Mutagenetix > Incidental Mutation

Incidental Mutation 'R8873:Dnah5'

676434

Institutional Source

Beutler Lab

Gene Symbol

Dnah5

Ensembl Gene

ENSMUSG00000022262

Gene Name

dynein, axonemal, heavy chain 5

Synonyms

b2b1565Clo, b2b1134Clo, Mdnah5, b2b1537Clo, b2b1154Clo, Dnahc5

MMRRC Submission

068686-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.776) question?

Stock #

R8873 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

28203752-28472052 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 28219188 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Aspartic acid at position 51 (N51D)

Ref Sequence

ENSEMBL: ENSMUSP00000069751 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000067048]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000067048
AA Change: N51D

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000069751
Gene: ENSMUSG00000022262
AA Change: N51D

Domain	Start	End	E-Value	Type
Pfam:DHC_N1	247	802	2.3e-163	PFAM
low complexity region	1077	1088	N/A	INTRINSIC
low complexity region	1113	1128	N/A	INTRINSIC
Pfam:DHC_N2	1399	1807	2.3e-134	PFAM
AAA	1972	2108	2e-3	SMART
AAA	2251	2424	4.3e-3	SMART
AAA	2579	2777	2.2e-3	SMART
low complexity region	2874	2889	N/A	INTRINSIC
Pfam:AAA_8	2914	3186	3.2e-70	PFAM
Pfam:MT	3198	3546	1e-44	PFAM
Pfam:AAA_9	3567	3792	1.4e-86	PFAM
low complexity region	3889	3899	N/A	INTRINSIC
Pfam:Dynein_heavy	3930	4618	4.4e-246	PFAM

Meta Mutation Damage Score

0.0804

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.4%

Validation Efficiency

98% (42/43)

MGI Phenotype

Strain: 2180081
Lethality: D14-D21
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a dynein protein, which is part of a microtubule-associated motor protein complex consisting of heavy, light, and intermediate chains. This protein is an axonemal heavy chain dynein. It functions as a force-generating protein with ATPase activity, whereby the release of ADP is thought to produce the force-producing power stroke. Mutations in this gene cause primary ciliary dyskinesia type 3, as well as Kartagener syndrome, which are both diseases due to ciliary defects. [provided by RefSeq, Oct 2009]
PHENOTYPE: Mice homozygous for a disruption in this gene display postnatal lethality, hydrocephalus, respiratory infections, situs inversus and ciliary immotility. [provided by MGI curators]

Allele List at MGI

All alleles(11) : Targeted(2) Gene trapped(1) Transgenic(1) Chemically induced(7)

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abhd15	C	A	11: 77,515,751 (GRCm38)	R185S	probably damaging	Het
Aoah	A	G	13: 20,905,682 (GRCm38)	N157D	probably benign	Het
Arhgap35	T	C	7: 16,561,490 (GRCm38)	N1217D	possibly damaging	Het
Asah2	A	T	19: 32,044,888 (GRCm38)		probably null	Het
Asb2	T	C	12: 103,333,466 (GRCm38)	N236D	probably damaging	Het
Auts2	A	G	5: 131,443,664 (GRCm38)	F317L		Het
Cfap74	T	C	4: 155,455,008 (GRCm38)	I930T	unknown	Het
Cmip	T	C	8: 117,377,190 (GRCm38)	V51A	probably damaging	Het
Col15a1	T	C	4: 47,247,552 (GRCm38)		probably null	Het
Cstf3	A	T	2: 104,645,010 (GRCm38)	H97L	possibly damaging	Het
Dip2c	A	T	13: 9,575,146 (GRCm38)	M559L	probably benign	Het
Dock4	T	A	12: 40,676,768 (GRCm38)	Y348*	probably null	Het
Ehhadh	C	T	16: 21,762,848 (GRCm38)	G465R	probably damaging	Het
Fam110b	C	T	4: 5,799,103 (GRCm38)	Q174*	probably null	Het
Fam124a	A	G	14: 62,606,575 (GRCm38)	T511A	probably benign	Het
Fbxl17	A	G	17: 63,384,976 (GRCm38)	V528A	probably damaging	Het
Fbxw24	C	A	9: 109,624,928 (GRCm38)	W50L	probably damaging	Het
Fyb2	A	T	4: 104,999,341 (GRCm38)	E582V	probably damaging	Het
Ganab	G	A	19: 8,910,879 (GRCm38)	W463*	probably null	Het
Gm10260	T	A	13: 97,760,335 (GRCm38)	N85I	probably damaging	Het
Gm11569	G	T	11: 99,798,384 (GRCm38)	T163N	unknown	Het
Gm8237	G	T	14: 5,862,453 (GRCm38)	Y86*	probably null	Het
Hrh4	T	A	18: 13,007,138 (GRCm38)	M30K		Het
Ifi209	A	G	1: 173,642,590 (GRCm38)	Y248C	probably damaging	Het
Jazf1	T	A	6: 52,812,180 (GRCm38)	H103L	probably damaging	Het
Ltbp1	A	G	17: 75,179,177 (GRCm38)	T66A	probably damaging	Het
Ndufa4	A	G	6: 11,907,361 (GRCm38)	L2P	probably benign	Het
Npnt	G	A	3: 132,950,055 (GRCm38)		probably benign	Het
Nrxn1	G	T	17: 90,565,393 (GRCm38)	C1052*	probably null	Het
Nsmce4a	G	T	7: 130,547,156 (GRCm38)	A40E	unknown	Het
Olfr720	A	T	14: 14,175,344 (GRCm38)	V246E	probably damaging	Het
Pcdhgb2	T	C	18: 37,691,288 (GRCm38)	V444A	probably damaging	Het
Pcdhgb7	C	T	18: 37,753,522 (GRCm38)	P582S	possibly damaging	Het
Phf3	T	C	1: 30,804,692 (GRCm38)	T1729A	possibly damaging	Het
Plod2	T	A	9: 92,607,059 (GRCm38)		probably benign	Het
Pramef20	G	T	4: 144,373,301 (GRCm38)	A298E	probably benign	Het
Rbm20	G	T	19: 53,677,480 (GRCm38)	V25F	probably benign	Het
Recql	G	T	6: 142,362,287 (GRCm38)	Q53K		Het
Rtel1	CAAA	CAA	2: 181,356,023 (GRCm38)		probably null	Het
Serpine2	A	G	1: 79,821,550 (GRCm38)		probably benign	Het
Siglecg	A	G	7: 43,418,024 (GRCm38)	T672A	probably benign	Het
Skil	T	C	3: 31,097,926 (GRCm38)	L199P	probably damaging	Het
Tmprss11f	C	T	5: 86,544,874 (GRCm38)	A64T	probably damaging	Het
Ttc3	C	T	16: 94,442,983 (GRCm38)	T1282M	probably damaging	Het

