Incidental Mutation 'R0732:Or5p72'
ID 67651
Institutional Source Beutler Lab
Gene Symbol Or5p72
Ensembl Gene ENSMUSG00000095239
Gene Name olfactory receptor family 5 subfamily P member 72
Synonyms MOR204-9, GA_x6K02T2PBJ9-10752603-10753547, Olfr497
MMRRC Submission 038913-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # R0732 (G1)
Quality Score 220
Status Not validated
Chromosome 7
Chromosomal Location 108021780-108022724 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 108021784 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Aspartic acid at position 2 (A2D)
Ref Sequence ENSEMBL: ENSMUSP00000150439 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076406] [ENSMUST00000213521]
AlphaFold Q8VG08
Predicted Effect probably benign
Transcript: ENSMUST00000076406
AA Change: A2D

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000075741
Gene: ENSMUSG00000095239
AA Change: A2D

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 5.5e-55 PFAM
Pfam:7tm_1 44 293 1.4e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208862
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211454
AA Change: A2D
Predicted Effect probably benign
Transcript: ENSMUST00000213521
AA Change: A2D

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.4%
  • 20x: 94.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 87 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2ml1 T C 6: 128,523,411 (GRCm39) Y1175C probably damaging Het
Acsm3 T C 7: 119,373,057 (GRCm39) S187P probably benign Het
Adam28 T C 14: 68,874,796 (GRCm39) I294V probably benign Het
Adgrv1 T C 13: 81,651,123 (GRCm39) I3057M possibly damaging Het
Aff4 T C 11: 53,266,423 (GRCm39) V304A probably benign Het
Akr1b10 T C 6: 34,367,044 (GRCm39) Y108H probably benign Het
Ankib1 T C 5: 3,763,163 (GRCm39) N522S possibly damaging Het
Ano1 T A 7: 144,173,225 (GRCm39) probably null Het
Antxr2 G T 5: 98,108,567 (GRCm39) probably null Het
Arc G A 15: 74,543,044 (GRCm39) T393I probably damaging Het
Arhgef33 A G 17: 80,688,783 (GRCm39) D5G possibly damaging Het
Atf2 A T 2: 73,675,844 (GRCm39) M169K possibly damaging Het
BC005624 T A 2: 30,863,949 (GRCm39) T215S possibly damaging Het
Bmp8b G A 4: 122,999,199 (GRCm39) G19D unknown Het
Cacna1d T C 14: 29,764,877 (GRCm39) N1987S probably damaging Het
Camta1 T A 4: 151,670,941 (GRCm39) probably null Het
Catsperg2 C T 7: 29,400,121 (GRCm39) G316D probably damaging Het
Cbs G T 17: 31,844,003 (GRCm39) N209K probably benign Het
Ccdc122 T A 14: 77,329,199 (GRCm39) M84K probably damaging Het
Cd5 C T 19: 10,700,649 (GRCm39) C285Y probably damaging Het
Chpf2 T C 5: 24,795,419 (GRCm39) M1T probably null Het
Coch T A 12: 51,642,155 (GRCm39) D42E probably damaging Het
Crip2 C T 12: 113,104,178 (GRCm39) probably benign Het
Crlf2 G C 5: 109,705,004 (GRCm39) P67R probably damaging Het
Cxcl16 G T 11: 70,346,234 (GRCm39) P233H probably damaging Het
Cyfip1 T C 7: 55,536,529 (GRCm39) I319T probably damaging Het
Ddhd2 T C 8: 26,231,348 (GRCm39) Q364R probably damaging Het
Ephx2 A G 14: 66,324,412 (GRCm39) probably null Het
Exoc6b C A 6: 84,832,504 (GRCm39) V397L probably damaging Het
Fam83b T A 9: 76,400,210 (GRCm39) K298* probably null Het
Fbxo8 T A 8: 57,044,564 (GRCm39) I289N probably damaging Het
Fkbp9 T A 6: 56,855,089 (GRCm39) M536K probably benign Het
Flot1 C T 17: 36,136,416 (GRCm39) R190W possibly damaging Het
Gbp2b T A 3: 142,312,739 (GRCm39) V374E probably benign Het
Gna15 T A 10: 81,348,390 (GRCm39) S114C probably damaging Het
Gstt4 T A 10: 75,653,155 (GRCm39) T136S probably benign Het
Hcn3 C T 3: 89,056,093 (GRCm39) V524M probably damaging Het
Kctd16 A T 18: 40,391,616 (GRCm39) D68V probably damaging Het
Kics2 T C 10: 121,586,852 (GRCm39) V253A possibly damaging Het
Krt90 G T 15: 101,468,860 (GRCm39) F227L possibly damaging Het
Lrrc37 T C 11: 103,510,664 (GRCm39) T435A unknown Het
Maip1 A G 1: 57,450,994 (GRCm39) Y212C probably damaging Het
Mamdc2 C T 19: 23,356,233 (GRCm39) D72N probably damaging Het
Marveld3 A T 8: 110,675,115 (GRCm39) Y234N probably damaging Het
Mas1 A G 17: 13,060,634 (GRCm39) I263T probably benign Het
Matk T A 10: 81,094,140 (GRCm39) probably null Het
