Incidental Mutation 'R8875:Vmn2r85'
| ID |
676534 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r85
|
| Ensembl Gene |
ENSMUSG00000092048 |
| Gene Name |
vomeronasal 2, receptor 85 |
| Synonyms |
EG623734 |
| MMRRC Submission |
068687-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.073)
|
| Stock # |
R8875 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
10 |
| Chromosomal Location |
130253658-130266615 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 130254171 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 838
(S838P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000128792
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000171811]
|
| AlphaFold |
G3UW56 |
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000075147
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000171811
AA Change: S838P
PolyPhen 2
Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000128792
Gene: ENSMUSG00000092048
AA Change: S838P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
425 |
9e-26 |
PFAM |
|
Pfam:NCD3G
|
508 |
562 |
1.1e-18 |
PFAM |
|
Pfam:7tm_3
|
595 |
831 |
3.7e-54 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.8%
|
| Validation Efficiency |
100% (49/49) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 50 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 0610010K14Rik |
A |
G |
11: 70,126,380 (GRCm39) |
V140A |
|
Het |
| Ablim1 |
G |
T |
19: 57,119,386 (GRCm39) |
H233N |
probably benign |
Het |
| Adra1a |
A |
T |
14: 66,875,214 (GRCm39) |
Y63F |
possibly damaging |
Het |
| Ank3 |
A |
G |
10: 69,660,233 (GRCm39) |
D245G |
unknown |
Het |
| Ap4e1 |
T |
C |
2: 126,877,100 (GRCm39) |
I279T |
probably damaging |
Het |
| Bap1 |
T |
G |
14: 30,975,522 (GRCm39) |
F122C |
probably damaging |
Het |
| Cdc5l |
T |
C |
17: 45,703,915 (GRCm39) |
|
probably benign |
Het |
| Chd2 |
A |
T |
7: 73,151,783 (GRCm39) |
I309N |
probably damaging |
Het |
| Cnpy3 |
T |
C |
17: 47,048,185 (GRCm39) |
I177V |
probably damaging |
Het |
| Cp |
A |
G |
3: 20,027,994 (GRCm39) |
K467E |
possibly damaging |
Het |
| D630039A03Rik |
T |
G |
4: 57,910,320 (GRCm39) |
N164T |
probably benign |
Het |
| Dnah7a |
C |
A |
1: 53,682,682 (GRCm39) |
A263S |
probably benign |
Het |
| Eif2s1 |
G |
A |
12: 78,913,461 (GRCm39) |
R54Q |
probably damaging |
Het |
| Fasn |
A |
T |
11: 120,703,224 (GRCm39) |
D1600E |
possibly damaging |
Het |
| Fat1 |
T |
A |
8: 45,493,600 (GRCm39) |
F3915L |
probably damaging |
Het |
| Fiz1 |
A |
T |
7: 5,012,093 (GRCm39) |
S142T |
probably benign |
Het |
| Fnip1 |
A |
G |
11: 54,406,380 (GRCm39) |
Y1159C |
probably damaging |
Het |
| Fsip2 |
T |
A |
2: 82,820,782 (GRCm39) |
V5505D |
possibly damaging |
Het |
| Gabrg3 |
A |
G |
7: 56,379,514 (GRCm39) |
M296T |
probably damaging |
Het |
| Gm11562 |
A |
T |
11: 99,511,177 (GRCm39) |
S8T |
unknown |
Het |
| Hoxd11 |
A |
G |
2: 74,513,365 (GRCm39) |
D210G |
probably benign |
Het |
| Hsd17b2 |
T |
C |
8: 118,469,101 (GRCm39) |
V171A |
possibly damaging |
Het |
| Ifi206 |
T |
C |
1: 173,301,353 (GRCm39) |
Y775C |
unknown |
Het |
| Nherf2 |
T |
A |
17: 24,866,703 (GRCm39) |
|
probably null |
Het |
| Nr2f1 |
A |
C |
13: 78,337,970 (GRCm39) |
I382S |
probably damaging |
Het |
| Nrp1 |
T |
A |
8: 129,207,472 (GRCm39) |
|
probably null |
Het |
| Or51l4 |
G |
A |
7: 103,404,462 (GRCm39) |
S110F |
probably damaging |
Het |
| Or52h7 |
A |
G |
7: 104,213,670 (GRCm39) |
T81A |
probably benign |
Het |
| Pdcd1 |
C |
T |
1: 93,967,092 (GRCm39) |
D269N |
probably benign |
Het |
| Pira12 |
A |
G |
7: 3,897,256 (GRCm39) |
S527P |
probably damaging |
Het |
| Plbd2 |
A |
G |
5: 120,637,121 (GRCm39) |
Y114H |
probably damaging |
Het |
| Plch1 |
A |
G |
3: 63,618,391 (GRCm39) |
C715R |
probably damaging |
Het |
| Plin4 |
G |
A |
17: 56,411,010 (GRCm39) |
A1007V |
probably benign |