Other mutations in Dnah5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00226:Dnah5	APN	15	28,272,342 (GRCm38)	missense	probably benign
IGL00331:Dnah5	APN	15	28,421,620 (GRCm38)	missense	probably damaging	1.00
IGL00519:Dnah5	APN	15	28,444,218 (GRCm38)	missense	probably benign	0.10
IGL00537:Dnah5	APN	15	28,458,702 (GRCm38)	critical splice donor site	probably null
IGL01102:Dnah5	APN	15	28,410,003 (GRCm38)	critical splice donor site	probably null
IGL01126:Dnah5	APN	15	28,302,399 (GRCm38)	missense	possibly damaging	0.85
IGL01154:Dnah5	APN	15	28,458,656 (GRCm38)	missense	possibly damaging	0.75
IGL01349:Dnah5	APN	15	28,294,913 (GRCm38)	splice site	probably benign
IGL01353:Dnah5	APN	15	28,233,272 (GRCm38)	missense	probably benign	0.00
IGL01372:Dnah5	APN	15	28,230,490 (GRCm38)	missense	probably benign	0.00
IGL01390:Dnah5	APN	15	28,411,540 (GRCm38)	missense	probably benign	0.00
IGL01446:Dnah5	APN	15	28,326,669 (GRCm38)	missense	probably damaging	1.00
IGL01472:Dnah5	APN	15	28,331,726 (GRCm38)	missense	probably damaging	1.00
IGL01485:Dnah5	APN	15	28,331,726 (GRCm38)	missense	probably damaging	1.00
IGL01568:Dnah5	APN	15	28,229,652 (GRCm38)	missense	probably benign	0.01
IGL01592:Dnah5	APN	15	28,236,637 (GRCm38)	missense	probably benign	0.01
IGL01594:Dnah5	APN	15	28,311,334 (GRCm38)	missense	possibly damaging	0.87
IGL01677:Dnah5	APN	15	28,367,782 (GRCm38)	missense	probably damaging	1.00
IGL01845:Dnah5	APN	15	28,449,169 (GRCm38)	missense	probably benign	0.06
IGL01904:Dnah5	APN	15	28,307,364 (GRCm38)	missense	probably benign	0.09
IGL01913:Dnah5	APN	15	28,313,753 (GRCm38)	missense	possibly damaging	0.50
IGL01950:Dnah5	APN	15	28,290,289 (GRCm38)	missense	probably null	1.00
IGL01963:Dnah5	APN	15	28,370,536 (GRCm38)	missense	probably benign	0.12
IGL02008:Dnah5	APN	15	28,343,552 (GRCm38)	missense	probably damaging	0.98
IGL02088:Dnah5	APN	15	28,459,118 (GRCm38)	critical splice acceptor site	probably null
IGL02090:Dnah5	APN	15	28,240,041 (GRCm38)	splice site	probably benign
IGL02114:Dnah5	APN	15	28,397,124 (GRCm38)	missense	probably damaging	0.97
IGL02135:Dnah5	APN	15	28,247,885 (GRCm38)	missense	possibly damaging	0.50
IGL02232:Dnah5	APN	15	28,299,240 (GRCm38)	missense	probably damaging	1.00
IGL02386:Dnah5	APN	15	28,340,381 (GRCm38)	missense	probably damaging	1.00
IGL02475:Dnah5	APN	15	28,219,150 (GRCm38)	missense	probably benign	0.09
IGL02626:Dnah5	APN	15	28,307,276 (GRCm38)	missense	possibly damaging	0.94
IGL02650:Dnah5	APN	15	28,289,047 (GRCm38)	splice site	probably benign
IGL02651:Dnah5	APN	15	28,350,622 (GRCm38)	missense	probably benign	0.05
IGL02652:Dnah5	APN	15	28,366,187 (GRCm38)	missense	probably damaging	0.99
IGL02670:Dnah5	APN	15	28,409,296 (GRCm38)	missense	probably damaging	1.00
IGL02697:Dnah5	APN	15	28,445,143 (GRCm38)	missense	probably benign	0.00
IGL02721:Dnah5	APN	15	28,234,243 (GRCm38)	critical splice acceptor site	probably null
IGL02858:Dnah5	APN	15	28,453,212 (GRCm38)	missense	possibly damaging	0.65
IGL02859:Dnah5	APN	15	28,383,625 (GRCm38)	missense	probably benign	0.01
IGL02945:Dnah5	APN	15	28,270,426 (GRCm38)	missense	probably benign	0.00
IGL02949:Dnah5	APN	15	28,272,185 (GRCm38)	missense	probably benign	0.32
IGL02971:Dnah5	APN	15	28,384,461 (GRCm38)	missense	probably damaging	1.00
IGL03017:Dnah5	APN	15	28,340,325 (GRCm38)	missense	possibly damaging	0.93
