Mutagenetix > Incidental Mutation

Incidental Mutation 'R8866:Dnah11'

675952

Institutional Source

Beutler Lab

Gene Symbol

Dnah11

Ensembl Gene

ENSMUSG00000018581

Gene Name

dynein, axonemal, heavy chain 11

Synonyms

b2b598Clo, b2b1289Clo, b2b1203Clo, Dnahc11, avc4, b2b1279Clo, b2b1727Clo, lrd

MMRRC Submission

068742-MU

Accession Numbers

Essential gene?

Possibly essential (E-score: 0.603) question?

Stock #

R8866 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

117841717-118162778 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 118156107 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Leucine at position 181 (H181L)

Ref Sequence

ENSEMBL: ENSMUSP00000081867 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000084806]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000084806
AA Change: H181L

PolyPhen 2 Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000081867
Gene: ENSMUSG00000018581
AA Change: H181L

Domain	Start	End	E-Value	Type
low complexity region	18	28	N/A	INTRINSIC
Pfam:DHC_N1	218	794	1.6e-162	PFAM
low complexity region	1266	1282	N/A	INTRINSIC
Pfam:DHC_N2	1297	1705	1e-130	PFAM
low complexity region	1757	1773	N/A	INTRINSIC
AAA	1869	1963	1.51e0	SMART
Pfam:AAA_5	2150	2286	1.6e-12	PFAM
AAA	2474	2619	1.48e-1	SMART
AAA	2819	2931	4.57e-1	SMART
Pfam:MT	3069	3413	3.2e-162	PFAM
Pfam:AAA_9	3434	3656	2.9e-88	PFAM
Pfam:Dynein_heavy	3790	4486	7.1e-235	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.9%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a ciliary outer dynein arm protein and is a member of the dynein heavy chain family. It is a microtubule-dependent motor ATPase and has been reported to be involved in the movement of respiratory cilia. Mutations in this gene have been implicated in causing Kartagener Syndrome (a combination of situs inversus totalis and Primary Ciliary Dyskinesia (PCD), also called Immotile Cilia Syndrome 1 (ICS1)) and male sterility. [provided by RefSeq, Mar 2013]
PHENOTYPE: Approximately half of live-born homozygous mutants show situs inversus indicating that this gene is no longer properly controlling left-right asymmetry. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 68 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aadacl2	C	T	3: 59,914,511 (GRCm39)	T38I	probably benign	Het
Arhgap1	G	T	2: 91,499,744 (GRCm39)	S293I	probably benign	Het
Arhgap45	C	A	10: 79,853,750 (GRCm39)	P88Q	probably damaging	Het
Atg9a	A	C	1: 75,161,867 (GRCm39)	F560V	probably damaging	Het
Btaf1	T	A	19: 36,935,901 (GRCm39)	N230K	probably benign	Het
Ccne1	A	C	7: 37,800,046 (GRCm39)	H179Q	probably benign	Het
Dbr1	T	A	9: 99,460,497 (GRCm39)	L109*	probably null	Het
Dchs1	G	T	7: 105,404,597 (GRCm39)	N2648K	probably benign	Het
Ddx47	A	G	6: 135,000,356 (GRCm39)	K451E	probably benign	Het
Dlgap1	A	T	17: 70,823,435 (GRCm39)	H140L	probably damaging	Het
Dync1h1	T	C	12: 110,602,333 (GRCm39)	C2074R	probably damaging	Het
Ell2	A	T	13: 75,917,793 (GRCm39)	Q574H	probably damaging	Het
Eloa	A	C	4: 135,737,538 (GRCm39)		probably null	Het
Epha7	A	G	4: 28,821,614 (GRCm39)	I260V	probably benign	Het
Fbp2	T	C	13: 62,989,709 (GRCm39)	K199R	probably benign	Het
Fetub	A	T	16: 22,758,321 (GRCm39)	E368V	possibly damaging	Het
