Incidental Mutation 'R8870:Kif26b'
ID 676176
Institutional Source Beutler Lab
Gene Symbol Kif26b
Ensembl Gene ENSMUSG00000026494
Gene Name kinesin family member 26B
Synonyms D230039L06Rik, N-11 kinesin
MMRRC Submission 068684-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R8870 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 178356690-178766765 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 178692594 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Phenylalanine at position 512 (V512F)
Ref Sequence ENSEMBL: ENSMUSP00000124462 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000160789] [ENSMUST00000161017]
AlphaFold Q7TNC6
Predicted Effect probably damaging
Transcript: ENSMUST00000160789
AA Change: V65F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000124608
Gene: ENSMUSG00000026494
AA Change: V65F

DomainStartEndE-ValueType
KISc 1 362 2.48e-42 SMART
low complexity region 363 375 N/A INTRINSIC
low complexity region 402 416 N/A INTRINSIC
low complexity region 460 466 N/A INTRINSIC
low complexity region 560 600 N/A INTRINSIC
low complexity region 652 662 N/A INTRINSIC
low complexity region 822 841 N/A INTRINSIC
low complexity region 1038 1048 N/A INTRINSIC
low complexity region 1294 1322 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000161017
AA Change: V512F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000124462
Gene: ENSMUSG00000026494
AA Change: V512F

DomainStartEndE-ValueType
low complexity region 58 123 N/A INTRINSIC
low complexity region 144 155 N/A INTRINSIC
low complexity region 220 228 N/A INTRINSIC
Blast:KISc 365 446 4e-8 BLAST
KISc 448 809 2.48e-42 SMART
low complexity region 810 822 N/A INTRINSIC
low complexity region 849 863 N/A INTRINSIC
low complexity region 907 913 N/A INTRINSIC
low complexity region 1007 1047 N/A INTRINSIC
low complexity region 1099 1109 N/A INTRINSIC
low complexity region 1269 1288 N/A INTRINSIC
low complexity region 1485 1495 N/A INTRINSIC
low complexity region 1741 1769 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency 100% (76/76)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit neonatal lethality with impaired kidney development due to loss of cortical nephrogenic zone mesenchyme and failure of ureteric buds to invade and branch into the mesenchyme. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 79 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2210408I21Rik A T 13: 77,471,840 (GRCm39) N1082Y possibly damaging Het
4930444P10Rik G A 1: 16,136,451 (GRCm39) Q122* probably null Het
Afg2a A G 3: 37,502,661 (GRCm39) N607D probably benign Het
Ak8 C T 2: 28,625,602 (GRCm39) T215M probably benign Het
Ano3 T A 2: 110,614,074 (GRCm39) I210F probably benign Het
Atg9b A G 5: 24,592,032 (GRCm39) F656L probably damaging Het
Bscl2 T C 19: 8,824,793 (GRCm39) M292T probably benign Het
Cachd1 G T 4: 100,754,978 (GRCm39) C143F probably damaging Het
Calcoco2 GGGCCTTCTCTTTCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTTCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTTCTCCCAGGAGGCCTTCTCTTCC GGGCCTTCTCTTTCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTTCTCCCAGGAGGCCTTCTCTTCC 11: 95,990,808 (GRCm39) probably benign Het
Ccnb1ip1 C T 14: 51,029,450 (GRCm39) G204E probably benign Het
Ccr1 T A 9: 123,764,022 (GRCm39) L169F probably benign Het
Cdc42bpg A G 19: 6,364,550 (GRCm39) N593D possibly damaging Het
Cdh20 T C 1: 104,873,048 (GRCm39) S265P probably damaging Het
Cenpk A G 13: 104,367,365 (GRCm39) E67G probably damaging Het
Cep76 A T 18: 67,773,190 (GRCm39) I36K probably benign Het
Clock A T 5: 76,383,632 (GRCm39) I507N probably benign Het
Cpne1 T C 2: 155,920,873 (GRCm39) T110A probably benign Het
Crybg2 A T 4: 133,818,525 (GRCm39) E1427V possibly damaging Het
Ctu1 A C 7: 43,324,746 (GRCm39) K62Q probably damaging Het
Dnai4 C T 4: 102,944,529 (GRCm39) probably null Het
Drd5 C A 5: 38,477,747 (GRCm39) Q247K possibly damaging Het
Ect2l A T 10: 18,014,608 (GRCm39) L808* probably null Het
Efcab3 A G 11: 104,791,500 (GRCm39) T2905A probably benign Het
Ficd A T 5: 113,876,248 (GRCm39) D141V probably damaging Het
Fnbp1 A G 2: 30,938,222 (GRCm39) Y148H Het
Gm49368 A G 7: 127,700,685 (GRCm39) K485R probably benign Het
Gpr75 C A 11: 30,841,860 (GRCm39) A255D probably benign Het
Hcrtr2 G T 9: 76,153,666 (GRCm39) A242D probably damaging Het
Iapp G T 6: 142,244,602 (GRCm39) V10F probably benign Het
Ikzf2 A G 1: 69,722,417 (GRCm39) S31P possibly damaging Het
Il18rap G A 1: 40,564,280 (GRCm39) probably benign Het
Irak2 A T 6: 113,663,902 (GRCm39) N423Y probably damaging Het
Itpkb A G 1: 180,159,744 (GRCm39) probably benign Het
Itpr1 A G 6: 108,365,172 (GRCm39) I874M probably damaging Het
Lhx6 G A 2: 35,995,232 (GRCm39) probably benign Het
Lrfn1 A G 7: 28,158,918 (GRCm39) E279G possibly damaging Het
Masp1 A C 16: 23,314,882 (GRCm39) D126E probably damaging Het
Mef2a T C 7: 66,890,176 (GRCm39) I299V probably benign Het
Midn A G 10: 79,985,939 (GRCm39) S10G probably damaging Het
Mrps12 A T 7: 28,439,361 (GRCm39) L118Q probably damaging Het
Mxi1 G A 19: 53,360,126 (GRCm39) G283S probably damaging Het
Mzf1 A G 7: 12,786,836 (GRCm39) V78A probably benign Het
Ncoa6 A G 2: 155,263,078 (GRCm39) V452A probably damaging Het
Neb A G 2: 52,051,481 (GRCm39) Y6600H probably damaging Het
Nlgn2 A G 11: 69,716,297 (GRCm39) L748P possibly damaging Het
Nnmt A T 9: 48,514,801 (GRCm39) L72H probably damaging Het
Nrxn3 A G 12: 90,171,560 (GRCm39) T964A probably benign Het
Or12k7 A G 2: 36,958,982 (GRCm39) I222V probably benign Het
Or1e35 T G 11: 73,797,725 (GRCm39) M198L probably benign Het
Or2y16 T A 11: 49,335,350 (GRCm39) V224E probably damaging Het
Or4k35 T A 2: 111,100,464 (GRCm39) I83F possibly damaging Het
Or5h27 G A 16: 59,006,130 (GRCm39) P239S unknown Het
Or8c11 A G 9: 38,289,720 (GRCm39) N175S probably benign Het
Or8g33 A G 9: 39,337,548 (GRCm39) V273A probably damaging Het