IGL03177:Dnah5	APN	15	28,295,399 (GRCm38)	missense	probably damaging	0.97
IGL03212:Dnah5	APN	15	28,290,163 (GRCm38)	missense	probably benign	0.08
IGL03224:Dnah5	APN	15	28,459,154 (GRCm38)	missense	probably damaging	1.00
IGL03231:Dnah5	APN	15	28,311,148 (GRCm38)	missense	probably damaging	1.00
IGL03273:Dnah5	APN	15	28,458,649 (GRCm38)	missense	probably damaging	0.98
IGL03294:Dnah5	APN	15	28,233,295 (GRCm38)	critical splice donor site	probably null
IGL03331:Dnah5	APN	15	28,419,940 (GRCm38)	missense	probably damaging	1.00
IGL03337:Dnah5	APN	15	28,290,141 (GRCm38)	missense	probably benign	0.10
IGL03367:Dnah5	APN	15	28,234,327 (GRCm38)	missense	possibly damaging	0.95
Firtel	UTSW	15	28,448,367 (GRCm38)	missense	possibly damaging	0.95
lowbar	UTSW	15	28,311,133 (GRCm38)	splice site	probably null
notherone	UTSW	15	28,340,406 (GRCm38)	missense	probably benign	0.13
scheffler	UTSW	15	28,438,091 (GRCm38)	splice site	probably benign
IGL02837:Dnah5	UTSW	15	28,269,400 (GRCm38)	missense	probably benign
P0008:Dnah5	UTSW	15	28,302,387 (GRCm38)	missense	probably damaging	1.00
P0014:Dnah5	UTSW	15	28,403,473 (GRCm38)	missense	probably damaging	1.00
PIT4687001:Dnah5	UTSW	15	28,383,577 (GRCm38)	missense	probably damaging	0.98
R0030:Dnah5	UTSW	15	28,451,517 (GRCm38)	missense	probably benign	0.34
R0087:Dnah5	UTSW	15	28,350,613 (GRCm38)	missense	probably damaging	1.00
R0099:Dnah5	UTSW	15	28,239,934 (GRCm38)	missense	probably damaging	1.00
R0102:Dnah5	UTSW	15	28,245,751 (GRCm38)	splice site	probably benign
R0102:Dnah5	UTSW	15	28,245,751 (GRCm38)	splice site	probably benign
R0104:Dnah5	UTSW	15	28,453,353 (GRCm38)	missense	possibly damaging	0.88
R0112:Dnah5	UTSW	15	28,263,679 (GRCm38)	missense	probably benign	0.00
R0122:Dnah5	UTSW	15	28,378,363 (GRCm38)	missense	probably damaging	1.00
R0126:Dnah5	UTSW	15	28,246,319 (GRCm38)	missense	probably benign	0.00
R0127:Dnah5	UTSW	15	28,294,925 (GRCm38)	missense	probably damaging	1.00
R0233:Dnah5	UTSW	15	28,333,070 (GRCm38)	missense	probably damaging	1.00
R0310:Dnah5	UTSW	15	28,299,110 (GRCm38)	missense	probably benign	0.19
R0386:Dnah5	UTSW	15	28,383,581 (GRCm38)	missense	probably damaging	1.00
R0421:Dnah5	UTSW	15	28,229,541 (GRCm38)	missense	possibly damaging	0.79
R0481:Dnah5	UTSW	15	28,383,599 (GRCm38)	missense	probably benign	0.31
R0514:Dnah5	UTSW	15	28,366,321 (GRCm38)	missense	probably damaging	1.00
R0609:Dnah5	UTSW	15	28,327,779 (GRCm38)	missense	probably benign
R0720:Dnah5	UTSW	15	28,313,861 (GRCm38)	missense	probably null	0.98
R0731:Dnah5	UTSW	15	28,311,143 (GRCm38)	missense	possibly damaging	0.78
R0747:Dnah5	UTSW	15	28,444,187 (GRCm38)	missense	possibly damaging	0.64
R0747:Dnah5	UTSW	15	28,444,186 (GRCm38)	missense	probably damaging	0.99
R0766:Dnah5	UTSW	15	28,448,487 (GRCm38)	missense	probably null	0.89
R0849:Dnah5	UTSW	15	28,263,599 (GRCm38)	missense	probably damaging	0.96
R1034:Dnah5	UTSW	15	28,302,471 (GRCm38)	missense	probably damaging	1.00
R1084:Dnah5	UTSW	15	28,343,452 (GRCm38)	missense	probably benign	0.01
R1148:Dnah5	UTSW	15	28,421,690 (GRCm38)	missense	probably damaging	1.00
R1148:Dnah5	UTSW	15	28,421,690 (GRCm38)	missense	probably damaging	1.00
R1200:Dnah5	UTSW	15	28,246,257 (GRCm38)	missense	possibly damaging	0.88
R1208:Dnah5	UTSW	15	28,327,731 (GRCm38)	missense	probably damaging	1.00
R1208:Dnah5	UTSW	15	28,327,731 (GRCm38)	missense	probably damaging	1.00