Fsip2	A	G	2: 82,810,521 (GRCm39)	Q2280R	probably benign	Het
Fstl4	A	G	11: 52,963,233 (GRCm39)	E205G	possibly damaging	Het
Gm5592	A	T	7: 40,938,246 (GRCm39)	R509S	possibly damaging	Het
Gpld1	A	G	13: 25,170,890 (GRCm39)	T794A	probably benign	Het
Gsk3b	A	G	16: 38,004,900 (GRCm39)	Y157C	probably damaging	Het
Hgs	A	G	11: 120,360,464 (GRCm39)	N54S	probably benign	Het
Hydin	G	A	8: 111,308,779 (GRCm39)	V4022M	possibly damaging	Het
Kank1	T	C	19: 25,388,702 (GRCm39)	S792P	possibly damaging	Het
Kctd4	A	G	14: 76,200,465 (GRCm39)	I145M	probably benign	Het
Klra5	A	T	6: 129,880,533 (GRCm39)	W212R	probably damaging	Het
Lrp6	A	T	6: 134,445,785 (GRCm39)	N1009K	probably benign	Het
Lrrc10	T	A	10: 116,881,858 (GRCm39)	N177K	probably damaging	Het
Lrrc39	T	A	3: 116,363,790 (GRCm39)	I121N	probably damaging	Het
Mov10l1	A	T	15: 88,896,169 (GRCm39)	D671V	probably benign	Het
Ndel1	A	G	11: 68,734,645 (GRCm39)		probably null	Het
Or10g3	A	T	14: 52,610,196 (GRCm39)	Y105N	probably damaging	Het
Or1e27-ps1	A	G	11: 73,555,825 (GRCm39)	Y130C	probably damaging	Het
Or1e32	A	T	11: 73,705,237 (GRCm39)	S224T	probably damaging	Het
Or51a43	A	T	7: 103,718,119 (GRCm39)	S40T	probably damaging	Het
Otop2	A	G	11: 115,220,354 (GRCm39)	D398G	probably benign	Het
Pkd1	T	C	17: 24,792,051 (GRCm39)	V1246A	probably damaging	Het
Polr3b	T	A	10: 84,531,555 (GRCm39)	D810E	probably benign	Het
Ppl	T	A	16: 4,920,211 (GRCm39)	T395S	probably benign	Het
Ptprm	G	A	17: 67,116,630 (GRCm39)	A883V	probably benign	Het
Rapgef6	G	A	11: 54,443,700 (GRCm39)		probably null	Het
Rbm12	A	T	2: 155,938,693 (GRCm39)	Y526*	probably null	Het
Rbm15b	C	T	9: 106,763,595 (GRCm39)	R191Q	probably benign	Het
Rsf1	GCGGCGGCG	GCGGCGGCGACGGCGGCG	7: 97,229,120 (GRCm39)		probably benign	Het
Rxylt1	A	G	10: 121,924,953 (GRCm39)	Y250H	probably damaging	Het
Serpinb6c	A	T	13: 34,083,309 (GRCm39)	I35N	probably damaging	Het
Setd4	A	G	16: 93,386,961 (GRCm39)	F246L	probably damaging	Het
Shank2	A	G	7: 143,964,986 (GRCm39)	S865G	probably benign	Het
Skint6	T	C	4: 112,711,650 (GRCm39)	N956D	probably benign	Het
Slc30a3	C	A	5: 31,245,325 (GRCm39)	V332F	possibly damaging	Het
Smg1	A	G	7: 117,806,122 (GRCm39)	S240P	unknown	Het
Tank	T	A	2: 61,409,005 (GRCm39)	S7R	probably benign	Het
Tecpr1	T	C	5: 144,153,117 (GRCm39)	E204G	possibly damaging	Het
Tmem74	A	G	15: 43,730,231 (GRCm39)	S271P	probably damaging	Het
Tor4a	T	C	2: 25,084,965 (GRCm39)	M313V	probably benign	Het
Tpd52l2	A	G	2: 181,154,861 (GRCm39)	D192G	probably damaging	Het
Trim29	T	C	9: 43,222,945 (GRCm39)	V258A	probably damaging	Het
Ttc39c	A	T	18: 12,831,003 (GRCm39)	S288C	probably benign	Het
Ttn	T	C	2: 76,592,675 (GRCm39)	E20819G	probably damaging	Het
Twnk	C	T	19: 45,000,272 (GRCm39)	Q663*	probably null	Het
Ucn	T	A	5: 31,295,857 (GRCm39)	Q3L	probably benign	Het
Unc80	G	A	1: 66,629,388 (GRCm39)	G1295E	probably benign	Het
Usp9y	C	T	Y: 1,395,758 (GRCm39)	R492H	probably damaging	Het
Vars1	T	C	17: 35,234,620 (GRCm39)	S1150P	probably benign	Het
Vwa5b1	T	G	4: 138,327,628 (GRCm39)	E316A	probably damaging	Het
Zc3h7b	G	A	15: 81,656,681 (GRCm39)	R166Q	probably benign	Het
Zfp839	A	G	12: 110,834,848 (GRCm39)	E701G	probably benign	Het
Zfp931	A	T	2: 177,710,178 (GRCm39)	C69*	probably null	Het

