Mutagenetix > Incidental Mutation

Incidental Mutation 'R8876:Dnah2'

676587

Institutional Source

Beutler Lab

Gene Symbol

Dnah2

Ensembl Gene

ENSMUSG00000005237

Gene Name

dynein, axonemal, heavy chain 2

Synonyms

Dnahc2, Dnhd3, D330014H01Rik, 2900022L05Rik

MMRRC Submission

068688-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R8876 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

69420809-69549110 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 69491522 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 1254 (D1254G)

Ref Sequence

ENSEMBL: ENSMUSP00000104299 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000035539] [ENSMUST00000108659]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000035539
AA Change: D1254G

PolyPhen 2 Score 0.665 (Sensitivity: 0.86; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000047329
Gene: ENSMUSG00000005237
AA Change: D1254G

Domain	Start	End	E-Value	Type
low complexity region	4	25	N/A	INTRINSIC
Pfam:DHC_N1	273	429	6.6e-37	PFAM
Pfam:DHC_N1	432	761	1.3e-54	PFAM
Pfam:DHC_N2	1253	1668	3.4e-144	PFAM
AAA	1826	1962	2.95e-1	SMART
Pfam:AAA_5	2108	2251	1.3e-5	PFAM
AAA	2437	2584	3.63e-5	SMART
Pfam:AAA_8	2752	3022	1.1e-75	PFAM
Pfam:MT	3034	3370	8.7e-55	PFAM
Pfam:AAA_9	3386	3616	7.4e-68	PFAM
Pfam:Dynein_heavy	3748	4453	1.2e-220	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000108659
AA Change: D1254G

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000104299
Gene: ENSMUSG00000005237
AA Change: D1254G

Domain	Start	End	E-Value	Type
low complexity region	4	25	N/A	INTRINSIC
Pfam:DHC_N1	274	429	1.1e-47	PFAM
Pfam:DHC_N1	438	760	1.5e-75	PFAM
Pfam:DHC_N2	1255	1666	4.4e-144	PFAM
low complexity region	1711	1720	N/A	INTRINSIC
AAA	1832	1968	2.95e-1	SMART
Blast:AAA	2111	2251	2e-86	BLAST
AAA	2443	2590	3.63e-5	SMART
Pfam:AAA_8	2758	3028	5.5e-77	PFAM
Pfam:MT	3040	3376	7.6e-55	PFAM
Pfam:AAA_9	3396	3621	7.5e-94	PFAM
Pfam:Dynein_heavy	3759	4458	4.9e-264	PFAM

Meta Mutation Damage Score

0.0905

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.7%

Validation Efficiency

98% (55/56)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. The axonemal dyneins, found in cilia and flagella, are components of the outer and inner dynein arms attached to the peripheral microtubule doublets. DNAH2 is an axonemal inner arm dynein heavy chain (Chapelin et al., 1997 [PubMed 9256245]).[supplied by OMIM, Mar 2008]