R1269:Dnah5	UTSW	15	28,238,511 (GRCm38)	missense	probably damaging	1.00
R1373:Dnah5	UTSW	15	28,313,918 (GRCm38)	splice site	probably benign
R1401:Dnah5	UTSW	15	28,401,913 (GRCm38)	missense	probably damaging	1.00
R1413:Dnah5	UTSW	15	28,370,409 (GRCm38)	missense	probably benign
R1430:Dnah5	UTSW	15	28,345,857 (GRCm38)	missense	probably benign	0.37
R1457:Dnah5	UTSW	15	28,403,542 (GRCm38)	critical splice donor site	probably null
R1468:Dnah5	UTSW	15	28,230,463 (GRCm38)	nonsense	probably null
R1468:Dnah5	UTSW	15	28,230,463 (GRCm38)	nonsense	probably null
R1560:Dnah5	UTSW	15	28,420,003 (GRCm38)	missense	probably damaging	1.00
R1568:Dnah5	UTSW	15	28,409,177 (GRCm38)	missense	probably damaging	0.98
R1574:Dnah5	UTSW	15	28,252,423 (GRCm38)	missense	probably benign	0.00
R1574:Dnah5	UTSW	15	28,252,423 (GRCm38)	missense	probably benign	0.00
R1603:Dnah5	UTSW	15	28,449,180 (GRCm38)	missense	probably benign	0.09
R1603:Dnah5	UTSW	15	28,294,985 (GRCm38)	splice site	probably benign
R1673:Dnah5	UTSW	15	28,290,148 (GRCm38)	missense	probably benign
R1755:Dnah5	UTSW	15	28,326,636 (GRCm38)	missense	probably damaging	0.99
R1785:Dnah5	UTSW	15	28,313,786 (GRCm38)	missense	probably damaging	1.00
R1786:Dnah5	UTSW	15	28,313,786 (GRCm38)	missense	probably damaging	1.00
R1789:Dnah5	UTSW	15	28,270,426 (GRCm38)	missense	probably benign	0.00
R1817:Dnah5	UTSW	15	28,246,400 (GRCm38)	nonsense	probably null
R1819:Dnah5	UTSW	15	28,246,400 (GRCm38)	nonsense	probably null
R1834:Dnah5	UTSW	15	28,409,124 (GRCm38)	missense	probably benign	0.00
R1855:Dnah5	UTSW	15	28,411,669 (GRCm38)	missense	possibly damaging	0.88
R1870:Dnah5	UTSW	15	28,331,713 (GRCm38)	nonsense	probably null
R1871:Dnah5	UTSW	15	28,331,713 (GRCm38)	nonsense	probably null
R1987:Dnah5	UTSW	15	28,343,591 (GRCm38)	missense	probably damaging	0.99
R1988:Dnah5	UTSW	15	28,343,591 (GRCm38)	missense	probably damaging	0.99
R1989:Dnah5	UTSW	15	28,343,591 (GRCm38)	missense	probably damaging	0.99
R2062:Dnah5	UTSW	15	28,366,270 (GRCm38)	missense	probably damaging	1.00
R2069:Dnah5	UTSW	15	28,312,388 (GRCm38)	splice site	probably null
R2121:Dnah5	UTSW	15	28,297,005 (GRCm38)	splice site	probably benign
R2128:Dnah5	UTSW	15	28,408,321 (GRCm38)	missense	probably benign	0.00
R2129:Dnah5	UTSW	15	28,408,321 (GRCm38)	missense	probably benign	0.00
R2151:Dnah5	UTSW	15	28,444,091 (GRCm38)	missense	probably damaging	1.00
R2159:Dnah5	UTSW	15	28,252,545 (GRCm38)	missense	probably benign	0.00
R2207:Dnah5	UTSW	15	28,343,671 (GRCm38)	missense	probably benign	0.11
R2231:Dnah5	UTSW	15	28,408,417 (GRCm38)	critical splice donor site	probably null
R2232:Dnah5	UTSW	15	28,408,417 (GRCm38)	critical splice donor site	probably null
R2282:Dnah5	UTSW	15	28,327,302 (GRCm38)	missense	probably damaging	0.99
R2305:Dnah5	UTSW	15	28,387,767 (GRCm38)	missense	probably benign	0.25
R2339:Dnah5	UTSW	15	28,313,882 (GRCm38)	missense	probably benign	0.00
R2437:Dnah5	UTSW	15	28,307,391 (GRCm38)	critical splice donor site	probably null
R2696:Dnah5	UTSW	15	28,278,576 (GRCm38)	missense	probably benign	0.00
R3156:Dnah5	UTSW	15	28,438,091 (GRCm38)	splice site	probably benign
R3431:Dnah5	UTSW	15	28,295,267 (GRCm38)	missense	probably benign	0.20
R3700:Dnah5	UTSW	15	28,387,791 (GRCm38)	missense	possibly damaging	0.72
R3724:Dnah5	UTSW	15	28,270,420 (GRCm38)	missense	probably benign	0.08