Other mutations in Dnah11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00341:Dnah11	APN	12	118,162,480 (GRCm39)	missense	probably benign	0.28
IGL00422:Dnah11	APN	12	118,031,831 (GRCm39)	missense	probably damaging	1.00
IGL00436:Dnah11	APN	12	118,000,194 (GRCm39)	missense	possibly damaging	0.56
IGL00540:Dnah11	APN	12	118,150,657 (GRCm39)	missense	probably benign	0.01
IGL00687:Dnah11	APN	12	117,885,739 (GRCm39)	splice site	probably benign
IGL00833:Dnah11	APN	12	118,143,315 (GRCm39)	missense	probably damaging	1.00
IGL00906:Dnah11	APN	12	117,874,937 (GRCm39)	missense	probably damaging	1.00
IGL00952:Dnah11	APN	12	118,160,386 (GRCm39)	missense	possibly damaging	0.56
IGL01111:Dnah11	APN	12	118,106,669 (GRCm39)	splice site	probably benign
IGL01121:Dnah11	APN	12	118,014,430 (GRCm39)	missense	probably benign	0.02
IGL01143:Dnah11	APN	12	117,976,475 (GRCm39)	missense	probably damaging	1.00
IGL01359:Dnah11	APN	12	117,946,734 (GRCm39)	missense	probably damaging	0.99
IGL01372:Dnah11	APN	12	118,156,134 (GRCm39)	missense	probably damaging	1.00
IGL01410:Dnah11	APN	12	118,010,991 (GRCm39)	nonsense	probably null
IGL01418:Dnah11	APN	12	117,951,217 (GRCm39)	nonsense	probably null
IGL01444:Dnah11	APN	12	117,983,967 (GRCm39)	missense	possibly damaging	0.91
IGL01606:Dnah11	APN	12	117,946,767 (GRCm39)	missense	probably benign	0.15
IGL01645:Dnah11	APN	12	118,150,733 (GRCm39)	missense	possibly damaging	0.90
IGL01932:Dnah11	APN	12	118,156,005 (GRCm39)	splice site	probably benign
IGL02104:Dnah11	APN	12	118,156,125 (GRCm39)	missense	probably benign
IGL02151:Dnah11	APN	12	118,023,623 (GRCm39)	splice site	probably benign
IGL02189:Dnah11	APN	12	118,046,314 (GRCm39)	missense	probably benign	0.00
IGL02417:Dnah11	APN	12	118,020,915 (GRCm39)	missense	probably damaging	1.00
IGL02421:Dnah11	APN	12	118,150,637 (GRCm39)	missense	probably damaging	1.00
IGL02444:Dnah11	APN	12	117,939,608 (GRCm39)	splice site	probably benign
IGL02474:Dnah11	APN	12	117,991,180 (GRCm39)	splice site	probably null
IGL02526:Dnah11	APN	12	118,143,353 (GRCm39)	missense	possibly damaging	0.70
IGL02887:Dnah11	APN	12	117,874,775 (GRCm39)	missense	probably damaging	1.00
IGL03011:Dnah11	APN	12	117,976,112 (GRCm39)	missense	probably benign	0.08
IGL03061:Dnah11	APN	12	117,866,856 (GRCm39)	missense	probably damaging	1.00
IGL03182:Dnah11	APN	12	117,994,026 (GRCm39)	missense	probably damaging	0.99
IGL03220:Dnah11	APN	12	118,069,720 (GRCm39)	missense	probably benign
IGL03238:Dnah11	APN	12	118,073,633 (GRCm39)	missense	probably damaging	1.00
IGL03493:Dnah11	APN	12	117,976,533 (GRCm39)	missense	probably benign	0.00
P0045:Dnah11	UTSW	12	117,994,062 (GRCm39)	missense	probably benign
R0009:Dnah11	UTSW	12	118,009,257 (GRCm39)	missense	possibly damaging	0.90
R0066:Dnah11	UTSW	12	118,090,621 (GRCm39)	missense	probably benign	0.05
R0172:Dnah11	UTSW	12	117,951,188 (GRCm39)	missense	probably damaging	1.00
R0206:Dnah11	UTSW	12	118,007,509 (GRCm39)	missense	probably damaging	0.98
R0206:Dnah11	UTSW	12	118,007,509 (GRCm39)	missense	probably damaging	0.98
R0208:Dnah11	UTSW	12	118,007,509 (GRCm39)	missense	probably damaging	0.98
R0230:Dnah11	UTSW	12	117,946,791 (GRCm39)	nonsense	probably null