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110004E09Rik	A	G	16: 90,927,393	I164T	possibly damaging	Het
Accs	A	C	2: 93,838,058	L356R	probably damaging	Het
Acvr1	A	T	2: 58,448,410	D433E	possibly damaging	Het
Aldh3b1	A	G	19: 3,921,502	L122P	probably damaging	Het
Ap3b1	T	G	13: 94,404,078	N169K	possibly damaging	Het
Apbb2	A	G	5: 66,451,657	S216P	probably benign	Het
Arap3	T	A	18: 37,997,024	H28L	possibly damaging	Het
Arhgap44	C	T	11: 65,008,070	M760I	possibly damaging	Het
Arhgef19	G	T	4: 141,247,882	A304S	probably benign	Het
Arntl2	G	A	6: 146,821,994	G274D	probably benign	Het
Atpaf1	T	C	4: 115,788,351	I139T	possibly damaging	Het
BC024139	G	T	15: 76,126,120	T62K	possibly damaging	Het
Capn5	T	C	7: 98,131,695	T292A	probably benign	Het
Card19	T	C	13: 49,205,338	N53S	possibly damaging	Het
Cep97	A	G	16: 55,922,104	V232A	possibly damaging	Het
Clca2	G	T	3: 145,071,599	T837K	probably benign	Het
Col8a2	G	C	4: 126,310,854	G219A	probably damaging	Het
Ctu2	T	C	8: 122,480,212	S365P		Het
Dscam	A	G	16: 96,619,628	L1686S	probably damaging	Het
Fgr	A	G	4: 132,998,760		probably benign	Het
Frmd4a	T	A	2: 4,601,300	S612T	probably damaging	Het
Gadd45gip1	T	C	8: 84,834,119	I121T	probably damaging	Het
Gapvd1	A	G	2: 34,678,548	V1353A	possibly damaging	Het
Gdf3	G	A	6: 122,606,983	P142S	probably damaging	Het
Gm19965	G	A	1: 116,822,046	G486R	unknown	Het
Gpatch2l	T	C	12: 86,261,631	L307P	probably damaging	Het
Grm3	T	C	5: 9,511,580	K757E	probably damaging	Het
Inppl1	T	A	7: 101,823,543	H1218L	possibly damaging	Het
Jag2	T	C	12: 112,909,637	I1055V	probably benign	Het
Krtap9-5	G	T	11: 99,949,514	C347F	unknown	Het
Magi2	T	A	5: 20,651,192	Y1050*	probably null	Het
Myrf	A	G	19: 10,229,014		probably benign	Het
Ntpcr	T	G	8: 125,738,046		probably benign	Het
Olfr1386	T	C	11: 49,470,559	M136T	probably damaging	Het
Olfr404-ps1	C	T	11: 74,240,020	T152I	probably damaging	Het
Olfr525	T	C	7: 140,322,803	Y35H	probably damaging	Het
Palmd	T	G	3: 116,927,250	D145A	probably damaging	Het
Pdcd1	A	G	1: 94,052,430	S21P	probably benign	Het
Pkn1	T	C	8: 83,672,250	T696A	possibly damaging	Het
Pnpt1	T	A	11: 29,146,769		probably benign	Het
Sbf2	T	A	7: 110,449,939	I273F	probably damaging	Het
Slc16a4	A	T	3: 107,300,785	N204Y	probably benign	Het
Slc38a1	T	C	15: 96,616,210	I44V	possibly damaging	Het
Smpdl3a	T	C	10: 57,809,070	V312A	probably damaging	Het
Ston1	A	G	17: 88,635,172	Y2C	probably benign	Het
Syde1	A	T	10: 78,589,491	Y229N	probably damaging	Het
Ttc37	T	G	13: 76,175,284	D1382E	probably benign	Het
Ttc6	T	A	12: 57,737,703	C1853S	possibly damaging	Het
Ttn	A	G	2: 76,778,905	I17650T	possibly damaging	Het
Upf1	T	C	8: 70,344,268	E105G	possibly damaging	Het
Wrn	A	G	8: 33,324,394	W341R	probably benign	Het
Xndc1	C	T	7: 102,080,547	P267L	probably benign	Het
Zbtb26	T	C	2: 37,436,884	T47A	probably benign	Het
Zc3h10	A	T	10: 128,544,294	V398E	probably damaging	Het
Zfp652	G	T	11: 95,749,095		probably benign	Het