R3732:Dnah5	UTSW	15	28,409,122 (GRCm38)	missense	possibly damaging	0.64
R3872:Dnah5	UTSW	15	28,411,510 (GRCm38)	missense	possibly damaging	0.50
R4063:Dnah5	UTSW	15	28,420,998 (GRCm38)	missense	probably damaging	0.98
R4072:Dnah5	UTSW	15	28,340,298 (GRCm38)	nonsense	probably null
R4075:Dnah5	UTSW	15	28,293,791 (GRCm38)	missense	probably benign
R4245:Dnah5	UTSW	15	28,219,189 (GRCm38)	missense	probably benign
R4254:Dnah5	UTSW	15	28,438,102 (GRCm38)	missense	probably benign	0.07
R4255:Dnah5	UTSW	15	28,438,102 (GRCm38)	missense	probably benign	0.07
R4392:Dnah5	UTSW	15	28,289,229 (GRCm38)	missense	probably benign	0.19
R4552:Dnah5	UTSW	15	28,397,154 (GRCm38)	missense	probably benign	0.19
R4574:Dnah5	UTSW	15	28,367,763 (GRCm38)	missense	probably benign	0.05
R4577:Dnah5	UTSW	15	28,289,250 (GRCm38)	missense	probably benign	0.06
R4587:Dnah5	UTSW	15	28,304,599 (GRCm38)	missense	probably damaging	1.00
R4631:Dnah5	UTSW	15	28,419,994 (GRCm38)	missense	probably damaging	1.00
R4631:Dnah5	UTSW	15	28,401,953 (GRCm38)	missense	probably damaging	1.00
R4676:Dnah5	UTSW	15	28,295,260 (GRCm38)	missense	possibly damaging	0.65
R4707:Dnah5	UTSW	15	28,372,375 (GRCm38)	missense	probably damaging	0.97
R4754:Dnah5	UTSW	15	28,420,955 (GRCm38)	splice site	probably null
R4767:Dnah5	UTSW	15	28,270,474 (GRCm38)	missense	probably benign	0.02
R4857:Dnah5	UTSW	15	28,345,807 (GRCm38)	missense	probably benign	0.00
R4883:Dnah5	UTSW	15	28,343,638 (GRCm38)	missense	probably benign	0.00
R4889:Dnah5	UTSW	15	28,235,792 (GRCm38)	missense	probably benign	0.01
R4946:Dnah5	UTSW	15	28,387,904 (GRCm38)	missense	probably damaging	1.00
R4946:Dnah5	UTSW	15	28,326,557 (GRCm38)	missense	probably damaging	0.96
R4947:Dnah5	UTSW	15	28,272,372 (GRCm38)	missense	probably benign
R5033:Dnah5	UTSW	15	28,421,678 (GRCm38)	missense	probably damaging	0.96
R5164:Dnah5	UTSW	15	28,408,292 (GRCm38)	missense	probably benign	0.00
R5175:Dnah5	UTSW	15	28,448,404 (GRCm38)	missense	probably damaging	1.00
R5182:Dnah5	UTSW	15	28,311,278 (GRCm38)	missense	probably damaging	0.99
R5187:Dnah5	UTSW	15	28,272,172 (GRCm38)	missense	probably benign	0.41
R5272:Dnah5	UTSW	15	28,350,665 (GRCm38)	missense	probably benign
R5308:Dnah5	UTSW	15	28,229,651 (GRCm38)	missense	possibly damaging	0.80
R5310:Dnah5	UTSW	15	28,311,328 (GRCm38)	missense	probably damaging	1.00
R5322:Dnah5	UTSW	15	28,384,244 (GRCm38)	missense	probably benign	0.41
R5398:Dnah5	UTSW	15	28,293,726 (GRCm38)	missense	probably benign
R5596:Dnah5	UTSW	15	28,343,608 (GRCm38)	missense	probably damaging	1.00
R5603:Dnah5	UTSW	15	28,419,932 (GRCm38)	missense	probably damaging	1.00
R5619:Dnah5	UTSW	15	28,302,435 (GRCm38)	missense	probably damaging	1.00
R5656:Dnah5	UTSW	15	28,421,064 (GRCm38)	missense	probably benign	0.03
R5741:Dnah5	UTSW	15	28,246,367 (GRCm38)	missense	probably benign	0.11
R5754:Dnah5	UTSW	15	28,401,868 (GRCm38)	missense	probably benign	0.01
R5763:Dnah5	UTSW	15	28,311,152 (GRCm38)	missense	probably damaging	1.00
R5824:Dnah5	UTSW	15	28,313,821 (GRCm38)	missense	probably benign	0.00
R5836:Dnah5	UTSW	15	28,383,592 (GRCm38)	missense	probably damaging	1.00
R5838:Dnah5	UTSW	15	28,290,195 (GRCm38)	missense	probably benign	0.00
R5864:Dnah5	UTSW	15	28,297,013 (GRCm38)	missense	possibly damaging	0.83
R5895:Dnah5	UTSW	15	28,234,453 (GRCm38)	splice site	probably null