R0270:Dnah11	UTSW	12	118,004,748 (GRCm39)	missense	probably damaging	1.00
R0311:Dnah11	UTSW	12	118,090,868 (GRCm39)	missense	probably benign	0.03
R0325:Dnah11	UTSW	12	117,976,074 (GRCm39)	missense	probably benign
R0370:Dnah11	UTSW	12	117,958,962 (GRCm39)	missense	probably benign
R0416:Dnah11	UTSW	12	117,874,793 (GRCm39)	missense	probably damaging	1.00
R0505:Dnah11	UTSW	12	118,070,245 (GRCm39)	missense	probably damaging	1.00
R0540:Dnah11	UTSW	12	118,046,246 (GRCm39)	missense	probably damaging	1.00
R0554:Dnah11	UTSW	12	117,894,913 (GRCm39)	missense	probably benign	0.01
R0607:Dnah11	UTSW	12	118,046,246 (GRCm39)	missense	probably damaging	1.00
R0620:Dnah11	UTSW	12	117,951,204 (GRCm39)	missense	probably damaging	1.00
R0635:Dnah11	UTSW	12	117,971,731 (GRCm39)	missense	probably damaging	1.00
R0755:Dnah11	UTSW	12	118,162,360 (GRCm39)	missense	probably benign	0.17
R0755:Dnah11	UTSW	12	117,918,564 (GRCm39)	missense	possibly damaging	0.95
R0789:Dnah11	UTSW	12	117,874,967 (GRCm39)	missense	probably damaging	1.00
R0833:Dnah11	UTSW	12	118,160,397 (GRCm39)	missense	probably benign	0.01
R0835:Dnah11	UTSW	12	117,880,523 (GRCm39)	missense	probably damaging	1.00
R0836:Dnah11	UTSW	12	118,160,397 (GRCm39)	missense	probably benign	0.01
R0846:Dnah11	UTSW	12	117,897,585 (GRCm39)	missense	probably damaging	0.97
R0865:Dnah11	UTSW	12	118,154,579 (GRCm39)	nonsense	probably null
R0928:Dnah11	UTSW	12	118,009,297 (GRCm39)	missense	probably damaging	1.00
R0939:Dnah11	UTSW	12	118,024,142 (GRCm39)	missense	probably damaging	1.00
R1203:Dnah11	UTSW	12	117,897,547 (GRCm39)	missense	possibly damaging	0.81
R1394:Dnah11	UTSW	12	117,936,099 (GRCm39)	missense	possibly damaging	0.75
R1398:Dnah11	UTSW	12	118,020,841 (GRCm39)	nonsense	probably null
R1465:Dnah11	UTSW	12	118,002,430 (GRCm39)	missense	probably damaging	1.00
R1465:Dnah11	UTSW	12	118,002,430 (GRCm39)	missense	probably damaging	1.00
R1500:Dnah11	UTSW	12	117,976,564 (GRCm39)	splice site	probably null
R1535:Dnah11	UTSW	12	117,982,465 (GRCm39)	missense	probably damaging	1.00
R1539:Dnah11	UTSW	12	117,894,991 (GRCm39)	missense	probably benign	0.01
R1554:Dnah11	UTSW	12	118,046,234 (GRCm39)	missense	possibly damaging	0.92
R1574:Dnah11	UTSW	12	118,024,052 (GRCm39)	missense	probably damaging	1.00
R1574:Dnah11	UTSW	12	118,024,052 (GRCm39)	missense	probably damaging	1.00
R1615:Dnah11	UTSW	12	118,014,457 (GRCm39)	missense	probably damaging	1.00
R1618:Dnah11	UTSW	12	117,979,200 (GRCm39)	missense	probably damaging	0.98
R1638:Dnah11	UTSW	12	117,979,154 (GRCm39)	missense	possibly damaging	0.81
R1659:Dnah11	UTSW	12	118,084,459 (GRCm39)	missense	possibly damaging	0.94
R1671:Dnah11	UTSW	12	117,880,523 (GRCm39)	missense	probably damaging	1.00
R1678:Dnah11	UTSW	12	117,897,580 (GRCm39)	missense	possibly damaging	0.50
R1699:Dnah11	UTSW	12	118,154,603 (GRCm39)	missense	probably damaging	1.00
R1712:Dnah11	UTSW	12	118,160,379 (GRCm39)	missense	probably benign	0.32
R1728:Dnah11	UTSW	12	117,880,666 (GRCm39)	missense	probably damaging	1.00
R1729:Dnah11	UTSW	12	117,880,666 (GRCm39)	missense	probably damaging	1.00
R1764:Dnah11	UTSW	12	118,154,560 (GRCm39)	missense	probably benign	0.31
R1780:Dnah11	UTSW	12	117,991,293 (GRCm39)	missense	probably damaging	1.00