Osbpl11 A G 16: 33,034,850 (GRCm39) N280D probably benign Het
Peg10 A T 6: 4,754,825 (GRCm39) Y202F probably damaging Het
Pick1 A G 15: 79,140,107 (GRCm39) R469G unknown Het
Rev3l A G 10: 39,738,786 (GRCm39) I2847V probably damaging Het
Rmc1 A G 18: 12,321,618 (GRCm39) E473G probably benign Het
Rnaseh2b T A 14: 62,569,617 (GRCm39) L18Q probably damaging Het
Rpl19 A G 11: 97,920,615 (GRCm39) Y122C probably benign Het
Selp A G 1: 163,964,787 (GRCm39) Y483C probably damaging Het
Setd2 T A 9: 110,423,321 (GRCm39) F347L Het
Snx14 A G 9: 88,295,541 (GRCm39) I208T probably benign Het
Spag16 T A 1: 70,036,017 (GRCm39) F348L probably benign Het
Spata22 A T 11: 73,231,091 (GRCm39) N115I probably damaging Het
Spata31 T C 13: 65,068,818 (GRCm39) V322A probably benign Het
Stc1 A T 14: 69,275,825 (GRCm39) H206L probably benign Het
Tas2r129 A G 6: 132,928,522 (GRCm39) D153G probably damaging Het
Tmem196 T A 12: 119,982,268 (GRCm39) N167K possibly damaging Het
Tmpo T C 10: 90,987,581 (GRCm39) T356A probably damaging Het
Tnks A G 8: 35,314,433 (GRCm39) probably null Het
Ttbk1 A C 17: 46,781,661 (GRCm39) L364R probably damaging Het
Vmn1r176 A T 7: 23,534,480 (GRCm39) N224K probably damaging Het
Vmn1r36 T A 6: 66,693,720 (GRCm39) M52L probably benign Het
Vmn2r93 A T 17: 18,525,320 (GRCm39) H326L possibly damaging Het
Wrn A T 8: 33,819,220 (GRCm39) M244K probably benign Het
Zcchc24 C T 14: 25,757,578 (GRCm39) A102T probably benign Het
Zfp1010 T A 2: 176,957,312 (GRCm39) Q62L probably benign Het
Other mutations in Kif26b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00337:Kif26b APN 1 178,743,213 (GRCm39) missense probably damaging 1.00
IGL00425:Kif26b APN 1 178,743,866 (GRCm39) missense probably damaging 0.96
IGL00952:Kif26b APN 1 178,759,770 (GRCm39) missense probably damaging 1.00
IGL01100:Kif26b APN 1 178,744,809 (GRCm39) missense probably benign
IGL01347:Kif26b APN 1 178,698,240 (GRCm39) missense probably damaging 1.00
IGL01543:Kif26b APN 1 178,506,526 (GRCm39) missense probably benign 0.41
IGL01938:Kif26b APN 1 178,743,603 (GRCm39) missense probably damaging 0.99
IGL02100:Kif26b APN 1 178,743,512 (GRCm39) missense probably damaging 0.99
IGL02262:Kif26b APN 1 178,743,633 (GRCm39) missense probably benign 0.05
IGL02576:Kif26b APN 1 178,743,912 (GRCm39) missense probably benign
IGL02673:Kif26b APN 1 178,649,170 (GRCm39) missense probably damaging 1.00
IGL03078:Kif26b APN 1 178,698,291 (GRCm39) missense probably damaging 1.00
IGL03155:Kif26b APN 1 178,701,693 (GRCm39) missense probably damaging 1.00
IGL03157:Kif26b APN 1 178,743,930 (GRCm39) missense probably damaging 1.00
IGL03162:Kif26b APN 1 178,744,497 (GRCm39) missense probably benign
IGL03220:Kif26b APN 1 178,692,434 (GRCm39) missense probably damaging 1.00
IGL03299:Kif26b APN 1 178,649,125 (GRCm39) missense probably benign 0.09
IGL03368:Kif26b APN 1 178,743,773 (GRCm39) missense probably damaging 1.00
IGL03370:Kif26b APN 1 178,742,946 (GRCm39) missense probably benign 0.39
