Incidental Mutation 'R8876:Or13a19'
ID 676576
Institutional Source Beutler Lab
Gene Symbol Or13a19
Ensembl Gene ENSMUSG00000061489
Gene Name olfactory receptor family 13 subfamily A member 19
Synonyms Olfr525, MOR251-2, GA_x6K02T2PBJ9-42472898-42473827
MMRRC Submission 068688-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.069) question?
Stock # R8876 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 139902614-139903543 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 139902716 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 35 (Y35H)
Ref Sequence ENSEMBL: ENSMUSP00000149361 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078103] [ENSMUST00000214594]
AlphaFold Q8VGL5
Predicted Effect probably damaging
Transcript: ENSMUST00000078103
AA Change: Y35H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000077243
Gene: ENSMUSG00000061489
AA Change: Y35H

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.1e-53 PFAM
Pfam:7TM_GPCR_Srsx 35 260 1.5e-5 PFAM
Pfam:7tm_1 41 290 1.3e-26 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214594
AA Change: Y35H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.6329 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 98% (55/56)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Accs A C 2: 93,668,403 (GRCm39) L356R probably damaging Het
Acvr1 A T 2: 58,338,422 (GRCm39) D433E possibly damaging Het
Aldh3b1 A G 19: 3,971,502 (GRCm39) L122P probably damaging Het
Ap3b1 T G 13: 94,540,586 (GRCm39) N169K possibly damaging Het
Apbb2 A G 5: 66,609,000 (GRCm39) S216P probably benign Het
Arap3 T A 18: 38,130,077 (GRCm39) H28L possibly damaging Het
Arhgap44 C T 11: 64,898,896 (GRCm39) M760I possibly damaging Het
Arhgef19 G T 4: 140,975,193 (GRCm39) A304S probably benign Het
Atpaf1 T C 4: 115,645,548 (GRCm39) I139T possibly damaging Het
BC024139 G T 15: 76,010,320 (GRCm39) T62K possibly damaging Het
Bmal2 G A 6: 146,723,492 (GRCm39) G274D probably benign Het
Capn5 T C 7: 97,780,902 (GRCm39) T292A probably benign Het
Card19 T C 13: 49,358,814 (GRCm39) N53S possibly damaging Het
Cep97 A G 16: 55,742,467 (GRCm39) V232A possibly damaging Het
Cfap298 A G 16: 90,724,281 (GRCm39) I164T possibly damaging Het
Clca3a2 G T 3: 144,777,360 (GRCm39) T837K probably benign Het
Col8a2 G C 4: 126,204,647 (GRCm39) G219A probably damaging Het
Ctu2 T C 8: 123,206,951 (GRCm39) S365P Het
Dnah2 T C 11: 69,382,348 (GRCm39) D1254G probably damaging Het
Dscam A G 16: 96,420,828 (GRCm39) L1686S probably damaging Het
Fgr A G 4: 132,726,071 (GRCm39) probably benign Het
Frmd4a T A 2: 4,606,111 (GRCm39) S612T probably damaging Het
Gadd45gip1 T C 8: 85,560,748 (GRCm39) I121T probably damaging Het
Gapvd1 A G 2: 34,568,560 (GRCm39) V1353A possibly damaging Het
Gdf3 G A 6: 122,583,942 (GRCm39) P142S probably damaging Het
Gm19965 G A 1: 116,749,776 (GRCm39) G486R unknown Het
Gpatch2l T C 12: 86,308,405 (GRCm39) L307P probably damaging Het
Grm3 T C 5: 9,561,580 (GRCm39) K757E probably damaging Het
Inppl1 T A 7: 101,472,750 (GRCm39) H1218L possibly damaging Het
Jag2 T C 12: 112,873,257 (GRCm39) I1055V probably benign Het
Krtap9-5 G T 11: 99,840,340 (GRCm39) C347F unknown Het
Magi2 T A 5: 20,856,190 (GRCm39) Y1050* probably null Het
Myrf A G 19: 10,206,378 (GRCm39) probably benign Het
Ntpcr T G 8: 126,464,785 (GRCm39) probably benign Het
Or1p1b C T 11: 74,130,846 (GRCm39) T152I probably damaging Het