R5896:Dnah5	UTSW	15	28,272,060 (GRCm38)	missense	probably benign
R5899:Dnah5	UTSW	15	28,448,367 (GRCm38)	missense	possibly damaging	0.95
R5905:Dnah5	UTSW	15	28,387,833 (GRCm38)	missense	probably damaging	1.00
R5924:Dnah5	UTSW	15	28,307,327 (GRCm38)	missense	probably benign	0.41
R5927:Dnah5	UTSW	15	28,335,718 (GRCm38)	missense	probably benign	0.00
R5929:Dnah5	UTSW	15	28,311,208 (GRCm38)	missense	probably damaging	1.00
R5929:Dnah5	UTSW	15	28,311,207 (GRCm38)	missense	probably benign	0.01
R5931:Dnah5	UTSW	15	28,453,279 (GRCm38)	missense	probably damaging	0.99
R5964:Dnah5	UTSW	15	28,458,584 (GRCm38)	missense	possibly damaging	0.49
R5975:Dnah5	UTSW	15	28,234,282 (GRCm38)	missense	probably damaging	1.00
R5993:Dnah5	UTSW	15	28,299,226 (GRCm38)	missense	probably benign	0.09
R6016:Dnah5	UTSW	15	28,327,884 (GRCm38)	missense	probably damaging	1.00
R6028:Dnah5	UTSW	15	28,387,833 (GRCm38)	missense	probably damaging	1.00
R6065:Dnah5	UTSW	15	28,230,468 (GRCm38)	missense	possibly damaging	0.47
R6117:Dnah5	UTSW	15	28,270,420 (GRCm38)	missense	probably damaging	0.99
R6143:Dnah5	UTSW	15	28,233,231 (GRCm38)	missense	probably benign	0.05
R6146:Dnah5	UTSW	15	28,459,185 (GRCm38)	missense	probably benign
R6154:Dnah5	UTSW	15	28,204,031 (GRCm38)	missense	probably benign	0.15
R6164:Dnah5	UTSW	15	28,378,343 (GRCm38)	missense	probably benign	0.08
R6266:Dnah5	UTSW	15	28,335,627 (GRCm38)	missense	possibly damaging	0.67
R6321:Dnah5	UTSW	15	28,372,411 (GRCm38)	missense	probably damaging	0.99
R6349:Dnah5	UTSW	15	28,238,511 (GRCm38)	missense	probably damaging	1.00
R6431:Dnah5	UTSW	15	28,349,824 (GRCm38)	missense	possibly damaging	0.52
R6467:Dnah5	UTSW	15	28,438,183 (GRCm38)	missense	probably benign	0.10
R6564:Dnah5	UTSW	15	28,367,745 (GRCm38)	missense	probably benign
R6607:Dnah5	UTSW	15	28,445,200 (GRCm38)	missense	possibly damaging	0.95
R6619:Dnah5	UTSW	15	28,409,120 (GRCm38)	missense	probably benign	0.03
R6633:Dnah5	UTSW	15	28,293,787 (GRCm38)	missense	probably benign	0.27
R6647:Dnah5	UTSW	15	28,403,487 (GRCm38)	missense	probably benign	0.02
R6782:Dnah5	UTSW	15	28,449,156 (GRCm38)	missense	possibly damaging	0.89
R6797:Dnah5	UTSW	15	28,233,238 (GRCm38)	nonsense	probably null
R6797:Dnah5	UTSW	15	28,451,463 (GRCm38)	missense	probably damaging	1.00
R6831:Dnah5	UTSW	15	28,411,515 (GRCm38)	missense	possibly damaging	0.88
R6849:Dnah5	UTSW	15	28,278,624 (GRCm38)	missense	probably benign	0.14
R6871:Dnah5	UTSW	15	28,229,640 (GRCm38)	missense	probably benign	0.32
R6936:Dnah5	UTSW	15	28,409,268 (GRCm38)	missense	probably damaging	1.00
R6943:Dnah5	UTSW	15	28,235,720 (GRCm38)	missense	probably damaging	1.00
R7030:Dnah5	UTSW	15	28,333,062 (GRCm38)	missense	probably benign	0.00
R7030:Dnah5	UTSW	15	28,238,592 (GRCm38)	missense	probably benign
R7032:Dnah5	UTSW	15	28,326,650 (GRCm38)	missense	probably damaging	1.00
R7063:Dnah5	UTSW	15	28,233,248 (GRCm38)	missense	probably benign	0.00
R7094:Dnah5	UTSW	15	28,453,336 (GRCm38)	missense	probably damaging	0.98
R7097:Dnah5	UTSW	15	28,453,264 (GRCm38)	missense	probably benign	0.00
R7126:Dnah5	UTSW	15	28,349,837 (GRCm38)	missense	probably benign	0.03
R7153:Dnah5	UTSW	15	28,365,522 (GRCm38)	splice site	probably null
R7209:Dnah5	UTSW	15	28,459,225 (GRCm38)	missense	possibly damaging	0.71
R7276:Dnah5	UTSW	15	28,367,838 (GRCm38)	missense	probably damaging	1.00