R1789:Dnah11	UTSW	12	118,002,515 (GRCm39)	missense	probably damaging	0.99
R1800:Dnah11	UTSW	12	117,880,523 (GRCm39)	missense	probably damaging	1.00
R1863:Dnah11	UTSW	12	118,027,587 (GRCm39)	missense	possibly damaging	0.92
R1892:Dnah11	UTSW	12	118,070,209 (GRCm39)	missense	possibly damaging	0.53
R1907:Dnah11	UTSW	12	118,091,291 (GRCm39)	missense	possibly damaging	0.66
R1964:Dnah11	UTSW	12	118,106,027 (GRCm39)	missense	possibly damaging	0.56
R1967:Dnah11	UTSW	12	117,880,523 (GRCm39)	missense	probably damaging	1.00
R1997:Dnah11	UTSW	12	118,046,203 (GRCm39)	missense	possibly damaging	0.64
R2086:Dnah11	UTSW	12	118,077,606 (GRCm39)	missense	possibly damaging	0.82
R2092:Dnah11	UTSW	12	117,976,451 (GRCm39)	missense	possibly damaging	0.50
R2108:Dnah11	UTSW	12	117,984,088 (GRCm39)	missense	probably damaging	1.00
R2140:Dnah11	UTSW	12	117,972,545 (GRCm39)	missense	probably benign	0.01
R2261:Dnah11	UTSW	12	117,930,374 (GRCm39)	missense	probably damaging	0.99
R2261:Dnah11	UTSW	12	117,843,760 (GRCm39)	missense	probably benign	0.06
R2262:Dnah11	UTSW	12	117,930,374 (GRCm39)	missense	probably damaging	0.99
R2262:Dnah11	UTSW	12	117,843,760 (GRCm39)	missense	probably benign	0.06
R2263:Dnah11	UTSW	12	117,843,760 (GRCm39)	missense	probably benign	0.06
R2263:Dnah11	UTSW	12	117,930,374 (GRCm39)	missense	probably damaging	0.99
R2328:Dnah11	UTSW	12	117,850,421 (GRCm39)	missense	probably damaging	0.98
R2352:Dnah11	UTSW	12	117,892,065 (GRCm39)	missense	probably damaging	1.00
R2410:Dnah11	UTSW	12	117,991,262 (GRCm39)	missense	probably damaging	1.00
R2885:Dnah11	UTSW	12	117,951,162 (GRCm39)	nonsense	probably null
R3499:Dnah11	UTSW	12	117,874,758 (GRCm39)	missense	probably damaging	1.00
R3741:Dnah11	UTSW	12	118,095,076 (GRCm39)	missense	probably benign	0.05
R3742:Dnah11	UTSW	12	118,095,076 (GRCm39)	missense	probably benign	0.05
R3779:Dnah11	UTSW	12	118,094,448 (GRCm39)	splice site	probably benign
R3785:Dnah11	UTSW	12	117,981,337 (GRCm39)	missense	probably damaging	1.00
R3883:Dnah11	UTSW	12	117,942,188 (GRCm39)	splice site	probably benign
R4014:Dnah11	UTSW	12	117,938,649 (GRCm39)	missense	probably benign	0.16
R4043:Dnah11	UTSW	12	117,843,678 (GRCm39)	missense	probably damaging	1.00
R4072:Dnah11	UTSW	12	118,070,227 (GRCm39)	missense	probably damaging	1.00
R4073:Dnah11	UTSW	12	118,009,413 (GRCm39)	missense	probably benign	0.01
R4074:Dnah11	UTSW	12	118,009,413 (GRCm39)	missense	probably benign	0.01
R4076:Dnah11	UTSW	12	118,009,413 (GRCm39)	missense	probably benign	0.01
R4201:Dnah11	UTSW	12	117,930,394 (GRCm39)	missense	possibly damaging	0.63
R4224:Dnah11	UTSW	12	118,094,627 (GRCm39)	missense	probably benign	0.06
R4233:Dnah11	UTSW	12	117,880,526 (GRCm39)	missense	probably damaging	1.00
R4358:Dnah11	UTSW	12	118,089,578 (GRCm39)	nonsense	probably null
R4430:Dnah11	UTSW	12	117,946,746 (GRCm39)	missense	probably benign	0.26
R4465:Dnah11	UTSW	12	117,951,186 (GRCm39)	missense	probably benign	0.09
R4489:Dnah11	UTSW	12	117,880,631 (GRCm39)	missense	probably benign	0.31
R4572:Dnah11	UTSW	12	117,973,860 (GRCm39)	missense	probably benign	0.00
R4574:Dnah11	UTSW	12	117,975,990 (GRCm39)	critical splice donor site	probably null
R4657:Dnah11	UTSW	12	118,156,162 (GRCm39)	missense	probably benign	0.02