Mrgpre T A 7: 143,335,303 (GRCm39) I67F possibly damaging Het
Mthfd1 T A 12: 76,340,948 (GRCm39) I449N probably damaging Het
Nacc1 C T 8: 85,402,830 (GRCm39) R321Q probably damaging Het
Neb T C 2: 52,148,693 (GRCm39) D2618G probably damaging Het
Neb T C 2: 52,181,280 (GRCm39) Y1109C probably damaging Het
Nell1 T G 7: 50,506,135 (GRCm39) W781G probably damaging Het
Or4g16 T A 2: 111,137,325 (GRCm39) Y258* probably null Het
Or4x6 A G 2: 89,949,666 (GRCm39) V92A probably benign Het
Or52d1 T C 7: 103,755,501 (GRCm39) L5P probably damaging Het
Or55b4 T C 7: 102,133,650 (GRCm39) I226V probably benign Het
Or6k4 A T 1: 173,964,981 (GRCm39) I224F possibly damaging Het
Or8s8 T C 15: 98,354,959 (GRCm39) L256S possibly damaging Het
Or8u10 A C 2: 85,915,928 (GRCm39) S64R probably benign Het
Pcdh7 C A 5: 57,878,657 (GRCm39) D737E probably damaging Het
Pdss1 T G 2: 22,791,324 (GRCm39) M55R probably benign Het
Pex6 C T 17: 47,035,626 (GRCm39) R889W probably damaging Het
Pigl T A 11: 62,349,307 (GRCm39) C8S possibly damaging Het
Plekha7 A T 7: 115,744,472 (GRCm39) M585K probably damaging Het
Ppp1r1a C T 15: 103,441,514 (GRCm39) M66I possibly damaging Het
Ptcd3 A T 6: 71,858,155 (GRCm39) probably benign Het
Rhov A T 2: 119,101,495 (GRCm39) V37E probably damaging Het
Rnf213 A T 11: 119,331,894 (GRCm39) M2368L probably damaging Het
Skida1 T C 2: 18,050,968 (GRCm39) probably benign Het
Slc25a28 T C 19: 43,655,392 (GRCm39) D161G probably benign Het
Smc6 T C 12: 11,340,818 (GRCm39) V490A probably damaging Het
Sohlh2 T A 3: 55,097,794 (GRCm39) probably null Het
Stk31 A G 6: 49,394,429 (GRCm39) T264A probably benign Het
Syngap1 T A 17: 27,173,962 (GRCm39) S190R possibly damaging Het
Tacr1 T A 6: 82,529,882 (GRCm39) V200E probably damaging Het
Tbrg4 C T 11: 6,570,812 (GRCm39) R220H probably benign Het
Tcf20 A G 15: 82,736,504 (GRCm39) L1649P probably benign Het
Tcirg1 A T 19: 3,947,866 (GRCm39) L523Q possibly damaging Het
Tinag T A 9: 76,908,936 (GRCm39) K335M possibly damaging Het
Tkt T G 14: 30,293,097 (GRCm39) probably null Het
Tnpo1 C T 13: 99,000,320 (GRCm39) R349H probably damaging Het
Trim26 T A 17: 37,163,510 (GRCm39) S230R possibly damaging Het
Trim8 T A 19: 46,503,178 (GRCm39) probably null Het
Trp53bp1 T C 2: 121,078,745 (GRCm39) R326G probably null Het
Ugt2a2 A T 5: 87,608,498 (GRCm39) I613N probably damaging Het
Vmn1r32 T C 6: 66,530,690 (GRCm39) I29V probably benign Het
Wnt5b C T 6: 119,423,543 (GRCm39) W27* probably null Het
Other mutations in Or5p72
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01448:Or5p72 APN 7 108,022,235 (GRCm39) nonsense probably null
IGL03145:Or5p72 APN 7 108,021,806 (GRCm39) missense probably benign 0.00
R1892:Or5p72 UTSW 7 108,022,147 (GRCm39) missense possibly damaging 0.61
R2008:Or5p72 UTSW 7 108,022,389 (GRCm39) missense probably benign 0.01
R3721:Or5p72 UTSW 7 108,022,326 (GRCm39) missense probably damaging 1.00
R4497:Or5p72 UTSW 7 108,022,122 (GRCm39) missense probably benign 0.37
R4674:Or5p72 UTSW 7 108,022,309 (GRCm39) missense possibly damaging 0.65
R4675:Or5p72 UTSW 7 108,022,309 (GRCm39) missense possibly damaging 0.65
R4695:Or5p72 UTSW 7 108,022,196 (GRCm39) missense probably benign 0.18
R5265:Or5p72 UTSW 7 108,022,609 (GRCm39) missense possibly damaging 0.94
R5656:Or5p72 UTSW 7 108,021,825 (GRCm39) missense probably benign 0.03
R5758:Or5p72 UTSW 7 108,022,369 (GRCm39) missense probably benign 0.02
R6124:Or5p72 UTSW 7 108,022,725 (GRCm39) splice site probably null
R6787:Or5p72 UTSW 7 108,021,889 (GRCm39) missense possibly damaging 0.52
R7174:Or5p72 UTSW 7 108,022,367 (GRCm39) missense probably benign 0.01
R7222:Or5p72 UTSW 7 108,021,844 (GRCm39) missense probably benign 0.00
R7240:Or5p72 UTSW 7 108,022,140 (GRCm39) missense probably damaging 1.00
R8752:Or5p72 UTSW 7 108,022,480 (GRCm39) missense probably benign
R9548:Or5p72 UTSW 7 108,022,416 (GRCm39) missense possibly damaging 0.75
R9786:Or5p72 UTSW 7 108,021,924 (GRCm39) missense probably benign 0.28
Predicted Primers PCR Primer
(F):5'- agccaactcaccagGCAAAATCTC -3'
(R):5'- GCTCTGCTGAATGCCACATCCAAG -3'

Sequencing Primer
(F):5'- ggatggggggacaaaatatgg -3'
(R):5'- TGATGAAAGGCCCATGTCAAC -3'
Posted On 2013-09-03