R7320:Dnah5	UTSW	15	28,270,470 (GRCm38)	missense	probably null	0.33
R7350:Dnah5	UTSW	15	28,235,819 (GRCm38)	critical splice donor site	probably null
R7380:Dnah5	UTSW	15	28,370,378 (GRCm38)	missense	probably damaging	1.00
R7438:Dnah5	UTSW	15	28,346,952 (GRCm38)	missense	probably damaging	0.99
R7499:Dnah5	UTSW	15	28,302,450 (GRCm38)	missense	probably damaging	1.00
R7513:Dnah5	UTSW	15	28,370,415 (GRCm38)	missense	probably benign
R7519:Dnah5	UTSW	15	28,390,483 (GRCm38)	missense	probably damaging	0.98
R7524:Dnah5	UTSW	15	28,297,066 (GRCm38)	missense	possibly damaging	0.50
R7556:Dnah5	UTSW	15	28,290,243 (GRCm38)	missense	probably null	0.43
R7570:Dnah5	UTSW	15	28,346,952 (GRCm38)	missense	probably damaging	1.00
R7585:Dnah5	UTSW	15	28,401,868 (GRCm38)	missense	probably benign	0.09
R7642:Dnah5	UTSW	15	28,247,979 (GRCm38)	critical splice donor site	probably null
R7670:Dnah5	UTSW	15	28,246,232 (GRCm38)	splice site	probably null
R7763:Dnah5	UTSW	15	28,313,855 (GRCm38)	missense	probably damaging	1.00
R7821:Dnah5	UTSW	15	28,411,532 (GRCm38)	missense	possibly damaging	0.89
R7826:Dnah5	UTSW	15	28,367,812 (GRCm38)	missense	probably damaging	1.00
R7872:Dnah5	UTSW	15	28,245,684 (GRCm38)	missense	probably damaging	0.99
R7889:Dnah5	UTSW	15	28,448,414 (GRCm38)	nonsense	probably null
R7919:Dnah5	UTSW	15	28,350,596 (GRCm38)	missense	probably damaging	1.00
R7920:Dnah5	UTSW	15	28,453,222 (GRCm38)	missense	probably benign	0.00
R7936:Dnah5	UTSW	15	28,345,837 (GRCm38)	missense	possibly damaging	0.64
R7996:Dnah5	UTSW	15	28,409,177 (GRCm38)	missense	probably damaging	0.98
R8063:Dnah5	UTSW	15	28,230,583 (GRCm38)	missense	probably benign
R8084:Dnah5	UTSW	15	28,387,953 (GRCm38)	missense	probably damaging	1.00
R8105:Dnah5	UTSW	15	28,372,402 (GRCm38)	missense	probably benign
R8114:Dnah5	UTSW	15	28,239,976 (GRCm38)	missense	probably benign	0.01
R8142:Dnah5	UTSW	15	28,384,373 (GRCm38)	missense	probably benign	0.36
R8153:Dnah5	UTSW	15	28,384,430 (GRCm38)	missense	probably damaging	1.00
R8161:Dnah5	UTSW	15	28,350,704 (GRCm38)	missense	possibly damaging	0.79
R8174:Dnah5	UTSW	15	28,311,133 (GRCm38)	splice site	probably null
R8187:Dnah5	UTSW	15	28,384,209 (GRCm38)	missense	probably damaging	1.00
R8194:Dnah5	UTSW	15	28,453,268 (GRCm38)	missense	probably damaging	0.99
R8280:Dnah5	UTSW	15	28,408,392 (GRCm38)	missense	probably benign	0.01
R8291:Dnah5	UTSW	15	28,263,597 (GRCm38)	missense	probably benign	0.03
R8324:Dnah5	UTSW	15	28,346,865 (GRCm38)	missense	probably damaging	1.00
R8347:Dnah5	UTSW	15	28,236,666 (GRCm38)	missense	possibly damaging	0.90
R8356:Dnah5	UTSW	15	28,444,167 (GRCm38)	missense	probably benign	0.03
R8356:Dnah5	UTSW	15	28,444,323 (GRCm38)	missense	probably null	0.02
R8361:Dnah5	UTSW	15	28,331,810 (GRCm38)	missense	probably damaging	0.98
R8375:Dnah5	UTSW	15	28,327,343 (GRCm38)	missense	probably benign	0.00
R8474:Dnah5	UTSW	15	28,247,832 (GRCm38)	missense	probably benign	0.00
R8481:Dnah5	UTSW	15	28,419,795 (GRCm38)	missense	probably benign	0.00
R8494:Dnah5	UTSW	15	28,345,831 (GRCm38)	missense	probably benign	0.32
R8495:Dnah5	UTSW	15	28,409,268 (GRCm38)	missense	probably damaging	0.97
R8519:Dnah5	UTSW	15	28,299,099 (GRCm38)	missense	probably benign	0.07
R8683:Dnah5	UTSW	15	28,289,221 (GRCm38)	missense	probably benign	0.00
R8739:Dnah5	UTSW	15	28,345,860 (GRCm38)	missense	probably benign	0.01