Other mutations in Dnah2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00087:Dnah2	APN	11	69,492,672 (GRCm38)	missense	possibly damaging	0.93
IGL00418:Dnah2	APN	11	69,495,066 (GRCm38)	splice site	probably benign
IGL00772:Dnah2	APN	11	69,451,257 (GRCm38)	missense	probably damaging	0.97
IGL00819:Dnah2	APN	11	69,473,350 (GRCm38)	critical splice donor site	probably null
IGL00827:Dnah2	APN	11	69,448,457 (GRCm38)	missense	probably damaging	1.00
IGL01060:Dnah2	APN	11	69,478,092 (GRCm38)	missense	possibly damaging	0.86
IGL01340:Dnah2	APN	11	69,493,184 (GRCm38)	missense	probably damaging	0.99
IGL01349:Dnah2	APN	11	69,475,606 (GRCm38)	missense	probably damaging	0.99
IGL01413:Dnah2	APN	11	69,432,964 (GRCm38)	missense	probably damaging	0.99
IGL01451:Dnah2	APN	11	69,474,191 (GRCm38)	splice site	probably benign
IGL01480:Dnah2	APN	11	69,458,371 (GRCm38)	missense	possibly damaging	0.91
IGL01537:Dnah2	APN	11	69,516,080 (GRCm38)	missense	probably benign	0.17
IGL01592:Dnah2	APN	11	69,431,087 (GRCm38)	missense	probably benign	0.14
IGL01612:Dnah2	APN	11	69,465,063 (GRCm38)	splice site	probably benign
IGL01667:Dnah2	APN	11	69,544,395 (GRCm38)	missense	probably benign
IGL01667:Dnah2	APN	11	69,520,941 (GRCm38)	missense	probably damaging	0.98
IGL01691:Dnah2	APN	11	69,539,443 (GRCm38)	missense	probably benign
IGL02019:Dnah2	APN	11	69,474,285 (GRCm38)	missense	probably damaging	1.00
IGL02039:Dnah2	APN	11	69,499,212 (GRCm38)	missense	probably damaging	1.00
IGL02076:Dnah2	APN	11	69,422,559 (GRCm38)	missense	probably damaging	0.99
IGL02085:Dnah2	APN	11	69,458,185 (GRCm38)	missense	probably benign	0.07
IGL02158:Dnah2	APN	11	69,458,123 (GRCm38)	missense	probably benign
IGL02381:Dnah2	APN	11	69,446,292 (GRCm38)	missense	probably benign	0.25
IGL02681:Dnah2	APN	11	69,452,933 (GRCm38)	missense	probably benign	0.40
IGL02957:Dnah2	APN	11	69,448,507 (GRCm38)	missense	possibly damaging	0.96
IGL02961:Dnah2	APN	11	69,518,414 (GRCm38)	missense	probably damaging	1.00
IGL02969:Dnah2	APN	11	69,521,187 (GRCm38)	missense	possibly damaging	0.80
IGL03117:Dnah2	APN	11	69,436,291 (GRCm38)	splice site	probably benign
IGL03120:Dnah2	APN	11	69,421,848 (GRCm38)	missense	probably damaging	1.00
IGL03183:Dnah2	APN	11	69,458,488 (GRCm38)	missense	possibly damaging	0.94
IGL03197:Dnah2	APN	11	69,459,263 (GRCm38)	missense	probably damaging	1.00
IGL03263:Dnah2	APN	11	69,529,381 (GRCm38)	critical splice donor site	probably null
IGL03333:Dnah2	APN	11	69,495,123 (GRCm38)	missense	probably damaging	1.00
IGL03338:Dnah2	APN	11	69,496,577 (GRCm38)	missense	probably benign	0.13
argyrios	UTSW	11	69,516,590 (GRCm38)	missense	possibly damaging	0.47
Aureus	UTSW	11	69,429,348 (GRCm38)	missense	probably damaging	1.00
platinum	UTSW	11	69,458,042 (GRCm38)	missense	probably damaging	0.96
R0334_dnah2_144	UTSW	11	69,436,836 (GRCm38)	missense	probably damaging	1.00
R2150_dnah2_212	UTSW	11	69,515,761 (GRCm38)	missense	probably benign	0.14
BB005:Dnah2	UTSW	11	69,430,835 (GRCm38)	missense	probably damaging	0.98
BB015:Dnah2	UTSW	11	69,430,835 (GRCm38)	missense	probably damaging	0.98
E0370:Dnah2	UTSW	11	69,515,615 (GRCm38)	splice site	probably null
P0026:Dnah2	UTSW	11	69,464,947 (GRCm38)	missense	probably damaging	1.00