Or2y1c T C 11: 49,361,386 (GRCm39) M136T probably damaging Het
Palmd T G 3: 116,720,899 (GRCm39) D145A probably damaging Het
Pdcd1 A G 1: 93,980,155 (GRCm39) S21P probably benign Het
Pkn1 T C 8: 84,398,879 (GRCm39) T696A possibly damaging Het
Pnpt1 T A 11: 29,096,769 (GRCm39) probably benign Het
Sbf2 T A 7: 110,049,146 (GRCm39) I273F probably damaging Het
Skic3 T G 13: 76,323,403 (GRCm39) D1382E probably benign Het
Slc16a4 A T 3: 107,208,101 (GRCm39) N204Y probably benign Het
Slc38a1 T C 15: 96,514,091 (GRCm39) I44V possibly damaging Het
Smpdl3a T C 10: 57,685,166 (GRCm39) V312A probably damaging Het
Ston1 A G 17: 88,942,600 (GRCm39) Y2C probably benign Het
Syde1 A T 10: 78,425,325 (GRCm39) Y229N probably damaging Het
Ttc6 T A 12: 57,784,489 (GRCm39) C1853S possibly damaging Het
Ttn A G 2: 76,609,249 (GRCm39) I17650T possibly damaging Het
Upf1 T C 8: 70,796,918 (GRCm39) E105G possibly damaging Het
Wrn A G 8: 33,814,422 (GRCm39) W341R probably benign Het
Xndc1 C T 7: 101,729,754 (GRCm39) P267L probably benign Het
Zbtb26 T C 2: 37,326,896 (GRCm39) T47A probably benign Het
Zc3h10 A T 10: 128,380,163 (GRCm39) V398E probably damaging Het
Zfp652 G T 11: 95,639,921 (GRCm39) probably benign Het
Other mutations in Or13a19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02143:Or13a19 APN 7 139,903,505 (GRCm39) nonsense probably null
IGL02450:Or13a19 APN 7 139,903,140 (GRCm39) missense possibly damaging 0.95
IGL02927:Or13a19 APN 7 139,902,654 (GRCm39) missense probably damaging 1.00
IGL03008:Or13a19 APN 7 139,903,445 (GRCm39) missense probably damaging 1.00
IGL03202:Or13a19 APN 7 139,903,019 (GRCm39) missense possibly damaging 0.96
R0268:Or13a19 UTSW 7 139,903,068 (GRCm39) missense possibly damaging 0.63
R0612:Or13a19 UTSW 7 139,903,101 (GRCm39) missense possibly damaging 0.63
R0751:Or13a19 UTSW 7 139,903,238 (GRCm39) missense probably benign
R0801:Or13a19 UTSW 7 139,902,831 (GRCm39) missense probably damaging 1.00
R0940:Or13a19 UTSW 7 139,903,065 (GRCm39) missense probably benign 0.01
R2220:Or13a19 UTSW 7 139,903,484 (GRCm39) missense probably benign 0.03
R3748:Or13a19 UTSW 7 139,903,041 (GRCm39) missense possibly damaging 0.87
R4660:Or13a19 UTSW 7 139,903,325 (GRCm39) missense possibly damaging 0.67
R4683:Or13a19 UTSW 7 139,902,681 (GRCm39) missense probably benign 0.01
R4887:Or13a19 UTSW 7 139,903,014 (GRCm39) missense probably benign
R4919:Or13a19 UTSW 7 139,903,427 (GRCm39) nonsense probably null
R5097:Or13a19 UTSW 7 139,903,008 (GRCm39) missense probably damaging 1.00
R5836:Or13a19 UTSW 7 139,902,827 (GRCm39) missense probably benign
R7024:Or13a19 UTSW 7 139,902,759 (GRCm39) missense possibly damaging 0.75
R8242:Or13a19 UTSW 7 139,902,696 (GRCm39) nonsense probably null
R8390:Or13a19 UTSW 7 139,903,027 (GRCm39) missense possibly damaging 0.56
R8739:Or13a19 UTSW 7 139,902,647 (GRCm39) missense probably damaging 1.00
R8813:Or13a19 UTSW 7 139,902,793 (GRCm39) nonsense probably null
R8988:Or13a19 UTSW 7 139,902,938 (GRCm39) missense possibly damaging 0.87
R9044:Or13a19 UTSW 7 139,902,485 (GRCm39) splice site probably benign
R9176:Or13a19 UTSW 7 139,903,121 (GRCm39) missense probably damaging 1.00
R9626:Or13a19 UTSW 7 139,903,236 (GRCm39) missense probably benign 0.06
Predicted Primers PCR Primer
(F):5'- AGCATTGAGAAGCACTCCTACTC -3'
(R):5'- AAATGTGGCTGCTCTTACCC -3'

Sequencing Primer
(F):5'- TGAAATGATGGCTGCCTCAC -3'
(R):5'- GGCTGCTCTTACCCACCAAAC -3'
Posted On 2021-07-15