Het |
| Ptprs |
G |
T |
17: 56,742,946 (GRCm39) |
P399T |
probably damaging |
Het |
| Pum1 |
T |
A |
4: 130,507,186 (GRCm39) |
I1181N |
possibly damaging |
Het |
| Qrich1 |
A |
G |
9: 108,436,502 (GRCm39) |
|
probably benign |
Het |
| Rbm12 |
T |
C |
2: 155,938,841 (GRCm39) |
E477G |
probably damaging |
Het |
| Rpl7 |
T |
C |
1: 16,173,753 (GRCm39) |
K57R |
probably benign |
Het |
| Spata31h1 |
G |
A |
10: 82,123,476 (GRCm39) |
A3178V |
probably benign |
Het |
| Stab2 |
C |
T |
10: 86,832,728 (GRCm39) |
C99Y |
probably damaging |
Het |
| Tas1r1 |
T |
A |
4: 152,113,047 (GRCm39) |
T669S |
probably benign |
Het |
| Tle5 |
A |
T |
10: 81,400,534 (GRCm39) |
I73F |
probably benign |
Het |
| Tm2d2 |
T |
C |
8: 25,507,443 (GRCm39) |
L20P |
possibly damaging |
Het |
| Tmem158 |
G |
T |
9: 123,089,132 (GRCm39) |
A160E |
possibly damaging |
Het |
| Tpst2 |
T |
A |
5: 112,457,714 (GRCm39) |
Y347* |
probably null |
Het |
| Trpm3 |
T |
C |
19: 22,887,493 (GRCm39) |
I876T |
probably damaging |
Het |
| Ttc6 |
T |
C |
12: 57,751,199 (GRCm39) |
F1364L |
probably damaging |
Het |
| Ttc6 |
T |
A |
12: 57,776,194 (GRCm39) |
S1713T |
possibly damaging |
Het |
| Zc2hc1c |
T |
C |
12: 85,336,549 (GRCm39) |
S69P |
possibly damaging |
Het |
| Zfp982 |
C |
A |
4: 147,595,320 (GRCm39) |
N47K |
probably benign |
Het |
|
| Other mutations in Vmn2r85 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01160:Vmn2r85
|
APN |
10 |
130,254,690 (GRCm39) |
missense |
probably benign |
0.22 |
|
IGL01298:Vmn2r85
|
APN |
10 |
130,254,690 (GRCm39) |
missense |
probably benign |
0.22 |
|
IGL01361:Vmn2r85
|
APN |
10 |
130,254,690 (GRCm39) |
missense |
probably benign |
0.22 |
|
IGL02185:Vmn2r85
|
APN |
10 |
130,254,561 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL02505:Vmn2r85
|
APN |
10 |
130,261,449 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02607:Vmn2r85
|
APN |
10 |
130,262,290 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02755:Vmn2r85
|
APN |
10 |
130,261,381 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03188:Vmn2r85
|
APN |
10 |
130,254,612 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL03366:Vmn2r85
|
APN |
10 |
130,262,328 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03397:Vmn2r85
|
APN |
10 |
130,261,263 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4445001:Vmn2r85
|
UTSW |
10 |
130,261,572 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0066:Vmn2r85
|
UTSW |
10 |
130,261,770 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0128:Vmn2r85
|
UTSW |
10 |
130,255,054 (GRCm39) |
splice site |
probably benign |
|
|
R0130:Vmn2r85
|
UTSW |
10 |
130,255,054 (GRCm39) |
splice site |
probably benign |
|
|
R0503:Vmn2r85
|
UTSW |
10 |
130,258,609 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0827:Vmn2r85
|
UTSW |
10 |
130,265,387 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R1432:Vmn2r85
|
UTSW |
10 |
130,261,155 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R1521:Vmn2r85
|
UTSW |
10 |
130,261,788 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2029:Vmn2r85
|
UTSW |
10 |
130,261,443 (GRCm39) |
nonsense |
probably null |
|
|
R2034:Vmn2r85
|
UTSW |
10 |
130,262,242 (GRCm39) |
splice site |
probably benign |
|
|
R2852:Vmn2r85
|
UTSW |
10 |
130,255,035 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2853:Vmn2r85
|
UTSW |
10 |
130,255,035 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3084:Vmn2r85
|
UTSW |
10 |
130,261,081 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3085:Vmn2r85
|
UTSW |
10 |
130,261,081 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3430:Vmn2r85
|
UTSW |
10 |
130,254,758 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3694:Vmn2r85
|
UTSW |
10 |
130,254,171 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3932:Vmn2r85
|
UTSW |
10 |