R0133:Dnah2	UTSW	11	69,421,009 (GRCm38)	missense	probably damaging	1.00
R0190:Dnah2	UTSW	11	69,435,249 (GRCm38)	missense	probably damaging	1.00
R0334:Dnah2	UTSW	11	69,436,836 (GRCm38)	missense	probably damaging	1.00
R0359:Dnah2	UTSW	11	69,529,531 (GRCm38)	missense	probably benign	0.00
R0386:Dnah2	UTSW	11	69,447,861 (GRCm38)	missense	probably damaging	1.00
R0414:Dnah2	UTSW	11	69,499,238 (GRCm38)	missense	probably benign	0.26
R0427:Dnah2	UTSW	11	69,452,879 (GRCm38)	missense	probably damaging	0.99
R0433:Dnah2	UTSW	11	69,459,288 (GRCm38)	missense	probably damaging	1.00
R0442:Dnah2	UTSW	11	69,448,542 (GRCm38)	missense	probably damaging	1.00
R0462:Dnah2	UTSW	11	69,459,201 (GRCm38)	missense	probably damaging	1.00
R0463:Dnah2	UTSW	11	69,423,126 (GRCm38)	missense	probably damaging	1.00
R0611:Dnah2	UTSW	11	69,499,194 (GRCm38)	missense	probably damaging	1.00
R0626:Dnah2	UTSW	11	69,477,683 (GRCm38)	missense	probably benign	0.07
R0924:Dnah2	UTSW	11	69,421,308 (GRCm38)	missense	probably damaging	1.00
R0968:Dnah2	UTSW	11	69,448,519 (GRCm38)	missense	possibly damaging	0.67
R1066:Dnah2	UTSW	11	69,447,819 (GRCm38)	missense	probably damaging	1.00
R1183:Dnah2	UTSW	11	69,446,648 (GRCm38)	missense	possibly damaging	0.95
R1184:Dnah2	UTSW	11	69,499,190 (GRCm38)	missense	probably damaging	1.00
R1186:Dnah2	UTSW	11	69,515,700 (GRCm38)	missense	probably damaging	0.99
R1453:Dnah2	UTSW	11	69,451,050 (GRCm38)	missense	probably damaging	0.99
R1498:Dnah2	UTSW	11	69,520,667 (GRCm38)	splice site	probably null
R1538:Dnah2	UTSW	11	69,477,202 (GRCm38)	missense	probably benign	0.17
R1574:Dnah2	UTSW	11	69,514,688 (GRCm38)	missense	probably benign	0.26
R1574:Dnah2	UTSW	11	69,514,688 (GRCm38)	missense	probably benign	0.26
R1590:Dnah2	UTSW	11	69,521,198 (GRCm38)	missense	probably benign	0.00
R1590:Dnah2	UTSW	11	69,422,754 (GRCm38)	critical splice donor site	probably null
R1655:Dnah2	UTSW	11	69,473,854 (GRCm38)	missense	probably damaging	1.00
R1695:Dnah2	UTSW	11	69,514,691 (GRCm38)	missense	possibly damaging	0.74
R1726:Dnah2	UTSW	11	69,497,889 (GRCm38)	missense	probably damaging	1.00
R1764:Dnah2	UTSW	11	69,423,543 (GRCm38)	missense	probably damaging	1.00
R1815:Dnah2	UTSW	11	69,475,574 (GRCm38)	missense	probably damaging	1.00
R1822:Dnah2	UTSW	11	69,514,804 (GRCm38)	missense	probably damaging	1.00
R1859:Dnah2	UTSW	11	69,437,886 (GRCm38)	missense	probably damaging	0.99
R1911:Dnah2	UTSW	11	69,515,752 (GRCm38)	missense	possibly damaging	0.64
R1913:Dnah2	UTSW	11	69,464,930 (GRCm38)	missense	probably damaging	1.00
R1981:Dnah2	UTSW	11	69,474,325 (GRCm38)	missense	probably damaging	1.00
R2010:Dnah2	UTSW	11	69,458,358 (GRCm38)	critical splice donor site	probably null
R2016:Dnah2	UTSW	11	69,437,070 (GRCm38)	missense	probably damaging	0.97
R2017:Dnah2	UTSW	11	69,437,070 (GRCm38)	missense	probably damaging	0.97
R2044:Dnah2	UTSW	11	69,524,240 (GRCm38)	missense	probably benign	0.14
R2077:Dnah2	UTSW	11	69,496,606 (GRCm38)	missense	possibly damaging	0.73
R2096:Dnah2	UTSW	11	69,455,916 (GRCm38)	missense	probably damaging	0.98
R2099:Dnah2	UTSW	11	69,493,237 (GRCm38)	missense	probably damaging	1.00
R2127:Dnah2	UTSW	11	69,458,185 (GRCm38)	missense	probably benign	0.02
R2128:Dnah2	UTSW	11	69,458,185 (GRCm38)	missense	probably benign	0.02