R8752:Dnah5	UTSW	15	28,290,219 (GRCm38)	missense	probably benign	0.00
R8784:Dnah5	UTSW	15	28,387,951 (GRCm38)	missense	probably benign	0.16
R8813:Dnah5	UTSW	15	28,229,573 (GRCm38)	missense	probably damaging	1.00
R8862:Dnah5	UTSW	15	28,459,356 (GRCm38)	splice site	probably benign
R8885:Dnah5	UTSW	15	28,327,740 (GRCm38)	missense	probably damaging	1.00
R8901:Dnah5	UTSW	15	28,365,569 (GRCm38)	missense	possibly damaging	0.76
R9025:Dnah5	UTSW	15	28,409,266 (GRCm38)	missense	probably damaging	1.00
R9037:Dnah5	UTSW	15	28,247,958 (GRCm38)	missense	probably benign	0.05
R9057:Dnah5	UTSW	15	28,390,868 (GRCm38)	missense	probably damaging	1.00
R9059:Dnah5	UTSW	15	28,245,666 (GRCm38)	missense	probably benign
R9065:Dnah5	UTSW	15	28,293,790 (GRCm38)	missense	probably benign	0.09
R9098:Dnah5	UTSW	15	28,419,961 (GRCm38)	missense
R9118:Dnah5	UTSW	15	28,401,848 (GRCm38)	frame shift	probably null
R9149:Dnah5	UTSW	15	28,387,768 (GRCm38)	missense	probably benign	0.00
R9184:Dnah5	UTSW	15	28,340,406 (GRCm38)	missense	probably benign	0.13
R9205:Dnah5	UTSW	15	28,448,334 (GRCm38)	missense	possibly damaging	0.88
R9297:Dnah5	UTSW	15	28,203,908 (GRCm38)	start gained	probably benign
R9302:Dnah5	UTSW	15	28,239,886 (GRCm38)	missense	probably benign	0.03
R9310:Dnah5	UTSW	15	28,448,433 (GRCm38)	missense	probably damaging	1.00
R9318:Dnah5	UTSW	15	28,203,908 (GRCm38)	start gained	probably benign
R9405:Dnah5	UTSW	15	28,272,160 (GRCm38)	missense	probably benign
R9424:Dnah5	UTSW	15	28,272,140 (GRCm38)	missense	probably benign	0.01
R9467:Dnah5	UTSW	15	28,366,147 (GRCm38)	missense	possibly damaging	0.94
R9469:Dnah5	UTSW	15	28,421,000 (GRCm38)	missense	probably benign	0.06
R9548:Dnah5	UTSW	15	28,327,879 (GRCm38)	missense	possibly damaging	0.79
R9564:Dnah5	UTSW	15	28,290,276 (GRCm38)	missense	probably benign	0.04
R9576:Dnah5	UTSW	15	28,272,140 (GRCm38)	missense	probably benign	0.01
R9593:Dnah5	UTSW	15	28,236,628 (GRCm38)	missense	probably benign
R9644:Dnah5	UTSW	15	28,230,504 (GRCm38)	missense	probably damaging	0.98
R9655:Dnah5	UTSW	15	28,242,754 (GRCm38)	missense	probably benign
R9657:Dnah5	UTSW	15	28,409,943 (GRCm38)	missense	probably damaging	1.00
R9704:Dnah5	UTSW	15	28,247,819 (GRCm38)	missense	probably benign	0.00
R9797:Dnah5	UTSW	15	28,233,170 (GRCm38)	missense	probably benign	0.34
RF009:Dnah5	UTSW	15	28,204,019 (GRCm38)	missense	probably benign	0.00
X0011:Dnah5	UTSW	15	28,408,381 (GRCm38)	missense	probably benign	0.16
X0018:Dnah5	UTSW	15	28,269,354 (GRCm38)	missense	probably benign	0.00
X0022:Dnah5	UTSW	15	28,270,411 (GRCm38)	missense	probably benign	0.01
X0023:Dnah5	UTSW	15	28,384,308 (GRCm38)	missense	probably damaging	0.99
X0028:Dnah5	UTSW	15	28,470,477 (GRCm38)	missense	probably damaging	1.00
Z1088:Dnah5	UTSW	15	28,366,357 (GRCm38)	missense	probably null	0.10
Z1088:Dnah5	UTSW	15	28,384,230 (GRCm38)	missense	probably damaging	1.00
Z1177:Dnah5	UTSW	15	28,295,311 (GRCm38)	missense	probably damaging	0.98
Z1177:Dnah5	UTSW	15	28,270,403 (GRCm38)	missense	probably benign	0.00
Z1177:Dnah5	UTSW	15	28,270,354 (GRCm38)	missense	probably benign	0.32
Z1177:Dnah5	UTSW	15	28,387,763 (GRCm38)	missense	possibly damaging	0.72

Predicted Primers

PCR Primer
(F):5'- CTGCTATGCGAAACTCTTAAGACTTG -3'
(R):5'- TTCAACCTGGAGAGCAGGAG -3'

Sequencing Primer
(F):5'- TGCGAAACTCTTAAGACTTGAAAACC -3'
(R):5'- TCTGGAACCTAGAGAGTGGG -3'

Posted On

2021-07-15