R4709:Dnah11	UTSW	12	117,982,495 (GRCm39)	missense	probably benign	0.26
R4740:Dnah11	UTSW	12	118,084,279 (GRCm39)	missense	probably benign	0.28
R4803:Dnah11	UTSW	12	118,091,343 (GRCm39)	missense	possibly damaging	0.50
R4896:Dnah11	UTSW	12	117,958,935 (GRCm39)	missense	probably damaging	1.00
R4908:Dnah11	UTSW	12	118,090,618 (GRCm39)	missense	probably benign	0.37
R5018:Dnah11	UTSW	12	118,094,463 (GRCm39)	missense	probably benign	0.00
R5071:Dnah11	UTSW	12	118,046,188 (GRCm39)	nonsense	probably null
R5074:Dnah11	UTSW	12	118,046,188 (GRCm39)	nonsense	probably null
R5080:Dnah11	UTSW	12	118,162,565 (GRCm39)	start codon destroyed	probably null	0.01
R5097:Dnah11	UTSW	12	117,981,435 (GRCm39)	missense	probably damaging	1.00
R5131:Dnah11	UTSW	12	117,918,486 (GRCm39)	missense	probably damaging	1.00
R5215:Dnah11	UTSW	12	118,121,096 (GRCm39)	missense	probably benign	0.09
R5252:Dnah11	UTSW	12	118,089,676 (GRCm39)	missense	probably damaging	1.00
R5296:Dnah11	UTSW	12	117,847,151 (GRCm39)	missense	probably damaging	1.00
R5308:Dnah11	UTSW	12	118,049,415 (GRCm39)	missense	possibly damaging	0.60
R5368:Dnah11	UTSW	12	117,918,628 (GRCm39)	missense	probably damaging	1.00
R5383:Dnah11	UTSW	12	118,049,432 (GRCm39)	missense	probably damaging	0.99
R5499:Dnah11	UTSW	12	118,070,209 (GRCm39)	missense	possibly damaging	0.53
R5503:Dnah11	UTSW	12	117,844,186 (GRCm39)	critical splice donor site	probably null
R5546:Dnah11	UTSW	12	117,939,583 (GRCm39)	missense	possibly damaging	0.83
R5578:Dnah11	UTSW	12	117,982,537 (GRCm39)	missense	probably damaging	0.99
R5657:Dnah11	UTSW	12	117,847,352 (GRCm39)	missense	probably damaging	1.00
R5702:Dnah11	UTSW	12	118,077,642 (GRCm39)	missense	probably benign	0.04
R5706:Dnah11	UTSW	12	117,987,670 (GRCm39)	missense	probably damaging	1.00
R5727:Dnah11	UTSW	12	118,090,841 (GRCm39)	missense	probably damaging	1.00
R5737:Dnah11	UTSW	12	118,156,125 (GRCm39)	missense	probably benign
R5884:Dnah11	UTSW	12	118,141,269 (GRCm39)	missense	probably benign	0.00
R5900:Dnah11	UTSW	12	118,046,166 (GRCm39)	splice site	probably null
R5905:Dnah11	UTSW	12	117,918,659 (GRCm39)	missense	probably damaging	1.00
R5928:Dnah11	UTSW	12	117,878,371 (GRCm39)	splice site	probably null
R5973:Dnah11	UTSW	12	118,074,687 (GRCm39)	missense	probably benign	0.02
R6024:Dnah11	UTSW	12	117,994,007 (GRCm39)	missense	probably benign	0.34
R6056:Dnah11	UTSW	12	117,892,191 (GRCm39)	missense	probably benign	0.03
R6075:Dnah11	UTSW	12	118,068,586 (GRCm39)	missense	probably damaging	1.00
R6092:Dnah11	UTSW	12	117,892,191 (GRCm39)	missense	probably benign
R6191:Dnah11	UTSW	12	118,154,632 (GRCm39)	missense	probably benign
R6197:Dnah11	UTSW	12	118,143,482 (GRCm39)	missense	probably benign	0.03
R6262:Dnah11	UTSW	12	117,894,913 (GRCm39)	missense	probably damaging	0.98
R6321:Dnah11	UTSW	12	118,106,027 (GRCm39)	missense	possibly damaging	0.56
R6454:Dnah11	UTSW	12	117,880,590 (GRCm39)	missense	probably benign	0.01
R6614:Dnah11	UTSW	12	117,850,411 (GRCm39)	missense	possibly damaging	0.72
R6694:Dnah11	UTSW	12	118,150,617 (GRCm39)	splice site	probably null
R6712:Dnah11	UTSW	12	118,014,457 (GRCm39)	missense	probably damaging	1.00
R6720:Dnah11	UTSW	12	118,009,381 (GRCm39)	missense	probably damaging	1.00