R2146:Dnah2	UTSW	11	69,515,761 (GRCm38)	missense	probably benign	0.14
R2147:Dnah2	UTSW	11	69,515,761 (GRCm38)	missense	probably benign	0.14
R2150:Dnah2	UTSW	11	69,515,761 (GRCm38)	missense	probably benign	0.14
R2404:Dnah2	UTSW	11	69,437,221 (GRCm38)	missense	probably damaging	0.99
R2510:Dnah2	UTSW	11	69,524,206 (GRCm38)	nonsense	probably null
R2517:Dnah2	UTSW	11	69,516,644 (GRCm38)	missense	probably damaging	1.00
R3014:Dnah2	UTSW	11	69,430,478 (GRCm38)	missense	probably benign
R3741:Dnah2	UTSW	11	69,448,469 (GRCm38)	missense	probably damaging	1.00
R3814:Dnah2	UTSW	11	69,492,650 (GRCm38)	splice site	probably null
R3872:Dnah2	UTSW	11	69,429,348 (GRCm38)	missense	probably damaging	1.00
R3873:Dnah2	UTSW	11	69,429,348 (GRCm38)	missense	probably damaging	1.00
R3874:Dnah2	UTSW	11	69,429,348 (GRCm38)	missense	probably damaging	1.00
R3875:Dnah2	UTSW	11	69,429,348 (GRCm38)	missense	probably damaging	1.00
R3881:Dnah2	UTSW	11	69,451,347 (GRCm38)	missense	possibly damaging	0.94
R3953:Dnah2	UTSW	11	69,454,103 (GRCm38)	missense	probably damaging	1.00
R3956:Dnah2	UTSW	11	69,484,021 (GRCm38)	missense	probably benign	0.00
R4501:Dnah2	UTSW	11	69,477,659 (GRCm38)	missense	probably benign
R4515:Dnah2	UTSW	11	69,465,631 (GRCm38)	missense	possibly damaging	0.61
R4612:Dnah2	UTSW	11	69,483,367 (GRCm38)	missense	possibly damaging	0.93
R4625:Dnah2	UTSW	11	69,463,661 (GRCm38)	missense	probably damaging	1.00
R4627:Dnah2	UTSW	11	69,465,376 (GRCm38)	missense	probably damaging	1.00
R4642:Dnah2	UTSW	11	69,496,559 (GRCm38)	missense	probably benign	0.00
R4683:Dnah2	UTSW	11	69,458,942 (GRCm38)	missense	probably damaging	1.00
R4698:Dnah2	UTSW	11	69,498,532 (GRCm38)	missense	probably damaging	1.00
R4710:Dnah2	UTSW	11	69,478,077 (GRCm38)	missense	probably damaging	1.00
R4712:Dnah2	UTSW	11	69,516,590 (GRCm38)	missense	possibly damaging	0.47
R4713:Dnah2	UTSW	11	69,476,688 (GRCm38)	missense	probably damaging	1.00
R4717:Dnah2	UTSW	11	69,429,357 (GRCm38)	missense	probably benign	0.00
R4740:Dnah2	UTSW	11	69,458,042 (GRCm38)	missense	probably damaging	0.96
R4780:Dnah2	UTSW	11	69,473,871 (GRCm38)	missense	probably damaging	0.97
R4825:Dnah2	UTSW	11	69,423,205 (GRCm38)	missense	probably damaging	1.00
R4864:Dnah2	UTSW	11	69,422,590 (GRCm38)	missense	probably damaging	0.98
R4868:Dnah2	UTSW	11	69,463,648 (GRCm38)	missense	probably damaging	1.00
R4879:Dnah2	UTSW	11	69,476,691 (GRCm38)	missense	probably damaging	1.00
R4908:Dnah2	UTSW	11	69,521,147 (GRCm38)	missense	probably benign	0.00
R4911:Dnah2	UTSW	11	69,499,104 (GRCm38)	critical splice donor site	probably null
R4954:Dnah2	UTSW	11	69,539,496 (GRCm38)	missense	possibly damaging	0.61
R4962:Dnah2	UTSW	11	69,455,973 (GRCm38)	nonsense	probably null
R5015:Dnah2	UTSW	11	69,497,882 (GRCm38)	missense	possibly damaging	0.89
R5049:Dnah2	UTSW	11	69,448,166 (GRCm38)	missense	probably damaging	1.00
R5055:Dnah2	UTSW	11	69,520,773 (GRCm38)	missense	possibly damaging	0.67
R5153:Dnah2	UTSW	11	69,520,933 (GRCm38)	missense	possibly damaging	0.84
R5155:Dnah2	UTSW	11	69,422,536 (GRCm38)	missense	probably damaging	1.00
R5186:Dnah2	UTSW	11	69,435,884 (GRCm38)	missense	probably damaging	1.00