PIT4449001:Kif26b UTSW 1 178,745,651 (GRCm39) missense probably damaging 1.00
R0142:Kif26b UTSW 1 178,742,954 (GRCm39) missense probably damaging 1.00
R0621:Kif26b UTSW 1 178,743,218 (GRCm39) missense probably benign 0.02
R0987:Kif26b UTSW 1 178,649,185 (GRCm39) missense probably damaging 1.00
R1107:Kif26b UTSW 1 178,745,238 (GRCm39) missense probably benign 0.03
R1367:Kif26b UTSW 1 178,744,028 (GRCm39) missense probably damaging 1.00
R1386:Kif26b UTSW 1 178,743,209 (GRCm39) missense probably benign
R1619:Kif26b UTSW 1 178,744,043 (GRCm39) missense probably benign 0.00
R1664:Kif26b UTSW 1 178,759,704 (GRCm39) missense probably damaging 1.00
R2240:Kif26b UTSW 1 178,543,488 (GRCm39) missense probably benign 0.00
R2264:Kif26b UTSW 1 178,756,407 (GRCm39) critical splice acceptor site probably null
R2443:Kif26b UTSW 1 178,742,579 (GRCm39) missense probably damaging 0.99
R3023:Kif26b UTSW 1 178,692,433 (GRCm39) missense probably damaging 0.99
R3744:Kif26b UTSW 1 178,506,595 (GRCm39) missense probably benign 0.00
R3831:Kif26b UTSW 1 178,744,181 (GRCm39) frame shift probably null
R3832:Kif26b UTSW 1 178,744,181 (GRCm39) frame shift probably null
R3833:Kif26b UTSW 1 178,744,181 (GRCm39) frame shift probably null
R3843:Kif26b UTSW 1 178,755,742 (GRCm39) missense probably damaging 1.00
R4108:Kif26b UTSW 1 178,744,530 (GRCm39) missense possibly damaging 0.88
R4181:Kif26b UTSW 1 178,742,991 (GRCm39) missense probably damaging 0.98
R4551:Kif26b UTSW 1 178,711,600 (GRCm39) missense probably damaging 1.00
R4552:Kif26b UTSW 1 178,711,600 (GRCm39) missense probably damaging 1.00
R4597:Kif26b UTSW 1 178,744,358 (GRCm39) missense probably damaging 1.00
R4599:Kif26b UTSW 1 178,358,024 (GRCm39) missense unknown
R4610:Kif26b UTSW 1 178,506,920 (GRCm39) missense probably damaging 1.00
R4746:Kif26b UTSW 1 178,701,546 (GRCm39) nonsense probably null
R4873:Kif26b UTSW 1 178,742,892 (GRCm39) missense probably benign 0.38
R4875:Kif26b UTSW 1 178,742,892 (GRCm39) missense probably benign 0.38
R5015:Kif26b UTSW 1 178,755,895 (GRCm39) missense probably damaging 0.99
R5060:Kif26b UTSW 1 178,358,195 (GRCm39) missense unknown
R5301:Kif26b UTSW 1 178,358,233 (GRCm39) missense unknown
R5368:Kif26b UTSW 1 178,743,449 (GRCm39) missense probably damaging 1.00
R5387:Kif26b UTSW 1 178,742,441 (GRCm39) missense probably benign 0.01
R5589:Kif26b UTSW 1 178,743,864 (GRCm39) missense probably benign 0.05
R6150:Kif26b UTSW 1 178,743,111 (GRCm39) missense probably damaging 1.00
R6259:Kif26b UTSW 1 178,744,970 (GRCm39) missense probably damaging 0.97
R6355:Kif26b UTSW 1 178,743,743 (GRCm39) missense probably damaging 1.00
R6408:Kif26b UTSW 1 178,745,133 (GRCm39) missense probably damaging 1.00
R6488:Kif26b UTSW 1 178,357,138 (GRCm39) missense unknown
R6546:Kif26b UTSW 1 178,755,871 (GRCm39) missense probably damaging 1.00
R6702:Kif26b UTSW 1 178,744,852 (GRCm39) missense possibly damaging 0.90
R6886:Kif26b UTSW 1 178,701,703 (GRCm39) missense probably damaging 1.00