130,254,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4207:Vmn2r85
|
UTSW |
10 |
130,254,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4628:Vmn2r85
|
UTSW |
10 |
130,261,235 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4814:Vmn2r85
|
UTSW |
10 |
130,254,567 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4948:Vmn2r85
|
UTSW |
10 |
130,254,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4951:Vmn2r85
|
UTSW |
10 |
130,261,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4959:Vmn2r85
|
UTSW |
10 |
130,257,302 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5336:Vmn2r85
|
UTSW |
10 |
130,258,574 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R5643:Vmn2r85
|
UTSW |
10 |
130,262,343 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6061:Vmn2r85
|
UTSW |
10 |
130,261,531 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6115:Vmn2r85
|
UTSW |
10 |
130,258,672 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6190:Vmn2r85
|
UTSW |
10 |
130,261,330 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6518:Vmn2r85
|
UTSW |
10 |
130,265,281 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6533:Vmn2r85
|
UTSW |
10 |
130,262,529 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6610:Vmn2r85
|
UTSW |
10 |
130,261,838 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6809:Vmn2r85
|
UTSW |
10 |
130,261,795 (GRCm39) |
missense |
probably benign |
|
|
R6962:Vmn2r85
|
UTSW |
10 |
130,261,452 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7075:Vmn2r85
|
UTSW |
10 |
130,258,557 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7104:Vmn2r85
|
UTSW |
10 |
130,262,376 (GRCm39) |
missense |
probably benign |
|
|
R7424:Vmn2r85
|
UTSW |
10 |
130,254,849 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7516:Vmn2r85
|
UTSW |
10 |
130,254,852 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7537:Vmn2r85
|
UTSW |
10 |
130,258,735 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7768:Vmn2r85
|
UTSW |
10 |
130,254,562 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7810:Vmn2r85
|
UTSW |
10 |
130,261,081 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8078:Vmn2r85
|
UTSW |
10 |
130,265,364 (GRCm39) |
nonsense |
probably null |
|
|
R8115:Vmn2r85
|
UTSW |
10 |
130,261,820 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8262:Vmn2r85
|
UTSW |
10 |
130,254,738 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8395:Vmn2r85
|
UTSW |
10 |
130,261,797 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8409:Vmn2r85
|
UTSW |
10 |
130,261,257 (GRCm39) |
missense |
probably benign |
0.16 |
|
R8547:Vmn2r85
|
UTSW |
10 |
130,261,311 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9035:Vmn2r85
|
UTSW |
10 |
130,261,479 (GRCm39) |
missense |
probably benign |
|
|
R9040:Vmn2r85
|
UTSW |
10 |
130,254,311 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9115:Vmn2r85
|
UTSW |
10 |
130,254,153 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9182:Vmn2r85
|
UTSW |
10 |
130,265,350 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9245:Vmn2r85
|
UTSW |
10 |
130,261,534 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9245:Vmn2r85
|
UTSW |
10 |
130,255,033 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9405:Vmn2r85
|
UTSW |
10 |
130,261,215 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9502:Vmn2r85
|
UTSW |
10 |
130,261,387 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9520:Vmn2r85
|
UTSW |
10 |
130,254,993 (GRCm39) |
missense |
probably benign |
|
|
R9653:Vmn2r85
|
UTSW |
10 |
130,261,694 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Vmn2r85
|
UTSW |
10 |
130,261,713 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Vmn2r85
|
UTSW |
10 |
130,254,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
|
| Posted On |
2021-07-15 |
Incidental Mutation