R5187:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5208:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5252:Dnah2	UTSW	11	69,529,469 (GRCm38)	missense	probably damaging	0.98
R5296:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5298:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5299:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5301:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5324:Dnah2	UTSW	11	69,457,993 (GRCm38)	missense	probably benign	0.07
R5350:Dnah2	UTSW	11	69,516,036 (GRCm38)	missense	possibly damaging	0.48
R5377:Dnah2	UTSW	11	69,421,848 (GRCm38)	missense	probably damaging	1.00
R5393:Dnah2	UTSW	11	69,500,857 (GRCm38)	missense	probably benign
R5421:Dnah2	UTSW	11	69,435,636 (GRCm38)	missense	probably damaging	1.00
R5452:Dnah2	UTSW	11	69,524,383 (GRCm38)	missense	probably damaging	1.00
R5461:Dnah2	UTSW	11	69,473,351 (GRCm38)	critical splice donor site	probably null
R5474:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5476:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5477:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5510:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5527:Dnah2	UTSW	11	69,437,188 (GRCm38)	nonsense	probably null
R5566:Dnah2	UTSW	11	69,516,569 (GRCm38)	nonsense	probably null
R5587:Dnah2	UTSW	11	69,437,242 (GRCm38)	missense	probably damaging	1.00
R5628:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5688:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5690:Dnah2	UTSW	11	69,491,544 (GRCm38)	missense	probably benign	0.15
R5711:Dnah2	UTSW	11	69,435,390 (GRCm38)	missense	probably damaging	1.00
R5735:Dnah2	UTSW	11	69,430,817 (GRCm38)	missense	possibly damaging	0.93
R5826:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5913:Dnah2	UTSW	11	69,448,430 (GRCm38)	missense	probably damaging	1.00
R5914:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5960:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5961:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5961:Dnah2	UTSW	11	69,431,148 (GRCm38)	missense	probably damaging	1.00
R5977:Dnah2	UTSW	11	69,520,881 (GRCm38)	missense	possibly damaging	0.79
R6020:Dnah2	UTSW	11	69,500,839 (GRCm38)	missense	probably benign
R6036:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R6036:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R6050:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R6086:Dnah2	UTSW	11	69,516,008 (GRCm38)	missense	probably benign	0.30
R6115:Dnah2	UTSW	11	69,446,649 (GRCm38)	missense	probably damaging	1.00
R6123:Dnah2	UTSW	11	69,518,359 (GRCm38)	missense	probably benign	0.29
R6159:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R6159:Dnah2	UTSW	11	69,458,542 (GRCm38)	missense	probably damaging	1.00
R6163:Dnah2	UTSW	11	69,520,903 (GRCm38)	nonsense	probably null
R6171:Dnah2	UTSW	11	69,423,042 (GRCm38)	missense	probably damaging	1.00
R6263:Dnah2	UTSW	11	69,457,412 (GRCm38)	missense	probably damaging	1.00
R6298:Dnah2	UTSW	11	69,491,641 (GRCm38)	missense	probably benign	0.25
R6352:Dnah2	UTSW	11	69,448,227 (GRCm38)	missense	probably damaging	1.00
R6399:Dnah2	UTSW	11	69,458,518 (GRCm38)	missense	probably damaging	0.98
R6466:Dnah2	UTSW	11	69,539,415 (GRCm38)	missense	probably benign
R6478:Dnah2	UTSW	11	69,516,010 (GRCm38)	missense	probably benign	0.01