R6742:Dnah11	UTSW	12	118,077,629 (GRCm39)	missense	possibly damaging	0.82
R6806:Dnah11	UTSW	12	117,951,411 (GRCm39)	splice site	probably null
R6895:Dnah11	UTSW	12	117,958,926 (GRCm39)	missense	probably damaging	0.99
R6939:Dnah11	UTSW	12	118,070,297 (GRCm39)	missense	probably damaging	1.00
R6940:Dnah11	UTSW	12	118,162,503 (GRCm39)	missense	probably benign
R6945:Dnah11	UTSW	12	118,024,045 (GRCm39)	missense	probably damaging	1.00
R6958:Dnah11	UTSW	12	117,897,544 (GRCm39)	missense	probably damaging	1.00
R6970:Dnah11	UTSW	12	118,072,679 (GRCm39)	missense	probably benign	0.00
R6976:Dnah11	UTSW	12	118,162,378 (GRCm39)	missense	probably benign	0.16
R7000:Dnah11	UTSW	12	117,981,396 (GRCm39)	missense	probably damaging	1.00
R7011:Dnah11	UTSW	12	117,885,753 (GRCm39)	frame shift	probably null
R7101:Dnah11	UTSW	12	118,031,880 (GRCm39)	missense	probably benign
R7106:Dnah11	UTSW	12	117,924,884 (GRCm39)	missense	probably benign	0.15
R7203:Dnah11	UTSW	12	118,009,257 (GRCm39)	missense	possibly damaging	0.90
R7219:Dnah11	UTSW	12	118,090,624 (GRCm39)	missense	probably benign	0.00
R7219:Dnah11	UTSW	12	118,004,830 (GRCm39)	missense	possibly damaging	0.95
R7308:Dnah11	UTSW	12	117,959,010 (GRCm39)	missense	probably damaging	1.00
R7361:Dnah11	UTSW	12	117,982,477 (GRCm39)	missense	probably damaging	1.00
R7367:Dnah11	UTSW	12	117,951,177 (GRCm39)	missense	possibly damaging	0.59
R7399:Dnah11	UTSW	12	118,089,520 (GRCm39)	missense	probably damaging	1.00
R7399:Dnah11	UTSW	12	117,991,212 (GRCm39)	missense	probably benign	0.00
R7404:Dnah11	UTSW	12	118,068,543 (GRCm39)	missense	probably benign	0.36
R7473:Dnah11	UTSW	12	117,866,911 (GRCm39)	missense	probably benign	0.19
R7545:Dnah11	UTSW	12	117,894,939 (GRCm39)	missense	probably damaging	1.00
R7608:Dnah11	UTSW	12	118,104,505 (GRCm39)	splice site	probably null
R7625:Dnah11	UTSW	12	118,160,377 (GRCm39)	missense	probably benign
R7761:Dnah11	UTSW	12	117,987,648 (GRCm39)	missense	probably damaging	1.00
R7879:Dnah11	UTSW	12	118,004,744 (GRCm39)	missense	probably damaging	1.00
R7881:Dnah11	UTSW	12	117,951,237 (GRCm39)	missense	probably benign	0.04
R7904:Dnah11	UTSW	12	117,867,003 (GRCm39)	missense	possibly damaging	0.72
R8100:Dnah11	UTSW	12	117,930,368 (GRCm39)	missense	probably damaging	0.99
R8179:Dnah11	UTSW	12	117,842,284 (GRCm39)	missense	possibly damaging	0.90
R8192:Dnah11	UTSW	12	117,976,181 (GRCm39)	missense	probably benign
R8254:Dnah11	UTSW	12	117,842,259 (GRCm39)	missense	possibly damaging	0.89
R8268:Dnah11	UTSW	12	117,991,243 (GRCm39)	nonsense	probably null
R8272:Dnah11	UTSW	12	118,074,752 (GRCm39)	missense	probably benign	0.01
R8344:Dnah11	UTSW	12	118,049,466 (GRCm39)	missense	probably benign	0.00
R8515:Dnah11	UTSW	12	117,939,533 (GRCm39)	missense	probably damaging	1.00
R8528:Dnah11	UTSW	12	117,972,538 (GRCm39)	missense	probably damaging	0.96
R8557:Dnah11	UTSW	12	117,842,247 (GRCm39)	missense	probably benign
R8676:Dnah11	UTSW	12	118,154,539 (GRCm39)	missense	probably damaging	1.00
R8738:Dnah11	UTSW	12	118,049,384 (GRCm39)	critical splice donor site	probably null
R8773:Dnah11	UTSW	12	117,958,950 (GRCm39)	missense	possibly damaging	0.94
R8818:Dnah11	UTSW	12	117,874,764 (GRCm39)	missense	probably damaging	1.00