R6953:Kif26b UTSW 1 178,701,637 (GRCm39) missense possibly damaging 0.89
R7262:Kif26b UTSW 1 178,745,219 (GRCm39) missense possibly damaging 0.84
R7291:Kif26b UTSW 1 178,506,611 (GRCm39) missense possibly damaging 0.86
R7346:Kif26b UTSW 1 178,358,306 (GRCm39) missense probably damaging 1.00
R7383:Kif26b UTSW 1 178,358,275 (GRCm39) missense probably damaging 1.00
R7448:Kif26b UTSW 1 178,742,339 (GRCm39) missense probably damaging 1.00
R7506:Kif26b UTSW 1 178,357,064 (GRCm39) start gained probably benign
R7562:Kif26b UTSW 1 178,742,541 (GRCm39) missense probably damaging 1.00
R7583:Kif26b UTSW 1 178,358,010 (GRCm39) nonsense probably null
R7585:Kif26b UTSW 1 178,744,061 (GRCm39) missense probably benign 0.01
R7644:Kif26b UTSW 1 178,506,839 (GRCm39) missense probably benign 0.04
R7759:Kif26b UTSW 1 178,506,509 (GRCm39) missense probably damaging 1.00
R7775:Kif26b UTSW 1 178,692,441 (GRCm39) missense probably benign 0.15
R7954:Kif26b UTSW 1 178,696,944 (GRCm39) missense probably damaging 0.99
R7960:Kif26b UTSW 1 178,506,484 (GRCm39) missense probably damaging 1.00
R8012:Kif26b UTSW 1 178,743,815 (GRCm39) missense probably benign 0.20
R8152:Kif26b UTSW 1 178,506,794 (GRCm39) missense possibly damaging 0.46
R8320:Kif26b UTSW 1 178,711,641 (GRCm39) critical splice donor site probably null
R8360:Kif26b UTSW 1 178,743,938 (GRCm39) missense probably benign 0.18
R8428:Kif26b UTSW 1 178,744,923 (GRCm39) missense probably benign 0.09
R8670:Kif26b UTSW 1 178,741,349 (GRCm39) missense probably damaging 1.00
R8737:Kif26b UTSW 1 178,692,430 (GRCm39) missense probably damaging 0.99
R8788:Kif26b UTSW 1 178,357,090 (GRCm39) start gained probably benign
R8854:Kif26b UTSW 1 178,743,948 (GRCm39) missense possibly damaging 0.93
R8963:Kif26b UTSW 1 178,743,714 (GRCm39) missense probably benign 0.00
R9232:Kif26b UTSW 1 178,742,511 (GRCm39) missense probably damaging 1.00
R9297:Kif26b UTSW 1 178,543,374 (GRCm39) nonsense probably null
R9338:Kif26b UTSW 1 178,744,058 (GRCm39) missense probably damaging 1.00
R9572:Kif26b UTSW 1 178,745,042 (GRCm39) missense probably benign
R9580:Kif26b UTSW 1 178,506,643 (GRCm39) nonsense probably null
R9694:Kif26b UTSW 1 178,743,815 (GRCm39) missense probably benign 0.20
X0021:Kif26b UTSW 1 178,755,724 (GRCm39) missense probably damaging 1.00
X0024:Kif26b UTSW 1 178,506,647 (GRCm39) missense probably benign 0.14
X0025:Kif26b UTSW 1 178,742,948 (GRCm39) missense possibly damaging 0.70
X0025:Kif26b UTSW 1 178,742,831 (GRCm39) nonsense probably null
Z1177:Kif26b UTSW 1 178,742,970 (GRCm39) nonsense probably null
Z1177:Kif26b UTSW 1 178,649,115 (GRCm39) nonsense probably null
Z1177:Kif26b UTSW 1 178,649,113 (GRCm39) missense probably benign 0.11
Predicted Primers PCR Primer
(F):5'- GTAGCCCGCTCTTTAATCCG -3'
(R):5'- ACTTGGAAGAGCTGGGGTATTC -3'

Sequencing Primer
(F):5'- CAGGTGAAAGTCATGCTGCGTATC -3'
(R):5'- ATTCCGTGGAGCTCAGAATGACTTC -3'
Posted On 2021-07-15