R6516:Dnah2	UTSW	11	69,465,386 (GRCm38)	missense	probably benign	0.34
R6538:Dnah2	UTSW	11	69,437,197 (GRCm38)	missense	possibly damaging	0.87
R6802:Dnah2	UTSW	11	69,423,690 (GRCm38)	missense	probably damaging	1.00
R6861:Dnah2	UTSW	11	69,455,963 (GRCm38)	missense	possibly damaging	0.64
R6869:Dnah2	UTSW	11	69,429,471 (GRCm38)	missense	probably damaging	1.00
R6894:Dnah2	UTSW	11	69,484,260 (GRCm38)	missense	probably benign	0.12
R6935:Dnah2	UTSW	11	69,421,741 (GRCm38)	missense	probably damaging	1.00
R7017:Dnah2	UTSW	11	69,491,547 (GRCm38)	nonsense	probably null
R7073:Dnah2	UTSW	11	69,430,492 (GRCm38)	nonsense	probably null
R7111:Dnah2	UTSW	11	69,446,753 (GRCm38)	splice site	probably null
R7125:Dnah2	UTSW	11	69,436,182 (GRCm38)	missense	probably damaging	0.99
R7137:Dnah2	UTSW	11	69,491,555 (GRCm38)	missense	probably damaging	1.00
R7190:Dnah2	UTSW	11	69,549,097 (GRCm38)	splice site	probably null
R7214:Dnah2	UTSW	11	69,431,109 (GRCm38)	missense	probably damaging	1.00
R7227:Dnah2	UTSW	11	69,421,396 (GRCm38)	missense	probably damaging	0.99
R7238:Dnah2	UTSW	11	69,459,146 (GRCm38)	critical splice donor site	probably null
R7256:Dnah2	UTSW	11	69,431,094 (GRCm38)	missense	probably damaging	1.00
R7267:Dnah2	UTSW	11	69,500,817 (GRCm38)	missense	probably damaging	1.00
R7420:Dnah2	UTSW	11	69,478,797 (GRCm38)	missense	possibly damaging	0.94
R7421:Dnah2	UTSW	11	69,492,805 (GRCm38)	missense	probably benign	0.25
R7437:Dnah2	UTSW	11	69,498,627 (GRCm38)	missense	probably damaging	1.00
R7461:Dnah2	UTSW	11	69,548,990 (GRCm38)	critical splice donor site	probably null
R7473:Dnah2	UTSW	11	69,491,658 (GRCm38)	missense	probably damaging	0.99
R7528:Dnah2	UTSW	11	69,500,796 (GRCm38)	missense	probably damaging	0.99
R7613:Dnah2	UTSW	11	69,548,990 (GRCm38)	critical splice donor site	probably null
R7615:Dnah2	UTSW	11	69,435,304 (GRCm38)	missense	probably damaging	0.99
R7626:Dnah2	UTSW	11	69,498,685 (GRCm38)	missense	probably damaging	0.99
R7745:Dnah2	UTSW	11	69,451,318 (GRCm38)	nonsense	probably null
R7764:Dnah2	UTSW	11	69,458,158 (GRCm38)	missense	probably benign	0.29
R7793:Dnah2	UTSW	11	69,495,214 (GRCm38)	missense	probably benign	0.00
R7819:Dnah2	UTSW	11	69,516,593 (GRCm38)	missense	probably benign	0.01
R7881:Dnah2	UTSW	11	69,431,238 (GRCm38)	missense	probably damaging	1.00
R7900:Dnah2	UTSW	11	69,518,428 (GRCm38)	missense	probably damaging	1.00
R7916:Dnah2	UTSW	11	69,421,148 (GRCm38)	critical splice acceptor site	probably null
R7921:Dnah2	UTSW	11	69,520,834 (GRCm38)	missense	probably benign
R7928:Dnah2	UTSW	11	69,430,835 (GRCm38)	missense	probably damaging	0.98
R7937:Dnah2	UTSW	11	69,517,685 (GRCm38)	nonsense	probably null
R7995:Dnah2	UTSW	11	69,520,737 (GRCm38)	missense	possibly damaging	0.77
R8202:Dnah2	UTSW	11	69,478,823 (GRCm38)	missense	probably benign	0.00
R8208:Dnah2	UTSW	11	69,520,852 (GRCm38)	missense	probably benign	0.05
R8215:Dnah2	UTSW	11	69,435,367 (GRCm38)	missense	probably damaging	1.00
R8279:Dnah2	UTSW	11	69,475,573 (GRCm38)	missense	probably damaging	1.00
R8338:Dnah2	UTSW	11	69,487,296 (GRCm38)	missense	probably damaging	1.00
R8348:Dnah2	UTSW	11	69,429,447 (GRCm38)	missense	possibly damaging	0.95
R8405:Dnah2	UTSW	11	69,458,463 (GRCm38)	missense	probably damaging	1.00
