00
R9355:Lrrc10 UTSW 10 116,881,881 (GRCm39) missense probably damaging 1.00
X0020:Lrrc10 UTSW 10 116,881,335 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GGCAATAACAAACTCTGTGACCTC -3'
(R):5'- TACCGCCTAGCTTTTCTGGG -3'

Sequencing Primer
(F):5'- AAACTCTGTGACCTCCCGGATG -3'
(R):5'- GTCAGGCTCTGGTGTCTCC -3'
Posted On 2021-07-15