R8855:Dnah11	UTSW	12	118,156,107 (GRCm39)	missense	probably benign	0.03
R8881:Dnah11	UTSW	12	118,090,550 (GRCm39)	missense	probably benign	0.05
R8881:Dnah11	UTSW	12	118,077,647 (GRCm39)	missense	probably benign	0.00
R8920:Dnah11	UTSW	12	118,077,674 (GRCm39)	missense	probably damaging	0.99
R8944:Dnah11	UTSW	12	118,091,381 (GRCm39)	missense	possibly damaging	0.63
R8945:Dnah11	UTSW	12	117,987,718 (GRCm39)	missense	probably benign	0.36
R8962:Dnah11	UTSW	12	117,918,630 (GRCm39)	missense	probably damaging	1.00
R8962:Dnah11	UTSW	12	117,916,273 (GRCm39)	missense	probably damaging	1.00
R9059:Dnah11	UTSW	12	118,094,578 (GRCm39)	missense	probably benign	0.00
R9155:Dnah11	UTSW	12	117,991,251 (GRCm39)	missense	probably damaging	0.99
R9162:Dnah11	UTSW	12	117,991,251 (GRCm39)	missense	probably damaging	0.99
R9164:Dnah11	UTSW	12	117,991,251 (GRCm39)	missense	probably damaging	0.99
R9171:Dnah11	UTSW	12	117,894,918 (GRCm39)	missense	probably damaging	0.99
R9186:Dnah11	UTSW	12	118,154,632 (GRCm39)	missense	probably benign
R9205:Dnah11	UTSW	12	117,991,251 (GRCm39)	missense	probably damaging	0.99
R9208:Dnah11	UTSW	12	117,991,251 (GRCm39)	missense	probably damaging	0.99
R9234:Dnah11	UTSW	12	117,951,095 (GRCm39)	missense	probably damaging	1.00
R9264:Dnah11	UTSW	12	117,991,262 (GRCm39)	missense	probably damaging	1.00
R9290:Dnah11	UTSW	12	117,991,251 (GRCm39)	missense	probably damaging	0.99
R9291:Dnah11	UTSW	12	117,991,251 (GRCm39)	missense	probably damaging	0.99
R9315:Dnah11	UTSW	12	118,143,341 (GRCm39)	missense	probably benign	0.11
R9353:Dnah11	UTSW	12	118,143,434 (GRCm39)	missense	probably benign	0.00
R9375:Dnah11	UTSW	12	117,884,703 (GRCm39)	missense	possibly damaging	0.67
R9392:Dnah11	UTSW	12	118,141,290 (GRCm39)	missense	probably benign	0.00
R9392:Dnah11	UTSW	12	118,011,055 (GRCm39)	nonsense	probably null
R9433:Dnah11	UTSW	12	117,976,007 (GRCm39)	missense	probably damaging	1.00
R9511:Dnah11	UTSW	12	117,878,352 (GRCm39)	missense	probably damaging	1.00
R9526:Dnah11	UTSW	12	118,150,711 (GRCm39)	missense	probably damaging	0.98
R9566:Dnah11	UTSW	12	117,938,728 (GRCm39)	missense	possibly damaging	0.69
R9673:Dnah11	UTSW	12	117,982,513 (GRCm39)	missense	possibly damaging	0.91
R9705:Dnah11	UTSW	12	118,094,770 (GRCm39)	missense	probably damaging	1.00
R9716:Dnah11	UTSW	12	118,024,148 (GRCm39)	missense	probably damaging	0.99
R9746:Dnah11	UTSW	12	117,842,311 (GRCm39)	nonsense	probably null
R9764:Dnah11	UTSW	12	117,884,704 (GRCm39)	missense	probably benign	0.05
RF023:Dnah11	UTSW	12	117,918,585 (GRCm39)	missense	probably damaging	1.00
RF047:Dnah11	UTSW	12	117,973,818 (GRCm39)	missense	probably damaging	1.00
Z1088:Dnah11	UTSW	12	117,858,747 (GRCm39)	missense	probably damaging	1.00
Z1088:Dnah11	UTSW	12	117,946,704 (GRCm39)	missense	probably damaging	1.00
Z1176:Dnah11	UTSW	12	118,094,534 (GRCm39)	missense	probably damaging	0.97
Z1176:Dnah11	UTSW	12	118,090,854 (GRCm39)	missense	probably benign	0.00
Z1176:Dnah11	UTSW	12	117,894,912 (GRCm39)	missense	possibly damaging	0.81

Predicted Primers

PCR Primer
(F):5'- TCCCCTAAAGGAATATTGCTGAG -3'
(R):5'- TGCACAACAACAGGTTTAAAGGTAC -3'

Sequencing Primer
(F):5'- GGCTGCATAAAACCCTGTTG -3'
(R):5'- ACTTACTGTCTGCTAAATAACTGCC -3'

Posted On

2021-07-15