R8407:Dnah2	UTSW	11	69,459,278 (GRCm38)	missense	probably benign	0.00
R8493:Dnah2	UTSW	11	69,452,978 (GRCm38)	missense	probably damaging	1.00
R8673:Dnah2	UTSW	11	69,514,697 (GRCm38)	missense	probably benign	0.23
R8725:Dnah2	UTSW	11	69,524,179 (GRCm38)	missense	probably damaging	1.00
R8727:Dnah2	UTSW	11	69,524,179 (GRCm38)	missense	probably damaging	1.00
R8730:Dnah2	UTSW	11	69,493,261 (GRCm38)	missense	possibly damaging	0.73
R8804:Dnah2	UTSW	11	69,465,685 (GRCm38)	missense	probably benign	0.01
R8894:Dnah2	UTSW	11	69,492,222 (GRCm38)	missense	probably benign	0.01
R8938:Dnah2	UTSW	11	69,437,928 (GRCm38)	missense	probably damaging	0.99
R9044:Dnah2	UTSW	11	69,529,421 (GRCm38)	missense	probably benign
R9085:Dnah2	UTSW	11	69,429,398 (GRCm38)	missense	possibly damaging	0.69
R9110:Dnah2	UTSW	11	69,544,382 (GRCm38)	missense	probably benign
R9156:Dnah2	UTSW	11	69,422,861 (GRCm38)	missense
R9251:Dnah2	UTSW	11	69,515,793 (GRCm38)	missense	probably damaging	1.00
R9258:Dnah2	UTSW	11	69,477,253 (GRCm38)	missense	probably damaging	1.00
R9279:Dnah2	UTSW	11	69,518,278 (GRCm38)	missense	probably benign	0.01
R9318:Dnah2	UTSW	11	69,484,329 (GRCm38)	missense	probably benign	0.07
R9321:Dnah2	UTSW	11	69,448,113 (GRCm38)	critical splice donor site	probably null
R9350:Dnah2	UTSW	11	69,493,247 (GRCm38)	missense	probably benign	0.10
R9358:Dnah2	UTSW	11	69,515,766 (GRCm38)	missense	probably damaging	0.99
R9417:Dnah2	UTSW	11	69,436,164 (GRCm38)	missense	probably damaging	1.00
R9420:Dnah2	UTSW	11	69,478,116 (GRCm38)	missense	probably benign	0.09
R9438:Dnah2	UTSW	11	69,473,394 (GRCm38)	missense	probably damaging	1.00
R9469:Dnah2	UTSW	11	69,431,070 (GRCm38)	missense	probably damaging	1.00
R9487:Dnah2	UTSW	11	69,515,791 (GRCm38)	missense	possibly damaging	0.47
R9495:Dnah2	UTSW	11	69,454,382 (GRCm38)	missense	possibly damaging	0.89
R9579:Dnah2	UTSW	11	69,477,215 (GRCm38)	missense	probably damaging	1.00
R9608:Dnah2	UTSW	11	69,454,062 (GRCm38)	missense	probably null	1.00
R9651:Dnah2	UTSW	11	69,450,998 (GRCm38)	critical splice donor site	probably null
R9662:Dnah2	UTSW	11	69,452,937 (GRCm38)	missense	probably benign
RF004:Dnah2	UTSW	11	69,437,187 (GRCm38)	missense	probably benign	0.24
U24488:Dnah2	UTSW	11	69,483,822 (GRCm38)	missense	probably damaging	0.99
X0021:Dnah2	UTSW	11	69,448,562 (GRCm38)	missense	possibly damaging	0.81
Z1088:Dnah2	UTSW	11	69,430,793 (GRCm38)	missense	probably damaging	1.00
Z1176:Dnah2	UTSW	11	69,421,821 (GRCm38)	missense	possibly damaging	0.46
Z1176:Dnah2	UTSW	11	69,516,523 (GRCm38)	missense	probably damaging	1.00
Z1176:Dnah2	UTSW	11	69,516,481 (GRCm38)	missense	probably damaging	1.00
Z1176:Dnah2	UTSW	11	69,498,667 (GRCm38)	missense	probably benign	0.12
Z1176:Dnah2	UTSW	11	69,487,054 (GRCm38)	missense	possibly damaging	0.46
Z1176:Dnah2	UTSW	11	69,451,120 (GRCm38)	missense	probably benign
Z1177:Dnah2	UTSW	11	69,544,557 (GRCm38)	critical splice acceptor site	probably null
Z1177:Dnah2	UTSW	11	69,463,453 (GRCm38)	missense	possibly damaging	0.63

Predicted Primers

PCR Primer
(F):5'- TACCCAGTGATCTCAGCTACC -3'
(R):5'- TGTGTCTGAGCCACACCTTG -3'

Sequencing Primer
(F):5'- AGTTTAAAGCCAGCCTGGTC -3'
(R):5'- ACACCTTGGCTTCCTGCAGG -3'

Posted On

2021-07-15